Cell-Type-Dependent Differential Cytotoxic and Genotoxic Effects: Comprehensive Mechanistic Insights of L-Ascorbic Acid on Healthy Lymphocytes and HL-60 Cancer Cells.

l-Ascorbic acid exhibits paradoxical behavior as both antioxidant and pro-oxidant in cancer treatment, with mechanisms and optimal dosing remaining unclear. This in vitro study investigated l-ascorbic acid's effects on healthy lymphocytes and HL-60 leukemia cells using concentrations of 0.5-2 mg/mL for 6 and 24 h.

An Eocene shallow water isselicrinid sea lilies from the Northern Hemisphere.

Stalked crinoids are uncommon fossils in the Cenozoic. This is particularly due to their continuous decline starting from the Late Cretaceous and gradual restriction to the deep-sea environment, which bears a fossil record bias. On the other hand, in recent times, new data have emerged documenting some relict populations of sea lilies in the shallow marine facies from the Cenozoic.

A hybrid framework of statistical, machine learning, and explainable AI methods for school dropout prediction.

Student dropout is a significant challenge in Bangladesh, with serious impacts on both educational and socio-economic outcomes. This study investigates the factors influencing school dropout among students aged 6-24 years, employing data from the 2019 Multiple Indicator Cluster Survey (MICS). The research integrates statistical analysis with machine learning (ML) techniques and explainable AI (XAI) to identify key predictors and enhance model interpretability.

Comparison of antirotation proximal femoral nail and talon locking nail systems in the treatment of intertrochanteric fractures: functional and cost-effectiveness outcomes.

Purpose: This study aimed to compare the clinical outcomes and cost-effectiveness of two widely used intramedullary fixation systems-the Proximal Femoral Nail Antirotation (PFNA) and the Proximal Femoral Nail with Talon Locking System (PFN-TLS)-in the treatment of intertrochanteric femur fractures (ITFF).

Methods: A retrospective cohort study was conducted on 118 patients aged 65-90 years who underwent surgical treatment for ITFF using either PFNA (n = 53) or PFN-TLS (n = 65). All patients were followed for a minimum of 24 months.

Therapeutic Power of Date Fruit ( L.): A Nutrient-Rich Superfood for Holistic Health and Disease Prevention.

Date fruit ( L.) is a highly nutritious and therapeutic food with substantial potential to improve human health. This review emphasizes the nutritional and therapeutic traits of date fruit, focusing on its role as a functional food and dietary supplement.

Early versus Delayed Plate Fixation in Pilon Fractures.

Background: Pilon fractures refer to distal tibial fractures that may involve extra-articular, partial articular, or complete intra-articular components, most commonly caused by high-energy trauma. The choice between early (<72 hours) and delayed (>7 days) surgical fixation significantly impacts clinical outcomes. This study aimed to compare the effects of early vs.

Association of missense variant DCLRE1B rs3761936 with breast and cervical cancer risk-A case-control study.

Background: Overexpression of rs3761936 of DCLRE1B gene has been observed in both breast cancer and cervical cancer patients. To justify the association of this polymorphism with these cancers, we performed this case-control study.

Method: A total of 245 cancer patients and 108 healthy controls participated in the research.

16S rRNA metagenome analysis of gut bacteriome of Rohu () from Halda River and Kaptai Lake, Bangladesh.

This research evaluated the gut microbiota of Rohu fish from the Halda River and Kaptai Lake in Bangladesh by 16S rRNA sequencing. Distinct microbial profiles were identified, with Halda samples concentrated in pathogens and Kaptai samples abundant in probiotics.

Comprehensive Analysis for Low-Cost and Highly Efficient Perovskite Solar Cells Using SCAPS-1D with an Inexpensive Hole Transport Material, Electron Transport Material, and Back Contact Considering the Toxicity.

Perovskite solar cells (PSCs) are rapidly advancing due to their high power conversion efficiencies (PCEs) and low fabrication costs. However, their commercialization is hindered by lead toxicity and the use of expensive materials, such as Spiro-OMeTAD and gold electrodes. This study presents a comprehensive SCAPS-1D simulation-based analysis of 14 perovskite absorber materials, spanning both Pb-based and lead-free compounds, under a unified device architecture using low-cost, nontoxic components: ZnO as the electron transport material (ETM), PEDOT:PSS + WO as a dual hole transport material, and nickel as the back contact.

