Association between building density and screening myopia in children and adolescents: a 5-year longitudinal study from China.

Background: This study explored the relationship between school-level built environment factors (building density and height) and myopia prevalence.

Methods: In all 16 districts of Shanghai, students from public schools and kindergartens underwent visual acuity testing and non-cycloplegic refraction between 2019 and 2023. Building density and height within 500-metre and 1,000-metre buffers around the schools were obtained using GIS (Geographic Information System)-based spatial and network analyses from the Tianditu database.

Orthokeratology, 0.04% Atropine, and 0.01% Atropine for Myopia Control: A Randomized Clinical Trial.

Importance: Investigating the antimyopia efficacy and safety of orthokeratology and varying atropine doses in specific age groups could optimize personalized treatment choices.

Objective: To evaluate the efficacy and safety of orthokeratology, 0.04% atropine, and 0.

Kinsenoside attenuates ER stress and inhibits inflammatory responses through IL-10/STAT/SOCS3 pathway in chronic pain relief.

Neuro-inflammation contributes to neuropathic pain by sensitizing ionic channels. Kinsenoside, a traditional Chinese medicine, has recognized anti-inflammatory properties. However, it remains unclear whether kinsenoside can be used for pain therapy.

Spinal ultrasound imaging implied the vascular dynamics in chronic and acute pain.

Neurovascular coupling links local neural activity to cerebral blood flow changes, crucial for pain transduction. In this undertaking, we present an advanced spinal functional ultrasound imaging that exhibits precise observation capabilities of the influence of analgesic medications on spinal cord blood flow, encompassing both acute and chronic pain scenarios. Utilizing gabapentin as the primary analgesic agent, we have observed that intrathecal administration of gabapentin notably augments the blood flow intensity in neuropathic rats while exerting minimal influence on the blood flow of the sham rats.

Comparison of Corneal Power Assessment Methods for True Corneal Power After Myopic Small-Incision Lenticule Extraction.

Purpose: We sought to compare the accuracy of different corneal curvature parameters in estimating corneal power change in eyes that underwent myopic small-incision lenticule extraction (SMILE).

Design: Prospective cross-sectional trial.

Methods: 89 eyes of 48 patients who had undergone SMILE at Shanghai Eye Disease and Prevention & Treatment Center were enrolled.

The Association of Peripheral Refraction and Relative Peripheral Refraction with Astigmatism in Shanghai Schoolchildren's Myopia: A Cross-Sectional Study.

Purpose: Currently, no relevant studies have reported a relationship between astigmatism and peripheral refraction (PR). We aimed to describe the association between PR and relative peripheral refraction (RPR) with astigmatism in Chinese children with mild to moderate myopia, and to provide new insights into the influence of astigmatism.

Methods: Three-hundred-and-seven children (6-14 years old) from Shanghai were included in this study.

Analysis of differences between keratometric astigmatism and total corneal astigmatism measured by IOLMaster 700.

Purpose: To compare keratometric astigmatism (ΔK) and total corneal astigmatism (ΔTK) calculated by the IOLMaster 700 in cataract cases with regular corneal astigmatism ≥ 0.75 diopters (D).

Methods: This study was a secondary analysis of a database of cataract patients who had undergone examination with IOLMaster 700 between May 2021 and March 2022 at Shanghai Eye Disease Prevention and Treatment Center.

Hyperopia shift in the long term after cataract surgery: a case report.

Background: Long-term hyperopia shift is a rare complication following cataract surgery, presenting significant clinical challenges in analysis and management.

Case Presentation: A 52-year-old female with a history of high myopia and laser-assisted in-situ keratomileusis (LASIK) surgery presented with decreased vision in her left eye at the very fifth year after cataract surgery. The spherical equivalent in her left eye had increased to + 6.

Intraocular pressure measurement and association with corneal biomechanics in patients underwent Descemet's stripping with endothelial keratoplasty: a comparative study.

Purpose: To compare corneal biomechanical properties and intraocular pressure (IOP) measurements in patients who underwent Descemet's stripping with endothelial keratoplasty (DSEK) with those of the follow healthy eyes.

Methods: In this retrospective comparative study, a total of 35 eyes of 35 patients who underwent DSEK by a single surgeon from 2015.02 to 2019.

Correlation between pupillary size and depth of focus after the implantation of extended depth of focus intraocular lenses.

Purpose: To evaluate whether depth of focus after the implantation of extended depth of focus (EDoF) intraocular lenses (IOLs) correlates with pupillary size.

Methods: This retrospective case series study evaluated eyes undergoing cataract surgery with implantation of EDoF IOLs. At least one month postoperatively, the depth of focus (DoF) was measured to determine the correlation with pupillary size, age, anterior chamber depth (ACD), axial length (AXL), and corneal spherical aberrations (SA).

Development and validation of a smartwatch algorithm for differentiating physical activity intensity in health monitoring.

To develop and validate a machine learning based algorithm to estimate physical activity (PA) intensity using the smartwatch with the capacity to record PA and determine outdoor state. Two groups of participants, including 24 adults (13 males) and 18 children (9 boys), completed a sequential activity trial. During each trial, participants wore a smartwatch, and energy expenditure was measured using indirect calorimetry as gold standard.

Early Retinal Microvasculopathy in Prediabetic Patients and Correlated Factors.

Introduction: We aimed to detect early retinal microcirculation changes in prediabetic patients and investigate their correlation with clinical examinations.

Methods: Forty-seven prediabetic individuals, 29 controls, and 81 type 2 diabetic mellitus (T2DM) patients were enrolled in this study. A review of clinical data and spectral-domain optical coherence tomography angiography (SD-OCTA) parameters of macular vessel diameter (VD), foveal avascular zone (FAZ), and macular vessel area density (VAD) was performed.

tiRNA-Val promotes angiogenesis via Sirt1-Hif-1α axis in mice with diabetic retinopathy.

Background: Diabetic retinopathy (DR) is a specific microvascular complication arising from diabetes, and its pathogenesis is not completely understood. tRNA-derived stress-induced RNAs (tiRNAs), a new type of small noncoding RNA generated by specific cleavage of tRNAs, has become a promising target for several diseases. However, the regulatory function of tiRNAs in DR and its detailed mechanism remain unknown.

Telescreening satisfaction: disparities between individuals with diabetic retinopathy and community health center staff.

Background: The success of telescreening and the management of diabetic retinopathy (DR) in communities depends on stakeholder satisfaction, including both individuals with diabetes and community health center (CHC) staff. In this study, we investigated the satisfaction of both individuals with vision-threatening DR (VTDR) and CHC staff within the Shanghai Eye Disease Study (SEDS) comprehensive system for managing diabetic eye diseases at the primary care level.

Methods: The cross-sectional survey of patients receiving the service included 3,817 respondents with VTDR and focused on their satisfaction with the SEDS system, including the telescreening process, speed of feedback, interpretation of results, increased awareness of related diseases, and eye care services.

Hinokiflavone induces apoptosis via activating mitochondrial ROS/JNK/caspase pathway and inhibiting NF-κB activity in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the sixth most common malignancy with limited treatment options. Hinokiflavone (HF), a natural biflavonoid, has shown to inhibit the proliferation of melanoma, whereas its antitumour effect against HCC and the underlying mechanisms remain elusive. Here, we aimed at evaluating its antitumour effect against HCC in both in vitro and in vivo.