Thermoresponsive dynamic wet-adhesive epidermal interface for motion-robust multiplexed sweat biosensing.

Wearable sweat sensors offer noninvasive health monitoring through multiplexed biomarker analysis, delivering real-time diagnostics with continuous operational capability. However, chronic cutaneous interface hydration during prolonged monitoring induces adhesive delamination phenomena that manifest as signal attenuation, which fundamentally limits their clinical reliability. To address this challenge, we developed a thermodynamically adaptive polymer interface combining three functional components: mussel-inspired catechol moieties for moisture-tolerant adhesion, hydrophobic acrylates ensuring mechanical stability, and N-isopropylacrylamide enabling thermal responsiveness.

Association between paramyosin and the heat-induced toughening of adductor muscle in Pacific oysters (Crassostrea gigas).

Background: The phenomenon of increased toughness of adductor muscle of Pacific oysters (Crassostrea gigas) during heat treatment considerably impacts their palatability. Thus, the present study was conducted aiming to investigate the relationship between the adductor muscle proteins and observed toughness.

Results: During heat treatment with boiling, the smooth muscle exhibited greater difficulty in detaching from the shell compared to the striated muscle, indicating more pronounced toughness.

Adsorption of Phenolic Allelochemicals by P‑Doped Distiller's Grains Biochar: A Synergistic Mechanism to Reduce the Accumulation of Autotoxic Substances.

Continuous cropping obstacles are a significant challenge to sustainable agricultural development, with the accumulation of phenolic allelopathic substances being one of the main causes of these obstacles. In this study, different modified biochars (10P-BC, 30P-BC, and 50P-BC) were prepared by modifying distiller's grains biochars with different proportions of HPO (1:9, 3:7, and 1:1), and their ability to remove representative phenolic allelochemicals (p-hydroxybenzoic acid (p-HBA), vanillin (Van), and coumarin (Cou)) was investigated. The physicochemical properties were determined by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy.

Nonlinear Nernst effect in trilayer graphene at zero magnetic field.

The Nernst effect, that is, the generation of a transverse voltage in response to a temperature gradient, enables thermoelectric energy conversion. In the absence of an external magnetic field, the linear Nernst effect is forbidden in non-magnetic materials because of time-reversal symmetry constraints, but the recently predicted nonlinear Nernst effect (NNE) is allowed. Here we report the experimental observation of the NNE in non-magnetic ABA trilayer graphene, even in the absence of an external magnetic field.

Critical role of spread through air spaces in prognosis of stage IA3 non-small cell lung cancer: insights from a real-world multicenter study.

Background: Pathological stage IA3 non-small cell lung cancer (NSCLC) has higher recurrence rates and poorer prognosis than stages IA1 and IA2. This study systematically evaluates the prognostic impact of spread through air spaces (STAS) subtypes and related histomorphological factors, providing new insights for risk stratification in stage IA3 NSCLC.

Methods: We analyzed 256 pathological stage IA3 NSCLC patients from multiple thoracic centers in Fujian Province between January 2013 and June 2019.

[Research progress and current situation of oral surgery robots based on published papers and patents analysis].

Purpose: To analyze the research progress and technological development of oral surgery robots, reveal the future development trend of oral surgery robots and put forward policy suggestions.

Methods: Focusing on the topic of oral surgery robots, literature review and patent data retrieval methods were used to analyze data from 2011 to 2023 from the perspectives of quantity, source, and technical field.

Results: The number of academic papers and patent applications in the field of oral surgery robots had explosive growth since 2015.

Verteporfin-Mediated In Situ Nanovaccine Based on Local Conventional-Dose Hypofractionated Radiotherapy Enhances Antitumor and Immunomodulatory Effect.

In situ radiotherapy is the most successful cytotoxic therapy available for the treatment of solid tumors, while high-dose radiotherapy per fraction is not yet widely and reliably used. To some extent, the major considerations of the disappointing results are on the risk of high-dose irradiation-induced damage to the surrounding normal tissues and the difficulty in distant metastasis control. To break these restraints, a gelatinase-responsive amphiphilic methoxypolyethyleneglycol-PVGLIG-polycaprolactone (mPEG-PVGLIG-PCL) nanoparticles' loading verteporfin (N@VP), a special photosensitizer that can also be excited by X-rays to produce cytotoxic singlet oxygen and greatly enhance radiotherapy efficacy, is prepared in this study.

Tribenuron-methyl inhibited greenhouse gas emission and impacted the related functional pathways.