Okra Mucilage as a Multifunctional Fat Replacer in Mozzarella Cheese: A Nutritious and Sustainable Solution for the Food Industry.

Mozzarella is a white, soft, fermented cheese that is often recognized for its stretchability and typically contains approximately 40% total fat (dry basis), a considerable portion of which is saturated fat. Low-fat mozzarella cheese (LFMC) has started to increase in popularity among health-conscious consumers. Unfortunately, the inadequate meltability and rubbery texture of LFMC make it undesirable for many consumers.

Taste of Tradition: Perceptual Quality Aspects and Future Prospects of Three Swedish Classic Cheeses.

Traditional cheese production represents an important aspect of gastronomic heritage, blending cultural identity with sensory characteristics. This study investigates the sensory characteristics, consumer preferences, and physicochemical properties of three traditional Swedish hard cheeses-Grevé, Herrgård, and Präst-matured for 12 and 18 months. Using Quantitative Descriptive Analysis (QDA), instrumental color and texture profiling, and a hedonic consumer study, the research explores how cheese type and maturation influence sensory perception and liking.

Mechanically Tunable Biofabricated Channels Enable Mimicking Arterial Pulsatility and Dynamic Tissue Actuation.

Dynamic alteration of blood vessel geometry is an inherent feature of the circulatory system. However, while the engineering of multiscale, branched, and interconnected blood vessels has been well explored, mimicking the dynamic behavior (e.g.

Effect of LPJZ-658 on caecum microbiota and serum metabolomics of Luhua broiler.

Introduction: The purpose of this study was to investigate the effects of dietary supplementation of LPJZ-658 on body weight and serum indexes of Luhua broiler, and to explore the relevant mechanism of probiotic function of LPJZ-658 based on intestinal microbiota and serum metabolomics.

Methods: One hundred one-day-old Luhua broiler were randomly divided into the control group (CON) and LPJZ-658 treatment group (LPJZ-658). The CON group was fed a basal diet, and the LPJZ-658 group was fed the basal diet supplemented with 2 × 10 cfu/kg of LPJZ-658.

Dietary Phytochemicals in Cardiovascular Disease Prevention and Management: A Comprehensive Review.

Cardiovascular disease (CVD) is the leading cause of death worldwide and a major public health issue. According to recent World Health Organization (WHO) estimates, CVD causes approximately 17.9 million deaths annually, accounting for 32% of global mortality.

Synthesis of three-dimensional nitrogen-doped reduced graphene oxide catalyst with high activity in acidic.

In this study, we synthesized a novel three-dimensional nitrogen-doped reduced graphene oxide (3D-NRGO) by integrating a sulfonated polystyrene (PSS) template method with nitrogen doping. The resulting 3D-NRGO was applied as an electrocatalyst for the oxygen reduction reaction (ORR) in acidic electrolyte. Owing to the synergistic effect arising from its three-dimensional structure and nitrogen doping, the catalyst demonstrates substantially augmented catalytic current density, a more positive ORR potential, excellent methanol tolerance, and prolonged operational stability.

Transcriptome Analysis Reveals Candidate Pathways and Genes Involved in Wheat ( L.) Response to Zinc Deficiency.

Zinc (Zn) deficiency poses a major global health challenge, and wheat grains generally contain low Zn concentrations. In this study, the wheat cultivar 'Zhongmai 175' was identified as zinc-efficient. Hydroponic experiments demonstrated that Zn deficiency induced the secretion of oxalic acid and malic acid in root exudates and significantly increased total root length in 'Zhongmai 175'.

Nanogel Loaded with Leaf-Derived Exosome-like Nanovesicles and Indomethacin for the Treatment of Inflammatory Arthritis.

Inflammatory arthritis (IA) is a chronic condition marked by joint dysfunction and pain, posing significant challenges for effective drug delivery. This study separated leaf-derived exosome-like nanovesicles (PFE) to effectively penetrate the stratum corneum barrier. These nanovesicles and indomethacin (IND) were subsequently developed into a nanogel designed for topical drug delivery systems (PFE-IND-GEL).

