Article Synopsis
- Diabetic macroangiopathy is a major cause of diabetes-related deaths globally, influenced by both genetic and environmental factors.
- MicroRNAs (miRNAs) play significant roles in the development and progression of diabetes and its complications, highlighting their potential as targets for research and treatment.
- This review focuses on the formation and functions of miRNAs in conditions like atherosclerosis and heart disease, aiming to enhance understanding and innovation in diagnosing and treating diabetic macroangiopathy.
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Article Abstract
Diabetic macroangiopathy is a leading cause of diabetes-related mortality worldwide. Both genetic and environmental factors, through a multitude of underlying molecular mechanisms, contribute to the pathogenesis of diabetic macroangiopathy. MicroRNAs (miRNAs), a class of non-coding RNAs known for their functional diversity and expression specificity, are increasingly recognized for their roles in the initiation and progression of diabetes and diabetic macroangiopathy. In this review, we will describe the biogenesis of miRNAs, and summarize their functions in diabetic macroangiopathy, including atherosclerosis, peripheral artery disease, coronary artery disease, and cerebrovascular disease, which are anticipated to provide new insights into future perspectives of miRNAs in basic, translational and clinical research, ultimately advancing the diagnosis, prevention, and treatment of diabetic macroangiopathy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406791 | PMC |
| http://dx.doi.org/10.1186/s12933-024-02405-w | DOI Listing |
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