Modular One-Pot Access to Boron-Carboxylated Dipyrromethene Dyes as Visible-Light and Two-Photon Activatable Photocages.

The photocage, an advanced platform for drug delivery and photoactivation imaging, has attracted wide attention in biomedicine. Despite recent advancements in shifting irradiation wavelengths to visible and near-infrared light, improving photolysis quantum yield and the corresponding uncaging cross section, key parameters for efficient photocages, remains highly challenging. Here, we address this challenge by introducing light-controlled COO-B bond cleavage from tetracoordinate boron linked to dipyrrin, aryl, and carboxylic acid groups.

Incidence of Vaginal Intraepithelial Neoplasia After Hysterectomy for Cervical Cancer or Cervical Intraepithelial Neoplasia: A Systematic Review and Meta-analysis.

Objective: To investigate the incidence of vaginal intraepithelial neoplasia (VAIN) 1+ in patients after hysterectomy for cervical intraepithelial neoplasia (CIN) or cervical cancer.

Data Sources: A systematic search was conducted in PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from inception to January 2025.

Methods Of Study Selection: We identified 7,234 studies, 48 of which were included in the meta-analysis.

Combined Analysis of Transcriptome and Mendelian Randomization Reveals and as Biomarkers Related to Glucose Metabolism in Sepsis.

Introduction: This study aimed to identify diagnostic and therapeutic biomarkers related to glucose metabolism in sepsis, as hyperglycemia and blood glucose fluctuations influence sepsis progression.

Methods: Datasets from public databases were analyzed using various methods, including differential expression analysis, PPI network screening, machine learning algorithms and Mendelian randomization. A nomogram model was developed, and biomarker functions were explored through enrichment analysis, immunoinfiltration analysis, transcription factors (TFs) and microRNA (miRNA) prediction, and drug prediction.

Modular Assembly of B(III)-Coordinated Fluorophores with Quantitatively Predictable Photoinduced Electron Transfer for Chemosensing and Bioimaging.

Photoinduced electron transfer (PeT), a foundational mechanism for constructing stimuli-responsive fluorescent probes, faces persistent challenges, including the lack of generalizable quantitative models, limited systematic case studies, signal interference, and synthetic complexity. Herein, we propose a boron-centric PeT molecular engineering strategy that harnesses the unique tetrahedral coordination geometry of B(III) centers. This approach leverages the programmable nature of boron coordination chemistry to precisely tailor dye electronic energy levels and photophysical properties.

Engineering Compartmentalization and Cofactor Regulation for 10-Hydroxy-2-decenoic Acid Biosynthesis in .

10-Hydroxy-2-decenoic acid (10-HDA), a bioactive component of royal jelly, exhibits significant pharmacological value in various applications. To date, its biosynthesis has been reported exclusively in endotoxin-prone , which limits its biomedical utility. In this study, we successfully engineered the Generally Recognized As Safe (GRAS) yeast as a biosynthetic platform for producing 10-HDA, thereby addressing the limitations associated with systems.

Study on the Action Mechanism of a Nontraditional Thioamide-Based Leveler of 1-Phenyl 2-Thiourea for Microvia Void-Free Filling.

Leveler is the key additive for achieving microvia void-free filling in the high-density integration of electronic components for miniaturization, lightweighting, and intelligent development of electronic devices. Traditional organic levelers are mostly quaternary ammonium salts and nitrogen-containing heterocyclic compounds. In this study, thiosemicarbazide (TA) and 1-phenyl 2-thiourea (PTA), which are the thioamino compounds with different substituents of amino and phenyl, are used for the first time as levelers for microvia filling in an acidic copper sulfate bath of Cu electroplating (Cu-EP).

Histone H4K8hib modification promotes gene expression and regulates rice immunity.

This study uncovers the role of H4K8hib as an active epigenetic mark in rice that positively correlates with gene expression and enhances immune responses. Furthermore, HDA705 was identified as the key enzyme regulating H4K8hib. Mutation of HDA705 led to hyper-H4K8hib, which in turn activated the expression of defense-related genes and enhanced rice resistance to pathogens.