Mechanoenzymatic Reactions: Current Applications, Mechanistic Insights, and Future Challenges.

In the context of the escalating shortage of global resources, mechanoenzymology has emerged as a transformative platform for the production of economically viable, high-value products. This innovative method employs mechanical force to drive enzyme-catalyzed reactions, demonstrating significant advantages in terms of green chemistry indicators, catalytic efficiency, and process sustainability. It has proven successful in various fields, including food processing, biopharmaceutical, and biomass resources development.

Multifunctional PVDF membranes incorporating graphene, TiO, and nanocellulose: synergistic effects on filtration and antifouling performance.

Methylene blue (MB) remains one of the most resilient contaminants in industrial wastewater which presents serious threats to both environmental integrity and human health. Its high chemical stability and resistance to natural degradation render most conventional treatment methods ineffective. As such, this study aimed to develop a multifunctional nanocomposite membrane that mitigates membrane fouling, enhances dye separation, and improves water permeability.

Synthesis of flexible SERS sensing platform of graphene/Ag-popcorns/ PMMA for ultrasensitive detection.

Surface-enhanced Raman scattering (SERS) with ultrahigh sensitivity has garnered significant attention for quantitative analysis and chemically specific detection. However, conventional SERS platforms, typically structured by depositing plasmonic micro/nanoparticles onto rigid substrates, face limitations in further advancement and applications. In this study, we present a novel method to prepare a flexible SERS film substrate composed of graphene overlayer (G) atop a self-assembled array of silver micropopcorns (Ag MPs) and a polymethyl methacrylate (PMMA) membrane.

Arsenic bioaccumulation in fish of the lower meghna river: Seasonal dynamics, species sensitivity, and public health implications.

The Lower Meghna River (LMR), located in one of Bangladesh's most arsenic-contaminated regions, is essential for local fisheries and provides water for drinking, irrigation, and daily use. Consequently, this study investigates arsenic accumulation in ten edible, small indigenous species (SIS) of fish, considering their morphology, habitats, diets, and water and sediment conditions. Samples were analysed across three distinct river segments during three seasons.

Cheminformatics-based screening and evaluation of phytochemicals as CDK2 inhibitors in colorectal cancer therapy.

Colorectal cancer (CRC) poses a significant global health issue. It ranks as the third most common type of cancer and the second leading cause of cancer-related deaths. Among the molecular factors driving its progression, cyclin-dependent kinase 2 (CDK2) plays a key role.

Innovative Strategies for Postharvest Disease Management in Fruits and Vegetables: A Comprehensive Treatise.

Postharvest diseases, driven by necrotrophic fungi such as , , and , pose a significant threat to global fruit and vegetable supply chains, resulting in annual losses of 20%-40% and economic impacts exceeding $10 billion. This review critically evaluates innovative, sustainable strategies for biological control, nanotechnology, edible coatings, and plant growth regulators (PGRs) to mitigate these losses, emphasizing their mechanisms and efficacy. Biological agents like and reduce disease incidence by 60%-85% through volatile organic compounds (VOCs) and nutrient competition.

Impact of Nanonutrient Complex on Growth Performance, Feed Efficiency, and Hematobiochemical Profiles in Asian Catfish, .

Understanding how nanonutrients influence the growth and physiological processes of cultivable fish can boost fish production efficiency with less management, advancing aquaculture toward global food security. In this study, a 60-day feeding trial was conducted to determine the effects of a nanonutrient complex (NNC) on the growth performances and physiology of Asian catfish, . Nanoparticles (NPs; Zn, Cu, and Fe) were synthesized from their metallic salts using an established acoustic method and characterized via scanning electron microscopy.

A Prelude to Conservation Genomics: First Chromosome-Level Genome Assembly of a Flying Squirrel (Pteromyini: ).

The Siberian flying squirrel () represents the only European Pteromyini species. Thus, it is biogeographically unique due to its specialised anatomy and biology as a volant rodent. As a result of habitat fragmentation and destruction, Siberian flying squirrels experience severe and ongoing population declines throughout most of their distribution.