Performance of digital breast tomosynthesis with digital mammography for detecting breast cancer in the diagnostic setting: a meta-analysis.

To systematically determine the diagnostic accuracy of digital breast tomosynthesis (DBT) in combination with digital mammography (DM) compared with DM alone for breast cancer. We searched multiple English and Chinese databases from January 2010 to October 2023. Eligible diagnostic studies comparing DBT/DM with DM alone for breast cancer in women were included.

Immunological biomarkers and gene signatures predictive of radiotherapy resistance in non-small cell lung cancer.

Introduction: A significant challenge in treating non-small cell lung cancer (NSCLC) is its inherent resistance to radiation therapy, leading to poor patient prognosis. This study aimed to identify key genes influencing radiotherapy resistance in NSCLC through comprehensive bioinformatics analysis.

Methods: A total of 103 common genes were identified, enriched in critical biological pathways such as coagulation, complement activation, growth factor activity, and cytokine signaling.

Synthesis of noble metal nanoarrays via agglomeration and metallurgy for acidic water electrolysis.

Noble metal electrocatalysts remain the mainstay for proton exchange membrane water electrolysis, majorly due to their exceptional activity and durability in acidic media. However, conventional powder and particle catalysts intensively suffer from aggregation, shedding and poor electron conductivity in practical applications. Here, we develop a micellar brush-guided method to agglomerate and smelt metal nanoparticles into erect nanoarrays with designable constitutions on various substrates.

Discovery and evaluation of a novel selective fluorescent substrate for CYP3A4 based on sulfoxidation characteristics.

This study for the first time reports the design and application of a novel type of selective fluorescent substrate NESF for cytochrome P450 3A4 (CYP3A4) based on sulfoxidation reaction. NESF has been successfully applied for imaging endogenous CYP3A4 in living cells and for high-throughput screening of CYP3A4 inhibitors.

Supramolecular Polyanions as Effective Interphase Layers for Anode-Free Lithium Metal Batteries.

Supramolecular polymers (SPs) driven by host-guest interactions have seen considerable advancements over the past decade, but the guest species involved are predominantly neutral molecules or cations. Strong and dependable macrocycle-anion interactions for supramolecular polymerization are highly sought after, yet the functionalities of this class of SPs featuring negatively charged backbones remain largely unexplored. Here, we report a novel host-guest interaction between one tetraurea macrocycle and two organophosphate anions with high affinity (association constant K = 1.

Preoperative hemoglobin predicts clinical outcomes after percutaneous coronary intervention.

Background: Concurrent anemia is associated with an increased risk of major adverse cardiac events (MACE) in patients with myocardial infarction. The study aimed to assess the value of anemia and preoperative hemoglobin levels in predicting clinical outcomes in stable coronary artery disease (SCAD) patients receiving percutaneous coronary intervention (PCI).

Methods: This is a secondary analysis based on a retrospective cohort study in which 204 patients with SCAD who received PCI were recruited.

Multifunctional Alternating Copolymer Nanoflower Iodine Hosts for Long-Term Zinc-Iodine Batteries.

Aqueous Zn-iodine (Zn-I) batteries are considered to be potential energy storage systems due to their safety, environmental friendliness, and cost-effectiveness. However, the shuttle effect of polyiodide leads to cathode active mass loss and anode Zn corrosion, which greatly reduces the cycle life of Zn-I batteries. Herein, we report an N-modified alternating copolymer nanoflower composite (NH-NFs-PDA) as a new type of iodine host candidate to effectively inhibit the polyiodide shuttle effect in Zn-I battery.

Microplastics enhance laccase-driven bisphenol A removal in multipollutant wastewater.

Bisphenol A (BPA) is recognized as a significant constituent of environmental pollutants and could be efficiently removed from wastewater by laccase (Lac). Microplastics (MPs) was found to be present in wastewater contained BPA. This work was to realize BPA removal from wastewater in the presence of MPs by Lac and to reveal the possible mechanism for MPs enhancing Lac-driven BPA removal.

Supermolecular poly-N-acryloyl glycinamide/polyglutamic acid/Fe hydrogel incorporated with bioactive small extracellular vesicles promote diabetic wound healing by suppressing ferroptosis.

Poorly-controlled blood glucose frequently develop in diabetic wounds and hydrogel has been reported of great performance for diabetic wound healing. Consequently, we prepared poly-N-acryloyl glycinamide (PNAGA) and introduced polyglutamic acid (γ-PGA), Fe, small extracellular vesicles (sEVs) into PNAGA to form a dual physical cross-linking supramolecular hydrogel system (PFF) for diabetic wound healing. In this study, we successfully synthesized the PFF hydrogel and extracted the sEVs that were incorporated into PPF as PPF/sEVs.

Hippocampus- and neocortex-specific deletion of Aeg-1 causes learning memory impairment and depression in mice.

Astrocyte elevated gene-1 (AEG-1) has been characterized as an oncogene promoting the progression of various tumors. The role of AEG-1 in neurological diseases was highlighted by recent researches. However, the physiological function of AEG-1 remains elusive.

A molecular dynamics simulation study on hydrocarbon ladder polymer membranes for gas separation.

To address global environmental challenges and support the transition of energy systems, the study of CO capture and separation is at the forefront of scientific research. Utilizing membranes based on polymers of intrinsic microporosity (PIMs) for CO separation presents a promising approach. However, the mechanisms of CO separation in PIMs are not fully understood.

Aminated lignin improved enzymatic hydrolysis of cellulosic substrate treated by p-toluenesulfonic acid.

