Evaluating high-protein wheat as a protein source for broiler chicken.

Today, broiler feed formulators focus not only on minimizing costs but also on reducing environmental impact and maintaining broiler health. Lowering crude protein (CP) levels is a key strategy for addressing these concerns. The least cost formulation of diets based on the ideal protein concept - where amino acids are provided in appropriate proportions - is the most effective way to supply an economically viable and balanced amino acids feed for broilers.

Psoriasis Does Not Seem to Impair Glomerular and Tubular Function - The Comprehensive Study on Serum and Urine.

Introduction: There is a dispute as to whether patients with psoriasis have impaired kidney function. We aimed to assess several recognized and experimental markers of glomerular filtration and tubular function in such patients to find out whether they have decreased kidney function.

Methods: The study involved 60 patients with psoriasis and 30 volunteers without dermatoses.

Early plasma changes of HIF-1 alpha, matrix metalloproteinases-2 and - 9, and tissue inhibitor of matrix metalloproteinase-1 in patients with infantile hemangiomas treated with propranolol.

Background: Infantile hemangiomas (IH) are the most prevalent benign vascular tumors diagnosed in the pediatric population. Propranolol, a nonselective beta-adrenergic receptor antagonist, is the first-line treatment for IH. In this study, we aimed to assess the changes in plasma levels of HIF-1α, MMP-2, MMP-9, and TIMP-1 in patients with IH before and after one month of propranolol treatment.

Elevated Expression of in PBMCs Is Associated with Intracranial Aneurysm Formation, but Expression Implicated Rupture.

The transforming growth factor beta (TGF-β) signaling pathway plays a critical role in cellular processes, including maintaining vascular integrity and regulating vascular remodeling. Aneurysm rupture is associated with pathological changes in the arterial wall. We aimed to investigate the gene expression of transforming growth factors (, , ) in peripheral blood mononuclear cells (PBMCs) isolated from the blood of patients with unruptured intracranial aneurysms (UIAs) and ruptured intracranial aneurysms (RIAs), and from a control group.

A knowledge-based equation of daily work exposure.

The objective of this study was to establish a predictive equation that expresses the daily work exposure as a function of variables that define complex work tasks. The equation was verified with data reported in reviewed publications. The ScienceDirect, PubMed, and ProQuest databases were searched using keywords related to variables that characterize intermittent tasks and those that describe muscle fatigue resulting from these tasks.

Impact of the Transforming Growth Factor β (TGF-β) on Brain Aneurysm Formation and Development: A Literature Review.

The mechanisms underlying the formation and rupture of intracranial aneurysms remain unclear. Rupture of the aneurysmal wall causes subarachnoid hemorrhage, with a mortality rate of 35-50%. Literature suggests that rupture is associated with the remodeling of the aneurysmal wall, including endothelial cell damage, smooth muscle cells (SMCs) proliferation, and inflammatory cell infiltration, particularly macrophages.

Preliminary results suggest the potential of evaluating combined bFGF and TNF-β concentrations for differentiating papillary thyroid cancer from benign nodular goiter.

Papillary thyroid cancer (PTC) is the most common type of thyroid cancer, accounting for approximately 80% of cases. Considering the lack of available blood diagnostic tests for detecting thyroid cancer, as well as the issue of overdiagnosis and overtreatment, our study aimed to investigate whether the concentrations of 48 selected proteins, including chemokines, interleukins, cytokines, and growth factors, could serve as indicators to distinguish patients with PTC from individuals with nodular goiter. The study group included 32 PTC patients and 26 nodular goiter patients as a comparative group.

Psychosocial working conditions and mental well-being of remote and stationary employees: a longitudinal study.

Objectives: The aim of the article is to compare people working remotely and people working at the employer's premises in terms of psychosocial working conditions and mental well-being.

Material And Methods: A longitudinal study conducted on a group of 494 people working remotely (N = 206) and those working stationary (N = 288) in 2021-2022 using the .

Results: The results of analysis of variance in the mixed design showed that some psychosocial conditions of their work (e.

Proteasomes and Ubiquitin C-Terminal Hydrolase L1 as Biomarkers of Tissue Damage and Inflammatory Response to Different Types of Injury-A Short Review.

The proteasomal system of protein degradation is crucial for various cellular processes, including transduction of signals and differentiation of cells. Proteasome activity rises after various traumatic stressors such as hyperoxia, radiation, or oxidative damage. Removal of damaged proteins is essential to provide the necessary conditions for cell repair.

Groundwater Safety and Availability Index (GSAI) and its association with salinity indicators.

This study assesses the quality of groundwater in the Odra River Basin in Poland, focussing on environmental health risks, temporal variability, and their association with salinity indices. A new indicator, the Groundwater Safety and Availability Index (GSAI), was developed to evaluate groundwater resources by integrating health risk and resource quantity factors, providing a novel tool for ranking water resources and informing environmental and administrative decision-making. Groundwater samples were collected between 2005 and 2021 and analysed in accordance with national standards.

The effect of broadcast struvite fertilization on element soil content and microbial activity changes in winter wheat cultivation in southwest Poland.

