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Today, broiler feed formulators focus not only on minimizing costs but also on reducing environmental impact and maintaining broiler health. Lowering crude protein (CP) levels is a key strategy for addressing these concerns. The least cost formulation of diets based on the ideal protein concept - where amino acids are provided in appropriate proportions - is the most effective way to supply an economically viable and balanced amino acids feed for broilers. Such formulations also help reduce nitrogen excretion during the rearing period. Reducing CP levels in feed mixtures is possible through the use of crystalline amino acids (AAs). Given the high and fluctuating prices of soybean meal (SBM), the European Union (EU) is actively seeking alternative protein sources to reduce dependence on imported protein. The study aimed to explore the potential of wheat-based broiler diets as an alternative to SBM. It also evaluated the impact of increasing high-protein wheat proportions on the nutritional value and quality of feed mixtures. High-protein wheat, when appropriately supplemented with crystalline amino acids (AAs) by current nutritional requirements, appears to be a cost-effective solution for farmers. The substitution of SBM with wheat increases the feed grain and starch content, potentially reducing CP levels. This, in turn, could lower nitrogen and ammonia emissions, benefiting the environment. While this approach could help cut feed costs, further research is required to assess the long-term effects of such diets, including the influence of wheat processing technologies and the optimal dosage of feed enzymes to counteract the anti-nutritional effects of non-starch polysaccharides in wheat.
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http://dx.doi.org/10.1038/s41598-025-17803-7 | DOI Listing |
Ann Med
December 2025
School of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Background: To review the biological functions of ergothioneine (ERGO), its correlation with plasma levels in cognitive frailty, and research progress in treating frailty and cognitive impairment, with the aim of providing a reference for ERGO application in cognitive frailty treatment.
Methods: A comprehensive review of existing literature on ERGO's chemical structure, sources, antioxidant and anti-inflammatory effects, and its role in cognitive frailty was conducted. Clinical trial data and metabolomic studies were also analyzed to understand ERGO's therapeutic potential.
Mol Nutr Food Res
September 2025
University of Southampton, Southampton, Hampshire, UK.
Potatoes are a global staple, yet their nutritional potential is underutilized. This study evaluates the biochemical and nutritional composition of Solanum okadae (S. okadae), a wild diploid potato species, compared to the cultivated S.
View Article and Find Full Text PDFMikrochim Acta
September 2025
The Third Affiliated Hospital of Anhui Medical University, The First People's Hospital of Hefei, Binhu Hospital of Hefei, Hefei, 230061, P. R. China.
Lung cancer, as one of the cancers with the highest morbidity and mortality rates in the world, requires accurate detection of its vital serum marker, neuron-specific enolase (NSE), which is a key challenge for early detection of lung cancer. However, traditional chemiluminescence immunoassay (CLIA) methods rely on labeled antibodies (Abs) and suffer from complex operations and high costs. In this work, a label-free CLIA based on CL-functionalized mesoporous magnetic nanoparticles (CuFeO@mSiO-Cys-Luminol-Au NPs) is developed for the rapid and sensitive detection of NSE.
View Article and Find Full Text PDFPlant Sci
September 2025
College of Horticulture, Gansu Agricultural University, Lanzhou 730070, China.
Branched-chain amino acid aminotransferases (BCATs) catalyze both the final anabolic step and the initial catabolic step of branched-chain amino acids (BCAAs), which are pivotal for the formation of plant branched-chain volatiles (BCVs). However, the members of BCAT family in apple (Malus domestica Borkh.) remain poorly characterized.
View Article and Find Full Text PDFJ Biol Chem
September 2025
Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. Electronic address:
Posttranslational modifications (PTMs) of proteins are efficient biological mechanisms for expanding the genetic code and for regulating cellular physiology. However, there have been no systematic approaches to profile all the PTMs critical for autoreactive neoantigen production or the etiology and pathology of autoimmune diseases. In the present study, to gain insight into protein PTMs associated with systemic lupus erythematosus (SLE), we applied a mass spectrometry-based method for the comprehensive analysis of modified amino acids ("adductome").
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