Chronic Heat Stress Caused Lipid Metabolism Disorder and Tissue Injury in the Liver of via Oxidative-Stress-Mediated Ferroptosis.

High-temperature stress has become an important factor that has restricted the aquaculture industry. is a high-economic-value fish that has faced the threat of thermal stress. Based on this point, our investigation aimed to explore the detailed mechanism of the negative impacts of heat stress on the liver metabolism functions in .

Application of porous bismuth-based materials in sodium ion batteries.

Sodium-ion batteries (SIBs) offer a sustainable alternative to lithium-ion systems, leveraging resource availability and enhanced safety. This review describes the application of porous bismuth (Bi)-based materials in sodium ion batteries. Bismuth-based materials are emerging as promising anode candidates due to their high capacity, manageable volume expansion, and tunable porosity.

Establishment and evaluation of a patient-derived organoids-based xenograft model of primary aldosteronism using [F]AlF-NOTA-pentixather PET/CT: bridging preclinical and clinical imaging.

Background: Primary aldosteronism (PA) is a leading cause of secondary hypertension, but the lack of representative preclinical models hampers translational research and imaging evaluation. We aimed to establish a patient-derived organoids-based xenograft (PDOX) model of PA and to assess its imaging characteristics using [F]AlF-NOTA-pentixather PET/CT, with validation in clinical patients.

Methods: Adrenal tissues from patients with PA were used to generate adrenal organoids in vitro.

Acute Leukemia Warning Model Combined CBC and CPD Data Based on Machine Learning.

Background: Early diagnosis plays a crucial role in improving the survival rate of acute leukemia (AL) patients. This study aims to develop a warning model for the detection of acute leukemia (AL) using complete blood count (CBC) and cell population data (CPD), which could aid in clinical diagnosis.

Methods: In this study, CBC and CPD were utilized to develop a warning model for assisting clinical diagnosis of AL.

Protective effects of propafenone, propranolol, and amiodarone against isoproterenol-induced lethal arrhythmias in IGF1R deficiency mice.

The study investigates the role of the insulin-like growth factor 1 receptor (IGF1R) in cardiac function and its impact on stress-induced arrhythmias. IGF1R is a key receptor involved in cardiomyocyte growth and metabolism, with significant implications for cardiac development and stress response. However, its role in arrhythmias remains underexplored.

A Framework Integrating GWAS and Genomic Selection to Enhance Prediction Accuracy of Economical Traits in Common Carp.

Common carp () is one of the most significant fish species worldwide, with its natural distribution spanning Europe and Asia. To conduct a genome-wide association study (GWAS) and compare the prediction accuracy of genomic selection (GS) models for the growth traits of common carp in spring and autumn at 2 years of age, a total of 325 carp individuals were re-sequenced and phenotypic measurements were taken. Three GWAS methods (FarmCPU, GEMMA, and GLM) were applied and their performance was evaluated in conjunction with various GS models, using significance levels based on -values.

Accumulation Patterns and Health Risk Assessment of Trace Elements in Intermuscular Bone-Free Crucian Carp.

This study investigated the accumulation characteristics and associated health risks of 11 trace elements (Al, Rb, Cr, Ni, Mo, Sr, Pb, Ba, Ag, As, and Ga) in four crucian carp varieties: gene-edited intermuscular bone-free crucian carp ( WUCI) and its sibling wild-type (, WT), Fangzheng silver crucian carp ( Fangzheng, FZYJ), and Songpu silver crucian carp ( Songpu, SPYJ). Results showed that Al and Rb were the most abundant elements across all groups. WUCI exhibited distinct accumulation patterns, including significantly higher hepatic Mo concentrations (0.

Primary aldosteronism patients with bilateral adrenal vein sampling success achieve better outcomes through unilateral adrenalectomy.

Background: Adrenal vein sampling (AVS) is the gold standard for diagnosing the dominant side in patients with primary aldosteronism (PA). encodes aldosterone synthase. The aim of this study was to investigate the prognosis of dominant-side adrenalectomy in patients with PA identified by AVS in the context of aldosterone synthase expression in the postoperative pathology of those patients.

