Characterization of azadirachtin resistance in a laboratory-selected strain of Drosophila. melanogaster.

Azadirachtin, a natural sesquiterpenoid compound, exhibits broad-spectrum insecticidal activity, yet its mechanism of action remains incompletely understood. This study aimed to elucidate its toxicological mechanisms by developing an azadirachtin-resistant Drosophila strain through continuous laboratory selection. After five years of directional screening, we successfully established the Aza-Sel strain with a resistance ratio of 86.

Significantly Enhanced Density and Mechanical Strength of Carbon/Graphite Blocks by Waste Gas Pressurized Sintering.

Carbonization under pressure is crucial for enhancing carbon/graphite materials. However, conventional pressure sintering, relying on mechanical or external gas pressure, often results in incomplete densification and structural defects due to uncontrolled volatile gas release. Herein, high-density and high-strength self-sintered carbon block in enclosed-space (SCB-E) are produced using waste gas pressurization (WGP) derived from green petroleum coke (GPC).

Analysis of Risk Factors for Multidrug-Resistant Organism (MDRO) Infections and Construction of a Risk Prediction Model in a Cancer Specialty Hospital.

Patients receiving treatment in specialized cancer hospitals are particularly susceptible to multidrug-resistant organisms (MDRO) infections due to factors such as weakened immune systems caused by intensive treatments and prolonged hospital stays. This study aims to investigate the risk factors for MDRO infections in the cancer specialty hospital setting and to develop a corresponding risk prediction model. Patients diagnosed with MDRO infections were selected for the MDRO infection group (n = 238), and those without for the non-MDRO infection group (n = 238).

Sodium Tanshinone IIA Sulfonate Protects Primary Cardiomyocytes Against Radiation-Induced Myocardial Injury via the p38 Pathway.

Sodium tanshinone IIA sulfonate (STS), which is extracted from a Chinese medicinal herb, possesses many pharmacologic functions, such as coronary dilation, anti-inflammatory properties, and antiapoptotic and antioxidant effects. It remains unknown whether STS can protect cardiomyocytes injured after radiation therapy. An in vitro Sprague-Dawley (SD) rat neonatal cardiomyocyte system was established.

Athlete Identity, Resilience, Satisfaction with Life and Well-Being of Para Badminton Players: A Multinational Survey.

Objective: To explore regional differences (i.e. Europe, Asia and others) in the well-being of para-athletes and its potential psychosocial determinants, including the Athletic Identity Measure Scale (AIMS), the Brief Resilience Scale (BRS) and the Satisfaction with Life Scale (SWLS).

The Effects of Exogenous Benzoic Acid on the Physicochemical Properties, Enzyme Activities and Microbial Community Structures of Inter-Root Soil.

This study analyzed the effects of benzoic acid (BA) on the physicochemical properties and microbial community structure of perilla rhizosphere soil. The analysis was based on high-throughput sequencing technology and physiological and biochemical detection. The results showed that with the increase in BA concentration, soil pH significantly decreased, while the contents of total nitrogen (TN), alkaline nitrogen (AN), available phosphorus (AP), and available potassium (AK) significantly increased.

Design and testing of an irradiation room with low room-scattering for neutron calibration.

Introduction: This laboratory plans to establish neutron reference radiation fields with three neutron sources to calibrate neutron-measuring devices. To perform calibration at multiple dose rates, neutron ambient dose equivalent rate H˙(10) needs to range 1 μSv/h to 10 mSv/h. The lower limit requires that the maximum available calibration distance should be at least 4.

[Predictive value of peripheral blood lymphocyte subsets for children with intravenous immunoglobulin-resistant Kawasaki disease].

Objectives: Based on peripheral blood lymphocyte subsets and common laboratory test indexes, this study aimed to construct a predictive scoring system for intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD).

Methods: Children hospitalized in Tianjin Children's Hospital from January 2021 to March 2023 were included in the study (185 cases of IVIG-sensitive KD and 41 cases of IVIG -resistant KD). Forty-six healthy children matched for age and gender were selected as controls.

Purification, Structural Characterization, and Antitumor Activity of a Polysaccharide from Seeds.

A previous study found that a crude seed polysaccharide (PFSP) fraction exhibited obviously antitumor activity; however, the structural characterization and antitumor properties of this polysaccharide remain unclear. In this study, the PFSP was extracted and purified via combined column chromatography, and the structure of a single polysaccharide fraction was characterized by methylation, IC, GC-MS, NMR, and AFM. The results demonstrated that the efficient antitumor polysaccharide fraction PFSP-2-1 was screened from PFSP with a relative molecular weight of 8.

