Combined Impacts of Acute Heat Stress on the Histology, Antioxidant Activity, Immunity, and Intestinal Microbiota of Wild Female Burbot () in Winter: New Insights into Heat Sensitivity in Extremely Hardy Fish.

Temperature fluctuations caused by climate change and global warming pose a threat to fish. The burbot () population is particularly sensitive to increased water temperature, but the systematic impacts of high-temperature exposure on their liver and intestinal health remain unclear. In January of 2025, we collected wild adult burbot individuals from the Ussuri River (water temperature: about 2 °C), China.

Chronic Heat Stress Caused Lipid Metabolism Disorder and Tissue Injury in the Liver of via Oxidative-Stress-Mediated Ferroptosis.

High-temperature stress has become an important factor that has restricted the aquaculture industry. is a high-economic-value fish that has faced the threat of thermal stress. Based on this point, our investigation aimed to explore the detailed mechanism of the negative impacts of heat stress on the liver metabolism functions in .

Theranostics targeting fibroblast activation protein in the pan-cancer field.

Fibroblast activation protein (FAP), a membrane-bound glycoprotein overexpressed in cancer-associated fibroblasts (CAFs), is a promising target for diagnostic and therapeutic interventions in oncology. Its elevated expression correlates with tumor progression and metastasis, with minimal presence in normal tissues. Recent advancements in FAP-targeted theranostics have focused on positron emission tomography/computed tomography (PET/CT), fluorescence imaging, and targeted radionuclide therapy (TRT).

Organoid models in oncology: advancing precision cancer therapy and vaccine development.

Organoids are three-dimensional stem cell-derived models that offer a more physiologically relevant representation of tumor biology compared to traditional two-dimensional cell cultures or animal models. Organoids preserve the complex tissue architecture and cellular diversity of human cancers, enabling more accurate predictions of tumor growth, metastasis, and drug responses. Integration with microfluidic platforms, such as organ-on-a-chip systems, further enhances the ability to model tumor-environment interactions in real-time.

Facet-Engineered Atomic Interface and On-Chip Continuous-Amplitude Modulated Recovery Enabling Ultra-High Endurance for Hafnium-Based Ferroelectric Memories.

Ferroelectric hafnia-based materials have made considerable progress toward ultradense nonvolatile memories and beyond-Moore devices. While doping, intercalation, and strain engineering have successfully stabilized the metastable orthorhombic phase─essential for ferroelectricity, device resilience against fatigue under repeated electric field cycling remains a critical challenge. The fatigue is primarily attributed to issues related to continuous interfacial charge injection, oxygen vacancy formation and aggregation, and subsequent polarization pinning and phase degradation.

Protective Effects of Deinoxanthin on Brain Oxidative Damage and Gut Microbiota in the D-Galactose-Induced Aging Mice.

Deinoxanthin (DX), a special hydroxylated tetraterpenoid synthesized by Deinococcus radiodurans, exhibits robust antioxidative activities in vitro and in vivo. The accumulation of excessive reactive oxygen species (ROS) and free radicals in the body would induce brain oxidative damage, thereby contributing to the process of aging. Whether the administration of DX could protect the brain against oxidative damage in aging is of great interest.

Cancer-Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic Targets.

Cancer-associated fibroblasts (CAFs) are functionally diverse stromal regulators that orchestrate tumor progression, metastasis, and therapy resistance through dynamic crosstalk within the tumor microenvironment (TME). Recent advances in single-cell multiomics and spatial transcriptomics have identified conserved CAF subtypes with distinct molecular signatures, spatial distributions, and context-dependent roles, highlighting their dual capacity to promote immunosuppression or restrain tumor growth. However, therapeutic strategies struggle to reconcile this functional duality, hindering clinical translation.

A Novel Time-Division Multiplexing Architecture Revealed by Reconfigurable Synapse for Deep Neural Networks.

Deep learning's growing complexity demands advanced AI chips, increasing hardware costs. Time-division multiplexing (TDM) neural networks offer a promising solution to simplify integration. However, it is difficult for current synapse transistors to physically implement TDM networks due to inherent device limitations, hindering their practical deployment in modern systems.

