Functional Study of the BMP Signaling Pathway in Appendage Regeneration of .

Appendage autotomy frequently occurs during the cultivation of , which severely impacts its survival and economic benefits. To investigate the molecular mechanism underlying appendage regeneration in , this study presents a comparative transcriptome analysis on samples from different stages of appendage regeneration in individuals of the same family of . A total of 6460 differentially expressed genes (DEGs) were identified between the samples collected at 0 h post-autotomy (D0) and those collected at 18 h post-autotomy (D18h).

Unlocking pH-universal charge storage: electrochemically engineered N-doped graphene beyond nanoporosity.

Despite excellent charge-discharge performance in carbon-based supercapacitors, their mechanisms across pH solutions remain unclear due to difficulties decoupling capacitive effects from porous structures and intricate micro-nano molecular/ionic channels. To investigate these mechanisms, we electrochemically synthesize structure-defined, nanohole-free N-doped graphene (ENG) as a model system. Attenuated total reflection in situ infrared spectroscopy (ATR-FTIR) reveals splendid electrochemical activity for pyridinic N and carboxyl functional groups in acidic medium.

Combined cryotherapy and photodynamic therapy for recurrent generalized giant plantar warts: A case report.

Background: Plantar warts, caused by human papillomavirus(HPV),often present therapeutic challenges due to high recurrence rates and deep tissue infiltration. Traditional modalities like cryotherapy, CO laser, and surgery show limited efficacy for large or recurrent lesions.

Objective: To evaluate the clinical efficacy of cryotherapy combined with photodynamic therapy (PDT) and immunomodulatory agents in treating refractory giant plantar warts.

DGEAHorNet: high-order spatial interaction network with dual cross global efficient attention for medical image segmentation.

Medical image segmentation is a complex and challenging task, which aims to accurately segment various structures or abnormal regions in medical images. However, obtaining accurate segmentation results is difficult because of the great uncertainty in the shape, location, and scale of the target region. To address these challenges, we propose a higher-order spatial interaction framework with dual cross global efficient attention (DGEAHorNet), which employs a neural network architecture based on recursive gate convolution to adequately extract multi-scale contextual information from images.

Dynamic Client Distillation for Semi-supervised Federated Learning in A Realistic Scenario.

Recent advancements in semi-supervised federated learning (SSFL) have significantly enhanced public health services by enabling medical institutions to share model updates via a central server. However, most SSFL approaches are based on conservative assumptions, such as labels-at-server and labels-at-client, which fail to fully capture the complex and diverse data distributions inherent in medical institutions. To address this limitation, we introduce a novel application of SSFL tailored to a realistic client data scenario, encompassing clients with fully-labeled, partially-labeled, and fully-unlabeled data.

Spatially synthesized fluorine-modified graphene improves double times higher capacitance than theoretical capacitance of graphene in alkaline medium.

The practically low energy density limits the large-scale application of graphene in supercapacitors. Here, we propose a space-confined method for the preparation of fluorine-modified graphene (FG) by using fluorine-containing groups (PF or BF) as co-intercalated ions and reactants. The semi-ionic C-F bonds in FG contribute a brilliant capacitive performance in both acidic and alkaline electrolytes.

Study on the Regulatory Mechanisms of Carapace Marking Formation in .

There are two phenotypes in the natural populations of , which is an ideal model for studying the formation of markings and body color in crustaceans. In a previous study, we used comparative transcriptome technology to screen some functional genes related to body color regulation. Here, high-throughput sequencing technology was used to perform microRNA (miRNA) sequencing analysis on the exoskeleton of with two types of carapace markings, and functional studies of related genes were performed.

Elucidating Mesostructural Effects on Thermal Conductivity for Enhanced Insulation Applications.

Thermal management is a key link in improving energy utilization and preparing insulation materials with excellent performance is the core technological issue. Complex and irregular pore structures of insulation materials hinder the exploration of structure-property relationships and the further promotion of material performance. Ordered mesoporous silica (OMS) is a kind of porous material with ordered frameworks.