Neutron spectrometry of DO-moderated Cf with Bonner sphere spectrometer.

For neutron spectrometry of the DO-moderated Cf source with a Bonner sphere spectrometer (BSS), it is difficult to use the large and heavy shadow cone to correct the neutron scattering effect. To overcome this problem, Monte Carlo (MC) simulation method was applied to calculate the neutron scattering ratio and to establish the BSS response functions. The simulated response functions were verified by experimental measurements in reference mono-energetic neutron fields.

ADA2 deficiency (DADA2) misdiagnosed as systemic onset juvenile idiopathic arthritis in a child carrying a novel compound heterozygous mutation: a case report.

Background: The deficiency of adenosine deaminase 2 (DADA2) is caused by an autosomal recessive bi-allelic loss-of-function mutation in the adenosine deaminase 2 () gene. DADA2 is a monogenic inherited autoinflammatory disorder characterized by early-onset vasculopathy for which the symptoms range from skin lesions to very severe multiorgan involvement, including life-threatening ischemia and/or hemorrhagic strokes. Owing to the diversity of clinical presentation and the absence of suggestive features, differentiating DADA2 from other inflammatory disorders in the early stages of disease presentation is difficult.

Activated PI3K syndrome 1 mimicking systemic lupus erythematosus and secondary Sjögren's syndrome-like phenotype without recurrent infections: A case report.

Activated phosphoinositide 3-kinase- syndrome 1 (APDS1) is a combined immunodeficiency caused by a heterozygous gain-of-function mutation in , encoding the p110 catalytic subunit of phosphoinositide 3-kinase (PI3K). APDS1 is characterized by recurrent sinopulmonary infections, leading to airway damage, chronic herpes viremia, lymphoproliferation, and autoimmune and inflammatory diseases. Several cases of systemic lupus erythematosus (SLE) have been reported in APDS1; however, Sjögren's syndrome (SS) or an SS-like phenotype is rarely described in patients with APDS1.

Responses of Bacterial Community Structure, Diversity, and Chemical Properties in the Rhizosphere Soil on Fruiting-Body Formation of .

Mycorrhiza helper bacteria (MHB) play an important role in driving mycorrhizal formation. There are few reports on the relationship between bacteria and fruiting growths. Taking mycorrhizal rhizosphere soil from sporocarps of the S.

The Structure and Function of Microbial Community in Rhizospheric Soil of American Ginseng (Panax quinquefolius L.) Changed with Planting Years.

The changes of microbial communities of rhizospheric soil in different ages are speculated to cause soil-borne diseases and replanting problem in American ginseng (Panax quinquefolius L.) cultivation. This study analyzed the physicochemical properties and microbial communities of rhizospheric soil during the planting of American ginseng in the Wendeng area of Weihai, China.

X-linked hyper IgM syndrome with severe eosinophilia: a case report and review of the literature.

Background: Hyper IgM syndromes (HIGMS) are a group of rare primary immunodeficiency disorders. There are limited reports about HIGMS combined with severe eosinophilia.

Case Presentation: In this report, we described a 2-year-old boy with chronic cough and symptoms of hypoxia.

De novo mutation of CYBB gene in a boy presenting as intra-abdominal infection of Burkholderia contaminans: a case report.

Background: Chronic granulomatous disease (CGD) is an inborn error of immunity. It is characterized by recurrent bacterial or fungal infections, including infections by Burkholderia species. This is due to respiratory burst dysfunction of phagocytes.

Chronic immune thrombocytopenia in a child with X-linked agammaglobulinemia-an uncommon phenotype.

Autoimmune disorders are common in patients with primary immunodeficiency diseases (PIDs). However, the prevalence of autoimmunity is low in patients with X-linked agammaglobulinemia (XLA), mostly due to the absence of antibodies. Chronic or persistent immune thrombocytopenia (ITP), which is usually considered an antibody-mediated disease, is uncommon in patients with XLA.

Spatially Confined Synthesis of SnSe Spheres Encapsulated in N, Se Dual-Doped Carbon Networks toward Fast and Durable Sodium Storage.

On account of the high theoretical capacity and preferable electrochemical reversibility, tin selenides have emerged as potential anode materials in the field of sodium ion batteries (SIBs). Unfortunately, the large volume changes, low electrical conductivity, and shuttling effect of polyselenides have impeded their real application. In this work, we present a spatially confined reaction approach for controllable fabrication of SnSe spheres, which are embedded in polydopamine (PDA)-derived N, Se dual-doped carbon networks (SnSe@NSC) through a one-step carbonization and selenization method.