New Insight into the Related Candidate Genes and Molecular Regulatory Mechanisms of Waterlogging Tolerance in Tree Peony .

Research on the waterlogging tolerance mechanisms of helps us to further understand these mechanisms in the root system and enhance its root bark and oil yields in southern China. In this study, root morphological identification, the statistics of nine physiological and biochemical indicators, and a comparative transcriptome analysis were used to investigate the waterlogging tolerance mechanism in this plant. As flooding continued, the roots' vigor dramatically declined from 6 to 168 h of waterlogging, the root number was extremely reduced by up to 95%, and the number of roots was not restored after 96 h of recovery.

Operando Evolution of a Hybrid Metallic Alloy Interphase for Reversible Aqueous Zinc Batteries.

Aqueous Zn-ion batteries (AZIBs) are widely acknowledged as viable future energy storage solutions, particularly for low-cost stationary applications. However, the interfacial instability of zinc anodes represents a major challenge to the commercial potential of Zn-ion systems, promoting an array of side reactions including spontaneous corrosion, hydrogen evolution, and dendrite growth that destabilize cell performance, lower Coulombic efficiency and ultimately lead to early cell failure. While other commercially relevant battery systems benefit from a spontaneously forming solid electrolyte interphase, no such layer forms in AZIBs.

Design, Synthesis, and Biological Evaluation of New Oxadiazole Derivatives as Efficient Antihypertension Drugs.

A series of novel oxadiazole derivatives were designed, synthesized, and evaluated for their pharmacological effects. All target compounds were subjected to analysis using H NMR, C NMR, and mass spectrometry. They showed a strong affinity to the AT1 receptor and effectively lowered blood pressure in spontaneously hypertensive rats at a nanomolar level.

Melatonin Attenuates PFOS-Induced Reproductive Toxicity of Pregnant Mice due to Placental Damage Via Antioxidant, Anti-Aging and Anti-Inflammatory Pathways.

Background: Perfluorooctane sulfonate (PFOS), an industrially synthesized persistent organic pollutant (POP), is intricately intertwined with human production and daily life. It has been discovered that PFOS is related to an elevated incidence of birth defects in fetuses. In contrast, melatonin (MLT), a hormone secreted by the pineal gland, has been demonstrated to exert a protective effect on reproductive development.

Curcumin mediates glutathione depletion via metal-organic framework nanocarriers to enhance cisplatin chemosensitivity on esophageal cancer.

Cisplatin (CDDP) is the primary drug used in the initial treatment of esophageal cancer (EC). However, its side effects and resistance can limit its effectiveness in clinical therapy. Curcumin (Cur)-mediated glutathione (GSH) depletion can reverse resistance, enhance the chemosensitivity of CDDP, and further improve the efficacy of platinum-containing chemotherapy in the treatment of esophageal cancer.

Surface Engineering of 2D Metal-Porphyrin Metal-Organic Frameworks Z-Scheme Heterostructure for Boosting and Stable Photocatalytic Hydrogen Evolution.

How to improve the stability and activity of metal-organic frameworks is an attractive but challenging task in energy conversion and pollutant degradation of metal-organic frameworks materials. In this paper, we developed a facile method by fabricating TiO nanoparticles (NPs) layer on 2D copper tetracarboxylphenyl-metalloporphyrin metal-organic frameworks (MOFs) with Zn2+ as the linkers (ZnTCuMT-X, "Zn" represented Zn2+ as the linkers, the first "T" represented tetracarboxylphenyl-metalloporphyrin (TCPP), "Cu" represented the Cu2+ coordinated into the porphyrin macrocycle, "M" represented MOFs, the second "T" represented TiO NPs layer, and "X" represented the added volume of n-tetrabutyl titanate (X = 100, 200, 300 or 400)). It was found that the optimized ZnTCuMT-200 showed greatly and stably enhanced H2 generation, which was about 28.

Copper-Catalyzed Asymmetric Tertiary Radical Cyanation for the Synthesis of Chiral Tetrasubstituted Monofluoroacyl Nitriles.

The construction of chiral tetrasubstituted α-fluoro-α-cyano carbonyl compounds remains a key challenge in synthetic organic chemistry because of their popularity in multiple disciplines. In this paper, we report the copper-catalyzed asymmetric fluorinated tertiary radical cyanation reaction of cyclic α-iodo-α-fluoroindanones with TMSCN to achieve chiral nitriles with carbon-fluorine quaternary stereogenic centers. Thus, an array of optically active tetrasubstituted monofluoroacyl nitriles were synthesized with high reaction efficiency and excellent enantioselectivities (up to 91% yield, 99% ee).

Enhancing urban traffic management through shared autonomous electric vehicles and dynamic simulation.

In the face of rapid urbanization and the increasing number of vehicles, urban centers are struggling with traffic congestion. This study presents a dynamic travel strategy using the MATSim platform to schedule urban travel, incorporating a model for shared autonomous electric vehicles. The model is evaluated using a baseline scenario for Shanghai, exploring the effects of vehicle range, charging capabilities, and power supply strategies on the uptake of shared autonomous electric vehicles.

Performance estimation of a piezoelectric energy harvester with rotatable external magnets.

This study estimates the performance of a piezoelectric energy harvester (PEH) with rotatable external magnets from the viewpoint of global dynamics. According to static analysis of the PEH dynamic system, the monostable and bistable potential wells are configured under different values of the inclined angle of the external magnets. In the monostable case, the method of multiple scales is applied for the analysis of periodic responses, while the extended averaging method and the Melnikov method are utilized to analyze the periodic and chaotic responses in the bistable case.

