Engineering of Core-Shell Pd/SSZ-13@AlO Zeolite: Unlocking Superior NO Adsorption and Chemical Durability.

Pd-zeolites are promising passive NO adsorber (PNA) materials for mitigating cold-start emissions from lean-burn engines. However, their practical deployment is constrained by insufficient densities and dispersion of isolated Pd active sites as well as their susceptibility to hydrothermal degradation and phosphorus poisoning encountered in vehicle exhaust environments. Herein, we develop a rationally engineered core-shell Pd/SSZ-13@AlO composite, featuring a Pd/SSZ-13 core encapsulated within a mesoporous AlO shell.

Characterization and Antimicrobial Efficacy of a Bacteriophage Targeting Multidrug-Resistant .

The emergence of multidrug-resistant (MDR) poses a significant threat to global public health, necessitating alternative therapeutic strategies. In this study, we isolated and characterized a novel lytic bacteriophage (phage), vB_EcoM_51, from poultry farm sewage and evaluated its potential against MDR . Transmission electron microscopy revealed that the phage exhibits morphological features typical of the family, including a polyhedral head (∼66.

Investigating the Mechanism of β-Elemene-Mediated LINC00511 Modulation to Suppress Cisplatin Resistance in Lung Cancer.

Cisplatin resistance significantly limits the efficacy of chemotherapy in non-small cell lung cancer, necessitating the development of new strategies to overcome this barrier. This in vitro study aimed to elucidate the mechanism by which β-Ele reverses cisplatin resistance in lung adenocarcinoma cells via the LINC00511-mediated glycolysis and Wnt/β-catenin signaling pathways. The cisplatin-resistant human lung adenocarcinoma cell line (A549/DDP), with either LINC00511 overexpression or knockdown, was established through plasmid transfection.

Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism.

Innate immune cells can acquire a memory phenotype, termed trained immunity, but the mechanism underlying the regulation of trained immunity remains largely elusive. Here, we demonstrate that inhibition of Aurora kinase A (AurA) dampens trained immunity induced by β-glucan. ATAC-seq and RNA-seq analysis reveal that AurA inhibition restricts chromatin accessibility of genes associated with inflammatory pathways such as JAK-STAT, TNF, and NF-κB pathways.

Effect of the DPP4 Inhibitor Sitagliptin on Ferroptosis in Epilepsy.

Background: Epilepsy, a significant neurological condition marked by the occurrence of repeated seizures, continues to pose a substantial health challenge. Previous studies have indicated that Dipeptidyl Peptidase-4 (DPP4) inhibitors may possess antiepileptic properties. Ferroptosis, a newly discovered type of programmed cell death, has recently surfaced as a promising therapeutic target in the management of epilepsy.

Risk Factors of Surgical Site Infection After Adult Closed Tibial Plateau Fractures Treated by Open Reduction and Internal Fixation.

Background: Surgical site infection (SSI) after surgery can cause serious sequelae in patients with tibial plateau fractures. This study aims to report the incidence and characteristics of SSI and to investigate the risk factors of SSI in adult patients with closed tibial plateau fracture, especially the relationship between SSI and preoperative hypoalbuminemia.

Methods: We retrospectively reviewed the records of adult patients with closed tibial plateau fracture who were treated at our institution from January 2016 to December 2022.

Association of dietary inflammatory index and oxidative balance score with all-cause and cardiovascular mortality in US non-diabetic adults.

Background: Inflammation and oxidative stress (OS) are critical factors in the pathogenesis of chronic diseases (CDs), with dietary factors being a central modifiable determinant. This study aimed to assess the association of the Dietary Inflammation Index (DII) and Dietary Oxidative Balance Score (DOBS) with all-cause and cardiovascular (CV) mortality in non-diabetic adults.

Methods: Data on non-diabetic adults were extracted from the National Health and Nutrition Examination Survey (NHANES) (2009-2018).

Oligochitosan-Ameliorated Gut Microbiome and Metabolic Homeostasis in Hybrid Groupers (Epinephelus lanceolatu ♂ × Epinephelus fuscoguttatus ♀) Infected With Vibrio harveyi.

Vibrio infections cause enteritis in grouper fish, leading to high mortality and stunted growth, which is a major challenge for aquaculture. Oligochitosans, marine prebiotics with bioactive properties, have proven their potential for growth promotion and immune regulation. However, the impacts of Vibrio harveyi on the gut microbiome of grouper fish and the potential of oligochitosans to modulate these effects remain poorly understood.