This study aimed to evaluate the potential of struvite as a phosphorus fertilizer in winter wheat cultivation in southwest Poland. The field experiment was conducted at Wroclaw University of Environmental and Life Sciences in Swojec in 2022/2023. The studied factors were two cultivars of winter wheat (Activus and Chevignon) and two phosphorus fertilization methods (traditional superphosphate and struvite).

A Role of Inflammation in Charcot-Marie-Tooth Disorders-In a Perspective of Treatment?

Despite the fact that there are published case reports and model work providing evidence of inflammation in Charcot-Marie-Tooth disorders (CMTs), in clinical practice, CMT and inflammatory neuropathies are always classified as two separate groups of disorders. This sharp separation of chronic neuropathies into two groups has serious clinical implications. As a consequence, the patients harboring CMT mutations are practically excluded from pharmacological anti-inflammatory treatments.

Plasma concentration of MMP-17 is elevated in boys with cryptorchidism and correlates with HSP-70.

Cryptorchidism, the absence of one or both testicles in the scrotum, is the most common anomaly of genitourinary tract in males. The pathogenesis of undescended testes is unknown however the role of inflammation, tissue remodeling and oxidative stress is postulated. The aim of this study was to explore the role of HSP-70, MMP-3, MMP-17 and IL-8 in possible pathogenic pathways connected with cryptorchidism.

Sex-dependent responses to acute sodium bicarbonate different dose treatment: A randomized double-blind crossover study.

Objectives: This study quantified blood bicarbonate (HCO) kinetics and gastrointestinal upset to determine the gender-related ergogenic potential of sodium bicarbonate (0.15-, 0.25- and 0.

Population-specific equations of age-related maximum handgrip force: a comprehensive review.

Background: The measurement of handgrip force responses is important in many aspects, for example: to complement neurological assessments, to investigate the contribution of muscle mass in predicting functional outcomes, in setting realistic treatment goals, evaluating rehabilitation strategies. Normative data about handgrip force can assist the therapist in interpreting a patient's results compared with healthy individuals of the same age and gender and can serve as key decision criteria. In this context, establishing normative values of handgrip strength is crucial.

20S constitutive proteasome, 20S immunoproteasome, and cathepsin S are high-sensitivity and independent markers of immunological activity in relapsing-remitting type of multiple sclerosis.

Research on the markers of autoimmune response in multiple sclerosis (MS) is still of great importance. The aim of our study was the evaluation of plasma 20S constitutive proteasome, 20S immunoproteasome, and cathepsin S concentrations as potential biomarkers of a relapsing-remitting type of MS (RRMS). Surface plasmon resonance imaging (SPRI) biosensors were used for the evaluation of protein concentrations.

The preliminary study suggests an association between NF-ĸB pathway activation and increased plasma 20S proteasome activity in intracranial aneurysm patients.

The significant role of increased activation of 20S proteasomes in the development of abdominal aortic aneurysms has been well-established in a mouse model. The available literature lacks similar studies concerning brain aneurysms. The aim of the study was to verify the hypothesis that patients with unruptured intracranial aneurysms (UIA) have increased 20S proteasome ChT-L activity compared to the control group of individuals without vascular lesions in the brain.

Diversity of chemical composition and nutritional value in grain from selected winter wheat cultivars grown in south-western Poland.

Given the low protein coverage by legumes in Poland, alternatives (with high protein content and high nutritional value) are being sought (with high protein content and high nutritional value of protein) that could replace these plants. Cereal cultivation dominates in Poland; hence, the search for high-value plants will also consider this group of plants. The aim of the study was to compare the nutritional value of proteins from two wheat cultivars.

Does sodium bicarbonate based extra-cellular buffering support reduce high intensity exercise-induced fatigue and enhance short-term recovery assessed by selected blood biochemical indices?

Exercise-induced metabolic processes induce muscle acidification which contributes to a reduction in the ability to perform repeated efforts. Alkalizing agents such as sodium bicarbonate (NaHCO) prevent large blood pH changes, however, there is no evidence on whether regulation of acid-base balance may also support whole body homeostasis monitored through heamatological and biochemical blood markers in a dose-dependent manner. Thirty Cross-Fit-trained participants were studied in a randomized, multi cross-over, placebo (PLA)-controlled double-blind manner in which they performed a control session (CTRL, without supplementation), three NaHCO visits (three different doses) and PLA (sodium chloride in an equimolar amount of sodium as NaHCO).

New Insights on the Progesterone (P4) and PGRMC1/NENF Complex Interactions in Colorectal Cancer Progression.

The literature data regarding the risk of colorectal cancer (CRC) in the context of hormone therapy (HT), including both estrogen-progestogen combinations and estrogen alone, are inconclusive. The precise relationship underlying the action of progesterone (P4) and progesterone receptors in CRC has yet to be determined. We characterized the expression profiles of both nuclear and membrane progesterone receptors and their potential cofactors in CRC tissues.

Differences in lumbar spine intradiscal pressure between standing and sitting postures: a comprehensive literature review.

Background: Musculoskeletal disorders (MSDs), especially in the lumbar spine, are a leading concern in occupational health. Work activities associated with excessive exposure are a source of risk for MSDs. The optimal design of workplaces requires changes in both sitting and standing postures.