Targeting to Intensify M2 Macrophage Polarization Ameliorate Podocyte Lipid Accumulation and Damage by Tea Polyphenols via Activating SIRT1 in the Aged Model Rats With DKD.

Tea polyphenols (TP), as representative bioactive compounds of tea, exhibit anti-inflammatory and hypolipidemic effects on aging-associated Diabetic kidney disease (DKD), but the exact mechanism is unclear. Inflammation resulting from the dynamic imbalance of macrophage polarization and the injury of podocytes caused by lipid accumulation together drives the disease process. This study aims to explore the mechanism of TP alleviating aging with DKD via macrophage polarization and podocyte lipid accumulation.

The IbMYB52/IbARF11L-IbDRM1 module negatively regulates the root development of sweetpotato.

The formation and development of sweetpotato (Ipomoea batatas (L.) Lam) storage roots directly affect its yield and quality. This process involves a multidimensional interaction of genetic regulation, signal transduction of hormones, environmental response, and cultivation management are all interconnected.

Deformation-Resilient Multigranularity Learning for Unaligned RGB-T Semantic Segmentation.

RGB-Thermal semantic segmentation (SS) aims to combine visual light and thermal images to determine the semantic category for each pixel and create an object mask. While existing methods typically rely on well-aligned RGB-T image pairs, real-world RGB-T pairs are often unaligned, and pixel-by-pixel alignment is both challenging and time-consuming. To address this critical issue, we introduce a new unaligned RGB-T SS benchmark and propose the deformation-resilient multigranularity learning (DML) method.

The E3 ubiquitin ligase SCF mediates salt stress response by degradation of IbPP2CA2 to regulate ABA signaling in sweetpotato.

The phytohormone abscisic acid (ABA) plays a critical role as a signaling molecule, mediating adaptive responses of plants to salt stress. However, the orchestration of ABA signaling in response to salt stress in sweetpotato remains poorly understood. In this study, we cloned a gene of unknown function, IbEDL3, which is significantly upregulated in sweetpotato under salt stress conditions.

The Effectiveness of Picture Books on Reducing Preoperative Anxiety in Children: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Background: Children experience significant psychological and physical stress during medical procedures. Picture books can help reduce anxiety by familiarising children with their upcoming procedures.

Aim: To synthesise and evaluate the effectiveness of picture books on reducing preoperative anxiety in children and their parents.

The inflammation burden index can predict the cardiac injury following antitumour therapy in lung cancer patients with diabetes.

Lung cancer is a leading cause of cancer-related morbidity and mortality worldwide. Diabetes, as a common metabolic disorder, further increases the risk of cardiovascular damage. Studies have shown that myocardial cells in diabetic patients are more vulnerable to the toxic effects of cancer treatments, thereby raising the risk of heart failure.

A new online dynamic nomogram based on the inflammation burden index to predict cardiac injury after antitumor therapy in lung cancer patients.

Introduction: Cardiotoxicity has become a major concern in cancer patients, especially those with lung cancer, as anti-tumor therapies can significantly affect patient survival and quality of life. This study aims to develop and validate a dynamic nomogram based on the Inflammation Burden Index (IBI) to predict the risk of cardiac injury within one year after anti-tumor treatment in lung cancer patients.

Methods: This single-center, retrospective study included 1386 lung cancer patients who underwent myocardial enzyme testing between July 2018 and January 2023.

Modulating Activity of Lattice Oxygen of ABO Perovskite Oxides in Redox Reactions: A Review.

Perovskites, owing to their unique structure, tunable chemical composition, and versatile physicochemical properties, have garnered extensive applications, particularly in redox reactions where the lattice oxygen and/or oxygen vacancies within perovskite are identified as active sites. The modulation of lattice oxygen activity in perovskites is crucial for enhancing the performance of perovskite-type oxides in redox reactions. This review delineates the key factors affecting lattice oxygen activity, including lattice distortions, crystal defects, surface and interface effects, and the migration rate of oxygen ions, and elucidates how these factors synergistically influence the activity of lattice oxygen.