Autophagy-related biomarkers in non-obstructive azoospermia: insights from transcriptomics and single-cell sequencing.

Objective: Autophagy, by modulating cellular degradation and recycling processes, affects sperm cell survival and differentiation and may be linked to the pathophysiology of non-obstructive azoospermia (NOA). However, the role of autophagy-related genes (ARGs) in NOA has not yet been fully explored.

Methods: Transcriptomic datasets for NOA from public databases were used.

Interface Engineering for Constructing Air-Stable and Lithiophilic Garnet-Type Solid Electrolytes.

Garnet-type solid electrolytes (SEs) exhibit high ionic conductivity, a wide electrochemical window, and lithium stability, making them ideal for solid-state Li metal batteries. However, their air sensitivity leads to LiCO formation, causing poor Li wettability, high interfacial resistance, and dendrite growth. To address this, Mg(PO) is coated via a wet chemistry method, converting LiCO into a LiPO/MgO composite upon heating.

The impact of film audio description style on presence in Chinese visually impaired audiences.

This study investigates the impact of film audio description (AD) styles on dimensions of presence-spatial presence, engagement, ecological validity, and negative effects-among visually impaired audiences in China. Two distinct styles of AD were evaluated: objective AD and subjective AD. Using a mixed-methods methodology that integrated quantitative surveys with qualitative focus group discussions, the study examined participants' emotional and perceptual responses.

Transcriptomic Analysis of Skin Tissue Reveals Molecular Mechanisms of Thermal Adaptation in Cold-Exposed Lambs.

Cold stress impacts lamb mortality, welfare, and productivity. Wool and skin insulate lambs, but the mechanisms underlying their response to colder environments remain unclear. Shorn lambs ( = 20) of similar age (8 months), of the Hulunbuir ( = 10; average 34.

MOFChecker: a package for validating and correcting metal-organic framework (MOF) structures.

Metal-organic frameworks are promising porous materials for applications like gas adsorption, separation, transportation, and photocatalysis, but their large-scale computational screening requires high-quality, computation-ready structural data. Existing databases often contain errors due to experimental limitations, including inaccurately determined hydrogen positions, atomic overlaps, and missing components. We introduce MOFChecker to address these issues, providing tools for duplicate detection, geometric and charge error checking, and structure correction.

Microneedle biosensor for real-time monitoring of hydrogen sulfide release from paraventricular nucleus of hypertension rats stimulated by electroacupuncture.

Acupuncture therapy reduces blood pressure in hypertensive patients by stimulating acupoints located at specific anatomical positions with needles. Hydrogen sulfide (HS) release and accumulation in the paraventricular nucleus (PVN) might be a pivotal step for triggering blood pressure reduction. But to date, the dynamics of HS in the PVN during acupuncture treatment remain unclear.

Differential Cell Death Pathways Induced by Oxidative Stress in Multi-Organs of Amur Grayling () Under Gradient Ammonia Stress.

Ammonia nitrogen is a common contaminant in aquatic environments, and its potential toxicity to organisms has attracted extensive attention. However, few studies have comprehensively evaluated the negative impacts of ammonia stress on cold-water fish. In this study, liver, gill, and intestine specimens of Amur grayling () from three treatment groups (control (0 mg/L), low ammonia (43.

Effects of foliar fertilizer additives on grape fruit quality and endogenous hormones in leaves.

Background: Foliar fertilizer adjuvant is a fertilizer adjuvant that can improve the efficiency of plant leaf nutrient absorption. It is an effective means to reduce fertilizer usage and protect the environment, and plays an important role in agricultural production. However, under drought stress, traditional foliar fertilizers are susceptible to photolysis and evaporation loss, which affects the efficiency of nutrient absorption.

Relaxor Antiferroelectric Dynamics for Neuromorphic Computing.

Relaxor antiferroelectric (AFE) materials display a gradual polarization response and high energy storage density with polarization slowly reverting after removing an external field. This distinctive polarization-switching behavior closely resembles synaptic plasticity in biological nervous systems, presenting substantial potential for neuromorphic computing applications. Especially, its 2D scenario exhibits unique physical properties and maintains stability at atomic thickness due to their antipolar alignment, which effectively eliminates the depolarization field effect.

