Polymeric immunoglobulin receptor (pIgR) in cancer progression: a critical role and potential therapeutic target.

Polymeric immunoglobulin receptor (pIgR) is a crucial receptor that primarily mediates the transcytosis of immunoglobulins A and M across epithelial cells, emerging as an essential participant in modulating both mucosal immunity and innate immunity. Recently, pIgR dysregulation in cancer has garnered widespread attention. It exhibits distinct mechanisms and effects across various cancer types with significant clinical value as a biomarker for malignant tumor diagnosis and prognosis evaluation.

Innovative use of gram-positive enhancer matrix particles and affinity peptides in a vaccine against Coxsackievirus B3.

Viral myocarditis (VM) is an inflammatory disease posing a serious threat to public health, with various viral pathogens contributing to its pathogenesis. Coxsackievirus B3 (CVB3) is the most frequently implicated causative agent and has been extensively studied because of its high prevalence and severity. No specific therapeutic interventions for VM exist, and vaccine development has encountered substantial challenges.

Effect of Strengthening Mechanism of Alkali Curing on Mechanical Properties of Fly Ash Lightweight Aggregates and Its Concrete.

The low hydration degree of fly ash in Fly Ash Unburned Lightweight Aggregate (FULA) is not conducive to the development of the mechanical properties of lightweight aggregates and their concrete. In this paper, FULA was immersed in an alkaline solution with the purpose of improving the mechanical properties of FULA and its concrete. Firstly, FULA was prepared using fly ash as the main raw material.

Bacterial and host fucosylation maintain IgA homeostasis to limit intestinal inflammation in mice.

Inflammatory bowel disease is associated with several genetic risk loci. Loss-of-function mutation in the α1,2-fucosyltransferase (fut2) gene, which alters fucosylation on the surface of intestinal epithelial cells, is one example. However, whether bacterial fucosylation can contribute to gut inflammation is unclear.

Exosomal miR‑194 from adipose‑derived stem cells impedes hypertrophic scar formation through targeting TGF‑β1.

Hypertrophic scars, which result from aberrant fibrosis and disorganized collagen synthesis by skin fibroblasts, emerge due to disrupted wound healing processes. These scars present significant psychosocial and functional challenges to affected individuals. The current treatment limitations largely arise from an incomplete understanding of the underlying mechanisms of hypertrophic scar development.

Human adipose mesenchymal stem cell-derived exosomes alleviate fibrosis by restraining ferroptosis in keloids.

Background: Keloid is a fibroproliferative disease with unsatisfactory therapeutic effects and a high recurrence rate. exosomes produced by adipose-derived mesenchymal stem cells (ADSC-Exos) have attracted significant interest due to their ability to treat fibrosis. However, the molecular mechanisms of ADSC-Exos in keloids remain inconclusive.

A Flexible Skin Bionic Thermally Comfortable Wearable for Machine Learning-Facilitated Ultrasensitive Sensing.

Tremendous popularity is observed for multifunctional flexible electronics with appealing applications in intelligent electronic skins, human-machine interfaces, and healthcare sensing. However, the reported sensing electronics, mostly can hardly provide ultrasensitive sensing sensitivity, wider sensing range, and robust cycling stability simultaneously, and are limited of efficient heat conduction out from the contacted skin interface after wearing flexible electronics on human skin to satisfy thermal comfort of human skin. Inspired from the ultrasensitive tactile perception microstructure (epidermis/spinosum/signal transmission) of human skin, a flexible comfortably wearable ultrasensitive electronics is hereby prepared from thermal conductive boron nitride nanosheets-incorporated polyurethane elastomer matrix with MXene nanosheets-coated surface microdomes as epidermis/spinosum layers assembled with interdigitated electrode as sensing signal transmission layer.

Flexible Conformally Bioadhesive MXene Hydrogel Electronics for Machine Learning-Facilitated Human-Interactive Sensing.

Wearable epidermic electronics assembled from conductive hydrogels are attracting various research attention for their seamless integration with human body for conformally real-time health monitoring, clinical diagnostics and medical treatment, and human-interactive sensing. Nevertheless, it remains a tremendous challenge to simultaneously achieve conformally bioadhesive epidermic electronics with remarkable self-adhesiveness, reliable ultraviolet (UV) protection ability, and admirable sensing performance for high-fidelity epidermal electrophysiological signals monitoring, along with timely photothermal therapeutic performances after medical diagnostic sensing, as well as efficient antibacterial activity and reliable hemostatic effect for potential medical therapy. Herein, a conformally bioadhesive hydrogel-based epidermic sensor, featuring superior self-adhesiveness and excellent UV-protection performance, is developed by dexterously assembling conducting MXene nanosheets network with biological hydrogel polymer network for conformally stably attaching onto human skin for high-quality recording of various epidermal electrophysiological signals with high signal-to-noise ratios (SNR) and low interfacial impedance for intelligent medical diagnosis and smart human-machine interface.

Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages.

The tumor microenvironment is reprogrammed by cancer cells and participates in all stages of tumor progression. Neutral ceramidase is a key regulator of ceramide, the central intermediate in sphingolipid metabolism. The contribution of neutral ceramidase to the reprogramming of the tumor microenvironment is not well understood.

Alcohol-mediated susceptibility to lung fibrosis is associated with group 2 innate lymphoid cells in mice.

Chronic alcohol ingestion promotes acute lung injury and impairs immune function. However, the mechanisms involved are incompletely understood. Here, we show that alcohol feeding enhances bleomycin-induced lung fibrosis and inflammation via the regulation of type 2 innate immune responses, especially by group 2 innate lymphoid cells (ILC2s).

Solidification Mechanism of Pb and Cd in S-Enriched Alkali-Activated Municipal Solid Waste Incineration Fly Ash.

S-enriched alkali-activator (SEAA) was prepared by modifying the alkali activator through NaS. The effects of S-enriched alkali-activated slag (SEAAS) on the solidification performance of Pb and Cd in MSWI fly ash were investigated using SEAAS as the solidification material for MSWI fly ash. Combined with microscopic analysis through scanning electron microscopy (SEM), X-ray fluorescence spectroscopy (XRF), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR), the effects of SEAAS on the micro-morphology and molecular composition of MSWI fly ash were studied.

A Half-Sandwich Ruthenium(II) (N^N) Complex: Inducing Immunogenic Melanoma Cell Death in Vitro and in Vivo.

Efficacy of clinical chemotherapeutic agents depends not only on direct cytostatic and cytotoxic effects but also involves in eliciting (re)activation of tumour immune effects. One way to provoke long-lasting antitumour immunity is coined as immunogenic cell death (ICD), exploiting the host immune system against tumour cells as a "second hit". Although metal-based antitumour complexes hold promise as potential chemotherapeutic agents, ruthenium (Ru)-based ICD inducers remain sparse.

Strengthening Mechanism for the Mechanical Properties of Cement-Based Materials after Internal Nano-SiO Production.

This study focuses on overcoming the agglomeration issue of nano-SiO powder in cement, facilitating the strengthening mechanism of cement-based materials. A nano-SiO precursor solution (NSPS) was added to cement-based materials to replace nano-SiO powder. The influencing laws of the alkalinity and dosage of the NSPS on the mechanical properties of cement were investigated.

The Stabilization Mechanism of Nano-SiO Precursor Solution.

The issues associated with the fabrication of nano-silica (NS) mineral powder, such as high cost and agglomeration, can be effectively mitigated by using a precursor solution of NS as the external mixture of cement-based materials. Based on the liquid-phase preparation of NS mineral powder, its preparation technology was thoroughly investigated herein. The precursor solution of NS was synthesized using acid media (HCL, HNO, HBO, HCOOH, CHCOOH)-the acetic acid concentration was 1~15%-and siliceous materials.

scRNA-seq reveals ATPIF1 activity in control of T cell antitumor activity.

ATP synthase inhibitory factor 1 (ATPIF1) is a mitochondrial protein with an activity in inhibition of FF-ATP synthase. ATPIF1 activity remains unknown in the control of immune activity of T cells. In this study, we identified ATPIF1 activity in the induction of CD8 T cell function in tumor models through genetic approaches.

H3K4 demethylase KDM5B regulates cancer cell identity and epigenetic plasticity.

The H3K4 demethylase KDM5B is overexpressed in multiple cancer types, and elevated expression levels of KDM5B is associated with decreased survival. However, the underlying mechanistic contribution of dysregulated expression of KDM5B and H3K4 demethylation in cancer is poorly understood. Our results show that loss of KDM5B in multiple types of cancer cells leads to increased proliferation and elevated expression of cancer stem cell markers.

Positive Influence of Liquid Sodium Silicate on the Setting Time, Polymerization, and Strength Development Mechanism of MSWI Bottom Ash Alkali-Activated Mortars.