Serum heat shock protein family A member 9 protein as a biomarker for bortezomib resistance and poor prognosis in patients with multiple myeloma.

Bortezomib resistance in multiple myeloma (MM) is a significant clinical challenge that limits the long-term effectiveness. Currently, there is a lack of reliable biomarkers to predict bortezomib resistance. Previous studies reported that several proteins regulate bortezomib resistance through targeting ubiquitin-proteasome pathways, including heat shock protein family A member 9 (HSPA9), dickkopf Wnt signaling pathway inhibitor 1 (DKK1), proteasome 26S subunit non-ATPase 14 (PSMD14), and tripartite motif containing 21 (TRIM21).

In-depth investigation of the spatial variations of DOM components in sediments under the influence of cascade dams and their interactions with microbial communities.

Small cascade dams drive spatial divergence in the composition of dissolved organic matter (DOM) in local sediments. Taking Xixi River in the southeast of China, a representative small cascade-dammed watershed, as an example, this study explored the spatial variations of DOM components and its interactions with microbial communities under the influence of cascade dams. Results revealed that DOM composition differed significantly, i.

Hedgehog-like Pd/Nitride Nanocone Facilitates Bubble Detachment for High-Rate Photothermal Hydrogen Release.

The practical application of formic acid for large-scale hydrogen storage is constrained by its low H production rates. Conventional strategies rely on excessive chemical additives to accelerate the initial deprotonation step for efficient dehydrogenation. However, this approach is energy-consuming and compromises the intrinsic hydrogen storage density (53 g L) of formic acid.

Study on toughening polylactic acid/poly(butylene adipate-co-terephthalate) with a curing network based on dynamically crosslinked epoxidized soybean oil.

A dynamically crosslinked network VEC (vulcanized ESO and CA) was synthesized in situ via zinc acetate-catalyzed epoxy ring-opening between epoxidized soybean oil (ESO) and anhydrous citric acid (CA), then incorporated into polylactic acid (PLA)/polybutylene adipate terephthalate (PBAT) blends to enhance interfacial compatibility. The dynamic ester-exchange network acted as an intermediate phase, improving the integration of the flexible PBAT phase within the rigid PLA matrix. VEC content critically influenced mechanical properties, with in-situ crosslinking during dynamic vulcanization enhancing chain interactions and blend homogeneity.

Resolving tumor microenvironment heterogeneity to forecast immunotherapy response in triple-negative breast cancer through multi-scale analysis.

Background: Immunotherapy has been used in the clinical management of TNBC. While BRCA1 mutations are associated with immunotherapy response, the therapeutic outcomes in TNBC patients are not promising.

Methods: This study integrated spatial, single-cell, and bulk RNA-seq data to explore the role of BRCA1 in reshaping the TNBC microenvironment.

Association between neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and psoriasis risk: a nationally representative cross-sectional study.

Objective: To investigate the association between the neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and the risk of psoriasis.

Methods: This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey (NHANES) for the periods 2003-2006 and 2009-2014, including 21,723 adults aged ≥20 years. Weighted multivariable logistic regression models were used to examine the association between NHR and psoriasis, with stepwise adjustments for demographic, metabolic parameters, and comorbid factors.

[Study on strategies and methods for discovering risk of traditional Chinese medicine-related liver injury based on real-world data: an example of Corydalis Rhizoma].

In recent years, there have been frequent adverse reactions/events associated with traditional Chinese medicine(TCM), especially liver injury related to traditional non-toxic TCM, which requires adequate attention. Liver injury related to traditional non-toxic TCM is characterized by its sporadic and insidious nature and is influenced by various factors, making its detection and identification challenging. There is an urgent need to develop a strategy and method for early detection and recognition of traditional non-toxic TCM-related liver injury.

[Research progress in machine learning in processing and quality evaluation of traditional Chinese medicine decoction pieces].

Traditional Chinese medicine(TCM) decoction pieces are a core carrier for the inheritance and innovation of TCM, and their quality and safety are critical to public health and the sustainable development of the industry. Conventional quality control models, while having established a well-developed system through long-term practice, still face challenges such as relatively long inspection cycles, insufficient objectivity in characterizing complex traits, and urgent needs for improving the efficiency of integrating multidimensional quality information when confronted with the dual demands of large-scale production and precision quality control. With the rapid development of artificial intelligence, machine learning can deeply analyze multidimensional data of the morphology, spectroscopy, and chemical fingerprints of decoction pieces by constructing high-dimensional feature space analysis models, significantly improving the standardization level and decision-making efficiency of quality evaluation.

