Chiral Phosphoric Acid-Catalyzed Asymmetric Doyle Indolization: Enantiodivergent Access to Indolizinylindoles.

We present here a chiral phosphoric acid-catalyzed asymmetric Doyle indolization enabling efficient construction of axially chiral indolizinylindoles with stable C-N stereogenic axes. Importantly, this intriguing cascade cyclization realized the highly enantioselective synthesis of axially chiral quarteraryl skeletons containing two contiguous stereogenic axes in good to high yields and excellent stereoselectivities. Furthermore, an atropo-divergent synthesis was achieved via switching the 3,3'-substituents of the CPA catalyst.

Legal barriers and reflections on the use of assisted reproductive technology by single women in China.

This study analyzed the legal obstacles on the access to assisted reproductive technology (ART) by single women in mainland China, focusing on the period from 2001 to 2024, and reassessed the Chinese regulatory framework. The study employed legal text data sourced from the PKU Law database, and the case data from the China Judgments Online. Results revealed that the Chinese prevailing legislative framework prohibits single women to use ART and the courts oppose egg freezing for this group too, which creating regulatory obstacles to their reproductive rights.

-Loaded Bioglue with Antibacterial, Antioxidant, and Immunomodulatory Properties for Accelerated Wound Healing.

Biological glue (bioglue) can noninvasively seal and reattach wound tissue outside the hospital, which has been extensively studied recently. Nevertheless, the commercial bioglue lacks constant oxygen supply, antioxidation, and anti-inflammation, three other key factors for bacteria-infected wound healing in plateau areas. Herein, a multifunctional bioglue (LA-DESP/ε-PLL@) is simply fabricated by encapsulating into a matrix composed of α-lipoic acid (LA), α-lipoic acid sodium (LANa), and ε-polylysine (ε-PLL).

Modulation of the electronic structure of NiS/NiS Fe and Mn dual-doping to boost the oxygen evolution reaction.

Doping in transition metal sulfides can effectively induce lattice distortion and introduce asymmetry, thereby lowering the energy required to overcome the rate-controlling step in the oxygen evolution reaction (OER). This work presents a simple hydrothermal synthesis strategy combined with vapor-phase vulcanization to prepare iron and manganese dual-doped NiS/NiS nanoflowers with a heterogeneous interface, directly supported on nickel foam (NF). In this approach, NF was adopted not only as a self-supporting conductive substrate but also as the nickel source for the composite.

First record of Okabe, Motokawa, Koizumi, Nguyen, Nguyen & Bui, 2024 (Squamata, Scincidae) from China.

Background: The Fansipan ground skink, Okabe, Motokawa, Koizumi, Nguyen, Nguyen & Bui, was recently described from Fansipan Mountain, Lao Cai Province, northern Vietnam. Herein, we report the first national record of this species from China, based on four specimens collected from Ailao Mountain, Jingdong Yi Autonomous County, Yunnan Province.

New Information: Morphologically, the Chinese specimens are consistent with the type series, but differ slightly in possessing a higher number of ventral scales (including gulars) and relatively shorter fore-limbs.

Designing mesostructured bimetallic selenide derived from room-temperature prepared metal-organic frameworks as a sodium-ion battery anode with high performance and fast reaction kinetics.

Mesostructured materials are considered to be promising candidates for use in high-performance secondary batteries due to their specific properties, which are beneficial for electrochemical redox and ion diffusion; however, the synergistic mechanism is still unclear, and a general preparation approach is highly needed. Here, we report a mesostructured nitrogen-doped CoNiSe as a high-performance sodium-ion battery anode derived from room-temperature-synthesized CoNi-metal organic frameworks, and in-depth insight into the synergistic effect during charge-discharge is demonstrated. The mesostructure provides three-dimensional ion transport channels, which are conducive to the stable insertion/extraction of Na ions.

Machine learning unveils the impact of anthropogenic emission changes on urban PM and O: A case study in Wuhu.

PM and O are two major issues hindering air quality improvement in China. However, the response of these two pollutants to anthropogenic emission variations in the real atmosphere was not yet well understood. Here, we selected the short-term epidemic lockdown in Wuhu in 2022 as a case study and evaluated the impacts of meteorology and anthropogenic emission on PM and O using field observations combined with machine learning algorithms.

A medium-bandgap acceptor incorporating a novel electron-rich building block enables efficient organic photovoltaics.

