Preliminary exploration of prediction model and nomograph drawing of Doppler peak systolic velocity ratio, peak systolic velocity 1 and peak systolic velocity 2 of ophthalmic artery in pregnant women for small for gestational age infants.

Objective: To explore the predictive value of peak systolic velocity (PSV) ratio, PSV1 and PSV2 of ophthalmic artery Doppler in pregnant women for small for gestational age (SGA) infants and to construct a nomogram prediction model.

Methods: A total of 201 pregnant women who visited our hospital from March 2022 to June 2024 were selected as the research subjects, and their clinical data and ophthalmic artery Doppler parameters were collected. The data were randomly divided into a training set ( = 295) and a verification set ( = 126) in a 7:3 ratio.

Caulerpin suppresses tumor-associated angiogenesis and tumor growth via Hippo signaling in cervical cancer.

Caulerpin, a bisindole alkaloid derived from green algae of the genus Caulerpa, has exhibited a promising anti-proliferative effect on various tumor cells in vitro. However, its pharmacological potential has not been intensively explored in cervical cancer. In this study, the antitumor property of caulerpin was assessed in cervical cancer cells (HeLa and SiHa cells) and xenograft mouse models.

[Total 3D laparoscopic ileal ureters replacement for bilateral ureters combined with bladder augmentation in the management of post-radiotherapy bilateral ureteral strictures and contracted bladder].

Objective: To retrospectively evaluate the clinical efficacy and safety of total 3D laparoscopic ileal ureters replacement for bilateral ureters combined with bladder augmentation in patients with post-radiotherapy long-segment bilateral ureteral strictures and contracted bladder.

Methods: Clinical data of two patients (aged 72 and 54 years) with radiation-induced long-segment bilateral ureteral strictures and reduced bladder capacity, treated at the Sixth Affiliated Hospital of Jinan University from October 2023 to June 2024, were analyzed. Both presented with bilateral flank pain, recurrent chills/fever, urinary frequency, and urgency.

A novel non-nad-based PARP1 inhibitor, Japoflavone B, triggered Caspase-3/GSDME-mediated pyroptosis through ROS/p38/p53 pathway in NSCLC.

Pyroptosis has gotten more and more attention, in view of its link with innate immunity and disease. Most chemotherapy drugs could cause pyroptosis through caspase-3/GSDME pathway, which reshapes our understanding about the mechanism of anticancer. In our previous study, we found that a novel flavonoid, Japoflavone B (JFB), exhibited an excellent activity in vitro against the growth of cancer cells.

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40.

SUMOylation, a reversible post-translational modification, regulates various mitochondrial processes, including biogenesis, dynamics, mitophagy, and the mitochondrial unfolded protein response. Although SUMOylation is shown to be triggered by mitochondrial protein import failure in yeast, its impact on mammalian mitochondrial protein import remains unclear. Here, it is demonstrated that SENP6 knockdown-induced SUMOylation causes loss of mitochondrial proteostasis, which impairs mitochondrial morphology and function.

Phosphorylation of USP33 by CDK1 stabilizes the mTORC2 component SIN1.

Understanding the mechanisms underlying chemoresistance is critical for improving cancer therapies. SIN1 plays a pivotal role in maintaining mTORC2 integrity and activation, which regulates key cellular processes. In this study, we demonstrate that elevated SIN1 expression in pancreatic ductal adenocarcinoma (PDAC) correlates with poor patient survival outcomes.

Optimizing efficacy: Hyaluronic acid liposomes encapsulating minoxidil for enhanced transdermal delivery and treatment of androgenetic alopecia.

Minoxidil (Mi) is currently one of the most commonly used drugs for the treatment of hair loss in clinical settings. It works by accelerating blood flow around the hair follicles, enhancing local oxygen and nutrient supply, thereby promoting hair growth. However, traditional formulations of Mi have a short residence time on the skin, are prone to causing allergic reactions, scaling, and may even induce systemic hypertrichosis as side effects.

Inhibition of neuronal necroptosis via disruption of RIPK1-RIPK3 Interactions: The role of neural stem cell-derived exosomes in spinal cord injury recovery.