First-principles study on promoting the performance of graphene as an anode material for alkali metal ion batteries by covalent cross-linking of rigid molecules.

In this work, to study the influence of covalent cross-linking on the properties of a layered carbon structure, bilayered graphenes with a larger layer distance were built, supported by covalently cross-linked molecules, 1,4-phenylene (GPG) or -phenylenediamine (GPPG). Based on first-principles calculations, it was found that both structures are thermally stable at a temperature of 500 K. The internal covalently cross-linked molecule can effectively expand the layer distance, enhance the adsorption stability, increase the theoretical specific capacity, and reduce the diffusion energy barrier.

Study on Design, Synthesis and Herbicidal Activity of Novel 4-Amino-6-(5-Aryl-Substituted-1-Pyrazolyl)-3-Chloro-5-Fluoro-2-Picolinic Acids.

6-Aryl-2-picolinic acid herbicides are an important subclass of auxin herbicides, characterized by their good absorption and conductivity, broad weed control spectrum, and excellent herbicidal activity against some resistant weeds. Based on previous studies from our group and the distinct characteristics of physico-chemical properties and biological activities of active skeleton structure containing fluorine atoms, this paper introduces the design and synthesis of 41 novel 4-amino-6-(5-aryl-substituted-1-pyrazolyl)-3-chloro-5-fluoro-2-picolinic acid compounds. The test of inhibiting roots growth showed that most of the -series compounds exhibited superior inhibitory effects compared to picloram, with six compounds demonstrated even better inhibitory capability than the new herbicidal molecule florpyrauxifen.

Dynamic Responses and Crack Propagation of Rock with Crossed Viscoelastic Joints Under Blasting Loads.

To investigate the propagation of stress waves in viscoelastic joints under blasting loads, and their impact on crack propagation and dynamic response in rock masses, a numerical model incorporating intersecting viscoelastic joints was developed using LS-DYNA. This study focuses on the influence of various joint geometric parameters, including thickness and angle, on stress wave propagation and damage patterns in rock. The Riedel-Hiermaier-Thoma (RHT) model was employed to simulate the dynamic behavior of rock, while the Poynting-Thomson model was used to describe the viscoelastic properties of the joint fillings.

Exploring experiences and needs among children with cancer undergoing peripherally inserted central catheter insertion: A qualitative study.

Objective: This study aimed to explore the experiences of children with cancer undergoing peripherally inserted central catheter (PICC) insertion.

Methods: This study employed a descriptive qualitative approach. A total of 20 children undergoing PICC insertion were enrolled through purposive sampling.

Incidence and Associated Factors of Postoperative Delirium in Adults Undergoing Cardiac Surgery With Cardiopulmonary Bypass: A Prospective Cohort Study.

Background: Delirium is one of the most common and serious complications after cardiac surgery with cardiopulmonary bypass (CPB). A comprehensive assessment of independent risk factors for postoperative delirium (POD) is essential for early detection and prevention.

Aims And Objectives: To investigate the incidence and independent associated factors of POD in adults undergoing cardiac surgery with CPB.

A threshold activation-based simplified Lv's transform algorithm for transient multi-component linear frequency modulation signals analysis.

The high sampling rate in modern digital systems generates a large scale of data. To address the computational burden, this paper proposes a threshold activation-based simplified Lv's transform (SLVT) algorithm to analyze the transient multi-component linear frequency modulation signals. Only the signal arrival can trigger the signal analysis.

The effect of mobile application based genetic counseling on the psychosocial well-being of thalassemia patients and caregivers: A randomized controlled trial.

Objective: This study was carried out to investigate the effects of mobile application based genetic counseling on the psychosocial well-being of thalassemia patients and caregivers.

Methods: A randomized controlled trial was conducted with 80 patients, divided equally between the intervention and control groups. Additionally, 192 caregivers were included, with an equal distribution of 96 in the two groups.

Learn2Talk: 3D Talking Face Learns From 2D Talking Face.

