Mapping Key Nodes and Global Trends in AI and Large Language Models for Medical Education: A Bibliometric Study.

Background: Artificial intelligence (AI) and large language models (LLMs) are transforming medical education by enhancing teaching and assessment methods. Research output has surged, but key bibliometric trends remain underexplored.

Methods: We retrieved 547 publications using the Web of Science Core Collection and conducted bibliometric analysis with CiteSpace and other bibliometric tools to examine publication volume, collaboration networks, citations, keywords, and other important bibliometric indicators.

Efficacy of combined rigid and flexible ureteroscopy for complex ureteral stones in type 2 diabetes mellitus.

Background: Type 2 Diabetes Mellitus (T2DM) patients with complex ureteral stones face significant challenges in terms of treatment outcomes, including higher risk for complications such as sepsis and prolonged recovery times. The efficacy of combined rigid and flexible ureteroscopy in managing these stones in T2DM patients remains underexplored.

Methods: A retrospective cohort study was conducted at our hospital from January 2021 to August 2024.

Impact of negative-pressure ureteral access sheath on preventing "boiled ureter" during holmium laser lithotripsy.

Purpose: To evaluate the impact of negative-pressure ureteral access sheath (NP-UAS) on thermal effects during holmium laser lithotripsy.

Materials And Methods: A 3D-printed urinary model was used. A ureteroscope, traditional UAS (T-UAS) or NP-UAS, and a 200 µm hollium laser fiber were introduced into the model's proximal ureter, with the fiber activated for 90 s.

A nanoprobe-integrated capillary sensing system for highly sensitive SERS detection of neutral α-glucosidase in semen.

The incidence of male infertility is increasing year by year, with obstructive azoospermia being the main cause of infertility. The activity of neutral α-glucosidase plays an important role in diagnosing obstructive azoospermia. In order to effectively and non-invasively distinguish obstructive azoospermia, we have developed a rapid and sensitive surface-enhanced Raman spectroscopy (SERS) detection platform for neutral α-glucosidase in semen by combining nanoprobes with capillary systems labeled with capture antibodies.

Ten-year follow-up of atypical small acinar hyperplasia cases diagnosed by initial prostate biopsy.

Objective: To investigate the clinical outcomes and diagnostic strategies for patients with atypical small acinar hyperplasia (ASAP) in their initial prostate biopsy in a real-world setting.

Methods: A retrospective analysis was conducted on the data of 170 patients who received their first prostate biopsy result as ASAP. The lost follow-up rate, clinical interventions, subsequent pathological results, prostate cancer detection rate, and Gleason scores were analyzed.

In-depth exploration and initial clinical practice of the ratio of endoscope-sheath diameter theory: smaller flexible ureteroscope with smaller ureteral access sheath.

Objectives: To assess the outcomes of combining a 7.5Fr flexible ureteroscope (fURS) with a 10/12F ureteral access sheath (UAS) through a comprehensive in vitro and in vivo evalu-ation.

Methods: We conducted a comparative analysis, evaluating the impact of a 7.

Clinical Outcomes and Safety Profile of Neoadjuvant PD-1 Inhibitors Combined With VEGFR-TKI Versus VEGFR-TKI in Nonmetastatic Renal Cell Carcinoma.

Objective: The effectiveness of combining immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs) in neoadjuvant therapy for renal cell carcinoma (RCC) remains unclear. This study aim to compare the efficacy and safety of neoadjuvant ICI plus TKI combination therapy versus TKI monotherapy in locally RCC patients.

Methods: This study included 185 cases of locally RCC disease(TanyNanyM0) receiving neoadjuvant therapy from 29 centers across China from January 2019 to Feburary 2024.

Sinularin induces autophagy-dependent cell death by activating ULK1 and enhancing FOXO3-ATG4A axis in prostate cancer cells.

Sinularin is a natural product extracted from soft coral and is shown to exhibit antitumor effects against multiple human cancers. We previously showed that Sinularin induces apoptotic cell death via stabilizing the FOXO3 protein in prostate cancer cells. In this study, we demonstrated that Sinularin triggers autophagy via two different mechanisms in prostate cancer cells.

Association between dietary index for gut microbiota and chronic kidney disease: A cross-sectional study from U.S. population.

Emerging evidence suggests that diet modulates gut microbiota, which in turn influences chronic kidney disease (CKD) progression. This study investigates the association between the newly proposed Dietary Index for Gut Microbiota (DI-GM) and the prevalence and prognosis of CKD. This cross-sectional study analyzed data from the U.

SPOP mutations increase PARP inhibitor sensitivity via CK2/PIAS1/SPOP axis in prostate cancer.

It is well documented that impaired DNA damage repair (DDR) induces genomic instability that can efficiently increase the sensitivity of prostate cancer (PCa) cells to PARP inhibitors; however, the underlying mechanism remains elusive. Here, we found profound genomic instability in PCa cells with SPOP gene mutations and confirmed the sensitivity of SPOP-mutated PCa cells to olaparib-induced apoptosis. Mechanistically, we identified olaparib-induced CK2-mediated phosphorylation of PIAS1-S468, which in turn mediated SUMOylation of SPOP, thus promoting its E3 ligase activity in the DDR.

