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Recent advancements in semi-supervised federated learning (SSFL) have significantly enhanced public health services by enabling medical institutions to share model updates via a central server. However, most SSFL approaches are based on conservative assumptions, such as labels-at-server and labels-at-client, which fail to fully capture the complex and diverse data distributions inherent in medical institutions. To address this limitation, we introduce a novel application of SSFL tailored to a realistic client data scenario, encompassing clients with fully-labeled, partially-labeled, and fully-unlabeled data. This approach effectively navigates varying levels of data annotation by maximizing the utility of unlabeled samples within the client federation. To tackle the challenges posed by such a complex scenario, we propose a new SSFL framework, FedCD. FedCD incorporates three client-distilled models, each corresponding to a distinct client data distribution, alongside server-client federation. First, each client-distilled model condenses the diverse parameters of the client federation into robust knowledge through distillation. The contribution of each client model is then dynamically adjusted based on its proximity to the client-distilled model, ensuring that the framework adapts to the heterogeneous characteristics of individual clients. By aggregating client-distilled models, FedCD implements model drift correction, effectively mitigating parameter drift across heterogeneous models. This dynamic federated approach not only harnesses unlabeled data efficiently but also accommodates diverse annotation levels while adapting to varying data distributions. Extensive experiments on two medical image segmentation tasks and one classification task demonstrate the superiority of our method, highlighting its ability to address realistic challenges in medical data scenarios.
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http://dx.doi.org/10.1109/TMI.2025.3570054 | DOI Listing |
Stat Biosci
August 2024
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Large-scale genomics data combined with Electronic Health Records (EHRs) illuminate the path towards personalized disease management and enhanced medical interventions. However, the absence of "gold standard" disease labels makes the development of machine learning models a challenging task. Additionally, imbalances in demographic representation within datasets compromise the development of unbiased healthcare solutions.
View Article and Find Full Text PDFEntropy (Basel)
July 2025
School of Mathematical Sciences, Sichuan Normal University, Chengdu 610066, China.
Federated semi-supervised learning (Fed-SSL) has emerged as a powerful framework that leverages both labeled and unlabeled data distributed across clients. To reduce communication overhead, real-world deployments often adopt partial client participation, where only a subset of clients is selected in each round. However, under non-i.
View Article and Find Full Text PDFIEEE Trans Neural Netw Learn Syst
July 2025
Federated semi-supervised learning (FSSL) has recently emerged as a promising approach for enhancing the performance of federated learning (FL) using ubiquitous unlabeled data. However, this approach encounters challenges when learning a global model using both fully labeled and fully unlabeled clients. Previous works overlook the dissimilarities between labeled and unlabeled clients, predominantly using shared parameters for local training across these two types of clients, thereby inducing intertask interference during local training.
View Article and Find Full Text PDFMicrosc Res Tech
July 2025
Department of Electronics and Communication Engineering, Ponjesly College of Engineering, Nagercoil, Tamil Nadu, India.
In the rapidly advancing field of histopathological image analysis, accurate segmentation of critical features is crucial for medical diagnostics, as it enables pathologists to make precise decisions. The proposed One Former-based Mean Teacher Model with Federated Learning (OF-MTMFL) system combines cutting-edge semi-supervised learning and federated learning techniques to tackle issues such as limited annotated data and class imbalance. The framework utilizes a mean teacher architecture, where the student model, guided by a focal loss function, prioritizes high-confidence regions in unlabeled data, while the teacher model ensures consistency through Exponential Moving Average (EMA) updates.
View Article and Find Full Text PDFMed Image Anal
October 2025
Intelligent Vision Research Lab, Institute of Computing, Federal University of Bahia, Bahia, Brazil. Electronic address:
Dental panoramic radiographs offer vast diagnostic opportunities, but the shortage of labeled data hampers the training of supervised deep-learning networks for the automatic analysis of these images. To address this issue, we introduce a holistic learning approach to classify dental conditions on panoramic radiographs, exploring tooth segmentation and textual reports, without a direct tooth-level annotated dataset. Large language models were used to identify the prevalent dental conditions in these reports, acting as an auto-labeling procedure.
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