Nanogel Loaded with Leaf-Derived Exosome-like Nanovesicles and Indomethacin for the Treatment of Inflammatory Arthritis.

Inflammatory arthritis (IA) is a chronic condition marked by joint dysfunction and pain, posing significant challenges for effective drug delivery. This study separated leaf-derived exosome-like nanovesicles (PFE) to effectively penetrate the stratum corneum barrier. These nanovesicles and indomethacin (IND) were subsequently developed into a nanogel designed for topical drug delivery systems (PFE-IND-GEL).

In Situ Polymerized Organic Salt Interlayer for Enhanced Performance in Printable Mesoscopic Perovskite Solar Cells.

Achieving high efficiency in perovskite solar cells (PSCs) requires a stable and robust buried interface. In this work, a durable buffer layer at the buried interface of printable mesoscopic PSCs (p-MPSCs) is introduced by modifying the mesoporous TiO electron transport layer with sodium thioctate (ST), a self-polymerizing organic salt. Under relatively mild conditions, ST undergoes in situ polymerization on the inner surface of TiO, forming a cross-linked poly(ST) interfacial buffer layer at the junction with the perovskite.

Wettability Sequence Optimization and Interface Strain Buffering in Triple Mesoporous Layer-Based Printable Perovskite Solar Cells for Enhanced Performance.

Perovskite solar cells have achieved remarkable progress in photovoltaic performance, driven by advancements in interface engineering. The buried interface between the electron transport layer and the perovskite layer is particularly critical, as it governs both perovskite crystallization and the formation of residual strain. In this study, the buried interface in printable mesoscopic perovskite solar cells (p-MPSCs) based on a triple-mesoporous scaffold of TiO/ZrO/carbon is reconstructed by employing dodecaethylene glycol (DEG), a long chain molecule rich in polar oxygen atoms, to enhance device performance.

Recent Progress and Advances of Perovskite Crystallization in Carbon-Based Printable Mesoscopic Solar Cells.

Carbon-based printable mesoscopic solar cells (p-MPSCs) offer significant advantages for industrialization due to their simple fabrication process, low cost, and scalability. Recently, the certified power conversion efficiency of p-MPSCs has exceeded 22%, drawing considerable attention from the community. However, the key challenge in improving device performance is achieving uniform and high-quality perovskite crystallization within the mesoporous structure.

Room-Temperature Ripening Enabled by Hygroscopic Salts for Hole-conductor-Free Printable Perovskite Solar Cells with Efficiency Over 20 .

Solution-processed perovskite films generally possess small grain sizes and high density of grain boundaries, which intensify non-radiative recombination of carriers and limit the power conversion efficiency (PCE) of solar cells. In this study, we report the room-temperature ripening enabled by the synergy of hygroscopic salts and moisture in air for efficient hole-conductor-free printable mesoscopic perovskite solar cells (p-MPSCs). Treating perovskite films with proper hygroscopic salts in damp air induces obvious secondary recrystallization, which coarsens the grains size from hundreds of nanometers to several micrometers.

Record-Efficiency Printable Hole-Conductor-Free Mesoscopic Perovskite Solar Cells Enabled by the Multifunctional Schiff Base Derivative.

Tailoring multifunctional additives for performing interfacial modifications, improving crystallization, and passivating defects is instrumental for the fabrication of efficient and stable perovskite solar cells (PSCs). Here, a Schiff base derivative, (chloromethylene) dimethyliminium chloride (CDCl), is introduced as an additive to modify the interface between the mesoporous TiO electron transport layer and the MAPbI light absorber during the annealing process. CDCl chemically links to TiO and MAPbI through coordination and hydrogen bonding, respectively, and results in the construction of fast electron extraction channels.

Immune cells and RBCs derived from human induced pluripotent stem cells: method, progress, prospective challenges.

Blood has an important role in the healthcare system, particularly in blood transfusions and immunotherapy. However, the occurrence of outbreaks of infectious diseases worldwide and seasonal fluctuations, blood shortages are becoming a major challenge. Moreover, the narrow specificity of immune cells hinders the widespread application of immune cell therapy.

Lipid metabolism in malignant tumor brain metastasis: reprogramming and therapeutic potential.