Amorphous-Nanocrystalline Fluorinated Halide Electrolytes with High Ionic Conductivity and High-Voltage Stability.

All-solid-state sodium-ion batteries (ASSSIBs) offer a cost-effective, scalable alternative to rechargeable lithium-ion batteries, but their advancement requires solid electrolytes with high ionic conductivity, wide electrochemical stability, and robust interfacial compatibility. Here, a fluorine-doped halide solid electrolyte (2NaF-ZrCl, 2-NFZC) featuring an amorphous-nanocrystalline structure with high ionic conductivity (2.35 × 10 S cm at 25 °C) and good high-voltage stability is presented.

The association between sports social capital and cognitive health: A longitudinal study of middle-aged and elderly adults in China.

This study examines the association between sports social capital and cognitive health in middle-aged and elderly individuals in China. Using data from the China Health and Retirement Longitudinal Study (CHARLS) and deep learning methods, we analyze interactions between sports social capital, cognitive function, and various health behaviors across multiple time points. Findings reveal that baseline cognitive scores and education are key predictors of cognitive health, consistent with cognitive reserve theory.

Enhancing the purity and intrinsic properties of ovine dermal papilla cells through flow cytometry sorting and cellular interactions.

Objective: Dermal Papilla Cells (DPCs) play a crucial role in regulating hair follicle development and serve as a valuable in vitro model for screening and analyzing the genes associated with this process. However, current methods for isolating ovine DPCs primarily rely on mechanical techniques, which present several limitations. The aim of this study is to establish a method for isolating and culturing ovine DPCs with high purity and retaining their intrinsic properties.

Dual-antibody functionalized transistor biosensor for specific diagnosis of liver cancer.

Selectively and sensitively detecting specific exosomal markers is critical for early diagnosis of liver cancer. However, identifying specific exosomal biomarkers and establishing accurate, convenient detection methods remain challenging. In this study, we used bioinformatics to identify the higher levels of EpCAM and GPC-3 proteins on liver cancer exosomes.

Self-Regulating the Local Conjugation of Tertiary Aniline toward Highly Stable Polymer Li Metal Batteries.

Pursuing high energy/power density lithium metal batteries (LMBs) with good safety and lifespan is essential for developing next-generation energy-storage devices. Nevertheless, the uncontrollable degradation of the electrolyte and the subsequent formation of inferior electrolyte/electrode interfaces present formidable challenges to this endeavor, especially when paring with transition metal oxide cathode. Herein, a fireproof polymeric matrix with a local conjugated structure is constructed by 4,4'-methylenebis (N, N-diglycidylaniline) (NDA) monomer via in situ polymerization, which promotes the use of ester-based liquid electrolyte for highly stable LMBs.

Partition-Less Digital Immunoassay Using Configurable Topographic Nanoarrays for Extracellular Vesicle Diagnosis of Ewing Sarcoma.

Emerging digital bioassays provide opportunities for bioanalysis and clinical diagnostics due to their improved analytical performance. Prevailing digitization strategies rely on partitioning single molecules into discrete compartments for which bead-based capture may be used. Herein we report a partition-free digital enzyme-linked immunosorbent assay (dELISA) named microfluidic Topographically Intensified, Partition-less dELISA (μTIP-dELISA).

Multifunctional Lactiplantibacillus plantarum SQ1 from Baijiu Daqu: Application of histamine degradation and probiotic potential in yogurt production.

Yogurt in this study is a milk drink with probiotics added during the fermentation process and has a variety of ingredients. To identify microorganisms capable of efficiently degrading histamine, thereby enhancing yogurt's quality and safety. This study focused on screening Lactiplantibacillus plantarum (L.

Dynamic Impacts of Stock Enhancement on Kaluga Sturgeon (): Novel Conservation Strategy Insights from the Gut Microbe Composition and Gene Expression Mode.

The sturgeon population has experienced strict threats due to inordinate human activities in the last decade and has been classified into the Red List of Threatened Species in recent years. Stock enhancement is one effective practice for the conservation of wild sturgeons. However, the survival conditions for sturgeon were not satisfactory after they were directly restocked into their natural habitat.