The cachexia index as a prognostic indicator in patients with cervical cancer treated with radiotherapy: A retrospective study.

Objective: The cachexia index (CXI) demonstrates potential as both a diagnostic tool for cachexia and a prognostic tool for survival in cancer. However, CXI's predictive value has not been verified in cervical cancer. The purpose of this study is to investigate the prognostic value of the CXI in patients with cervical cancer treated with radiotherapy.

A simplified clinical frailty scale predicts mortality in emergency department patients with acute dyspnea.

To evaluate a simplified version of the Clinical Frailty Scale (SCFS) among older adults presenting to the emergency department (ED) with acute dyspnea. In this retrospective single-center cohort study, we included patients from the Acute Dyspnea Study (ADYS) cohort. Severity of illness was assessed using the Medical Emergency Triage and Treatment System (METTS).

Tissue bridges offer valuable insights into bladder and bowel outcomes in chronic cervical spinal cord injury.

Purpose: This study aimed to investigate the relationship between tissue bridges and bladder and bowel outcomes in chronic cervical spinal cord injury (SCI).

Methods: Between July 2020 and January 2024, 44 patients with chronic cervical SCI were retrospectively included in this cross-sectional study at a specialized SCI center. Lesion severity was assessed by tissue bridges, lesion length, lesion width, and lesion area.

Graded nomograms based on perioperative parameters for predicting New-Onset severe acute kidney injury following liver transplantation in patients with normal preoperative renal function: the SALT scale.

This study aimed to develop a predictive model and construct a graded nomogram to estimate the risk of severe acute kidney injury (AKI) in patients without preexisting kidney dysfunction undergoing liver transplantation (LT). Patients undergoing LT between January 2022 and June 2023 were prospectively screened. Severe AKI was defined as Kidney Disease: Improving Global Outcomes stage 3.

Validation of Hounsfield units for preoperative bone mineral density assessment in intertrochanteric femoral fractures.

Background: Hounsfield units (HU) on computed tomography (CT) are strongly correlated with bone mineral density (BMD) and may aid in osteoporosis screening. However, there is no standardized method for assessing bone density in displaced femoral head fractures. This study aimed to measure HU values in the femoral head using preoperative post-fracture CT images of patients with intertrochanteric femoral fractures and investigate whether it correlated with BMD measured by dual-energy X-ray absorptiometry (DXA).

Enhancing bonding and durability of polyaryletherketone (PAEK) restorations with nonthermal plasma activation and monomer-based priming.

Statement Of Problem: While valued for their durability in dental prosthetics, polyaryletherketone (PAEK) materials, known for their chemical inertness and low surface energy, pose significant challenges in achieving durable adhesion to resin cements, a critical factor for the long-term success of dental restorations.

Purpose: This study evaluates the novel application of a methyl methacrylate-urethane dimethacrylate (MMA-UDMA) bonding primer following handheld nonthermal plasma (HNP) treatment to enhance the bonding performance and aging durability of PAEK materials with varying microfiller compositions, addressing the persistent challenge of achieving long-term adhesion in dental restorations.

Material And Methods: Three PAEK types, ceramic-filled polyetheretherketone (PEEK), titanium dioxide-filled polyetherketoneketone (PEKK), and PEEK with disk shape (Ø10×2.

Interdisciplinary Analysis of Cues to Triage Gastric Lymphoid Proliferations: Role of the Surgical Pathologist Revisited.

Surgical pathologists who examine gastric biopsies must triage exuberant lymphoid infiltrates for hematopathology consultation, a task that should account for resource and time utilization. We assembled all cases of chronic gastritis sent by surgical pathologists to hematopathology due to concern for low-grade lymphoma over a 4-year interval. The cases were ultimately classified as reactive (n=37), atypical (n=9), or lymphoma (n=18).

Immunometabolic biomarkers of brain aging: Nonlinear association between neutrophil-to-HDL cholesterol ratio and cognitive decline in older adults.

Background: Immune dysregulation and metabolic disturbances contribute to cognitive decline in aging populations. The neutrophil-to-HDL cholesterol ratio (NHR), an emerging immunometabolic biomarker, reflects systemic inflammation and vascular dysfunction. However, its role in predicting cognitive impairment in older adults remains unclear.

Association Between the Frailty Index Based on Laboratory Tests and All-Cause Mortality in Hospitalized Older Adults: Retrospective Cohort Study.

Background: Frailty is a common issue among hospitalized older adult patients and is associated with numerous adverse health outcomes. Assessing frailty facilitates better decision-making for treatment plans, patient placement, and discharge planning. Approximately a decade ago, the frailty index based on laboratory tests (FI-Lab) metric was introduced.