TaHSP18.6 and TaSRT1 interact to confer resistance to crown rot by regulating the auxin content in common wheat.

crown rot (FCR) is one of the most serious soil-borne diseases in common wheat and has caused major wheat yield losses worldwide. Here, we identified an 18.6 kDa heat shock protein gene () through combining a transcriptome analysis and a genome-wide association study.

Regulating d-p Orbital Hybridized Electronic Structure via Doping Engineering for Advanced Sodium-Ion Batteries.

Transition-metal selenides are promising anodes for energy storage due to their high energy density but face challenges, including volume expansion and sluggish kinetics. Herein, a doping engineering strategy is proposed to synthesize N-rich carbon-coated bimetallic zinc selenides doped with various transition metals (TM-ZnSe@NC, TM = Fe, Co, Ni) employing bimetallic zeolite imidazole frameworks as precursors through carbonization and selenization. The introduction of Fe, Co, and Ni with unpaired 3d-orbital electrons effectively reconfigures the electronic structure and crystal lattice of ZnSe.

Clinical and radiological features of acinic cell carcinoma in the parotid gland: a contrast-enhanced CT evaluation.

Objective: To analyze the clinical and computed tomography (CT) features of acinic cell carcinomas (AciCCs) of the parotid gland in comparison with Warthin tumors (WTs), pleomorphic adenomas (PAs), basal cell adenomas (BCAs), and mucoepidermoid carcinomas (MECs).

Study Design: This retrospective study included 359 patients with primary parotid gland tumors, all of whom underwent contrast-enhanced CT scans prior to treatment. Clinical manifestations, treatment regimens, and follow-up information were also reviewed.

Use peripheral blood leukocyte parameters combined with inflammatory indicators in diagnosis and severity assessment of mycoplasma pneumoniae pneumonia in children.

Background: Mycoplasma pneumoniae is a common cause of pneumonia in children over 5 years of age. Cell Population Data (CPD) is valuable for screening various diseases, including certain infections and myeloproliferative disorders, but less used in the diagnosis of children mycoplasma pneumoniae pneumonia (MPP).

Aims: To improve the diagnostic efficacy and severity assessment of MPP in children by combining CPD with inflammatory markers.

Resection of Midfacial Tumors Assisted by Virtual Planning Based on CT/MRI Multimodal Image Fusion: A Cohort Study.

Objective: This cohort study aimed to preliminarily explore the effect of midfacial tumor resection procedure with assistance of virtual planning based on CT/MRI multimodal image fusion.

Methods: For the experimental cohort, patients with midfacial tumors receiving treatment from February 2019 to March 2021 were enrolled. Virtual planning was completed preoperatively based on CT/MRI multimodal image fusion.

High-entropy-doping effect in a rapid-charging NbO lithium-ion battery negative electrode.

Doping is an important approach to tailor materials' properties, yet the success of doping can depend on factors such as ionic radii similarities. For materials like silicon or perovskite, doping is not only facile to implement but can also enhance material properties. However, for host lattice structures like NbO, doping without causing phase change is challenging.

Multi-Strategy Enhancement of YOLOv8n Monitoring Method for Personnel and Vehicles in Mine Air Door Scenarios.

The mine air door is the primary facility for regulating airflow and controlling the passage of personnel and vehicles. Intelligent monitoring of personnel and vehicles within the mine air door system is a crucial measure to ensure the safety of mine operations. To address the issues of slow speed and low efficiency associated with traditional detection methods in mine air door scenarios, this study proposes a CGSW-YOLO man-vehicle monitoring model based on YOLOv8n.

Establishment and Characteristics of the Spermatogonial Stem Cell Line from the Yellow River Carp ().

To address the growing consumer demands for improved fish meat quality, desirable morphological traits, and sustainable production practices, researchers have intensified efforts in the selective breeding and genetic improvement of carp () varieties. However, traditional breeding methods are often time-consuming and inefficient, which poses challenges to the sustainable development of the carp aquaculture industry. The establishment of germ stem cell lines offers a crucial tool for the study of germ cells, genetic improvement, and species conservation.

