A multiplexed electrochemical biosensor for simultaneous discrimination of cancer cell subtypes using multi-nanoparticle labeling.

Chem Commun (Camb)

Anhui Key Province Key Laboratory of Biomedical Materials and Chemical Measurement, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, P. R. China.

Published: September 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Herein, an electrochemical sensing detection platform based on Y shaped DNA structures and the redox properties of metal nanoparticles (MNPs) - including AgNPs, PtFeNPs, and AuNPs, was developed for simultaneous detection of distinct cancer cell types, presenting a promising avenue for early-stage and prognostic cancer diagnostics in biologically complex environments.

Download full-text PDF

Source
http://dx.doi.org/10.1039/d5cc04129eDOI Listing

Publication Analysis

Top Keywords

cancer cell
8
multiplexed electrochemical
4
electrochemical biosensor
4
biosensor simultaneous
4
simultaneous discrimination
4
discrimination cancer
4
cell subtypes
4
subtypes multi-nanoparticle
4
multi-nanoparticle labeling
4
labeling electrochemical
4

Similar Publications

Caseinolytic protease P (ClpP) is a highly conserved serine protease that plays a pivotal role in protein homeostasis and quality control in bacteria, mitochondria of mammalian cells, and plant chloroplasts. As the proteolytic core of the ATP-dependent Clp protease complex, ClpP partners with regulatory ATPases (e.g.

View Article and Find Full Text PDF

IL-2 agonists significantly modulate T cell regulation, impacting activation, proliferation, differentiation, and immune homeostasis. Interleukin-2 (IL-2) is crucial for T cell growth and function, binding to the IL-2 receptor to trigger signaling pathways that balance immune responses. IL-2 promotes the expansion of effector T cells and enhances regulatory T cells (Tregs), preventing autoimmune responses.

View Article and Find Full Text PDF

Objective: This study aimed to probe the role of Shenling Baizhu powder (SLBZP) in inhibiting breast cancer (BC) lung metastasis, focusing on epithelial-to-mesenchymal transition (EMT) and ferroptosis.

Methods: BC 4T1 cells were treated with low (3.13 µg/mL) and high (12.

View Article and Find Full Text PDF

Immunomodulatory Roles of Tonsil-Derived Mesenchymal Stem Cells.

Crit Rev Immunol

January 2025

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China.

Stemming from human immune organs, tonsil-derived mesenchymal stem cells (TMSCs) hold unique strengths in differentiation potential and immune regulatory functions. These characteristics make them valuable for therapeutic applications, particularly in regenerative medicine and autoimmune disease treatment, as they can modulate immune responses and promote tissue repair. Their ability to interact with various cell types and secrete a range of bioactive molecules further enhances their role in orchestrating healing processes, making them a promising avenue for innovative therapies aimed at restoring balance in the immune system and facilitating recovery from injury or disease.

View Article and Find Full Text PDF

Breast cancer (BC) is one of the main causes of cancer-related death in women. The purpose of this study was to evaluate the expression of miR-605-5p in BC and its diagnostic and prognostic value. BC patients and healthy individuals who met the study criteria were included.

View Article and Find Full Text PDF