Galactofucan from Undaria pinnatifida sporophyll enhances immune function by restoring intestinal barrier and microbiota balance and evaluating serum guanidoacetic acid.

Currently, the immunoregulatory activity of natural polysaccharide has attracted widespread attention. Sporophyll of Undaria pinnatifida is the byproduct of the brown algae processing, and it contains bioactive polysaccharides. In order to explore U.

Optimal Pore Structure in Mesoporous MOFs for Selective Separation of Natural Bioactive Astaxanthin With Record Adsorption Capacity.

Separation of easily degradable bioactive compound of astaxanthin (AXT) from nature source with low content and several interfering carotenoid analogues is particularly challenge. Here, four mesoporous metal-organic frameworks (meso-MOFs) is reported with different pore chemistry and pore geometry of cage-type and channel-type feature for AXT adsorption and separation. The maximal adsorption capacities of AXT by cage-type PCN-777 and MIL-101-NH are higher than channel-type PCN-222 and NU-1000, and their adsorption capacities (40-469.

Exploring the Anti-Alzheimer's Disease Potential of C23-3 Through Genomic Insights, Metabolomic Analysis, and Molecular Docking.

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with a pressing need for novel therapeutics. However, current medications only offer symptomatic relief, without tackling the underlying pathology. To explore the bioactive potential of marine-derived fungi, this study focused on C23-3, a strain isolated from the coral in Xuwen County, China, which showed a richer metabolite fingerprint among the three deposited strains.

Enhancing polysaccharide release rate from sea cucumber powder by ultrafine milling: Improving ability to interfere with atherosclerosis.

Atherosclerosis (AS) is a chronic inflammatory disease caused by buildup of plaques in arteries that are made up of lipids. The present study investigated the interventional effects of sea cucumber ultrafine powder (SCUP) prepared by ultrafine grinding on AS by determining the changes in lipid levels, plaque formation, and expression of key proteins in an AS mouse model induced by high-fat feeding. The results showed that ultrafine grinding could effectively increase its polysaccharide release rate (up by 21 %).

Effects of Mytilus edulis derived plasmalogens against atherosclerosis via lipid metabolism and MAPK signaling pathway.

Mytilus edulis-derived plasmalogens (Pls) are rich in polyunsaturated fatty acids, which are reportedly effective in ameliorating cardiovascular disease. The purpose of this study was to clarify the underlying mechanisms of Pls against atherosclerosis (AS) in ApoE mice induced by a high-fat diet (HFD), through a comprehensive analysis of hepatic metabolomics and aortic transcriptomics data. The results demonstrated a significant reduction in pathological indicators associated with AS following Pls treatment.

Pacific Oyster-Derived Alcohol Dehydrogenase Activating Peptide Leu-Gln-Pro-Pro-Arg Ameliorates Alcoholic Liver Disease by Enhancing Alcohol Metabolism and Suppressing Mitochondrial-Mediated Apoptosis.

Alcohol dehydrogenase (ADH) plays an important role in improving alcohol metabolism. Bioactive peptides, as functional factors with low toxicity and easy absorption, have attracted increasing attention in the intervention of alcoholic liver disease (ALD). This study investigated the effects of LQPPR, an ADH-activating peptide from Pacific oysters, on ALD and further elucidated its mechanism.

Evolutionary Conservation and Immunoregulatory Function of LOXL3 Gene in Lamprey.

Lysyl oxidase (LOX) family enzymes play a pivotal role in extracellular matrix (ECM) remodeling and tissue homeostasis, and have evolved diverse functions in vertebrate immunity and metabolism. However, the evolutionary trajectory of these multifunctional roles-particularly in jawless vertebrates-remains obscure. Here, we investigate LOXL3 in the lamprey (Lethenteron reissneri), a jawless vertebrate that retains ancestral features of early vertebrate evolution.

Insights into volatile substance changes of tilapia fillets before and after steaming and boiling during refrigeration based on metabolomics.

This study investigated the key volatile substances using SPME-GC-MS and metabolites using LC-MS, as tilapia fillets before and after steaming and boiling during refrigeration. Results indicated untreated, steamed, and boiled tilapia fillets post-refrigeration exhibited 15, 22, and 23 key volatile substances, respectively, primarily aldehydes, alcohols, and ketones. 97, 70, and 67 differential metabolites were identified by PLS-DA, respectively.