The speech-driven facial animation technology is generally categorized into two main types: 3D and 2D talking face. Both of these have garnered considerable research attention in recent years. However, to our knowledge, the research into 3D talking face has not progressed as deeply as that of 2D talking face, particularly in terms of lip-sync and perceptual mouth movements.

Sweetpotato sucrose transporter IbSUT1 alters storage roots formation by regulating sucrose transport and lignin biosynthesis.

The formation and development of storage roots is the most important physiological process in sweetpotato production. Sucrose transporters (SUTs) regulate sucrose transport from source to sink organs and play important roles in growth and development of plants. However, whether SUTs involved in sweetpotato storage roots formation is so far unknown.

Effects of Digital Picture Books on Young Children Undergoing Cardiac Catheterisation and Their Family Caregivers: A Randomised Controlled Trial.

Aim: To assess the impact of digital picture books on preoperative anxiety, pain and sleep quality in young children undergoing cardiac catheterisation and the anxiety of their family caregivers.

Design: A randomised, single-blinded, two-arm, parallel-group controlled trial.

Methods: Participants are young children aged 2-7 years with congenital heart disease scheduled for cardiac catheterisation and their family caregivers.

Analysis of heavy metal and arsenic sources in mangrove surface sediments at Wulishan Port on Leizhou Peninsula, China, using the APCS-MLR model.

Mangrove forests are sources and sinks for various pollutants. This study analyzed the current status of heavy metal and arsenic (As) pollution in mangrove surface sediments in rapidly industrializing and urbanizing port cities. Surface sediments of mangroves at Wulishan Port on the Leizhou Peninsula, China, were analyzed using inductively coupled plasma emission spectrometry (ICP-AES) and inductively coupled plasma mass spectrometry (ICP-MS) for the presence of Cr, Pb, Ni, Zn, Cd, Cu, As, and Hg.

Telemedicine in Improving Glycemic Control Among Children and Adolescents With Type 1 Diabetes Mellitus: Systematic Review and Meta-Analysis.

Background: Type 1 diabetes mellitus (T1DM) is the most common chronic autoimmune disease among children and adolescents. Telemedicine has been widely used in the field of chronic disease management and can benefit patients with T1DM. However, existing studies lack high-level evidence related to the effectiveness of telemedicine for glycemic control in children and adolescents with T1DM.

Ni/Photoredox-Catalyzed Enantioselective Acylation of α-Bromobenzoates with Aldehydes: A Formal Approach to Aldehyde-Aldehyde Cross-Coupling.

The catalytic cross-coupling of identical or similar functional groups is a cornerstone strategy for carbon-carbon bond formation, as exemplified by renowned methods, such as olefin cross-metathesis, Kolbe electrolysis, and various cross-electrophile couplings. However, similar methodologies for coupling aldehydes─fundamental building blocks in organic synthesis─remain underdeveloped. While the benzoin-type condensation, first reported in 1832, offers a reliable route for aldehyde dimerization, the chemo- and enantioselective cross-coupling of nonidentical yet similar aldehydes remains an unsolved challenge.

Design, Modeling, and Experimental Validation of an Active Microcatheter Driven by Shape Memory Effects.

Microcatheters capable of active guidance have been proven to be effective and efficient solutions to interventional surgeries for cardiovascular and cerebrovascular diseases. Herein, a novel microcatheter made of two biocompatible materials, shape memory alloy (SMA) and polyethylene (PE), is proposed. It consists of a reconfigurable distal actuator and a separate polyethylene catheter.

Functional Divergence in Orthologous Transcription Factors: Insights from AtCBF2/3/1 and OsDREB1C.

Despite traditional beliefs of orthologous genes maintaining similar functions across species, growing evidence points to their potential for functional divergence. C-repeat binding factors/dehydration-responsive element binding protein 1s (CBFs/DREB1s) are critical in cold acclimation, with their overexpression enhancing stress tolerance but often constraining plant growth. In contrast, a recent study unveiled a distinctive role of rice OsDREB1C in elevating nitrogen use efficiency (NUE), photosynthesis, and grain yield, implying functional divergence within the CBF/DREB1 orthologs across species.