This study investigates the combined effects of tribenuron-methyl and urea on soil bacterial communities, greenhouse gases emissions, and carbon (C) and nitrogen (N) cycle-related functions. High-throughput sequencing revealed significant impacts on bacterial diversity and composition, with responses varying across different concentrations, sampling times, and the presence of urea. Tribenuron-methyl inhibited bacterial diversity at early sampling times but increased diversity after 60 days in the highest treatment.

Enzymatically responsive nanocarriers targeting PD-1 and TGF-β pathways reverse immunotherapeutic resistance and elicit robust therapeutic efficacy.

Immune checkpoint inhibitors (ICIs) have revolutionized lung cancer treatment, yet resistance remains a challenge. Co-inhibition of PD-1/PD-L1 and TGF-β shows promise but faces limited efficacy and systemic toxicity. We developed gelatinase-responsive nanoparticles (GPNPs) delivering anti-PD-1 antibody (αPD-1) and TGF-β receptor I inhibitor galunisertib (Gal).

Prognostic value of ground-glass opacity on computed tomography for patients with pathological stage IA3 lung adenocarcinoma: a multicenter retrospective cohort study.

Background: Ground-glass opacity (GGO) on computed tomography (CT) has been suggested as a potential prognostic factor in lung adenocarcinoma (LUAD), but its significance in patients with pathological stage IA3 LUAD, particularly in relation to micropapillary (MIP) status, remains unclear. This study addresses the clinical need to stratify patients based on GGO and MIP status to optimize prognosis prediction and follow-up strategies.

Methods: A multicenter retrospective study was conducted on 411 patients with pathological stage IA3 LUAD, enrolled between July 2012 and July 2020.

Severe postoperative complications after minimally invasive esophagectomy reduce the long-term prognosis of well-immunonutrition patients with locally advanced esophageal squamous cell carcinoma.

Background: While severe postoperative complications (SPCs) impact cancer prognosis, their effect on locally advanced esophageal squamous cell carcinoma (ESCC) patients with varying immunonutritional statuses after minimally invasive esophagectomy (MIE) is unclear.

Methods: This retrospective study analyzed 442 patients with locally advanced ESCC who underwent MIE, investigating the relationship between SPCs and survival based on preoperative immunonutritional status, determined by the prognostic nutritional index (PNI). Nomograms were developed for patients with preserved immunonutritional status using Cox regression, and their performance was assessed.

Chitooligosaccharides and Arbuscular Mycorrhizal fungi alleviate the damage by Phytophthora nicotianae to tobacco seedlings by inducing changes in rhizosphere microecology.

Arbuscular mycorrhizal fungi (AMF) and Chitooligosaccharide (COS) can increase the resistance of plants to disease. COS can also promote the symbiosis between AMF and plants. However, the effects of AMF & COS combined application on the rhizosphere soil microbial community of tobacco and the improvement of tobacco's resistance to black shank disease are poorly understood.

Adsorption Characteristics of Ball Milling-Modified Chinese Medicine Residue Biochar Toward Quercetin.

Using traditional Chinese medicine residues as raw materials, different biochars (BC) were prepared through oxygen-limited pyrolysis at 300 °C, 500 °C, and 700 °C, and BC was ball-milled to produce ball-milled biochar (BMC). Using these adsorbents to adsorb the allelopathic autotoxic substance quercetin. The physical and chemical properties of various biochars derived from traditional Chinese medicine residues were characterized using the Brunauer-Emmett-Teller-N2 surface areas (BET), scanning electron microscopy (SEM), Fourier transform IR spectroscopy (FTIR), X-ray diffraction (XRD), and Raman spectroscopy (Raman).

Dynamic Analysis of the Impact of Micropapillary Component on Different Recurrence Patterns of Pathological Stage IA3 Lung Adenocarcinoma: A Multicenter, Retrospective Study.

Background: This study aimed to evaluate the dynamic impact of the micropapillary (MIP) component on local recurrence (LR), distant metastasis (DM), and multiple recurrence (MR) of pathological stage IA3 lung adenocarcinoma.

Methods: Between July 2012 and July 2020, a total of 351 patients at two medical institutions were enrolled in this study. Cumulative incidence of curves, dynamic risk curves, and time-dependent multivariate analysis was performed to evaluate the effect of the MIP component on patients.

Symmetry dictionary on charge and spin nonlinear responses for all magnetic point groups with nontrivial topological nature.

Recently, charge or spin nonlinear transport with nontrivial topological properties in crystal materials has attracted much attention. In this paper, we perform a comprehensive symmetry analysis for all 122 magnetic point groups (MPGs) and provide a useful dictionary for charge and spin nonlinear transport from the Berry curvature dipole, Berry connection polarizability and Drude term with nontrivial topological nature. The results are obtained by conducting a full symmetry investigation of the matrix representations of six nonlinear response tensors.

