Computational imaging spectrometers using broad-bandpass filter arrays with distinct transmission functions are promising implementations of miniaturization. The number of filters is limited by the practical factors. Compressed sensing is used to model the system as linear underdetermined equations for hyperspectral imaging.
View Article and Find Full Text PDFJ Transl Med
August 2025
The immune microenvironment plays a critical role in pathogenesis and treatment response of cervical cancer. This review comprehensively examines the cellular and molecular components of the tumor immune microenvironment (TIME) in cervical cancer, encompassing patterns of immune cell infiltration (T cells, B cells, NK cells, DCs, TAMs), immune checkpoint molecules, and cytokine/chemokine networks. We emphasize recent advances in understanding TIME heterogeneity, enabled by high-resolution spatial mapping and single-cell sequencing technologies, focusing specifically on differences across disease stages and treatment approaches.
View Article and Find Full Text PDFCorrection for 'Phosphorus core-shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters' by Mengsi Zhan , , 2023, , 7387-7396.
View Article and Find Full Text PDFThe application of sulfate-reducing bacteria (SRB) for stabilizing heavy metals in chelator-washed soils is critical for enabling agricultural reuse, yet its impact on plant uptake of heavy metals remains understudied. In this study, a pot experiment was conducted to examine the effects of SRB-which include Shewanella JN01 (S), Clostridium ZG01 (C), and a mixture of the two strains (M)-on stabilization of heavy metal-chelant complexes and the uptake of heavy metals (Cd, Pb, Cu, and Zn) by Chinese cabbage. The results revealed that all SRB treatments significantly reduced available Pb, Cu, and Zn by 8.
View Article and Find Full Text PDFAims: Metabolic dysfunction associated steatotic liver disease (MASLD) is a universal hepatic disease, and many recent randomized clinical trials (RCTs) have explored whether hypoglycemic agents may be beneficial for its treatment. This study aimed to assess the relative effectiveness of each hypoglycemic agent for MASLD.
Methods: China National Knowledge Infrastructure(CNKI), WanFang, Weipu, PubMed, Embase, The Cochrane Library, and Web of Science Core Collection were searched for RCTs on the efficacy of hypoglycemic agents in MASLD published up to December 31, 2024.
Macromol Biosci
June 2025
The rapid development of nanotechnology enables wide exploration of biomimetic nanoplatforms, which can combine traditional nanoparticles and bio-derived materials to have a better performance. Exosomes work as a messenger between cells and specific biomarkers and are also involved in the developmental process of diseases. Dendrimers with high physical stability and unique structure are always used as carriers for drugs or genes, thereby realizing enhanced delivery and precise theranostics.
View Article and Find Full Text PDFThere are challenges involved in the synergistic dissipation of antibiotics and antibiotic resistance genes (ARGs) in soil because ARGs are affected by not only the selective pressure of antibiotics but also microbial community succession and co-existing pollutants. Here, magnetic biochars (MBCs) at various magnetic iron-to-biochar mass ratios (3:1, 2:1, 1:1, 1:2, 1:3, 1:5, and 1:7) were synthesized to develop a strategy for the synergistic dissipation of oxytetracycline (OTC) and its resistance gene (tet) in soils with and without polybutylene adipate terephthalate (PBAT) microplastics (MPs). The results showed that MBC12 (1:2) achieved the greatest dissipation efficiencies of OTC in soils without and with PBAT MPs (95.
View Article and Find Full Text PDFJ Colloid Interface Sci
May 2025
The facile development of advanced formulations capable of scavenging excess reactive oxygen species (ROS) and sustainably inhibiting inflammatory cytokine secretion is imminent for effective treatment of acute lung injury (ALI), but still remains a great challenge. This study presents an innovative core-shell carrier system via electrospray technology, characterized by a shell of poly(lactic acid-co-glycolic acid) (PLGA) and a core consisting of polycaprolactone-polyethylene glycol (PCL-PEG) micelles encapsulating resveratrol (Res), and surface modified with fibronectin (FN). The created drug-loaded core-shell microspheres (for short, RPG@FN) with a size of 1.
View Article and Find Full Text PDFHow plastics coupled with metals regulate microbial functions-diversity relationships remain unknown in plateau soil environment. Three representative catchments in the Qinghai-Tibet Plateau, focusing on microplastics, their plasticisers, and metals in soils, were investigated. This research explores responses of bacterial diversity and functions to the co-existence of target pollutants, and pathways by which target pollutants regulate the diversity.
View Article and Find Full Text PDFBackground: Ischemic stroke, accounting for 85% of stroke cases, leads to severe disabilities and increased mortality. Its global incidence rose by 87.55% from 1990 to 2019, posing significant health and economic burdens.
View Article and Find Full Text PDFThe biodegradable (polybutylene adipate terephthalate: PBAT) and conventional (polyethylene: PE) microplastics (MPs) at 0.5 %, 1 %, and 2 % dosages (w/w) were added into soils with and without Serratia marcescens ZY01 (ZY01, a tet-host strain) to understand their different effects on the dissipation of oxytetracycline (OTC) and tet. The results showed that the dosages of PBAT MP exhibited different inhibition degrees of OTC biodegradation in soils regardless of ZY01, while the dosages of PE MP did not change the enhancement degree of OTC biodegradation in soils without ZY01.