Analysing trunk and arm motion in volleyball jump serve: a comparison of straight line and diagonal line techniques.

This study aimed to clarify the disparities in trunk rotation and attack arm movement and their effect on hand kinematics adjustments between straight-line (SL) and diagonal-line (DL) volleyball jump serves. Thirteen male professional volleyball players (age 21.53 ± 5.

Quantifying and analysing the angular momentum in volleyball jump serve during the aerial phase: relationship to arm swing speed.

Background: In volleyball, the jump serve is a crucial and commonly used serving technique. Nonetheless, the angular momentum developed during the jump serve remains unexplored. The objectives of the current study were to determine the angular momentum manifesting during the airborne phase of the jump serve and to analyse the correlations between the angular momentum variables and arm swing speed.

Morphological and Molecular Changes during Limb Regeneration of the .

With the increase in breeding density of , appendage breakage may occur, which seriously affects survival and economic benefits. To study the limb regeneration process of , we induced autotomy of the pereopods. After a period of time, wound swelling disappeared, the pigment gradually accumulated, and a tawny film subsequently formed in the wound.

Intra-graph and Inter-graph joint information propagation network with third-order text graph tensor for fake news detection.

Although the Internet and social media provide people with a range of opportunities and benefits in a variety of ways, the proliferation of fake news has negatively affected society and individuals. Many efforts have been invested to detect the fake news. However, to learn the representation of fake news by context information, it has brought many challenges for fake news detection due to the feature sparsity and ineffectively capturing the non-consecutive and long-range context.

Associations of financial toxicity with symptoms and unplanned healthcare utilization among cancer patients taking oral chemotherapy at home: a prospective observational study.

Background: Cancer patients with financial toxicity experience psychological distress and often miss medical appointments and quit treatments early, which could be a barrier to the effective management of oral chemotherapy drugs at home. This study explores whether financial toxicity predicts symptoms and unplanned healthcare utilization among cancer patients taking oral chemotherapy at home, which will contribute to the safe management of oral chemotherapy.

Methods: Data in this study was from a prospective observational study, which was conducted between October 2018 and December 2019.

Effects of Variable Resistance Training Within Complex Training on Neuromuscular Adaptations in Collegiate Basketball Players.

The aim of this study was to investigate the differences in neuromuscular performance between variable resistance training and constant resistance training within complex training. Twenty-one well-trained collegiate basketball players were randomly assigned to either an experimental group (variable resistance training) or a control group (constant resistance training) and completed a twice weekly training program over an 8-week period. Training programs were the same except that the experimental group included variable resistance via elastic bands (40% of the total load).

Clinical significance of circulating tumor cells in predicating the outcomes of patients with colorectal cancer.

Background: Relapse and metastasis of patients with Colorectal Cancer (CRC) is the major obstacle to the long-term life of patients. Its mechanisms remain defined.

Methods: A total of 48 CRC patients were enrolled and 68 samples were obtained from the peripheral blood of patients before or after treatments in this study.

In silico-guided metabolic engineering of Bacillus subtilis for efficient biosynthesis of purine nucleosides by blocking the key backflow nodes.

Background: Purine nucleosides play essential roles in cellular physiological processes and have a wide range of applications in the fields of antitumor/antiviral drugs and food. However, microbial overproduction of purine nucleosides by de novo metabolic engineering remains a great challenge due to their strict and complex regulatory machinery involved in biosynthetic pathways.

Results: In this study, we designed an in silico-guided strategy for overproducing purine nucleosides based on a genome-scale metabolic network model in Bacillus subtilis.

DC-CNN: Dual-channel Convolutional Neural Networks with attention-pooling for fake news detection.

Fake news detection mainly relies on the extraction of article content features with neural networks. However, it has brought some challenges to reduce the noisy data and redundant features, and learn the long-distance dependencies. To solve the above problems, Dual-channel Convolutional Neural Networks with Attention-pooling for Fake News Detection (abbreviated as DC-CNN) is proposed.

Zeolitic imidazolate framework-based nanoparticles for the cascade enhancement of cancer chemodynamic therapy by targeting glutamine metabolism.