Organic photovoltaics (OPVs) have emerged as a highly promising renewable energy technology due to their solution-processability, mechanical flexibility, and potential for low-cost manufacturing. Despite remarkable progress, further improving the power conversion efficiencies (PCEs) remains a critical challenge for their commercial applications. The incorporation of medium-bandgap non-fullerene acceptors (NFAs) as third components in ternary OPV devices has proven particularly effective in enhancing device performance.

Association of compound exposure to heat wave and ozone pollution with cause-specific cardiopulmonary mortality: A space-time-stratified case-crossover study.

Heat wave and ozone (O) pollution events are increasingly co-occurring in the context of climate change, especially in China. However, the effects of compound exposure to both hazards on cause-specific cardiopulmonary mortality remain largely unclear. In this study, we conducted a space-time-stratified case-crossover study of 550,634 township-level cardiopulmonary deaths in Anhui Province, China, from 2013 to 2021 to systematically evaluate the associations of exposure to heat wave and O pollution with multi-cause cardiopulmonary mortality and quantify their interactive effects Under various definitions, the odds ratios (ORs) of cardiopulmonary mortality associated with heat wave-only events, O pollution-only events, and compound events exposure ranged from 1.

Active Learning-Assisted Exploration of [POMo] for Alzheimer's Therapy Insights.

Alzheimer's disease (AD), involving amyloid-β (Aβ) aggregation, has potential therapeutic modulators in polyoxometalates (POMs) like [PMoO]. To clarify their inhibitory mechanisms, a multiscale computational strategy integrating active-learning Bayesian Optimization (BO) and density functional theory (DFT) is employed to explore low-energy configurations of isolated amino acids, [PMoO] -amino acid complexes, and [PMoO] -peptide systems. Hydrogen bonding and Coulombic repulsion dominate adsorption stability.

New insights into the responding mechanism of Eriocheir sinensis hepatopancreas under nanoplastics and copper stress by transcriptome analysis.

Nanoplastics (NPs) possess adsorptive properties and can interact with pollutants such as heavy metals, raising concerns about their toxicological effects on aquatic organisms. However, systematic evaluations of the mechanisms underlying the impact of these pollutants on crustaceans are limited. To investigate the combined toxicological effects of NPs and copper (Cu), Eriocheir sinensis were exposed to 0.

Review of the wolf-spider genus Kronestedt, 2010 from China (Araneae, Lycosidae).

The wolf-spider genus Kronestedt, 2010 in China is reviewed. A new combination is proposed: (Chen, Song & Li, 2001), (ex. C L.

[70]Fullerene-fused lactones: synthesis, conversion and photovoltaic application.

Syntheses of [70]fullerene-fused lactones palladium-catalysed annulation and 1,4-dipolar cycloaddition with complementary regioselectivities were achieved. Efficient retro Baeyer-Villiger reaction electroreduction and trifluoromethanesulfonic anhydride treatment afforded [70]fullerene-fused ketones. Control experiments and theoretical calculations elucidated plausible reaction pathways.

Modular One-Pot Access to Boron-Carboxylated Dipyrromethene Dyes as Visible-Light and Two-Photon Activatable Photocages.

The photocage, an advanced platform for drug delivery and photoactivation imaging, has attracted wide attention in biomedicine. Despite recent advancements in shifting irradiation wavelengths to visible and near-infrared light, improving photolysis quantum yield and the corresponding uncaging cross section, key parameters for efficient photocages, remains highly challenging. Here, we address this challenge by introducing light-controlled COO-B bond cleavage from tetracoordinate boron linked to dipyrrin, aryl, and carboxylic acid groups.

A multiplexed electrochemical biosensor for simultaneous discrimination of cancer cell subtypes using multi-nanoparticle labeling.

Herein, an electrochemical sensing detection platform based on Y shaped DNA structures and the redox properties of metal nanoparticles (MNPs) - including AgNPs, PtFeNPs, and AuNPs, was developed for simultaneous detection of distinct cancer cell types, presenting a promising avenue for early-stage and prognostic cancer diagnostics in biologically complex environments.

Six new species of the spider genus Latreille, 1804 (Araneae, Clubionidae) from subtropical forests of Sichuan Province, China.

Six new species, belonging to three species groups of Latreille, 1804 are described from both males and females: Yu & Li, , Yu & Li, and Yu & Li, from the group; Yu & Li, and Yu & Li, from the group; Yu & Li, from the group. These species are currently known to occur only in subtropical forests, Sichuan, China. The DNA barcodes of all species were obtained for species delimitation, matching of sexes and future use.