Contrast-enhanced near-infrared photoacoustic microscopy and optical coherence tomography imaging of rat fundus.

In this paper, we design a multimodal visible/near-infrared photoacoustic microscopy and optical coherence tomography (VIS/NIR-PAM-OCT) system for imaging both retina and retinal pigment epithelium (RPE)/choroid complex layer. F127 and DSPE-PEG-cRGD encapsulated IR-1048 nanoparticles (FINPs) exhibiting absorption peak up to 1,064 nm were utilized as contrast agents to enhance NIR-PAM for imaging of fundus tissues. The fundus structure and vessels are clearly visualized by the multimodal imaging, and their parameters were quantitatively analyzed.

In-Plane Adaptive Heteroepitaxy of 2D Cesium Bismuth Halides with Engineered Bandgaps on c-Sapphire.

The heteroepitaxy of 2D materials with engineered bandgaps are crucial to broaden the spectral response for their integrated optoelectronic devices. However, it is a challenge to achieve the high-oriented epitaxy and integration of multicomponent 2D materials with varying lattice constants on the same substrate due to the limitation of lattice matching. Here, in-plane adaptive heteroepitaxy of a series of high-oriented 2D cesium bismuth halide (CsBiX X = I, Br, Cl) single crystals with varying lattice constants from 8.

[Spatial Distribution Characteristics and Ecological Risks of Typical Drugs in the Yongjiang River Basin].

In recent years, due to large-scale production and widespread use, drugs have posed a potential threat to biological and human health and have received increasing attention. The occurrence and distribution of drugs in urban rivers are influenced by various factors, such as urbanization level, population density, regional geographical and climatic characteristics, and drug consumption habits. In October 2022, the Yongjiang River Basin was divided into four sub-basins： upstream, midstream, tributaries, and downstream.

Out-of-pocket health expenditure, social protection, and life expectancy of female-headed households in China.

This study explores the relationship between out-of-pocket health expenditure, social protection interventions, and life expectancy of female-headed households in China. The study was based on data extracted from the World Bank (2021) Global Financial Inclusion Index (Global Findex) and applied the descriptive statistics and the Ordinary Least Squares Regression (OLS). The results show that there is a significant positive coefficient for social protection in total households, females, and males, indicating a beneficial link between social protection programs and life expectancy in female-headed households in China.

Corrigendum: Development and validation of the Chinese family environment influencing physical activity habits scale.

[This corrects the article DOI: 10.3389/fpsyg.2023.

Unlocking the access to nature-identical vanillin isoeugenol ozonation: ATR-IR monitoring and safety evaluation.

The transformation of renewable feedstocks into aromatic chemicals holds immense potential for advancing a green, low-carbon economy and fostering sustainable development. Herein, we present a novel approach for the conversion of isoeugenol, a renewable lignin derivative, into the valuable flavoring agent vanillin, utilizing ozone as an environmentally benign oxidant. The process optimization was significantly enhanced by the integration of Attenuated Total Reflectance Infrared (ATR-IR) monitoring.

Ionic conducting hydrogels as biomedical materials: classification, design strategies, and skin tissue engineering applications.

Ionically conductive hydrogels (ICHs) are considered promising flexible electronic devices and various wearable sensors due to the integration of the conductive performance and soft nature of human tissue-like materials with mechanical and sensory traits. Recently, substantial progress has been made in the research of ICHs, including high conductivity, solution processability, strong adhesion, high stretchability, high self-healing ability, and good biocompatibility. These advanced researches also promote their excellent application prospects in medical monitoring, sports health, smart wear, and other fields.

Discovery and synthesis of novel phenoxyacetate ester Schiff base α-glucosidase inhibitors.

A phenoxyacetate ester Schiff base lead compound 4a (ZINC20073984) was firstly discovered through molecular docking screening and molecular dynamics (MD) simulation, which could be used as an α-glucosidase (PDB: 3A4A) inhibitor. Then a series of α-glucosidase inhibitors 4b-4r with novel structures were designed and synthesized with the lead ZINC20073984 as a template. The results of in vitro α-glucosidase inhibitory activity show that the synthesized phenoxyacetate ester Schiff base compounds 4e, 4o-4r (IC values range from 5.

Exploring microbial dynamics and metabolic pathways shaping flavor profiles in Huangjiu through metagenomic analysis.

In the production of Huangjiu (Chinese rice wine), fermentation microbiota plays a crucial role in flavor formation. This study investigates the microbial dynamics and metabolic pathways that shape the flavor profiles of Huangjiu using different starters. Sensory evaluation and metabolite analysis of six starters revealed significant differences in ester, fruity, and sweet aromas.

A Polymeric Vesicle System for Combined Lung Cancer Therapy through Chemotherapy and Vasculature Normalization.

Lung cancer remains a great threat to human health despite the rapid development of various therapeutic methods. Chemotherapy continues to be the most commonly employed treatment for lung cancer; however, it often suffers from low drug delivery efficiency and severe side effects. To enhance the therapeutic efficacy of chemotherapy, we developed a novel strategy that integrates tumor vasculature normalization with the co-delivery of therapeutic agents.

Phosphorus removal in microalgal growth and harvesting using natural flocculant: Influence of microalgal characteristics and phosphorus forms.

Phosphorus-induced harmful algae blooms elicited attention, and both microalgae harvesting and phosphorus removal are essential, especially preventing secondary pollution. In this study, starved Chlorella vulgaris removed 68.73 % of dissolved inorganic phosphorus (DIP) compared to 37.