Mechanistic Insights into Nano-Maillard Reaction Products Regulating the Quality of Dried Abalones.

Broth cooking is a traditional pretreatment and ripening strategy for high-commercial-value dehydrated marine food, effectively enhancing its texture and rehydration properties. In this work, we characterized the structural information of Maillard reaction products (MRPs) derived from beef scrap stock and investigated their effects on the texture and rehydration performance of dehydrated abalone. The optical and structural properties of the MRPs were analyzed using X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), transmission electron microscopy (TEM), and fluorescence spectroscopy.

Pulp Residues Polysaccharide Alleviates High-Fat Diet-Induced Obesity by Modulating Intestinal Mucus Secretion and Glycosylation.

Although pulp residues polysaccharides (HPPP) have shown potential in improving metabolic disorders and intestinal barrier function, the mechanism by which they exert their effects through regulating O-glycosylation modifications in the mucus layer remains unclear. Therefore, this study established a HFD-induced obese colitis mouse model ( = 5 per group) and combined nano-capillary liquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) technology to quantitatively analyze the dynamic changes in O-glycosylation. Additionally, through quantitative O-glycosylation proteomics and whole-proteome analysis, we identified 155 specifically altered O-glycosylation sites in colon tissue, with the glycosylation modification level of the MUC2 core protein increased by approximately 2.

Modification of Spanish Mackerel () Surimi Gels by Three Anionic Polysaccharides.

This study investigated the gel performance of Spanish mackerel surimi gels (SMSGs) modified by three anionic polysaccharides: κ-carrageenan (KC), ι-carrageenan (IC), and gellan gum (GG). By incorporating polysaccharides, SMSGs showed a 24.9-103.

Aroma Formation, Release, and Perception in Aquatic Products Processing: A Review.

Flavor, as one of the primary factors that attracts consumers, has always been a crucial indicator for evaluating the quality of food. From processing to final consumption, the conditions that affect consumers' perception of the aroma of aquatic products can be divided into three stages: aroma formation, release, and signal transmission. Currently, there are few reviews on the formation, release, and perception of aroma in aquatic products, which has affected the product development of aquatic products.

Hydrogel-Shielded Ellagic Acid Nanoparticles Prolong Colonic Retention and Mitigate DSS-Induced Colitis via Reactive Oxygen Species Scavenging.

Inflammatory bowel disease (IBD) is characterized by oxidative stress imbalance and intestinal barrier disruption. Reducing excessive ROS has become a promising therapeutic strategy. Compared with conventional polyphenols, nanomaterials offer greater stability and bioavailability for ROS scavenging.

Fabrication of three-dimensional printable oleogel-in-water emulsion gels for dysphagia and oral delivery of astaxanthin.

Individuals with dysphagia are at heightened risk of aspiration, recent strategies for dysphagia management have largely focused on thickened liquids; however, these liquids have notable limitations, including inadequate nutrient delivery and unappealing appearance. Herein, three-dimensional (3D) printable oleogel-in-water emulsion gels were developed for dysphagia and oral delivery of astaxanthin. Oil-phase gelation was achieved via glycerol monostearate (GML), which reduced the size of oil droplets to 6.

DMU-SPME variable temperature extraction: Revealing the flavor characteristics of strong-aroma baijiu by volatilomics.

Comprehensive determination of volatilomics in strong-aroma Baijiu, including volatility and low-volatility, poses significant challenge but is crucial for volatilomics research in Baijiu and other spirits. This study developed a dual-mode unity solid-phase microextraction (DMU-SPME) approach combined with variable-temperature extraction (involving NaCl addition and fiber immersion depth optimization) and gas chromatography-mass spectrometry (GC-MS) to establish a rapid and simultaneous method for determining both volatility and low-volatility in strong-aroma Baijiu. DMU-SPME with variable-temperature extraction identified 103 substances, exceeding headspace SPME (HS-SPME) by 32 and immersion SPME (DI-SPME) by 25, while uniquely extracting 19 compounds undetectable by either method.

Gel properties of grass carp (Ctenopharyngodon idella) surimi treated by different calcium salts as sodium chloride substitutes.