Two new species of Tong & Li, 2007 (Araneae, Oonopidae) from Yunnan Province, China, with a key to all known species of Yunnan.

Two new species of the genus Tong & Li, 2007, Tong & Li, (♂♀) and Tong & Li, (♂♀), are described from Yunnan, China. Descriptions, diagnoses, photomicroscopy images and a key to species of Yunnan Province are provided.

Adsorptive Separation of Chlorobenzene and Chlorocyclohexane by Nonporous Adaptive Crystals of Perethylated Pillar[6]arene.

The separation of chlorobenzene () and chlorocyclohexane () using traditional industrial separation technologies (distillation, fractionation, and rectification) is a great challenge due to their close boiling points. Here, we report an innovative method for the separation of the mixture of and by nonporous adaptive crystals (NACs) of perethylated pillar[6]arene (). NACs of () can selectively adsorb vapor from the vapor mixture of and (: = 1:1) with a purity of 99.

Genome Survey and Evolutionary Analysis of Eight Lamprotula Species: SSR Profiling, Mitochondrial Characterization, and Population Dynamics Inference.

Freshwater bivalves are vital to aquatic ecosystems but face severe global threats. Understanding their genomic traits and evolution is crucial for effective conservation. This study conducted whole-genome sequencing on eight Lamprotula species.

The impact of mobile-based language learning on speaking and learning anxiety, engagement and achievement in Chinese language learning: The mediating role of cognitive load.

This study examines the impact of mobile-based language learning (MBLL) on speaking and learning anxiety, learning engagement, and language achievement among international students learning Chinese with a specific focus on cognitive load as a mediator. A cross-sectional survey of 175 international students enrolled in universities in Anhui province, China was conducted. Regression and mediation analyses indicated that MBLL was significantly associated with lower speaking and learning anxiety, higher learning engagement, and higher language achievement.

Thermally modulated triplet-triplet annihilation: Deciphering the temperature dependence of upconversion dynamics.

The quantum efficiency ceiling of triplet-triplet annihilation upconversion is intrinsically governed by the spin statistical factor (f), yet the physical origin of its anomalously elevated values (f > 0.6) remains a subject of intense debate. By conducting systematic variable-temperature kinetic studies, integrating time-resolved transient absorption spectroscopy with steady-state fluorescence spectral analysis, we elucidated the temperature-dependent reaction dynamics of the benchmark PtOEP/DPA system to investigate the interaction between f and high-energy excited-state (T2) decay pathways.

An annotated chromosome-level genome of a troglophilic spider (Pimoa clavata).

Climatic upheavals throughout Earth's history have driven species to subterranean refugia, where stable microclimates buffer environmental extremes. The spider family Pimoidae, relict lineages sensitive to thermal fluctuations, exemplifies this climate-driven habitat transition. Here, we present the first chromosome-level genome of Pimoa clavata, a troglophilic spider endemic to Beijing's mountainous caves.

Construction of a Self-Enhanced Fluorescent Aptasensor Based on Lanthanide Ligand Self-Assembly and Catalytic Hairpin Assembly for Highly-Sensitive Detection of Anatoxin-a.

Anatoxin-a (ATX-a) is a potent neurotoxin produced by cyanobacteria, with growing evidence unequivocally linking it to acute aquatic toxicity, neurological impairment, and increased mortality in wildlife and livestock, highlighting its significant threat to ecosystem stability and public health. Here, we report a novel fluorescent aptasensor system (FAS) that integrates novel DNA-functionalized Eu nanoparticles (DNA-Eu NPs) with a catalytic hairpin assembly (CHA) strategy for ultrasensitive ATX-a detection. We used single-stranded DNA CTA (ssDNA) oligomers rich in cytosine, thymine, and adenine as effective antenna ligands to sensitize the luminescence of Eu.

Comparative physiological and transcriptomic analyses identify computationally predicted key genes and regulatory pathways in non-heading Chinese cabbage under heat stress.

Background: Non-heading Chinese cabbage (Brassica campestris (syn. Brassica rapa) ssp. chinensis) (NHCC) is an important vegetable crop with economic benefits and is widely cultivated worldwide.

Chiral P,N,N-Ligands for the Manganese-Catalyzed Asymmetric Formal Hydroamination of Allylic Alcohols.

Application of chiral P,N,N-ligands in the manganese-catalyzed formal asymmetric hydroamination of allylic alcohols through a borrowing-hydrogen strategy was demonstrated. A series of racemic allylic alcohols could react with various secondary amines, affording chiral γ-amino alcohols in up to 93% yield with 96% ee.