OsLB2.2 negatively regulates rice disease resistance at seedling stage in rice.

Background: Rice blast disease, caused by the fungal pathogen , stands as the most destructive diseaset of rice, negatively impacting yield and quality. Identification of blast resistance genes is crucial for breeding disease resistant varieties. In this study, we conducted a genome-wide association analysis on rice blast with 295 Japonica rice varieties and the rice blast dominant physiological race ZD5 from Heilongjiang.

Nail Lichen Planus in 81 Patients: A Retrospective Study of Clinical Characteristics, Histopathological Features, and Long-Term Treatment Outcomes.

Nail lichen planus (NLP) is a rare, chronic inflammatory nail disorder that can result in irreversible damage. While clinical awareness is growing, long-term real-world data-particularly incorporating histopathological confirmation and treatment outcomes-remains limited. We retrospectively analyzed 81 biopsy-confirmed NLP cases (2016-2024) from a Chinese dermatology center to characterize their epidemiological, clinical, histological features, treatment responses, and long-term outcomes.

The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner.

Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by chronic inflammation, barrier impairment, and immunoglobulin E-mediated sensitization. Sodium dodecyl benzene sulfonate (SDBS) is a widely used anionic surfactant which are believed to exacerbate AD according to the hygiene hypothesis. However, recent studies have shown that SDBS does not significantly upregulate the expression of key proinflammatory cytokines, which is inconsistent with previous hypotheses.

Integrated transcriptome and co-expression network analysis revealed the molecular mechanism of cold tolerance in japonica rice at booting stage.

Background: Cold stress during the booting stage severely reduces rice yield by impairing pollen development and seed-setting rates. To uncover the molecular basis of cold tolerance, we analyzed phenotypic and transcriptomic data from 14 japonica rice varieties under cold stress, combined with WGCNA.

Results: The results demonstrated that cold stress significantly decreased yield traits, particularly seed-setting rate-a reliable cold tolerance indicator.

sp. nov., a novel actinobacterium isolated from the frass of larvae.

Four actinobacterial strains, designated NEAU-PBA1, NEAU-PB14, NEAU-PB65 and NEAU-PB77, were isolated from the frass of collected from Harbin, Heilongjiang Province, China. These strains were Gram-stain positive, aerobic and produced branched substrate mycelium and aerial hyphae, without producing diffusible pigments in the tested media. Upon maturity, spore chains formed on the aerial hyphae, while the mycelium fragmented with age.

Prognosis and Postoperative Complications of Wide-Field Isthmusectomy for Node-Negative Papillary Thyroid Carcinoma Limited to the Isthmus.

ImportanceThe extent of surgical resection for papillary thyroid carcinoma (PTCs) located in the isthmus has remained a matter of considerable debate.ObjectiveTo investigate the association between the extent of wide-field isthmusectomy and complications and recurrences.DesignClinicopathologic documents of patients who received total thyroidectomy and wide-field isthmusectomy were recorded.

Calcipotriol inhibits the proliferation of psoriasis HaCaT cells by activating the ferroptosis pathway.

Calcipotriol is a well-established treatment for psoriasis and other dermatological conditions. This study aimed to investigate whether calcipotriol exerts its therapeutic effects through ferroptosis and to elucidate its underlying molecular mechanisms using bioinformatics and cellular experiments. Differentially expressed genes (DEGs) and their functional enrichment were analyzed in psoriatic skin lesions using bioinformatics.

Investigation of the Efficacy and Safety of Xeligekimab (GR1501) in Patients with Moderate-to-Severe Plaque Psoriasis: A Multicenter, Randomized, Double-Blind Phase II Clinical trial.

Introduction: Psoriasis is a chronic inflammatory skin disease. This study evaluated the efficacy and safety of xeligekimab (GR1501), a novel anti-interleukin-17A (anti-IL-17A) monoclonal antibody, in Chinese patients with moderate-to-severe plaque psoriasis.