The reprogrammed amino acid metabolism maintains the powerful antioxidant defense and DNA damage repair capacity of cancer cells, which could promote their escape from reactive oxygen species (ROS)-induced damage and inevitably diminish the efficacy of ROS-based therapies. Herein, we propose a strategy to enhance the effect of chemodynamic therapy (CDT) glutaminolysis-targeted inhibition for cancer cells dependent on abnormal glutamine metabolism. To screen optimum drugs targeting glutamine metabolism, transcriptomic analysis is performed to identify predictive biomarkers.

Intention and Perceived Control: International Migrants' Assimilation in China.

Unlabelled: Using the unique Survey of Foreigner Residents in China from 2018 to 2019, this study examines the assimilation of international migrants in China by considering how migrants' intention to assimilate and perceptions of local control affect their behavior, which in turn affects their assimilation outcomes. The main behavior upon which we focus on is the formation of a host social network. Regression analyses and formal mediation analyses are performed to explore how intention and perceived control serve as motivators or barriers that facilitate or restrict international migrants' acculturation and structural assimilation via host social network formation or other behaviors.

Comparative Evaluation of Bandage Contact Lenses and Eye Patching after Bilateral Cataract Surgery.

Purpose: To comparatively evaluate the safety and satisfaction of bandage contact lens (BCL) and eye patching in patients after cataract surgery.

Methods: Sixteen (32 eyes) patients who planned to undergo bilateral cataract surgery were recruited. The two eyes of each patient were randomly divided into 2 groups.

Healthchain: A novel framework on privacy preservation of electronic health records using blockchain technology.

The privacy of Electronic Health Records (EHRs) is facing a major hurdle with outsourcing private health data in the cloud as there exists danger of leaking health information to unauthorized parties. In fact, EHRs are stored on centralized databases that increases the security risk footprint and requires trust in a single authority which cannot effectively protect data from internal attacks. This research focuses on ensuring the patient privacy and data security while sharing the sensitive data across same or different organisations as well as healthcare providers in a distributed environment.

MicroRNA-135a-5p Promotes the Functional Recovery of Spinal Cord Injury by Targeting SP1 and ROCK.

Emerging evidence indicates that microRNAs play a pivotal role in neural remodeling after spinal cord injury (SCI). This study aimed to investigate the mechanisms of miR-135a-5p in regulating the functional recovery of SCI by impacting its target genes and downstream signaling. The gene transfection assay and luciferase reporter assay confirmed the target relationship between miR-135a-5p and its target genes (specificity protein 1 [SP1] and Rho-associated kinase [ROCK]1/2).

Mechanisms Underlying Abnormal Expression of lncRNA H19 in Neonatal Hypoxic-Ischemic Encephalopathy.

Objective: Hypoxic-ischemic (HI)-related brain injury, especially HI encephalopathy (HIE) is a leading cause of morbidity and disability in newborns. Long noncoding RNAs (lncRNAs) are implicated in the progress of HI brain damage. However, the mechanisms underlying the regulatory effects of lncRNA H19 on autophagy in HIE remain unknown.

Improvement of Neural-Network Classifiers Using Fuzzy Floating Centroids.

In this article, a fuzzy floating centroids method (FFCM) is proposed, which uses a fuzzy strategy and the concept of floating centroids to enhance the performance of the neural-network classifier. The decision boundaries in the traditional floating centroids neural-network (FCM) classifier are "hard." These hard boundaries force a point, such as noisy or boundary point, to be assigned to a class exclusively, thereby frequently resulting in misclassification and influencing the performance of optimization methods to train the neural network.

Six1 is negatively correlated with poor prognosis and reduces 5-fluorouracil sensitivity via attenuating the stemness of hepatocellular carcinoma cells.

The promoting roles of transcriptional factor six1 have been shown in various tumors, such as breast cancer and colorectal Cancer. However, its roles in hepatocellular carcinoma (HCC) cell stemness and chemotherapeutic sensitivity are never been revealed. In the present study, we showed that six1 expression was negatively correlated the overall survival of HCC patients and significantly increased in HCC tissues.