Combined SHR and SIRI biomarkers predict increased coronary heart disease risk in type 2 diabetes.

Coronary heart disease (CHD) is a leading cause of morbidity and mortality; patients with type 2 diabetes mellitus (T2DM) are at particularly high risk, highlighting the need for reliable biomarkers for early detection and risk stratification. We investigated whether combining the stress hyperglycemia ratio (SHR) and systemic inflammation response index (SIRI) improves CHD detection in T2DM. In this retrospective cohort of 943 T2DM patients undergoing coronary angiography, associations of SHR and SIRI with CHD were evaluated using multivariable logistic regression and restricted cubic splines; robustness was examined with subgroup and sensitivity analyses.

DNA Binding and Electrochemical Characterization of Oxidative Products of the Cobalt(II) Complex.

The synthesis of -tetrakis(3,4,5-trimethoxyphenyl)porphyrin [HT(3,4,5-OCH)PP] and cobalt(II) -tetrakis(3,4,5-trimethoxyphenyl)porphyrin [Co(T(3,4,5-OCH)PP)] has been successfully accomplished. The oxidation properties of [Co(T(3,4,5-OCH)PP)] have been assessed through UV-vis, NMR, and EPR techniques. It can be seen in the UV-vis spectrum that adding SbCl caused extra peaks to appear at 674 nm, which means that a π-cation radical was formed.

The utility of thymus and spleen ultrasound in the early prediction of neonatal sepsis.

BackgroundThis investigation aimed to determine the utility of postnatal, ultrasonographically-derived dimensions of the thymus and spleen as imaging indicators for the prediction of early-onset neonatal sepsis (EOS).Material and MethodIn this case-control study, 30 term neonates diagnosed with Early-Onset Sepsis (EOS), based on European Medicines Agency (EMA) criteria, were compared to 30 healthy, matched control neonates. All participants underwent ultrasonography to quantify thymic and splenic dimensions.

Relationship between the blood urea nitrogen to serum albumin ratio and in-hospital mortality in patients with type 2 diabetes mellitus complicated with ischemic stroke.

Background: Type 2 diabetes mellitus (T2DM) complicated with ischemic stroke is a major challenge to global public health and is related to poor prognosis. However, the role of blood urea nitrogen(BUN)to serum albumin ratio (BAR) in predicting in-hospital mortality of T2DM patients with ischemic stroke has not been fully explored. This study was carried out to investigate the relationship between BAR level and in-hospital mortality of T2DM patients with ischemic stroke.

Visceral Adipose Tissue Cut-Points for Increased Metabolic Risk in Chinese Adults using Low Dose Computed Tomography: a Nationwide Multi-Centre Study.

Introduction: Visceral adipose tissue (VAT) is a significant driver for metabolic disease risk. Low dose computed tomography (LDCT) imaging obtained for other clinical indications is useful for the opportunistic screening of osteoporosis and demonstrates additional potential for the screening of metabolic risk through the measurement of visceral adipose tissue. In this study, we explored LDCT-derived VAT and calculated VAT thresholds indicative of elevated metabolic risk in a population cohort of Chinese men and women.

Novel Prognostic Scoring Systems for Severe CRS after Anti-CD19 CAR-T-Cells in Acute B-Lymphoblastic Leukemia.

Objective: To develop a novel prognostic scoring system for severe cytokine release syndrome (CRS) in patients with B-cell acute lymphoblastic leukemia (B-ALL) treated with anti-CD19 chimeric antigen receptor (CAR)-T-cell therapy, aiming to optimize risk mitigation strategies and improve clinical management.

Methods: This single-center retrospective cohort study included 125 B-ALL patients who received anti-CD19 CAR-T-cell therapy from January 2017 to October 2023. These cases were selected from a cohort of over 500 treated patients on the basis of the availability of comprehensive baseline data, documented CRS grading, and at least 3 months of follow-up.

Utility and performance of cerebrospinal fluid cytology in discriminating central nervous system infections and brain tumors.

Background And Objective: Differentiating central nervous system infections (CNSIs) from brain tumors (BTs) is difficult due to overlapping features and the limited individual indicators, and cerebrospinal fluid (CSF) cytology remains underutilized. To improve differential diagnosis, we developed a model based on 9 early, cost-effective cerebrospinal fluid parameters, including CSF cytology.

Methods: Patients diagnosed with CNSIs or BTs at Xiangya Hospital of Central South University between October 1st, 2017 and March 31st, 2024 were enrolled and divided into the training set and the test set.