The relationship between sleep disorder and mental health in athletes and its mediating role: a cross-sectional study.

The mental health of high-level athletes is a growing concern, especially in the context of the COVID-19 pandemic. Sleep is also an explicit health index closely related to mental health. This study aims to investigate the relationship between sleep, anxiety, depression, and perceived psychological stress among athletes, with a focus on sleep as a potential mediator in these mental health conditions.

Dysregulation of ubiquitination modification in renal cell carcinoma.

Renal cell carcinoma (RCC) is a malignant tumor of the renal tubular epithelial cells with a relatively high incidence rate worldwide. A large number of studies have indicated that dysregulation of the ubiquitination, including ubiquitination and dysregulation, is associated with the occurrence and development of RCC. This review focuses on several abnormal signaling pathways caused by E3 ligases and deubiquitinases.

Improving signal-to-noise ratio of Raman measurements based on ensemble learning approach.

Raman spectroscopy is an extensively explored vibrational spectroscopic technique to analyze the biochemical composition and molecular structure of samples, which is often assumed to be non-destructive when carefully using proper laser power and exposure time. However, the inherently weak Raman signal and concurrent fluorescence interference often lead to Raman measurements with a low signal-to-noise ratio (SNR), especially for biological samples. Great efforts have been made to develop experimental approaches and/or numerical algorithms to improve the SNR.

Association of biological aging with prostate cancer: insights from the National Health and Nutrition Examination Survey.

The link between biological aging and prostate cancer (PCa) risk, particularly as indicated by elevated prostate-specific antigen (PSA) levels, remains uncertain. This study utilized data from the National Health and Nutrition Examination Survey (2001-2010) to explore this association. Biological age was assessed using Klemera-Doubal method age (KDMAge) and phenotypic age (PhenoAge).

Urine-based SERS and multivariate statistical analysis for identification of non-muscle-invasive bladder cancer and muscle-invasive bladder cancer.

Bladder cancer (BC) is an epidemiological urologic malignancy that continues to increase each year. Early diagnosis and prognosis monitoring is always significant in clinical practice, especially in distinguishing non-muscle-invasive bladder cancer (NMIBC) from muscle-invasive bladder cancer (MIBC), due to the various depths of tumor invasion related to different therapeutic schedules and recurrence rates. Common diagnostic approaches are too invasive or generally inefficient in accuracy and specificity.

Establishment and validation of a nomogram for predicting overall survival of upper-tract urothelial carcinoma with bone metastasis: a population-based study.

Background: Bone metastasis (BM) carries a poor prognosis for patients with upper-tract urothelial carcinoma (UTUC). This study aims to identify survival predictors and develop a prognostic nomogram for overall survival (OS) in UTUC patients with BM.

Methods: The Surveillance, Epidemiology, and End Results database was used to select patients with UTUC between 2010 and 2019.

Early differential diagnosis of pancytopenia related diseases based on serum surface-enhanced Raman spectroscopy.

Pancytopenia is a common blood disorder defined as the decrease of red blood cells, white blood cells and platelets in the peripheral blood. Its genesis mechanism is typically complex and a variety of diseases have been found to be capable of causing pancytopenia, some of which are featured by their high mortality rates. Early judgement on the cause of pancytopenia can benefit timely and appropriate treatment to improve patient survival significantly.

Proteomic Identification of Small Extracellular Vesicle Proteins LAMB1 and Histone H4 for Prostate Cancer Diagnosis and Risk Stratification.

Diagnosis and stratification of prostate cancer (PCa) patients using the prostate-specific antigen (PSA) test is challenging. Extracellular vesicles (EVs), as a new star of liquid biopsy, has attracted interest to complement inaccurate PSA screening and invasiveness of tissue biopsy. In this study, a panel of potential small EV (sEV) protein biomarkers is identified from PCa cell lines using label-free LC-MS/MS proteomics.

Eph receptor B6 shapes a cold immune microenvironment, inhibiting anti-cancer immunity and immunotherapy response in bladder cancer.

Background: The role of Eph receptors and related ephrin (EFN) ligands (as the largest family of transmembrane-bound RTKs) in immunomodulation in many types of cancer, especially bladder cancer (BLCA), is scarcely known.

Methods: A pan-cancer dataset was retrieved from The Cancer Genome Atlas (TCGA) to explore the relation between Eph receptor/EFN ligand family genes and immunomodulators and tumor-infiltrated immune cells (TIICs). Local BLCA, GSE32894, and GSE31684 cohorts were applied to validate.

Gelatin-grafted tubular asymmetric scaffolds promote ureteral regeneration activation of the integrin/Erk signaling pathway.

The repair of a diseased ureter is an urgent clinical issue that needs to be solved. A tissue-engineered scaffold for ureteral replacement is currently insufficient due to its incompetent bioactivity, especially in long-segment abnormalities. The primary reason is the failure of urothelialization on scaffolds.