View Article and Find Full Text PDFDiabetic macroangiopathy is a leading cause of diabetes-related mortality worldwide. Both genetic and environmental factors, through a multitude of underlying molecular mechanisms, contribute to the pathogenesis of diabetic macroangiopathy. MicroRNAs (miRNAs), a class of non-coding RNAs known for their functional diversity and expression specificity, are increasingly recognized for their roles in the initiation and progression of diabetes and diabetic macroangiopathy.
View Article and Find Full Text PDFExploration of establishing a robust intergovernmental benefit compensation mechanism for water source areas holds significant importance in promoting regional coordinated development. Taking the Guanting Reservoir basin, a water source area in Beijing, China, as an example, we established an ecological location model with urban water sources as the core by drawing on the concept of spatial circle structure in traditional location theory. Based on this, we proposed the theory of ecological cost of water source land level difference and analyzed the basic composition of ecological cost of water source land.
View Article and Find Full Text PDFJ Colloid Interface Sci
November 2024
Traditional oxide electrocatalytic materials encounter significant challenges associated with sluggish reaction kinetics and formidable energy barriers for NH intermediates formation in electrocatalytic nitrogen fixation. The implementation of phase control emerges as an effective strategy to address these challenges. Herein, leveraging the energy localization of laser, this work achieved precise phase control of TiO.
View Article and Find Full Text PDFSci Total Environ
September 2024
Integrated health risk assessment strategies for emerging organic pollutants and heavy metals that coexist in water/soil media are lacking. Contents of perfluoroalkyl compounds and potentially toxic elements in multiple media were determined by investigating a county where a landfill and a tungsten mine coexist. The spatial characteristics and sources of contaminants were predicted by Geostatistics-based and multivariate statistical analysis, and their comprehensive health risks were assessed.
View Article and Find Full Text PDFObjective: To explore the application effect of the direct reporting system of adverse nursing events and special continuous nursing quality improvement measures in the management of these adverse events.
Methods: The implementation time of continuous nursing improvement based on the direct reporting system was the demarcation point. We retrospectively collected and analyzed nursing adverse event reports and hospitalization data from Xiangtan Central Hospital before implementation (2015-2018) and after implementation (2019-2022).
Due to the lack of research on the co-effects of microplastics and trace metals in the environment on nitrogen cycling-related functional microorganisms, the occurrence of microplastics and one of their plasticisers, phthalate esters, as well as trace metals, were determined in soils and river sediments in the Qinghai-Tibet Plateau. Relationship between microplastics and phthalate esters in the area was determined; the co-effects of these potentially toxic materials, and key factors and pathways affecting nitrogen functions were further explored. Significant correlations between fibre- and film-shaped microplastics and phthalate esters were detected in the soils from the plateau.
View Article and Find Full Text PDFPurpose: Quality follow-up (FU) is crucial after bariatric surgery. However, poor adherence after surgery is prevalent. This research aimed to explore the factors related to FU adherence after bariatric surgery in West China.
View Article and Find Full Text PDFDeveloping effective nanomedicines to cross the blood-brain barrier (BBB) for efficient glioma theranostics is still considered to be a challenging task. Here, we describe the development of macrophage membrane (MM)-coated nanoclusters (NCs) of ultrasmall iron oxide nanoparticles (USIO NPs) with dual pH- and reactive oxygen species (ROS)-responsivenesses for magnetic resonance (MR) imaging and chemotherapy/chemodynamic therapy (CDT) of orthotopic glioma. Surface citrate-stabilized USIO NPs were solvothermally synthesized, sequentially modified with ethylenediamine and phenylboronic acid, and cross-linked with gossypol to form gossypol-USIO NCs (G-USIO NCs), which were further coated with MMs.
View Article and Find Full Text PDFGlioma, as a disease of the central nervous system, is difficult to be treated due to the presence of the blood-brain barrier (BBB) that can severely hamper the efficacy of most therapeutic agents. Hence, drug delivery to glioma in an efficient, safe, and specifically targeted manner is the key to effective treatment of glioma. With the advances in nanotechnology, targeted drug delivery systems have been extensively explored to deliver chemotherapeutic agents, nucleic acids, and contrast agents.
View Article and Find Full Text PDFHerbicide abuse has a significantly negative impact on soil microflora and further influences the ecological benefit. The regulating measures and corresponding mechanisms mitigating the decreased bacterial diversity due to herbicide use have rarely been studied. A field experiment containing the application gradient of an efficient maize herbicide thiencarbazone-methyl·isoxaflutole was performed.
View Article and Find Full Text PDFBackground: Ovarian endometriomas, resulting from the invasion of endometriosis into ovarian tissue, can significantly affect ovarian reserve, potentially leading to infertility. When conservative treatments fail, it may further aggravate ovarian reserve decline by invading the ovarian cortex and, in severe cases, result in premature ovarian failure and infertility.
Objective: This study aimed to investigate the impact of various hemostasis methods on ovarian reserve function in cases of laparoscopic cystectomy for ovarian endometriomas.