Synergistic Amino and Hydroxyl Groups That Enhance SOD-Like Activity in Curcumin Carbon Dots for Improved Colitis Treatment.

Inflammatory bowel disease (IBD) is a globally prevalent inflammatory disorder with limited therapeutic options due to efficacy-safety trade-offs. Herein, we rationally designed polyethylenimine (PEI)-functionalized curcumin-derived carbon dots (cu@CDs-po) as a multifunctional nanotherapeutic agent for colitis management. Combined experimental and computational analyses revealed that the synergistic interplay between surface-engineered amino and hydroxyl groups significantly enhanced the superoxide dismutase (SOD)-like activity of cu@CDs-po by 5.

Lonicera japonica Thunb. in acute lung injury: A systematic review of bioactive components and multi-target mechanisms.

Background: Acute lung injury (ALI), characterized by dysregulated host-pathogen interactions and hyperinflammatory responses, poses a critical clinical burden in viral infections such as influenza and COVID-19. Lonicera japonica Thunb. (LJT), a cornerstone herb in traditional medicine for respiratory ailments exhibits multi-component synergy with documented anti-ALI properties.

Dual-Strategy Pullulan-Soluble Microneedles Based on LL37@ZIF-8 and Artificial Nanozyme Antioxidation for Infected Wound Healing.

Infected skin wound healing involves a series of dynamic and complex physiological processes. In this study, we reported a dissolvable microneedle (MN) with pullulan as the matrix material. The antimicrobial peptide LL37 was immobilized within ZIF-8 to form hybrid nanoparticle LL37@ZIF-8 (LZ).

Chitosan sponge doped with high-yield microporous carbon nanospheres for rapid hemostasis.

Rapid and effective hemostasis can immediately control blood loss and prevent fatal complications. Chitosan sponge loaded with carbon nanospheres PC-800 for rapid hemostasis was first reported here. Preparation process is simple, green and low-cost.

Chlorogenic acid targets SLC37A2 to inhibit macrophage activation via ER-dependent NF-κB and NLRP3 signaling pathways against sepsis-induced acute lung injury.

Sepsis-induced acute lung injury (SI-ALI) requires urgent treatment due to severe inflammation. Our study found chlorogenic acid (CGA) suppressed LPS-induced macrophage activation by lowering NO, TNF-α, and IL-6. TPP-based strategies identified SLC37A2 as the direct target of CGA, validated by CETSA/MST.

Chemoproteomic Strategy Identifies PfUCHL3 as the Target of Halofuginone.

The human malaria parasite Plasmodium falciparum (P. falciparum) continues to pose a significant public health challenge, leading to millions of fatalities globally. Halofuginone (HF) has shown a significant anti-P.