Setting time and mechanical properties are key metrics needed to assess the properties of municipal solid waste incineration (MSWI) bottom ash alkali-activated samples. This study investigated the solidification law, polymerization, and strength development mechanism in response to NaOH and liquid sodium silicate addition. Scanning electron microscopy and X-ray diffraction were used to identify the formation rules of polymerization products and the mechanism of the underlying polymerization reaction under different excitation conditions.

Potent half-sandwich Ru(Ⅱ) N^N (aryl-BIAN) complexes: Lysosome-mediated apoptosis, in vitro and in vivo anticancer activities.

Herein a new series of organometallic half-sandwich Ru(Ⅱ) complexes bearing aryl-BIAN chelating ligands with various electron-withdrawing and electron-donating substituents have been developed as theranostic agents. All the complexes display much higher anti-proliferative potency than the clinical chemotherapeutic drug cisplatin towards seven cancer cell lines. The anti-proliferative efficacy of these complexes is correlated to their electron-withdrawing ability.

Theranostic Lysosomal Targeting Anticancer and Antimetastatic Agents: Half-Sandwich Iridium(III) Rhodamine Complexes.

Two rhodamine-modified half-sandwich Ir(III) complexes with the general formula [(Cp)Ir(ĈN) Cl] were synthesized and characterized, where Cp is 1-biphenyl-2,3,4,5-tetramethylcyclopentadienyl (Cp). Both complexes showed potent anticancer activity against A549, HeLa, and HepG2 cancer cells and normal cells, and altered ligands had an effect on proliferation resistance. The complex enters cells through energy dependence, and because of the different ligands, not only could it affect the anticancer ability of the complex but also could affect the degree of complex lysosome targeting, lysosomal damage, and further prove the antiproliferative mechanism of the complex.

Potential anticancer agent for selective damage to mitochondria or lysosomes: Naphthalimide-modified fluorescent biomarker half-sandwich iridium (III) and ruthenium (II) complexes.

In this work, five naphthalimide-modified half-sandwich iridium and ruthenium complexes ([(η-Cp)Ir(NˆN)Cl]PF, [(η-p-cym)Ru(NˆN)Cl]PF) have been presented. The anticancer activities of the complexes against various cancer cell lines were investigated, among them, complexes 2 and 4 showed better anticancer activity than cisplatin, and their anticancer activity is better than complex 5 without fluorophore. In addition, a series of biological tests of complex 2 were performed using flow cytometry, the results indicated that the complex could induce cell death in a variety of ways.

miR-495 inhibits the growth of fibroblasts in hypertrophic scars.

Noncoding RNAs are known to be importantly involved in a variety physiological and pathophysiolgical processes. Their role in the pathogenesis of hypertrophic scars remains unclear, however. After preliminary screening of the microRNA (miRNA) gene expression profiles, we explored the role of miR-495 in the development of hypertrophic scar by comparing expression of miR-495 and focal adhesion kinase (FAK) between hypertrophic scar and normal skin tissue.

Design, synthesis, and evaluation of phosphorescent Ir(III) complexes with anticancer activity.

A range of phosphorescent Ir(III) complexes containing four diverse P^P-chelating ligands of the type [Ir(ppy)(L)][PF], (ppy = 2‑phenylpyridine) where L is 1,2‑bis(diphenylphosphino)benzene (L1), 1,2‑bis(diphenylphosphino)ethane (L2), 1,2‑bis(diphenylphosphino)propane(L3) and 1,8‑bis(diphenylphosphino)naphthalene (L4) were synthesized respectively. The iridium complexes possessed excellent antiproliferative properties, which was a substantial improvement over cisplatin, especially complex Ir1. Generally, the order of in vitro antiproliferative activity of the complexes is Ir1 > Ir2 = Ir3 > Ir4 > CDDP (Cisplatin).

The Differential Expression of miRNAs and a Preliminary Study on the Mechanism of miR-194-3p in Keloids.

The aim of this study was to detect abnormally expressed microRNA (miRNA) in keloids and to study their functions. The differential expression of miRNAs in keloids and normal tissue was detected by gene microarray. MiRNA expression was verified by real-time PCR.

Novel half-sandwich iridium OˆC (carbene)-Complexes: In vitro and in vivo tumor growth suppression and pro-apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes.

Herein we present half-sandwich Ir complexes [(η-Cp)Ir(OˆC)Cl] containing OˆC(NHC)-chelating ligand as anticancer and antimetastasis agents. All the complexes displayed high potency in vitro against a wide range of cancer cells. In addition, Ir2 significantly curb tumor growth in a colon cancer mouse xenograft model in vivo.