Lignin can affect the enzymatic hydrolysis efficiency of lignocellulose. In this study, the lignin isolated from sugarcane bagasse (SCB) pretreated with p-toluenesulfonic acid (PL) was firstly aminated, and then the effects of PL and aminated PL (APL) on the bagasse enzymatic hydrolysis efficiency (EHE) were investigated. The results showed that the addition of PL and APL promoted the EHE, and EHE with APL (73.

Ultrasmall Nanodots with Dual Anti-Ferropototic Effect for Acute Kidney Injury Therapy.

Ferroptosis is known to mediate the pathogenesis of chemotherapeutic drug-induced acute kidney injury (AKI); however, leveraging the benefits of ferroptosis-based treatments for nephroprotection remains challenging. Here, ultrasmall nanodots, denoted as FerroD, comprising the amphiphilic conjugate (tetraphenylethylene--serine-deferoxamine, TPE-lys-Ser-DFO (TSD)) and entrapped ferrostatin-1 are designed. After being internalized through kidney injury molecule-1-mediated endocytosis, FerroD can simultaneously remove the overloaded iron ions and eliminate the overproduction of lipid peroxides by the coordination-disassembly mechanisms, which collectively confer prominent inhibition efficiency of ferroptosis.

MgAl-LDH nanoflowers as a novel sensing material for high-performance humidity sensing.

This work details a novel application of MgAl-LDH nanoflowers, applied in the fabrication of humidity sensors using quartz crystal microbalance (QCM). An oscillating circuit approach has been utilized to thoroughly investigate the humidity detection characteristics of QCM sensors that are fabricated using MgAl-LDH nanoflowers. The examination encompassed various parameters such as the sensors' response, humidity hysteresis, repeatability, and stability.

Coassembly Nanomedicine Mediated by Intermolecular Interactions Between Methotrexate and Baricitinib for Improved Rheumatoid Arthritis Treatment.

The combination of anti-rheumatoid arthritis (RA) drugs methotrexate (MTX) and baricitinib (BTN) has been reported to improve RA treatment efficacy. However, study on the strategy of combination is elusive when considering the benefit of the synergy between MTX and BTN. In this study, we found that the N-heterocyclic rings in the MTX and BTN offer hydrogen bonds and π-π stacking interactions, driving the formation of exquisite vesicular morphology of nanovesicles, denoted as MB NVs.

Augmented reality-assisted cloud additive manufacturing with digital twin technology for multi-stakeholder value Co-creation in product innovation.

Industry 4.0, boosting the integration of sophisticated computational and manufacturing technologies, has profoundly reshaped the way to deal with market dynamics. It increases the capabilities of multi-stakeholders to engage in value co-creation for product innovation.

Trust in AI-augmented design: Applying structural equation modeling to AI-augmented design acceptance.

With the emergence of Artificial Intelligence (AI) 2.0, computers are now equipped with new creative capabilities and are playing an increasingly significant role in design. The use of AI augmentation has the potential to enhance design performance, however, there is limited research on the acceptance of AI-augmented design.

Expression of Serpin Family E Member 1 (SERPINE1) Is Associated with Poor Prognosis of Gastric Adenocarcinoma.

Background: The aberrant expression of serpin family E member 1 (SERPINE1) is associated with carcinogenesis. This study assessed the alteration of SERPINE1 expression for an association with gastric adenocarcinoma prognosis.

Methods: The Cancer Genome Atlas (TCGA) dataset was applied to investigate the impact of SERPINE1 expression on the survival of patients afflicted with gastric cancer.

Metal-organic framework-derived metal oxides for resistive gas sensing: a review.

Gas sensors with exceptional sensitivity and selectivity are vital in the real-time surveillance of noxious and harmful gases. Despite this, traditional gas sensing materials still face a number of challenges, such as poor selectivity, insufficient detection limits, and short lifespan. Metal oxides, which are derived from metal-organic framework materials (MOFs), have been widely used in the field of gas sensors because they have a high surface area and large pore volume.

Enhanced recovery after surgery in patients undergoing craniotomy: A meta-analysis.

Background And Objective: Enhanced recovery after surgery (ERAS) is a multidisciplinary,and evidence-based perioperative care method. It is effective in shortening hospital stays and improving clinical outcomes. However, the application of ERAS in craniotomy lacks reliable evidence.

Coacervate-Assisted Polymerization-Induced Self-Assembly of Chiral Alternating Copolymers into Hierarchical Bishell Capsules with Sub-5 nm Ultrathin Lamellae.

Hierarchical self-assembly of synthetic polymers in solution represents one of the sophisticated strategies to replicate the natural superstructures which lay the basis for their superb functions. However, it is still quite challenging to increase the degree of complexity of the as-prepared assemblies, especially in a large scale. Liquid-liquid phase separation (LLPS) widely exists in cells and is assumed to be responsible for the formation of many cellular organelles without membranes.

Polymeric Unimolecular CO Dehydrogenase Mimic with both Inner and Outer Spheres for Enhanced Photocatalytic CO Reduction in Aqueous Solution.

Inspired by carbon monoxide dehydrogenase (CODH), mimicking its inner and outer spheres is a promising strategy in CO reduction catalyst design. However, artificial CODH-like catalysts are generally limited to the inner sphere effect and only applicable in organic solvents or for electrocatalysis. Herein, an aqueous CODH mimic with both inner and outer spheres for photocatalysis is reported.

Insight into the Molecular Mechanism for Enhanced Longevity of Supramolecular Vesicular Photocatalysts.

Supramolecular self-assembly is a promising strategy for stabilizing the photo-sensitive components in photocatalysis. However, the underlying correlation between the enhanced photostability and supramolecular structure at the molecular level has not yet been fully understood. Herein, we develop a biomimetic vesicular membrane-based polyporphyrin photocatalyst exhibiting excellent photocatalytic stability with at least activity time of 240 h in hydrogen generation.