Microplastic contamination in kidney transplant donor tissues and its association with early post-transplant blood pressure changes in recipients: A multi-modal analytical study.

Microplastic (MP) contamination in human tissues is an emerging environmental and clinical concern, yet its relevance to organ transplantation remains poorly understood. This study characterized MPs in kidney transplantation-associated donor tissues and examined their relationship with early postoperative blood pressure (BP) in recipients. Tissue samples, including kidney, adrenal gland, renal artery, renal vein, and ureter, were collected from 28 kidney transplant donors.

Adverse events of pexidartinib for the treatment of TGCT: a real-world disproportionality analysis using FDA Adverse Event Reporting System database.

Introduction: Pexidartinib, an oral selective colony-stimulating factor 1 receptor (CSF1R) inhibitor, is the only systemic therapy approved by the U.S. Food and Drug Administration (FDA) for tenosynovial giant cell tumor (TGCT).

Inulin-Based Prebiotic Delivery System Enhances Gut Microbiota Modulation to Alleviate Enteric Infections.

Current antibiotic-based treatments for bacterial enteric infections often disrupt gut microbiota and face reduced efficacy due to gastrointestinal complexity and mucosal barriers. Here, we developed a genistein-loaded nanoparticle using whey protein isolate and prebiotic inulin (Gen_Wi) to improve the gut microbiome health. Gen_Wi nanoparticles mitigated oxidative stress and inflammation in intestinal epithelial cells by activating Nrf2 and suppressing NF-κB pathways, reducing TNF-α and IL-1β levels by nearly 39 and 55.

Precise Lower-Facial Feminization Surgery Using 3D-Printed Surgical Guides: Initial Clinical Experience From a Single Center in China.

While facial feminization surgery (FFS) gains prominence globally, clinical data from China remain scarce. This study presents our initial single-center experience using 3D-printed surgical guides for precise lower-facial feminization in Chinese patients. We utilized virtual surgical planning to guide the design and employed patient-specific metal guides to ensure precise osteotomy intraoperatively.

Carbon Decorated Pd Species within Zeolite for Selective Furfural Hydrogenation.

Selective hydrogenation of biomass-derived furfural to furfuryl alcohol is fundamentally challenged by the dual adsorption of its reactive furan ring and carbonyl group on Pd catalysts, which drives nonselective pathways. To modulate the adsorption mode of furfural, we rationally incorporate carbon species onto Pd subnanoclusters encapsulated in a siliceous zeolite (Pd-C@S-1), achieving 98% selectivity for furfuryl alcohol at full furfural conversion, vastly outperforming the carbon-free Pd@S-1 (11.6% selectivity).

Advancements in nanomedicine for modulating ischemic cardiomyopathy therapy.

Ischemic cardiomyopathy receives significant attention due to its high mortality and morbidity worldwide. Numerous research has revealed that blood supply, ROS, inflammation, and thrombus play pivotal roles in the progression of myocardial damage and remodeling. The central approach for managing ischemic cardiomyopathy is the administration of therapeutic drugs against the pathological mechanism.

The RNA-binding protein TRIM71 is essential for hearing in humans and mice and times auditory sensory organ development.

The RNA-binding protein TRIM71 is essential for brain development, and recent genetic studies in humans have identified as a risk gene for congenital hydrocephal-us (CH). Here, we show that monoallelic missense mutations in are associated with hearing loss (HL) and inner ear aplasia in humans. Utilizing conditional knockout mice carrying a CH and HL-associated mutation, we demonstrate that loss of TRIM71 function during early otic development (embryonic day 9 to 10) causes severe HL.

Disruption of electrophysiological rhythms and memory impairment in an Alzheimer's transgenic rat model.

Background: Alzheimer's disease (AD) is one of the most prevalent causes of dementia, characterized by progressive memory loss and cognitive decline. Abnormal electrophysiological patterns, especially interictal epileptiform discharges (IEDs) and high-frequency oscillations (HFOs), have been observed in mouse models of AD and are suggested to contribute to cognitive dysfunction. However, comprehensive evaluations of IEDs across different brain regions are limited, and their impact on cognitive performance and neuropathology remains unclear, particularly in more complex AD models with relevant comorbidities.

Increased plasma ceramide levels are associated with arterial stiffness and vascular ageing: a cross-sectional study.

Background: Cardiovascular (CV) events pose a substantial threat to human health. Plasma ceramides have been shown to exhibit predictive value for CV events; however, its correlation with arterial stiffness had yet to be fully elucidated. This study aimed to explore the associations of plasma ceramide levels and their ratios with arterial stiffness.