A secreted fungal laccase targets the receptor kinase OsSRF3 to inhibit OsBAK1-OsSRF3-mediated immunity in rice.

The identification effector targets and characterization of their functions are crucial for understanding pathogen infection mechanisms and components of plant immunity. Here, we identify the effector UgsL, a ustilaginoidin synthetase with a key role in regulating virulence of the rice false smut fungus Ustilaginoidea virens. Heterologous expression of UgsL in rice (Oryza sativa) enhances plant susceptibility to multiple pathogens, and host-induced gene silencing of UgsL enhances plant resistance to U.

Prognostic value of human papillomavirus cell-free DNA in cervical cancer patients: A systematic review and meta-analysis.

Objective: This meta-analysis aimed to investigate the association between circulating human papillomavirus (HPV) cell-free DNA and oncological outcomes of cervical cancer patients.

Methods: Searches were performed in MEDLINE, Embase, and CENTRAL from their inception until 26 November 2023. Inclusion criteria were: (1) pathologically confirmed cervical cancer with available HPV test results; (2) detection of HPV cell-free DNA was performed in serum/plasma before or at end of treatment; (3) studies reported oncological outcomes of cervical cancer patients according to the levels of HPV cell-free DNA.

Survival after minimally invasive radical hysterectomy with protective colpotomy for early-stage cervical cancer: A systematic review and meta-analysis.

Minimally invasive surgery on treatment of early-stage cervical cancer is debatable. Traditional approaches of colpotomy are considered responsible for an inferior oncological outcome. Evidence on whether protective colpotomy could optimize minimally invasive technique and improve prognoses of women with early-stage cervical cancer remains limited.

Key enzymes involved in the utilization of fatty acids by : a review.

is a eukaryotic organism with a clear genetic background and mature gene operating system; in addition, it exhibits environmental tolerance. Therefore, is one of the most commonly used organisms for the synthesis of biological chemicals. The investigation of fatty acid catabolism in is crucial for the synthesis and accumulation of fatty acids and their derivatives, with β-oxidation being the predominant pathway responsible for fatty acid metabolism in this organism, occurring primarily within peroxisomes.

Anion-doped polypyrrole three-dimensional framework enables adsorption and conversion in lithium-sulfur batteries.

Inhibiting the shuttle effect and propelling polysulfide conversion by introducing a suitable sulfur container has been proven as a promising strategy to enhance the cycle life of lithium-sulfur (Li-S) batteries. Here, a unique three-dimensional (3D) inter-connected framework assembled with SO-doped polypyrrole (PPy-SO) nanowires is proposed. The doping SO anion in a polymer skeleton could confine lithium polysulfides (LiPSs) by polar-polar interaction to inhibit the shuttle effect and enhance the conductivity of PPy to accelerate polysulfide conversion.

Ustilaginoidea virens-secreted effector Uv1809 suppresses rice immunity by enhancing OsSRT2-mediated histone deacetylation.

Rice false smut caused by Ustilaginoidea virens is a devastating rice (Oryza sativa) disease worldwide. However, the molecular mechanisms underlying U. virens-rice interactions are largely unknown.

Post-Translational Modification β-Hydroxybutyrylation Regulates Ustilaginoidea virens Virulence.

Lysine β-hydroxybutyrylation (K) is an evolutionarily conserved and widespread post-translational modification that is associated with active gene transcription and cellular proliferation. However, its role in phytopathogenic fungi remains unknown. Here, we characterized K in the rice false smut fungus Ustilaginoidea virens.

Advanced Ag nanoparticles for the catalyzation of glyoxylic acid oxidation in through-holes electroless copper metallization.

