Engineered S. cerevisiae-pYD1-ScFv-AFB1 mitigates aflatoxin B1 toxicity via bio-binding and intestinal microenvironment repair.

The highly toxic aflatoxin B1 (AFB1) is considered one of the primary risk factors for hepatocellular carcinoma, while effective measures after AFB1 exposure remain to be optimized. This study utilized cell-surface-display technique to construct an engineered S. cerevisiae-pYD1-ScFv-AFB1 (S.

Application of Polyvinyl Alcohol-Ethylene Glycol Hydrogel Technology for Removing Animal Glue in Book Restoration Based on Fluorescent Labeling Evaluation.

This study developed a novel material based on polyvinyl alcohol-ethylene glycol (PVA-EG) hydrogel and systematically evaluated its potential application in the removal of animal glue from book surfaces. The microstructure, surface properties, and mechanical characteristics of the PVA-EG hydrogel were analyzed using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), contact angle measurements, a universal testing machine, and a dynamic mechanical analysis (DMA). The introduction of ethylene glycol (EG) could weaken hydrogen bonding interactions between PVA chains to enhance the molecular chain flexibility of the hydrogel.

Evolution from a charge-ordered insulator to a high-temperature superconductor in BiSr(Ca,Dy)CuO.

How Cooper pairs form and condense has been the main challenge in the physics of copper-oxide high-temperature superconductors. Great efforts have been made in the 'underdoped' region of the phase diagram, through doping a Mott insulator or cooling a strange metal. However, there is still no consensus on how superconductivity emerges when electron-electron correlations dominate and the Fermi surface is missing.

The Next-Generation Probiotic -pSK18a-MT Ameliorates Cadmium-Induced Liver Injury by Surface Display of Metallothionein and Modulation of Gut Microbiota.

Cadmium (Cd) is recognized as being linked to several liver diseases. Currently, due to the limited spectrum of drugs available for the treatment of Cd intoxication, developing and designing antidotes with superior detoxification capacity and revealing their underlying mechanisms remains a major challenge. Therefore, we developed the first next-generation probiotic -pSK18a-MT that delivers metallothionein (MT) to overcome Cd-induced liver injury in C57BL/6 mice by utilizing bacterial surface display technology.

Prevailing Charge Order in Overdoped La_{2-x}Sr_{x}CuO_{4} beyond the Superconducting Dome.

The extremely overdoped cuprates are generally considered to be Fermi liquid metals without exotic orders, whereas the underdoped cuprates harbor intertwined states. Contrary to this conventional wisdom, using Cu L_{3}-edge and O K-edge resonant x-ray scattering, we reveal a charge order (CO) correlation in overdoped La_{2-x}Sr_{x}CuO_{4} (0.35≤x≤0.

Correlating the charge-transfer gap to the maximum transition temperature in BiSrCaCuO.

As the number of CuO layers, , in each unit cell of a cuprate family increases, the maximum transition temperature () exhibits a universal bell-shaped curve with a peak at = 3. The microscopic mechanism of this trend remains elusive. In this study, we used advanced electron microscopy to image the atomic structure of cuprates in the BiSrCaCuO family with 1 ≤ ≤ 9; the evolution of the charge-transfer gap size (Δ) with can be measured simultaneously.

Engineered probiotics Clostridium butyricum-pMTL007-GLP-1 improves blood pressure via producing GLP-1 and modulating gut microbiota in spontaneous hypertension rat models.

Hypertension is a significant risk factor of cardiovascular diseases (CVDs) with high prevalence worldwide, the current treatment has multiple adverse effects and requires continuous administration. The glucagon-like peptide-1 receptor (GLP-1R) agonists have shown great potential in treating diabetes mellitus, neurodegenerative diseases, obesity and hypertension. Butyric acid is a potential target in treating hypertension.

Engineered Bacteria EcN-MT Alleviate Liver Injury in Cadmium-Exposed Mice its Probiotics Characteristics and Expressing of Metallothionein.

Cadmium (Cd) exposure is a widespread problem in many parts of the world, but effective means to treat Cd exposure is still lacking. Hence, an engineered strain expressing metallothionein (MT) named Nissle 1917 (EcN)-MT was constructed, and its potential in the treatment of Cd exposure was evaluated. The studies showed that metallothionein expressed by EcN-MT could significantly bind Cd.

Differential Refractive Index Sensor Based on Coupled Plasmon Waveguide Resonance in the C-Band.

We proposed a differential fiber-optic refractive index sensor based on coupled plasmon waveguide resonance (CPWR) in the C-band. The sensor head is a BK7 prism coated with ITO/Au/ITO/TiO film. CPWR is excited on the film by the S-polarized components of an incident light.

Intraband hot-electron photoluminescence of a silver nanowire-coupled gold film high-order gap plasmons.

We report a strong one-photon photoluminescence (PL) behavior of a silver nanowire directly coupled gold film. The PL peak position of the silver nanowire-coupled gold film deviates from the intrinsic interband transition of gold materials and is not sensitive to the diameter change of the silver nanowire. We attribute this strong PL behavior to the intraband transition of hot electrons dominated by high-order gap plasmons, which are excited in the ultra-small gap formed by an ultra-thin polyvinyl pyrrolidone (PVP) layer coated on the silver nanowire.

Anomalous Doping Evolution of Superconductivity and Quasiparticle Interference in Bi_{2}Sr_{2}Ca_{2}Cu_{3}O_{10+δ} Trilayer Cuprates.