Key copper homeostasis genes and inflammatory mechanisms in ischemic stroke: A bioinformatics and experimental study.

Ischemic stroke (IS) has high morbidity/mortality with limited treatments. This study screened core copper homeostasis-related genes in IS and validated their function as precise intervention targets. Human IS gene chip data were retrieved from GEO, and copper homeostasis genes from multiple databases.

Diagnosis accuracy of ultrasonography for acute colonic diverticulitis: a diagnostic meta-analysis.

Objectives: This study aims to evaluate the diagnostic accuracy of ultrasonography for acute colonic diverticulitis (ACD) and its ability to differentiate between uncomplicated and complicated diverticulitis.

Methods: A comprehensive literature search was conducted from database inception to November 2024. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool was used to appraise study quality.

Association of preoperative cerebrospinal fluid sTREM2 concentration with postoperative delirium and three-year mortality in patients total knee or hip arthroplasty: a prospective cohort study.

Background: As a common postoperative neurological complication, postoperative delirium (POD) can lead to poor postoperative recovery in patients, prolonged hospitalization, and even increased mortality. However, POD's mechanism remains undefined and there are no reliable molecular markers of POD to date. The present work examined the associations of cerebrospinal fluid (CSF) sTREM2 with CSF POD biomarkers, and investigated whether the effects of CSF sTREM2 on POD were modulated by the core pathological indexes of POD (Aβ42, tau, and ptau).

Integrating Cell Population Data With Hematology Analyzer Messages for Improved Detection of Immature White Blood Cells and Laboratory Efficiency.

Background: Improving efficiency and reducing turnaround time are crucial in clinical laboratories. While automated analyzers such as the Beckman Coulter DxH 900 streamline workflow, subtle abnormalities like blasts and immature granulocytes (IGs) may be missed, especially in the absence of WBC-related suspect messages. This study evaluated whether integrating cell population data (CPD) with instrument messages could enhance detection accuracy.

Multifaceted roles of rice ABA/stress-induced intrinsically disordered proteins in augmenting drought resistance.

Water deficit stress causes devastating loss of crop yield worldwide. Improving crop drought resistance has become an urgent issue. Here we report that a group of abscisic acid (ABA)/drought stress-induced monocot-specific, intrinsically disordered, and highly proline-rich proteins, REPETITIVE PROLINE-RICH PROTEINS (RePRPs), play pivotal roles in drought resistance in rice seedlings.

Correlation between serum GFAP and 3-NT levels and the degree of neuronal injury in patients with glioma after surgery, and its diagnostic value.

Objective: To investigate the correlation between postoperative serum glial fibrillary acidic protein (GFAP) and 3-nitrotyrosine (3-NT) levels and neuronal injury severity in glioma patients.

Methods: 150 glioma patients were enrolled, with clinical baseline and pathological data recorded (age, sex, etc.).

Evaluation of Left Atrial Function in Patients with Hypertensive Heart Disease and Preserved Ejection Fraction Using Real-Time, Three- Dimensional Speckle Tracking Imaging.

Objective This research investigated the application of real-time, three-dimensional speckle tracking imaging (RT-3D-STI) to evaluate left atrial (LA) function in individuals suffering from hypertensive heart disease (HHD) and heart failure with preserved ejection fraction (HFpEF).Material and methods This retrospective study included 100 patients with HHD and HFpEF hospitalized from August 2023to June 2024 (HFpEF group). 100 healthy individuals undergoing physical examinations comprised the control group.

Dynamics of Conventional Metabolic Indices in Relation to Endometriosis Severity: A Retrospective Analysis.

Objective: This study aims to investigate the association between the dynamics of routine metabolic markers and endometriosis severity.

Methods: A retrospective analysis was conducted on patients diagnosed with endometriosis at Zhongshan Hospital, Xiamen, affiliated with Fudan University. The collected data encompassed demographic details and biochemical indicators related to lipid, hepatobiliary, renal metabolism, and electrolyte balance.

Gut microbiota dysbiosis in people living with HIV who have cancer: novel insights and diagnostic potential.

Background: People living with HIV(PLWH) are a high-risk population for cancer. We conducted a pioneering study on the gut microbiota of PLWH with various types of cancer, revealing key microbiota.

Methods: We collected stool samples from 54 PLWH who have cancer (PLWH-C), including Kaposi's sarcoma (KS, n=7), lymphoma (L, n=22), lung cancer (LC, n=12), and colorectal cancer (CRC, n=13), 55 PLWH who do not have cancer (PLWH-NC), and 49 people living without HIV (Ctrl).