In Situ Composite Strategy of O/F-Dual-Doped Soft-Hard Carbon Anode Promotes Ultrafast and Highly Durable Potassium Storage Performance.

Soft-hard carbon has been regarded as a suitable anode material for potassium-ion batteries (PIBs) due to synergistic effects between hard carbon (HC) and soft carbon. However, the cost-effective and precise structural control of these carbons remains a significant challenge. In this study, O/F-dual-doped soft-hard carbon (OFPC) composite materials with a porous honeycomb-like structure are simply synthesized by using an in situ, low-temperature pyrolysis strategy.

Metal-phenolic network coatings delivering stem cells from apical papilla derived nanovesicles for bone defect regeneration.

Bone defects have a broad impact, with over four million patients globally needing bone defect reconstruction every year due to various causes. Extracellular vesicle-functionalized scaffolds have recently emerged as a novel therapeutic approach for enhancing bone tissue regeneration. However, the clinical application of exosomes is limited by their low yield and rapid clearance.

Comprehensive Evaluation of Growth Performance, Hematological Parameters, Antioxidant Capacity, Innate Immunity, and Disease Resistance in Crucian Carp () Lacking Intermuscular Bones.

The presence of intermuscular bones severely affects the edibility and value-added processing of crucian carp (), becoming a constraint to the high-quality development of its industry. Our previous study identified as the key osteogenic regulator and successfully developed a new crucian carp strain lacking intermuscular bones (WUCI) using CRISPR/Cas9 technology. To accelerate its industrialization, we comprehensively assessed WUCI's growth performance, hematological parameters, antioxidant capacity, innate immunity, and disease resistance.

A multifunctional hydrogel loaded with magnesium-doped bioactive glass-induced vesicle clusters enhances diabetic wound healing by promoting intracellular delivery of extracellular vesicles.

The treatment of diabetic wounds (DWs) poses a significant medical challenge. Mesenchymal stem cell-derived small extracellular vesicles (sEVs) have demonstrated potential in accelerating healing by delivering growth factors and microRNAs. However, the rapid clearance by the circulatory system limits their concentration and bioavailability within cells.

Ceria Centre to Enhance Multi-Active and Photothermal Response Janus Patch for Chronic Wound Senescence Inhibition and Repair.

Bacterial infections and complex microenvironments induce cellular oxidative stress and cellular senescence severely affect chronic wound healing. However, the antibacterial effect of most dressings is single, which is only against the wound-breeding bacteria but cannot resist further invasion of bacteria in the environment into the wound. Few dressings can simultaneously fulfill antibacterial, antifouling, oxidative stress regulation, and cellular protection.

Multi-Strategy Improvement of Coal Gangue Recognition Method of YOLOv11.

The current methods for detecting coal gangue face several challenges, including low detection accuracy, a high probability of missed detections, and inadequate real-time performance. These issues stem from the complexities associated with diverse industrial environments and mining conditions, such as the mixing of coal gangue and insufficient illumination within coal mines. A detection model, referred to as EBD-YOLO, is proposed based on YOLOv11n.

High-Voltage Sodium Layered Cathode Stabilized by Bulk Complex-Composition Doping to Surface Phosphate Coating Design.

Layered oxides are considered promising cathode materials for sodium-ion batteries (SIBs) due to their high energy density, flexible compositions, and low cost. However, they encounter significant challenges, such as multiphase transitions and structural instability at high voltages, which limit their large-scale practical application. In this study, we employed a dual modification strategy involving complex composition doping and phosphate coating to fabricate the NaNiMn(TiMgCuZn)O@phosphate cathode (D-NNM).

Comprehensive pan-cancer analysis reveals CD70 as a promising therapeutic target and biomarker in clear cell renal cell carcinoma.

CD70, a member of the tumor necrosis factor family, has been implicated in various cellular processes associated with tumorigenesis. Despite its known expression in certain cancers, a detailed pan-cancer analysis and functional validation in clear cell renal cell carcinoma (ccRCC) have not been comprehensively explored. We conducted a pan-cancer analysis using publicly available databases to investigate the expression and prognostic significance of CD70 across various cancer types.