Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Hearing loss is one of the most common sensory disorders. Recent findings have shown that the apoptotic program and autophagy are related to hearing loss. The aim of the study was to explore the effects of noise and cisplatin exposure on apoptosis and autophagy in the hair cells of the cochleae.
Material And Methods: C57BL/6 mice were randomly divided into 3 groups ( = 10 for each): the control group, the noise model group and the cisplatin model group. Auditory brainstem response (ABR) measurements were used to detect the hearing thresholds. TUNEL assay was used to evaluate cell apoptosis. Western blot and immunofluorescence were performed to examine the apoptosis- and autophagy-related proteins.
Results: The mice exhibited substantial hearing loss after noise and cisplatin exposure. Additionally, more TUNEL positive cells were observed in the mice after noise and cisplatin exposure compared with the control group. Moreover, the protein expression levels of Beclin-1, LC3-II, Bax and cleaved caspase-3 were significantly increased, while the expression of Bcl-2 was notably decreased in the cochlea after noise ( = 0.0278, 0.0075, 0.0142, 0.0158, 0.0131 respectively) and cisplatin ( = 0.0220, 0.0075, 0.0024, 0.0161, 0.0452 respectively) exposure compared with the control group. Besides, the ratio of LC3-II/LC3-I was substantially higher in the mice treated by cisplatin ( = 0.0046) and noise ( = 0.0220) compared with the control group.
Conclusions: Our findings demonstrated for the first time that noise and cisplatin exposure promoted apoptosis and autophagy in the hair cells of the cochleae. This study provides new insights into the mechanisms of noise- or cisplatin-induced hearing loss.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959062 | PMC |
| http://dx.doi.org/10.5114/aoms.2018.75348 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tonal Tinnitus Does Not Interfere with Tone Detection at the Tinnitus Pitch-Matched Frequency.
Trends Hear
September 2025
Department of Otolaryngology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Individuals with tinnitus hear sounds that are not present in the external environment. Whereas hearing difficulties at frequencies near those matching the tinnitus pitch are a common complaint for individuals with tinnitus, it is unclear to what extent the internal tinnitus sounds interfere with the detection of external sounds. We therefore studied whether pure-tone detection at the estimated frequency corresponding to the tinnitus pitch (f) was affected by confusion with the tinnitus percept.
View Article and Find Full Text PDFNo Association Between Vocal Emotion Recognition and Subjective Parental Reporting of Alexithymia in School-Age Children With Hearing Aids.
Ear Hear
September 2025
Department of Otorhinolaryngology, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands.
Objectives: Alexithymia is characterized by difficulties in identifying and describing one's own emotions. Alexithymia has previously been associated with deficits in the processing of emotional information at both behavioral and neurobiological levels, and some studies have shown elevated levels of alexithymic traits in adults with hearing loss. This explorative study investigated alexithymia in young and adolescent school-age children with hearing aids in relation to (1) a sample of age-matched children with normal hearing, (2) age, (3) hearing thresholds, and (4) vocal emotion recognition.
View Article and Find Full Text PDFTransforming Access to Hearing Care: Community Perspectives on School-Based Telehealth in Rural Appalachia.
Ear Hear
September 2025
Department of Otolaryngology-Head and Neck Surgery, University of Kentucky Medical Center, Lexington, Kentucky, USA.
Objectives: School-based hearing screening serves as a critical resource for children in rural areas to be screened and connected to hearing healthcare. Telemedicine interventions in schools have shown promise in connecting children to providers; however, there is limited research on systematic adaptation and deployment of telemedicine in rural schools. Obtaining community perspectives and preferences on school-based telemedicine hearing evaluation is essential to ensure such interventions are deployable in a rural context.
View Article and Find Full Text PDFFully Endoscopic Microvascular Decompression for Hemifacial Spasm Using 2-Dimensional/3-Dimensional Endoscopy: Clinical Analysis of 204 Cases.
Oper Neurosurg
September 2025
Department of Neurosurgery and the Training Base of Neuroendoscopic Physicians under the Chinese Medical Doctor Association, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Background And Objectives: Microvascular decompression (MVD) for hemifacial spasm (HFS) is commonly conducted under a microscope. We report a large series of fully endoscopic MVDs for HFS and describe our initial experience with 3-dimensional (3D) endoscopy.
Methods: Clinical data of 204 patients with HFS who underwent fully endoscopic MVD using 2-dimensional (2D) and 3D endoscopy (191 and 13 patients, respectively) from July 2017 to October 2024 were retrospectively analyzed.
Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise-Induced Hearing Loss.
Adv Sci (Weinh)
September 2025
ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China.
Noise-induced hearing loss (NIHL), caused by irreversible cochlear hair cell (HC) damage, lacks effective therapies due to a limited understanding of endogenous protective mechanisms. The echolocating bats exhibit natural resistance to intense noise, and this suggested novel insights into methods to protect against NIHL. Here, through comparative transcriptomic analysis of noise-exposed cochleae from the eastern bent-winged bats (Miniopterus fuliginosus) and mice, the specific transcriptional dynamics in noise-resistant Miniopterus fuliginosus are revealed, thus highlighting potential mechanisms for preventing cochlear damage that mouse models cannot replicate, with Hras emerging as the most significant hub upregulator.
View Article and Find Full Text PDF