Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Unlabelled: produce prodigiosin as a high-value intracellular secondary metabolite. However, the effect of Tween-80 on prodigiosin release remains unclear. This study aimed to elucidate the physiological characteristics and metabolic mechanisms of in the presence of Tween-80. The results showed that Tween-80 significantly affected prodigiosin's synthesis and extracellular release. Significant changes in cell morphology and zeta (ζ) potential were observed during cell growth. In addition, 245 differential metabolites were identified by non-targeted metabolomics analysis, indicating that Tween-80 affects the metabolism of fatty acids, amino acids, extra-long-chain fatty acids, and their derivatives. Enrichment pathway analysis revealed significant enrichment of lipid metabolism, amino acid metabolism, and other pathways. Finally, in conjunction with the metabolomics results, a prodigiosin yield was achieved at 6.5 g/L in 5 L bioreactors using fed-batch fermentation. The results of this study have significant implications for the regulation of prodigiosin synthesis and metabolism.
Supplementary Information: The online version contains supplementary material available at 10.1007/s10068-024-01750-6.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903977 | PMC |
| http://dx.doi.org/10.1007/s10068-024-01750-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The renoprotective anti-hyperuricemia effect of Cornus officinalis extract in hyperuricemia rats based on network pharmacology and multiple omics.
J Ethnopharmacol
September 2025
Lab of Food Function and Nutrigenomics, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China; Institute of Integrative Medicine, Hunan Provincial Key Laboratory of Liver Visceral Manifestation in Traditional Chinese Medicine, Department of Integrated Traditio
Ethnopharmacological Relevance: Corus officinalis Siebold & Zucc belongs to the genus Cornus in the Cornaceae family, and was first recorded in the "Shennong Herbal Classic", now has been included in "according to the tradition of both food and Chinese herbal medicines", consist of kidney and liver tonifying, antioxidant substances including cycloid glycosides, flavonoids, polyphenols, organic acids, etc. AIM OF THE STUDY: This study was aimed at discovering the mechanism underlying the anti-hyperemia effect of Cor in rats, particularly its protective effect against liver and kidney dysfunction caused by HUA.
Materials And Methods: In this study, the effect of Cor extract against HUA was verified in rats, subsequently, network pharmacology combined with non-targeted metabolomic were performed to investigate its composition characteristics, and further multi-omics studies and molecular validation were performed to reveal molecular mechanism both in vivo and in vitro.
Integrated metabolomics and network pharmacology analysis of Yulan Jiangtang capsules in diabetic nephropathy.
Phytomedicine
August 2025
School of Chinese Materia Medica, Beijing University of Chinese Medicine, 102488, China. Electronic address:
Background: Diabetic nephropathy (DN), a serious diabetic complication, currently has limited treatment options. Yulan Jiangtang capsules (YL) are a clinically approved traditional Chinese medicine formula for glycemic control and diabetes-related complications. Nevertheless, the underlying mechanisms of their therapeutic effects remain incompletely elucidated.
View Article and Find Full Text PDFCharacterization of peptide-enriched walnut meal paste via microbial diversity and metabolite profiling.
Int J Food Microbiol
August 2025
School of Food and Health, Beijing Technology and Business University (BTBU), Beijing 100048, China. Electronic address:
Walnut meal (WM), a protein-rich byproduct of oil extraction, holds great potential for conversion into value-added food products but remains underutilized. In this study, a two-stage fermentation process involving Aspergillus oryzae inoculation for koji preparation followed by natural brine fermentation was developed to produce a peptide-enriched walnut meal paste (WMP). Physicochemical analysis showed significant increases in total acidity (0.
View Article and Find Full Text PDFEffect of LPJZ-658 on caecum microbiota and serum metabolomics of Luhua broiler.
Front Microbiol
August 2025
College of Animal Science and Technology, Jilin Agricultural Science and Technology University, Jilin, China.
Introduction: The purpose of this study was to investigate the effects of dietary supplementation of LPJZ-658 on body weight and serum indexes of Luhua broiler, and to explore the relevant mechanism of probiotic function of LPJZ-658 based on intestinal microbiota and serum metabolomics.
Methods: One hundred one-day-old Luhua broiler were randomly divided into the control group (CON) and LPJZ-658 treatment group (LPJZ-658). The CON group was fed a basal diet, and the LPJZ-658 group was fed the basal diet supplemented with 2 × 10 cfu/kg of LPJZ-658.
Artemisinin alleviates Parkinson's disease by targeting Adcy5-Gch1 axis to trigger a cascade generation of BH4 and dopamine in rats.
Genome Biol
September 2025
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education and Key Laboratory of Basic Pharmacology of Guizhou Province and Laboratory Animal Center, Zunyi Medical University, Zunyi, Guizhou, China. zhangfengzmc
Background: Parkinson's disease is a highly prevalent neurodegenerative disorder. Hyposecretion of dopamine (DA) is the end result in the pathology of Parkinson's disease. Unfortunately, safe and efficient therapeutic drugs are deficient.
View Article and Find Full Text PDF