This study investigated the effect of various calcium salts [calcium chloride (CaCl), calcium sulfate (CaSO), calcium β-hydroxy-β-methylbutyrate (CaHMB), calcium acetate (CaAc)] on gel properties of grass carp (Ctenopharyngodon idella) surimi gels (GCSGs). CaHMB and CaAc obviously improved the textural properties of GCSGs by 31.3 %-55.

Anserine alleviates atherosclerosis in ApoE mice by regulating lipid metabolism.

Background: Anserine is a bioactive and nutritional food supplement, widely used in the food health supplement, athletic nutrition, and medical fields. The aim was to investigate the mechanism of anserine in alleviating atherosclerosis. ApoE mice were fed a high-fat diet and orally administered anserine at doses of 30, 60, and 120 mg kg d for 16 weeks.

RNA-seq analysis of shrimp tropomyosin-induced allergic reactions through PI3K/Akt pathway.

Introduction: Tropomyosin (TM) is the primary allergen in , which usually causes allergic reactions that may be health or even life-threatening for consumers. Therefore, exploring the sensitization mechanism is of great significance for the prevention and treatment of tropomyosin allergy.

Methods And Results: In this study, TM sensitization models were using Balb/c mice, Caco-2 cells and RBL-2H3 cells to reveal the sensitization effect.

Molecular mechanism of Golden Pomfret myofibrillar protein digestion inhibition by malondialdehyde-mediated oxidation based on peptidomics analysis.

This study investigated the effects of malondialdehyde (MDA) induced oxidation on the digestion of the Golden Pomfret myofibrillar protein. Results showed that protein digestibility decreased significantly with increased MDA concentration ( < 0.05).

Ultrasonically Engineered Probiotic Particles as the Sole Stabilizer for Fucoxanthin-Loaded High Internal Phase Pickering Emulsions: Stability and Functional Study.

High internal phase Pickering emulsions (HIPPEs) are valued for their exceptional stability and versatility in delivering food bioactives. Here, we developed fucoxanthin (Fx)-loaded HIPPEs using ultrasonically engineered probiotic particles as the sole stabilizer and investigated their stabilization mechanism and functional characteristics. Ultrasonic power levels from 0 to 600 W were screened; at the optimal 450 W, the probiotic particles exhibited the lowest surface charge (-30.

The influence of homogenization-ultrasonic treatment on micro-nano particle characteristics, nutrient composition, flavor profile, and overall quality of Salmon head soup.

Despite the increasing global salmon production and the recognition of by-product value, nutrient-rich salmon heads are not fully utilized for direct consumption. This study explored the influence of homogenization combined with ultrasonic treatment (HUT) on micro-nano particle (MNPs) formation, nutrient composition, flavor profile, and overall quality of salmon head soup. Results showed that HUT effectively enhanced nutrient content.

Effects of ferrous ions partitioning at the oil-water interface on the oxidative stability of Antarctic krill (Euphausia superba) oil: Reverse micelles alter the physical location of ferrous ions.

This study investigates the role of ferrous ion partitioning in promoting lipid oxidation in Antarctic krill oil (AKO) containing reverse micelles. Cryogenic transmission electron microscopy and small-angle X-ray scattering confirmed the presence of reverse micelles in AKO. AKO with ferrous sulfate (FeSO, water-soluble iron) and ferrous fumarate (CHFeO, oil-soluble iron) were stored at 60 °C.

Characterization of Water-Soluble Oxidized Paramylon and Its Hypoglycemic Effects by Alleviating Insulin Resistance.

Paramylon (EP) is a type of β-glucan found in , which is characterized by a crystalline structure and insolubility, thereby limiting its practical applications. This study aimed to enhance its utility by preparing water-soluble oxidized EP (OEP) using a 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated oxidation process. When compared with EP, OEP was found to boost glucose intake in insulin-resistant cells while increasing insulin receptor substrate 1 (IRS1) and glucose transporter 4 (GLUT4) levels.

Pickering emulsion gels stabilized by sardine protein/konjac glucomannan complexes delivering astaxanthin for alleviating inflammatory bowel disease.

Astaxanthin (AXT) alleviates inflammatory bowel disease (IBD) by reducing inflammation, blocking NF-κB pathway, and modulating gut microbiota. However, the poor solubility and low bioavailability of AXT limit its applications in food. In this study, sardine protein (SDP)/konjac glucomannan (KGM)-stabilized Pickering emulsion gels (SKEGs) were developed for AXT delivery for IBD intervention.