Spin-regulated Fe-N-C catalyst enabled by adjusting coordination nitrogen species for robust oxygen reduction.

Fe-N-C catalysts have emerged as a promising substitute for the expensive Pt/C to boost the oxygen reduction reaction (ORR). However, conventional Fe-N active sites, which generally feature a low-spin configuration, strongly adsorb oxygen intermediates and necessitate structural optimization of the active sites for improved performance. Herein, graphitic nitrogen (N) adjacent to the Fe-N centers is straightforwardly introduced to modulate the spin state of Fe-N-C catalysts after elucidating the influence of nitrogen species on the Fe-N sites.

Prior identification method of safety performance boundary for autonomous vehicles based on Safety Threat Field.

Objective: Identifying the safety performance boundary (SPB) of autonomous vehicles (AVs) is crucial for verifying the coverage of scenario-based tests for AVs. Researchers proposed posteriori methods based on collected crash scenarios that demonstrated promising advancements in identifying the SPB. Nevertheless, the search for crash scenarios is often rendered complex and time-consuming due to the "curse of dimensionality and rarity.

Discovery of Novel TYRO3/MERTK Dual Inhibitors.

The TAM (TYRO3, AXL, MERTK) family of receptor tyrosine kinases has roles in oncogenesis and innate immunity, but the relative importance of the family members can differ in different contexts and between tumor types or individual tumors. Dual TYRO3 and MERTK inhibition may be advantageous for treatment of diseases or in tumors that are dependent on their coordinated action. Here, we report the discovery of the first potent dual TYRO3/MERTK inhibitor, UNC9435 ().

UNC9426, a Potent and Orally Bioavailable TYRO3-Specific Inhibitor.

TYRO3 plays a critical role in platelet aggregation as a platelet response amplifier. Selective inhibition of TYRO3 may provide therapeutic benefits for treating thrombosis and related diseases without increasing bleeding risk. We employed a structure-based approach and discovered a novel and potent TYRO3 inhibitor UNC9426 () with an excellent Ambit selectivity score ( (1.

Comprehensive analysis reveals the tumor suppressor role of macrophage signature gene FCER1G in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) progression is closely linked to the role of macrophages. This study utilized single-cell RNA sequencing and genomic analysis to explore the characteristic genes of macrophages in HCC and their impact on patient prognosis. We obtained single-cell se-quencing data from seven HCC samples in the GEO database.

An Investigation of the Influence of Paste's Rheological Characteristics on the Tensile Creep of HVFAC at Early Ages.

The rheological properties of concrete paste significantly influence its tensile creep behavior. In this study, the tensile creep behavior of high-volume fly ash concrete (HVFAC) employing the same cementitious pastes was experimentally investigated, and the rheological properties of the paste containing a high volume of fly ash using the (NI) technique was investigated in order to explore the influence of the paste's rheological properties (such as micro-mechanical properties and microscopic creep) on the early-age tensile creep of HVFAC. The results demonstrated that the micro-strain of paste containing a high volume of fly ash (HVFA) showed a larger value than that without fly ash.

Discovery of Thiochroman Derivatives as Potent, Oral Selective Estrogen Receptor Degraders and Antagonists for the Treatment of Endocrine-Resistant Breast Cancer.

Selective estrogen receptor degraders (SERDs) deplete the ER signaling pathway via antagonism and degradation of ERα and represent a promising strategy to tackle endocrine resistance. Here, we report a new class of SERDs by pharmacological evolution of a selective estrogen receptor modulator, lasofoxifene. The structure-activity relationship study and efforts to circumvent the issue of human ether-a-go-go-related gene led to the identification of compounds .

2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity.

c-di-GAMP was first identified in bacteria to promote colonization, while mammalian 2'3'-cGAMP is synthesized by cGAS to activate STING for innate immune stimulation. However, 2'3'-cGAMP function beyond innate immunity remains elusive. Here, we report that 2'3'-cGAMP promotes cell migration independent of innate immunity.

How did the floating Ulva prolifera develop into the world's largest green tide?

It has been 16 years since the world's largest Ulva bloom appeared in the Yellow Sea. However, it remains unclear how the floating Ulva prolifera developed into the immense green tide within two months especially considering that source control measures have been conducted since 2019. In this study, we investigated the growth mechanism of the floating population by examining the production and regeneration of U.

[Multidimensional supportive psychological intervention in clinical practice teaching of andrological nursing].

Objective: To examine the application of a novel pedagogical approach multidimensional supportive psychological intervention (MSPI) in the clinical practice teaching of andrological nursing care.

Methods: Using the Hamilton Depression Scale (HAMD), we assessed the psychology of 100 nursing interns about to enter clinical practice in the Department of Andrology from December 2021 to December 2022. We equally randomized the subjects into an experimental and a control group, the former receiving MSPI and the latter trained on the conventional teaching model without any psychological support intervention.

Why did the world's largest green tides occur exclusively in the southern Yellow Sea?

The world's largest green tide, caused by the nuisance green algae Ulva prolifera, has occurred in the southern Yellow Sea for 16 consecutive years. It is puzzling why the extensive floating green tide occurs exclusively in the southern Yellow Sea, rather than other waters. We speculate that the transition of U.

Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors.

MERTK and AXL are members of the TAM (TYRO3, AXL, MERTK) family of receptor tyrosine kinases that are aberrantly expressed and have been implicated as therapeutic targets in a wide variety of human tumors. Dual MERTK and AXL inhibition could provide antitumor action mediated by both direct tumor cell killing and modulation of the innate immune response in some tumors such as nonsmall cell lung cancer. We utilized our knowledge of MERTK inhibitors and a structure-based drug design approach to discover a novel class of macrocyclic dual MERTK/AXL inhibitors.

Experimental Study on Measuring and Tracking Structural Displacement Based on Surveillance Video Image Analysis.

The digital image method of monitoring structural displacement is receiving more attention today, especially in non-contact structure health monitoring. Some obvious advantages of this method, such as economy and convenience, were shown while it was used to monitor the deformation of the bridge structure during the service period. The image processing technology was used to extract structural deformation feature information from surveillance video images containing structural displacement in order to realize a new non-contact online monitoring method in this paper.

Exploring the importance of m5c in the diagnosis and subtype classification of COPD using the GEO database.

Background: 5-Methylcytosine (m5C) is an mRNA modifier that is associated with the occurrence and development of viral infection, pulmonary fibrosis, lung cancer, and other diseases. However, the role of m5C regulators in chronic obstructive pulmonary disease (COPD) remains unknown.

Methods: In this study, by analysing the GSE42057 dataset, the differential expression of m5c regulators in the COPD group and control group was obtained, and a correlation analysis was conducted.

Effects of Three-Dimensional Graphene-Carbon Nanotube Hybrid on the Mechanical Properties and Microstructure of Cement Paste.

This work experimentally studies the mechanical properties and microstructure of cementitious composites reinforced with a three-dimensional graphene-carbon nanotube (CNT) hybrid. Firstly, the graphene-CNT (GC) hybrid is dispersed in cement pastes using ultrasonication and surfactant, and then, the effect of the GC hybrid on the early hydration of the cement pastes is investigated. The experimental results show that adding the GC hybrid shortens the setting stage of cement hydration and accelerates the early hydration process.

In Situ Encapsulation of Graphene Quantum Dots in Highly Stable Porphyrin Metal-Organic Frameworks for Efficient Photocatalytic CO Reduction.

Photocatalytic CO reduction to valuable hydrocarbon solar fuel is of great significance but still challenging. Strong CO enrichment ability and easily adjustable structures make metal-organic frameworks (MOFs) potential photocatalysts for CO conversion. Even though pure MOFs have the potential for photoreduction of CO, the efficiency is still quite low due to rapid photogenerated electron-hole recombination and other drawbacks.

The Influence of Fly Ash on the Tensile Creep Prediction of High-Strength Concrete at Early Ages.

In this study, the tensile creep (TC) of high-strength concrete (HSC) containing 30 wt% fly ash was measured at early ages to investigate the applicability of creep prediction models for concrete containing FA, and to provide ideas to study the prediction model of concrete creep containing other SCMs in the future. The TC values obtained from the experiment were compared with the predicted values of six TC models. Then the accuracy of different models was evaluated by the ratio of predicted values to experimental values.

Testing and Analysis Method of Low Remanence Materials for Magnetic Shielding Device.

Magnetic shielding devices with a grid structure of multiple layers of highly magnetically permeable materials (such as permalloy) can achieve remanent magnetic fields at the nanotesla (nT) level or even lower. The remanence of the material inside the magnetic shield, such as the building materials used in the support structure, can cause serious damage to the internal remanence of the magnetic shield. Therefore, it is of great significance to detect the remanence of the materials used inside the magnetic shielding device.

AtomNet-Aided OTUD7B Inhibitor Discovery and Validation.

Protein deubiquitinases play critical pathophysiological roles in cancer. Among all deubiquitinases, an oncogenic function for OTUD7B has been established in genetic NSCLC murine models. However, few deubiquitinase inhibitors have been developed due to technical challenges.

Downregulated mitochondrial transcription factor A enhances mycoplasma infection to promote the metastasis of hepatocellular carcinoma.

Mycoplasma is widespread in various hosts and may cause various diseases in animals. Interestingly, the occurrence of mycoplasma infection was observed in many tumor types. However, the mechanism regulating its infection is far from clear.

Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis.

Background: The potential role of circFNDC3B in regulating oral tongue squamous cell carcinoma development (OTSCC) remains unknown.

Methods: The level of circFNDC3B in OTSCC tissues or cell lines was measured and its function in vitro and in vivo was analyzed. Interactions among circFNDC3B, miR-1322, and MED1 were verified by luciferase reporter and RNA pull-down assays.

Discovery of Thieno[2,3-]indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability.

Endocrine therapies in the treatment of early and metastatic estrogen receptor α positive (ERα+) breast cancer (BC) are greatly limited by and acquired resistance. Selective estrogen receptor degraders (SERDs) like fulvestrant provide new strategies for endocrine therapy combinations due to unique mechanisms. Herein, we disclose our structure-based optimization of LSZ102 by replacing 6-hydroxybenzothiophene with 6-thieno[2,3-]indazole.