Introduction: Brain metastasis is a highly traumatic event in the progression of malignant tumors, often symbolizing higher mortality. Metabolic alterations are hallmarks of cancer, and the mask of lipid metabolic program rearrangement in cancer progression is gradually being unraveled.

Areas Covered: In this work, we reviewed clinical and fundamental studies related to lipid expression and activity changes in brain metastases originating from lung, breast, and cutaneous melanomas, respectively.

Advances in the synthesis and modification of two-dimensional antimonene.

Antimonene with a honeycomb layered structure has great application prospects in a wide spectrum of domains due to its high carrier mobility, high thermal conductivity, and layer-dependent electrical properties. Since the first successful synthesis of antimonene by epitaxy in 2015, various fabrication methods have been proposed successively. Herein, several representative synthetic methods are described in detail, including mechanical exfoliation, epitaxial growth, liquid-phase exfoliation, electrochemical exfoliation, In addition, band engineering modification strategies of antimonene, particularly intercalation and doping, is discussed based on available theoretical studies.

Research progress of two-dimensional antimonene in energy storage and conversion.

Since the first proposal of antimonene in 2015, extensive research attention has been drawn to its application in energy storage and conversion because of its excellent layered structure and fast ion diffusion properties. However, in contrast to the revolutionary expansion of antimonene-based energy devices, reviews on this topic that summarize and further guide the design of 2D antimonene for energy storage and conversion are rare. In this review, the structure, physicochemical properties, and popular synthesis approaches of antimonene are first summarised.

A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques.

Nonalcoholic steatohepatitis (NASH) is a progressive liver disease and has become a leading indication for liver transplantation in the United States. The development of effective therapies for NASH is a major unmet need. Here, we identified a small molecule, IMA-1, that can treat NASH by interrupting the arachidonate 12-lipoxygenase (ALOX12)–acetyl-CoA carboxylase 1 (ACC1) interaction.

Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis.

Lipotoxicity is a recognized pathological trigger and accelerator of nonalcoholic steatohepatitis (NASH). However, the molecular basis of lipotoxicity-induced NASH remains elusive. Here, we systematically mapped the changes in hepatic transcriptomic landscapes in response to lipotoxic insults across multiple species.

Hepatocyte SH3RF2 Deficiency Is a Key Aggravator for NAFLD.

Background And Aims: NAFLD has become the most common liver disease worldwide but lacks a well-established pharmacological therapy. Here, we aimed to investigate the role of an E3 ligase SH3 domain-containing ring finger 2 (SH3RF2) in NAFLD and to further explore the underlying mechanisms.

Methods And Results: In this study, we found that SH3RF2 was suppressed in the setting of NAFLD across mice, monkeys, and clinical individuals.

Pou4f3 gene mutation promotes autophagy and apoptosis of cochlear hair cells in cisplatin-induced deafness mice.

Pou4f3 plays an important role in the development of hair cells in the inner ear sensory epithelia. Autophagy is related to the auditory damage. However, the role and mechanism of Pou4f3 on drug-induced ototoxicity are incompletely understood.

[Hemaorheology, Coagulation and Clinical Features of Malignant Lymphoma Combined with Venous Thromboembolism].

Objective: To explore the hematological and clinical features of patients with malignant lymphoma (ML) combined with venous thromboembolism (VTE).

Methods: Sixty patients with ML combined with VTE in our hospital from May 2014 to May 2016 were enrolled in ML+VTE group, out of them 42 patients were males and 18 patients with females; another 60 patients with ML alone were enrolled in control group, out of them 43 patients were males and 17 patients females. The hematological, coagulation and clinical datas of all the patients were collected and then retrospectively analyzed.

Up-regulation of autophagy and apoptosis of cochlear hair cells in mouse models for deafness.

Introduction: Hearing loss is one of the most common sensory disorders. Recent findings have shown that the apoptotic program and autophagy are related to hearing loss. The aim of the study was to explore the effects of noise and cisplatin exposure on apoptosis and autophagy in the hair cells of the cochleae.

Alleviation of Toxicity Caused by Overactivation of Pparα through Pparα-Inducible miR-181a2.

Widely varied compounds, including certain plasticizers, hypolipidemic drugs (e.g., ciprofibrate, fenofibrate, WY-14643, and clofibrate), agrochemicals, and environmental pollutants, are peroxisome proliferators (PPs).