Spinal cord injury (SCI) poses a significant economic and public health burden. Exosomes derived from neural stem cells (NSC-Exos) are emerging as a promising therapeutic strategy for SCI repair, overcoming several limitations associated with both autologous and allogeneic neural stem cell therapies. This study demonstrates that NSC-Exos are efficiently internalized by the injured spinal cord after co-injection, resulting in substantial motor function recovery in murine models.

Increased inflammation burden index increasing the risk of poor prognosis in patients with chronic kidney disease in NHANES study.

Objective: Several studies illustrated high level of inflammation is an important factor affecting the poor prognosis of patients with chronic kidney disease. Inflammatory burden index (IBI) is a composite maker by incorporating a variety of inflammatory markers to facilitate more in-depth assessment for systemic inflammation. The purpose of this research is to examine the correlation between IBI and prognosis in CKD population of American adults.

The protective mechanisms of glycyrrhizic acid for deoxynivalenol-induced toxicity in rabbit corneal stroma.

Objectives: This study aimed to investigate the effects and mechanisms of deoxynivalenol (DON) on rabbit corneal stroma cell culture and observe the protective effect of glycyrrhizic acid (GA) against DON-induced damage.

Methods: Rabbit corneal stromal cells (RCSCs) were isolated and divided into groups: control group (CON), 0.5 mmol/L GA (GA group), 400 ng/mL DON (DON group), and 0.

The autophagy-ferroptosis axis as a critical factor in diabetic-associated cognitive dysfunction.

Diabetic-associated cognitive dysfunction (DACD) is a critical complication of diabetes mellitus, characterized by progressive cognitive decline and neurodegeneration. This review synthesizes emerging evidence on the interplay between autophagy and ferroptosis, highlighting their roles in DACD pathogenesis. We emphasize the unique contribution of the autophagy-ferroptosis axis, particularly under hyperglycemic and insulin-resistant conditions, in driving iron overload, oxidative stress, and lipid peroxidation in brain tissue.

Autophagy inhibition induced by EM-2 augments apoptosis via ROS-mediated ATM-Chk2-p53-p21 and MAPK pathway in lung and breast carcinoma.

Lung cancer (LC) and breast cancer (BC) are two common malignant tumors with the highest incidence rate in men and women worldwide, respectively. As the treatment effect of currently available therapies for LC and BC is unsatisfying, searching for new therapeutic drugs has become an urgent need to be addressed. EM-2, a natural sesquiterpene lactone isolated from H.

A Deep Eutectic Solvent-Based Nanodelivery System for Enhanced Rice Blast Treatment.

The development of nanopesticides with minimized carriers (NMCs) through prodrug design and molecular self-assembly represents a transformative strategy for enhancing pesticide utilization efficiency and addressing global food security challenges. As a proof of concept, we developed A12@DES, a water-based nanodelivery system that combines a target-specific pesticide with a deep eutectic solvent (DES). The system utilizes a laccase inhibitor (A12, structurally optimized from lead compound PMDD-5Y) to self-assemble into monodisperse nanospheres (∼160 nm diameter) with an alkaline phosphatase (ALP)-responsive DES matrix.

Methylation: An Epigenetic Biomarker for Early Liver Damage Induced by Co-Exposure to Aflatoxin B1 and Hepatitis B Virus.

Aflatoxin B1 (AFB1), a well-established hepatic carcinogen, has limited research on early-stage epigenetic biomarkers for aflatoxin-induced liver damage. In this study, we investigated 168 unpackaged peanut oil (UPP) consumers to evaluate associations among AFB1 exposure, HBV infection, methylation, and liver function. Our findings indicated an average daily AFB1 intake of 3.

Clofarabine Enhances the Transduction Efficiency of Recombinant AAV2 in the Retina.

Purpose: Ribonucleotide reductase inhibitors, a class of antineoplastic agents, were investigated for their ability to enhance recombinant adeno-associated virus serotype 2 (rAAV2) transduction in the mouse retina and their underlying mechanisms.