Methods: In this multicenter, randomized, double-blind, phase II trial, 199 patients were assigned (1:1:1:1) to receive placebo (n = 49) or xeligekimab 100 mg (n = 50), 150 mg (n = 49), or 200 mg (n = 51) every 4 weeks for 12 weeks.

Combined low intensity blood flow restriction and high intensity half squat training improves lower limb force development in adolescent wrestlers.

Blood flow restriction training (BFRT) has attracted attention due to its advantages in muscle strength enhancement. This paper investigates the effects of different training programs on teenage female wrestlers' lower limb strength. Twenty-four teenage female wrestlers were recruited and randomly divided into three groups, namely the blood flow restriction training group (BFRT group), the regular group (HST group), and the combined group (BFRT-HST group).

Exploring Treatment Adherence in Children Aged 0-6 With Atopic Dermatitis: A Pilot Cross-Sectional Study in China.

Background/objectives: Atopic dermatitis (AD) is a common chronic inflammatory skin disease in pediatric populations, yet treatment adherence remains a persistent challenge. This study aims to assess caregivers' perceptions of treatment and investigate the factors influencing treatment adherence in children with AD in China.

Methods: A cross-sectional study was conducted at the Department of Dermatology, Peking University Shenzhen Hospital, between April and December 2023.

A dual-functional biodegradable composite coating fabricated on sulfonated PEEK vacuum cold spraying: immunomodulation-driven osteointegration.

Polyetheretherketone (PEEK) is a promising orthopedic implant alternative to metals due to its bone-mimetic modulus and biocompatibility; yet, its bioinert nature often triggers fibrous encapsulation and impedes osteointegration. Here, a biodegradable calcium silicate/β-tricalcium phosphate (CS/TCP) composite coating was fabricated on sulfonated PEEK (SP) vacuum cold spraying to address these limitations. The CS/TCP coating exhibited robust bonding strength, enhanced hydrophilicity, and sustained release of Ca/Si ions, fostering apatite deposition in simulated body fluid.

Causal relationship between psoriasis and psychiatric disorders with the potential mediating factors: a two-step Mendelian Randomization study.

Background: Psoriasis (PsO) is a chronic, recurrent inflammatory skin disorder, with a high prevalence of psychiatric comorbidities. Although various studies explore the association between the two diseases, the causal relationship and underlying mechanisms remain poorly understood. PsO may be linked to the aberrant secretion of circulating cytokines, and disturbances in peripheral inflammatory factors are considered substantial contributors to central pathophysiological abnormalities.

Elucidating the Sintering Mechanisms and Synergistic Doping Effects in CuO/FeO Codoped Gd-Doped Ceria Electrolytes for Advanced Low-Temperature Solid Oxide Fuel Cells (LT-SOFCs).

This paper presents a study of the synergistic effects on sintering activity and the electrical performance of a CuO and FeO codoped gadolinium-doped ceria (GDC) electrolyte. The isothermal sintering behavior is investigated, and the viscous flow sintering mechanism is validated. The findings indicate that when the molar ratio of CuO to FeO is 3:1, the sintering temperature can be reduced to 980 °C, which is approximately 450 °C lower than that of GDC (>1450 °C).

Superficial Mycoses: A Mapping Through Bibliometric Research.

Superficial mycosis is a common and recurrent infectious skin disease. It poses significant challenges, with high recurrence rates and drug resistance, which notably diminishes the quality of life for patients and presents substantial public health issues. Numerous publications on superficial mycosis have posed significant challenges for researchers to manage the overwhelming amount of information effectively.

Hematopoietic stem cell translation for relapse of psoriasis. Systematic review.

Psoriasis is a chronic, systemic, autoimmune disease with a high rate of progression and relapse, making treatment a challenge and requiring new therapeutic options. Hematopoietic stem cell transplantation (HSCT) is a promising therapeutic modality for hematological malignancies. Several clinical cases have found that psoriasis in patients with hematological tumor was effectively controlled after HSCT and did not have experienced recurrence during follow-up.