We use scanning tunneling microscopy to investigate Bi_{2}Sr_{2}Ca_{2}Cu_{3}O_{10+δ} trilayer cuprates from the optimally doped to overdoped regime. We find that the two distinct superconducting gaps from the inner and outer CuO_{2} planes both decrease rapidly with doping, in sharp contrast to the nearly constant T_{C}. Spectroscopic imaging reveals the absence of quasiparticle interference in the antinodal region of overdoped samples, showing an opposite trend to that in single- and double-layer compounds.

Highly sensitive differential fiber-optic SPR sensor in telecom band.

We proposed a differential fiber-optic SPR remote sensor with ultra-high sensitivity in telecom band. The working band of the sensor is designed as the C-band which is the low loss band of optical fiber communication aiming to improve the sensitivity and enable the capability of remote monitoring. The sensor head is a BK7 prism coated with Au/TiO films, enabling two channels for differential intensity interrogation.

Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.

There have been few studies investigating the potential effects of indoor sources of particulate matter on human health. In this study, the effect of different concentrations of fine particulate matter (PM2.5) collected from a printing room on lung health was examined using cultured cells and a mouse model.

Intestinal microbiota regulates anti-tumor effect of disulfiram combined with Cu in a mice model.

Background: A growing number of studies show that intestinal microbiota affect the therapeutic effects of antineoplastic agents. Disulfiram (tetraethylthiuram disulfide, DSF) is an old alcohol-aversion drug that has been shown to be effective against various types of cancers in preclinical studies, while few studies are carried out to explore its mechanism.

Methods: A mice model of melanoma xenograft was generated and treated with antibiotics (Abx), disulfiram/copper (DSF/Cu ), Abx + DSF/Cu , and the tumor volume and survival curve were observed.

Effect of Structural Supermodulation on Superconductivity in Trilayer Cuprate Bi_{2}Sr_{2}Ca_{2}Cu_{3}O_{10+δ}.

We investigate the spatial and doping evolutions of the superconducting properties of trilayer cuprate Bi_{2}Sr_{2}Ca_{2}Cu_{3}O_{10+δ} by using scanning tunneling microscopy and spectroscopy. Both the superconducting coherence peak and gap size exhibit periodic variations with structural supermodulation, but the effect is much more pronounced in the underdoped regime than at optimal doping. Moreover, a new type of tunneling spectrum characterized by two superconducting gaps emerges with increasing doping, and the two-gap features also correlate with the supermodulation.

A Polarization-Independent Fiber-Optic SPR Sensor.

Fiber-optic surface plasmon resonance (SPR) sensors possess the advantages of small size, flexible, allowing for a smaller sample volume, easy to be integrated, and high sensitivity. They have been intensively developed in recent decades. However, the polarizing nature of the surface plasmon waves (SPWs) always hinders the acquisition of SPR spectrum with high signal-noise ratio in wavelength modulation unless a polarizer is employed.

Simultaneous enhancement of photoluminescence and afterglow luminescence through Bi co-doping in the SrAlOCl:Eu phosphor.

In this work, the Sr3Al2O5Cl2:Eu2+ and Sr3Al2O5Cl2:Eu2+,Bi3+ phosphors are synthesized by high temperature solid state reactions. Various characterization techniques, such as X-ray diffraction (XRD), Rietveld refinement, photoluminescence (PL) spectroscopy, afterglow spectroscopy, decay curves and thermoluminescence (TL) spectroscopy, are used to examine the phase purity and PL properties of all samples. The XRD results show that all samples belong to the targeted orthorhombic Sr3Al2O5Cl2 phase with the space group of P212121.

Modification and Wettability Study ITO Glass Coated with ZnO Film by Electrochemical Deposition and Hydrothermal Deposition.

ITO glass is a substrate often utilized to construct various IT devices and sensors, favored for its excellent characteristics such as rapid electron transfer kinetics, non-toxicity, chemical stability, and high electron transmission. In this paper, film with ZnO-modified nanostructures on ITO glass was fabricated by both electrochemical deposition and hydrothermal deposition, respectively. The ZnO film as-deposited was then modified by surface modification reagent (FOTMS) to obtain a hydrophobic surface.

Carbonaceous aerosol characteristics in outdoor and indoor environments of Nanchang, China, during summer 2009.

A study of carbonaceous aerosol was initiated in Nanchang, a city in eastern China, for the first time. Daily and diurnal (daytime and nighttime) PM2.5 (particulate matter with aerodynamic diameter < or =2.

A novel gas ionization sensor using Pd nanoparticle-capped ZnO.

A novel gas ionization sensor using Pd nanoparticle-capped ZnO (Pd/ZnO) nanorods as the anode is proposed. The Pd/ZnO nanorod-based sensors, compared with the bare ZnO nanorod, show lower breakdown voltage for the detected gases with good sensitivity and selectivity. Moreover, the sensors exhibit stable performance after more than 200 tests for both inert and active gases.

Characteristics of indoor/outdoor PM2.5 and elemental components in generic urban, roadside and industrial plant areas of Guangzhou City, China.

Quantitative information on mass concentrations and other characteristics, such as spatial distribution, seasonal variation, indoor/outdoor (I/O) ratio, correlations and sources, of indoor and outdoor PM2.5 and elemental components in Guangzhou City were provided. Mass concentration of PM2.