Publications by authors named "Ruohang Weng"
Article Synopsis
- This study looked at how COVID-19 affects kids with rheumatic diseases in China.
- The researchers found that many kids showed symptoms like fever and cough, but most didn’t get very sick.
- Vaccinated kids had a quicker recovery time and were less likely to be hospitalized compared to those who weren’t vaccinated.
Effectiveness and safety of canakinumab in cryopyrin-associated periodic syndrome: a retrospective study in China.
Pediatr Rheumatol Online J
September 2024
Article Synopsis
- The study evaluates the effectiveness and safety of canakinumab in treating Cryopyrin-associated periodic syndrome (CAPS) specifically in Chinese patients, as its use in this demographic was previously underreported.
- Out of 10 patients analyzed, 60% achieved complete remission and showed significant improvement in symptoms like fever and rash after treatment, while some required dose adjustments.
- The treatment was generally well-tolerated, with infections being the most common side effect, but no serious adverse events were reported, indicating canakinumab could be a viable option for CAPS management in this population.*
Objective: Juvenile arthritis caused by loss-of-function LACC1 mutations is characterized by early onset of symmetric and chronic arthritis, associated with an elevation of inflammatory markers. We aimed to describe serum cytokine levels, explore the type I interferon pathway, and evaluate the efficacy of treatment in a patient presenting with polyarthritis and anemia caused by novel compound heterozygous variations in LACC1.
Methods: Clinical data of a patient with compound heterozygous variations in LACC1 was collected.
Objective: Systemic juvenile idiopathic arthritis (sJIA) is characterized by excessive production of proinflammatory cytokines. As an anti-IL-1 agent, canakinumab has been approved in the USA and Europe for the treatment of sJIA patients aged ≥2 years. However, the use of canakinumab has never been reported in China.
View Article and Find Full Text PDFTalaromyces marneffei Infections in 8 Chinese Children with Inborn Errors of Immunity.
Mycopathologia
December 2022
Article Synopsis
- Talaromyces marneffei (TM) is a dangerous fungus that affects immunocompromised individuals, particularly children, leading to significant health issues and high mortality rates.
- A study examined 8 HIV-negative children infected with TM, revealing common symptoms such as fever and pneumonia, and identifying several inborn errors of immunity (IEIs) present in these patients.
- The findings indicate that T cell immunity and specific signaling pathways are crucial for responding to TM infections, suggesting that in HIV-negative children, IEIs should be considered when evaluating TM cases.
Effect of Activin A on activation status of monocytes in acute-phase Kawasaki disease.
Clin Exp Med
August 2021
Kawasaki disease is a kind of self-limited systemic vasculitis involving middle and small arteries, which usually occurs in children under 5 years old. Excessive inflammatory response caused by activation of monocytes is one of the important mechanisms of Kawasaki disease. Activated monocytes secrete large amounts of inflammatory mediators such as TNF-α and IL-1β.
View Article and Find Full Text PDFActivin a suppresses peripheral CD8 T lymphocyte activity in acute-phase Kawasaki disease.
BMC Immunol
February 2021
Background: Kawasaki disease is an autoimmune disease characterized by systemic vasculitis of unknown aetiology and most commonly occurs in children under 5 years old. Previous studies have found that the over-activation of lymphocytes is an important mechanism of Kawasaki disease. Activin A, also known as immunosuppressive factor P, is a multifunctional growth and transforming factor.
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