The Global Burden of Atopic Dermatitis in Elderly Populations: Trends, Disparities, and Future Projections.

: Atopic dermatitis (AD) is a common chronic inflammatory skin disease often affecting infants. However, its significance in adult populations is increasingly recognized. Notably, its prevalence and impact among elderly individuals remain poorly understood, highlighting the need for a deeper understanding of its global burden.

Pt(IV)-PROTAC Complexes with Synergistic Antitumor Activity and Enhanced Membrane Permeability.

A class of Pt(IV)-PROTAC complexes was designed and synthesized with dual aims of inducing DNA strand damage and inhibiting DNA repair. These complexes showed good antiproliferative activity against a range of cancer cell lines. Enhanced intracellular uptake of platinum and PROTAC was observed.

[Risk factors for malnutrition in ulcerative colitis complicated with pyoderma gangrenosum and construction of a lasso regression-based prediction model].

Objectives: To explore the risk factors for malnutrition in patients with ulcerative colitis complicated with pyoderma gangrenosum and establish a nutritional risk prediction model for these patients.

Methods: A total of 277 patients with ulcerative colitis complicated with pyoderma gangrenosum treated from 2019 to 2024 were divided into malnutrition group (=185) and normal nutrition group (=92) according to whether malnutrition occurred. The data of 25 potential related factors pertaining to general demography, living and eating habits, and disease-related data were compared between the two groups.

Safety, Pharmacokinetics, and Efficiency of JS005, a Novel Anti-interleukin-17A Monoclonal Antibody, in Healthy Chinese Adults and Patients with Moderate to Severe Psoriasis.

JS005 is a novel anti-IL-17A monoclonal antibody. A Phase Ia study (Study 1) in healthy adults, followed by a Phase Ib/II study (Study 2) in patients with moderate to severe plaque psoriasis (PsO), were designed to evaluate the safety, efficacy, and pharmacokinetic characteristics of JS005. Study 1 was a double-blind, randomized, placebo-controlled, single dose-escalation (15, 60, 150, 300, and 600 mg) study.

Extracting mechanical quality factor and eliminating feedthrough using harmonics of thermal-piezoresistive micromechanical resonators.

Thermal-actuation and piezoresistive-detection effects have been employed to pump the effective quality factor of MEMS resonators, targeting simple self-oscillation and better sensing performance in the air. However, the ratio of the pumped effective quality factor to the inherent mechanical quality factor, crucial for characterizing the amplification, is hard to obtain. The main difficulty stems from hidden Lorentz peaks caused by feedthrough effects and the pump effect once the current is applied.

ITGA5 synovial fibroblasts orchestrate proinflammatory niche formation by remodelling the local immune microenvironment in rheumatoid arthritis.

Objectives: To investigate the phenotypic heterogeneity of tissue-resident synovial fibroblasts and their role in inflammatory response in rheumatoid arthritis (RA).

Methods: We used single-cell and spatial transcriptomics to profile synovial cells and spatial gene expressions of synovial tissues to identify phenotypic changes in patients with osteoarthritis, RA in sustained remission and active state. Immunohistology, multiplex immunofluorescence and flow cytometry were used to identify synovial fibroblasts subsets.

Skin Metabolic Signatures of Psoriasis and Psoriasis Concurrent with Metabolic Syndrome.

Purpose: Psoriasis is a complex inflammatory skin disorder that is closely associated with metabolic syndrome (MetS). Limited information is available on skin metabolic changes in psoriasis; the effect of concurrent MetS on psoriatic skin metabolite levels is unknown. We aimed to expand this information through skin metabolomic analysis.

In Situ Synthesis of Ternary Ni-Fe-Mo Nanosheet Arrays for OER in Water Electrolysis.

Water electrolysis is a promising path to the industrialization development of hydrogen energy. The exploitation of high-efficiency and inexpensive catalysts become important to the mass use of water decomposition. Ni-based nanomaterials have exhibited great potential for the catalysis of water splitting, which have attracted the attention of researchers around the world.