Impact of minimally invasive total mesoesophageal excision and minimally invasive esophagectomy on failure patterns of locally advanced esophageal squamous cell carcinoma: a matched cohort study with long-term follow-up.

Background: The effects of minimally invasive total mesoesophageal excision (MITME) on the long-term prognosis of locally advanced esophageal squamous cell carcinoma (ESCC) remain unknown. The objective of this study was to compare the static and dynamic failure patterns of MITME and minimally invasive esophagectomy (MIE) for locally advanced ESCC.

Methods: We use propensity score matching (PSM) method to analyze the postoperative failure patterns of the two groups.

Effects of a ground-glass opacity component on the recurrence and survival of pathological stage IA3 lung adenocarcinoma: a multi-institutional retrospective study.

Background: This study aimed to evaluate the effect of the presence of a radiographically manifested ground-glass opacity (GGO) component on the prognosis of patients with pathological stage IA3 lung adenocarcinoma.

Methods: Patients diagnosed with pathological stage IA3 lung adenocarcinoma who underwent radical surgery at two medical institutions in China between July 2012 and July 2020 were enrolled. The cumulative incidence of recurrence (CIR) and cumulative incidence of death (CID) in patients with and without a GGO component were compared.

A Multi-institutional Analysis of the Combined Effect of Micropapillary Component and Consolidation-to-Tumor Ratio >0.5 on the Prognosis of Pathological, Stage IA3, Lung Adenocarcinoma.

Introduction: The study investigated the synergistic effect of the micropapillary (MIP) component and consolidation-to-tumor ratio (CTR) on the recurrence and survival of patients with pathologic stage IA3 lung adenocarcinoma.

Methods: We enrolled 419 patients confirmed pathological stage IA3 adenocarcinoma from four institutions. Kaplan-Meier analysis was performed to examine the value of the MIP component and CTR on relapse-free survival (RFS) and overall survival (OS).

Does sense of work gain predict team creativity? The mediating effect of leader-member exchange and the moderating effect of work smoothness.

In the present study, we examined the link between the sense of work gain and team creativity and explored the mediating and moderating roles of Leader-member exchange (LMX) and work smoothness on it. The results of this study A moderated mediation model was constructed based on 484 valid samples from an on-line survey of a human resource company, revealed that the sense of work gain can positively predict team creativity, and LMX mediates the associations of the sense of work gain and team creativity. Moreover, work smoothness emerged as a significant moderator can moderate the associations between sense of work gain and team creativity, as well as moderating the relationship between LMX and team creativity.

Nanomodified Switch Induced Precise and Moderate Activation of CAR-T Cells for Solid Tumors.

Chimeric antigen receptor (CAR)-T cell therapy is a transformative treatment against advanced malignancies. Unfortunately, once administrated in vivo, CAR-T cells become out of artificial control, and fierce response to CAR-T therapy may cause severe adverse events, represented by cytokine-release syndrome and on-target/off-tumor effects. Here, a nanomodified switch strategy is developed, leading to sustained and precise "on-tumor only" activation of CAR-T cells.

Formation of Shaped Charge Projectile in Air and Water.

With the improvement of the antiknock performance of warships, shaped charge warheads have been focused on and widely used to design underwater weapons. In order to cause efficient damage to warships, it is of great significance to study the formation of shaped charge projectiles in air and water. This paper uses Euler governing equations to establish numerical models of shaped charges subjected to air and underwater explosions.

Impact of new health care reform on enabling environment for children's health in China: An interrupted time-series study.

Background: Creating an enabling environment (EE) can help foster the development and health of children. The Chinese government implemented a new health care reform (NHR) in 2009 in a move to promote an EE for health. The purpose of this study was to evaluate the impact of the NHR on EE for children's health.

Changes of Multisectoral Collaboration and Service Delivery in Hypertension Prevention and Control before and after the 2009 New Healthcare Reform in China: An Interrupted Time-Series Study.

Objectives: There is a need to assess the 2009 new healthcare reform in China on hypertension prevention. It helps to control from the perspectives of multisectoral participation, government responsibility assignment, performance assessment, and service delivery.

Design: Interrupted time-series study.

Herbicidal and Antifungal Xanthone Derivatives from the Alga-Derived Fungus D5.

Fungi have been proved as promising and prolific sources of functional secondary metabolites with potent agricultural applications. In this study, 14 xanthone derivatives (-), including six new ones, versicones I-N (, , ), and a biogenetically related derivative (), were isolated from the alga-derived fungus D5. Their structures were elucidated by comprehensive spectroscopic methods.