Advanced Ag nanoparticles (Ag NPs) were prepared by wet chemical oxidation-reduction method, using mainly the tannic acid as reducing agent and carboxymethylcellulose sodium as stabilizer. The prepared Ag NPs uniformly disperse and are stable for more than one month without agglomeration. The studies of transmission electron microscopy (TEM) and ultraviolet-visible (UV-vis) absorption spectroscopy indicate that the Ag NPs are in homogeneous sphere with only 4.

Molecular Hydrogen Confers Resistance to Rice Stripe Virus.

Although molecular hydrogen (H) has potential therapeutic effects in animals, whether or how this gas functions in plant disease resistance has not yet been elucidated. Here, after rice stripe virus (RSV) infection, H production was pronouncedly stimulated in Zhendao 88, a resistant rice variety, compared to that in a susceptible variety (Wuyujing No.3).

An improved method to efficiently acquire rice black-streaked dwarf virus viruliferous small brown planthoppers.

Accurate phenotypic identification is the basis of research for resistance genetics and rice breeding for resistance to RBSDV disease. Obtaining rice black-streaked dwarf virus (RBSDV) viruliferous small brown planthoppers (SBPHs) with high transmission efficiency is an essential part of accurate phenotypic identification. Here, through quantifying number of RBSDV copies in infected rice plants, optimizing times of SBPHs fed on RBSDV-infected rice plants and leaf stage of rice seedlings, a method to acquire an RBSDV-carrying SBPH population more efficiently was improved.

Aryl-Boron-Substituted BODIPYs: Direct Access via Aluminum-Chloride-Mediated Arylation from Arylstannanes and Tuning the Optoelectronic Properties.

An efficient procedure is presented for functionalization of BODIPYs at boron with arylstannanes as weak nucleophiles in the presence of aluminum chloride, providing new aryl-boron-substituted BODIPY and aza-BODIPY derivatives of singular importance. Most of these aryl-boron-substituted BODIPYs showed bright emission in the aqueous solution with significant aggregation-induced emission enhancement and high solid-state emission as a result of the restricted rotation of the -phenyl group and boron-substituted aryl groups as well as the formation of -type aggregates.

Mechanisms of N, N-dimethylacetamide-facilitated n-hexane removal in a rotating drum biofilter packed with bamboo charcoal-polyurethane composite.

n-Hexane and N, N-dimethylacetamide (DMAC) are two major volatile organic compounds (VOCs) discharged from the pharmaceutical industry. To enhance DMAC-facilitated n-hexane removal, we investigated the simultaneous removal of multiple pollutants in a rotating drum biofilter packed with bamboo charcoal-polyurethane composite. After adding 800 mg·L DMAC, the n-hexane removal efficiency increased from 59.

An OsPRMT5-OsAGO2/miR1875-OsHXK1 module regulates rice immunity to blast disease.

Rice ARGONAUTE2 (OsAGO2) is a core component of the rice RNA-induced silencing complex (RISC), which is repressed by Magnaporthe oryzae (M. oryzae) infection. Whether and how OsAGO2-mediated gene silencing plays a role in rice blast resistance and which sRNAs participate in this process are unknown.

Mechanisms of flame retardant tris (2-ethylhexyl) phosphate biodegradation via novel bacterial strain Ochrobactrum tritici WX3-8.

Tris (2-ethylhexyl) phosphate (TEHP) is a common organophosphorus flame retardant analog with considerable ecological toxicity. Here, novel strain Ochrobactrum tritici WX3-8 capable of degrading TEHP as the sole C source was isolated. Our results show that the strain's TEHP degradation efficiency reached 75% after 104 h under optimal conditions, i.

Efficient Biosynthesis of 10-Hydroxy-2-decenoic Acid Using a NAD(P)H Regeneration P450 System and Whole-Cell Catalytic Biosynthesis.

10-Hydroxy-2-decenoic acid (10-HDA) is an α,β-unsaturated medium-chain carboxylic acid containing a terminal hydroxyl group. It has various unique properties and great economic value. We improved the two-step biosynthesis method of 10-HDA.