Methods: Candidate ribonucleotide reductase inhibitors were screened in ARPE-19 cells to identify concentrations preserving cell viability while optimizing rAAV2 transduction. Clofarabine, which demonstrated superior enhancement of rAAV2 in vitro, was selected for in vivo evaluation via subretinal coadministration with rAAV2.

Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma.

Background: Dioscin (Dio) is an important anti-tumor active component found in the seeds of . However, the efficacy and mechanism of Dio in relation to the progression of glioblastoma (GBM) remain unclear.

Materials And Methods: Using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assays, flow cytometry, and Hoechst staining experiments.

Acetyl alkannin, a Shikonin monomer, inhibits the ATM/DDR pathway by targeting ATM and sensitizes cisplatin in solid tumors.

Platinum-based chemotherapy is limited by drug resistance and severe adverse effects. Although the DNA damage response (DDR) is known to affect drug sensitivity across cancer types, the role of its upstream regulator ATM in modulating cisplatin (DDP) resistance remains unclear. In this study, we investigated the role of the ATM/DDR pathway to DDP resistance and proposed a potential targeted strategy.

Viral Infections in Elderly Individuals: A Comprehensive Overview of SARS-CoV-2 and Influenza Susceptibility, Pathogenesis, and Clinical Treatment Strategies.

As age increases, the immune function of elderly individuals gradually decreases, increasing their susceptibility to infectious diseases. Therefore, further research on common viral infections in the elderly population, especially severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses, is crucial for scientific progress. This review delves into the genetic structure, infection mechanisms, and impact of coinfections with these two viruses and provides a detailed analysis of the reasons for the increased susceptibility of elderly individuals to dual viral infections.

Corrigendum: Association between Chinese visceral adiposity index and risk of new-onset hypertension in middle-aged and older adults with prediabetes: evidence from a large national cohort study.

[This corrects the article DOI: 10.3389/fpubh.2025.

Cyclodextrin-based self-assembling hydrogel for Photothermal-controlled nitric oxide release in stage-specific treatment of MRSA-induced arthritis.

MRSA-induced arthritis is a prevalent and highly debilitating orthopedic condition. The inflammatory response induced by bacterial infection hinders tissue repair and exacerbates bone loss. Traditional antibiotic therapies are limited by low bioavailability, substantial side effects, and narrow efficacy, rendering them inadequate for comprehensive treatment of arthritis.

Laparoscopic resection of an isolated iliac artery aneurysm with synthetic graft implantation.

The current treatment options for isolated iliac artery aneurysm (IIAA) are mainly endovascular treatment (ET) and open surgery. ET carries risks such as endoleaks and stent displacement, while open elective surgical repair of IIAAs carries significant risk of mortality. Therefore, this report presents a case of laparoscopic surgery for IIAA, providing a new approach for treating IIAA.

Construction and validation of risk prediction models for different subtypes of retinal vein occlusion.

Purpose: While prognostic models for retinal vein occlusion (RVO) exist, subtype-specific risk prediction tools for central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) remain limited. This study aimed to construct and validate distinct CRVO and BRVO risk stratification nomograms.

Methods: We retrospectively analyzed electronic medical records from a tertiary hospital in Guangzhou (January 2010-November 2024).

MDN1 variants cause susceptibility to epilepsy : For the China Epilepsy Gene 1.0 Project.

Background: The Midasin AAA (ATPase associated with various activities) ATPase 1 (MDN1) gene, a member of the AAA protein family, plays a crucial role in ribosome maturation. MDN1 is expressed in the human brain throughout life, especially during early development and adulthood. However, MDN1 variants have not been previously reported in patients with epilepsy.

Characterizing HLA-A2-restricted CD8 T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients.

Introduction: Recent surveillance has identified the emergence of the SARS-CoV-2 Omicron ariant, which exhibits the ability to evade multiple neutralizing antibodies generated by prior infection or vaccination. However, significant knowledge gaps remain regarding the CD8 T-cell immune reactivity to the Omicron variant. This study aims to evaluate the characteristics of HLA-A2-restricted CD8 T-cell epitopes from the Omicron variant and analyze epitope-specific CD8 T-cell responses to SARS-CoV-2 inactivated vaccines.