How youth engage in online deliberation: an empirical study based on individual psychological motivations from China.

Clarifying the youth expression patterns on the internet and guiding contemporary youth to participate in public deliberation in an orderly manner within the online society will contribute to their growth and development and further promote the democratic development of society. While many studies have explored the impact of structural factors in the online environment on public deliberation, they overlook the psychological processes of the participants themselves. This paper, based on the background of social conflict events, focuses on the online public deliberation behavior of young people and explores how the involvement and inter-group emotional contagion influence the level of online public deliberation from the perspective of individual psychological motivations, as well as the mediating role of selective exposure.

Concurrent joint contact in anterior cruciate ligament injury induces cartilage micro-injury and subchondral bone sclerosis, resulting in knee osteoarthritis.

Objective: Anterior cruciate ligament (ACL) injury initiates post-traumatic osteoarthritis (PTOA) via two distinct processes: initial direct contact injury of the cartilage surface during ACL injury, and secondary joint instability due to the ACL deficiency. Using the well-established Compression-induced ACL-rupture and a novel Non-Compression ACL-rupture mice model, we aimed to reveal the individual effects of cartilage compression and joint instability on PTOA progression.

Design: Twelve-week-old C57BL/6J males (n = 118) were divided to three experimental groups: Compression ACL-rupture, Non-Compression ACL-rupture, and Intact.

Empirical mode decomposition in clinical signal analysis: A systematic review.

This systematic review examines the transformative applications of empirical mode decomposition (EMD) in healthcare, focusing on its ability to analyse diverse physiological signals. By a thorough exploration of key databases and stringent study selection, the effectiveness of EMD has been highlighted across various medical fields. In cardiology, EMD has significantly improved electrocardiographic analysis, surpassing conventional techniques such as Fourier and wavelet transforms, with accuracy rates reaching up to 98 % for detecting subtle cardiac abnormalities.

The beneficial and detrimental effects of exercise and unloading on OA progression after anterior cruciate ligament injury.

Injury of the anterior cruciate ligament (ACL) is a common sports injury that can lead to post-traumatic osteoarthritis (PTOA) within 10-20 years. Surgical ACL reconstruction is often performed several weeks or months after injury, and this period between injury and ACL reconstruction may be a critical time for determining the risk of long-term PTOA progression. However, few (if any) studies in human patients have investigated the long-term effects of exercise or unloading between ACL injury and surgery.

Decadal variability and anthropogenic influence on trace element dynamics in the Bay of Bengal: Evidence from high-resolution coral records.

The Bay of Bengal (BoB) exhibits dynamic trace element (TE) chemistry shaped by a complex interplay of natural processes and anthropogenic influences. Despite its significance, the temporal variability of TEs in this region is poorly understood. This study investigates decadal (2011-2022) TE dynamics by analyzing trace element-to-calcium ratios (TEs/Ca: B/Ca, Mn/Ca, Fe/Ca, Ba/Ca, P/Ca, As/Ca, Zn/Ca, Cd/Ca, and Sn/Ca) and strontium-to-calcium (Sr/Ca) ratios in modern Porites corals, supplemented by data from a sub-fossil coral as a benchmark.

Flotation Assay With Fluorescence Readout to Study Membrane Association of the Enteroviral Peripheral Membrane Protein 2C.

Enteroviruses are abundant pathogens of humans and animals. Their replication is strictly dependent on the conserved, viral AAA+ ATPase 2C. 2C is an oligomerizing, peripheral membrane protein, and its low solubility as recombinant protein has hampered functional studies of the full-length, recombinant protein bound to a membrane.

Recent progress of nanomaterials-based composite hydrogel sensors for human-machine interactions.

Hydrogel-based flexible sensors have demonstrated significant advantages in the fields of flexible electronics and human-machine interactions (HMIs), including outstanding flexibility, high sensitivity, excellent conductivity, and exceptional biocompatibility, making them ideal materials for next-generation smart HMI sensors. However, traditional hydrogel sensors still face numerous challenges in terms of reliability, multifunctionality, and environmental adaptability, which limit their performance in complex application scenarios. Nanomaterial-based composite hydrogels significantly improve the mechanical properties, conductivity, and multifunctionality of hydrogels by incorporating conductive nanomaterials, thereby driving the rapid development of wearable sensors for HMIs.

Cutaneous wound healing functions of novel milk-derived antimicrobial peptides, hLFT-68 and hLFT-309 from human lactotransferrin, and bLGB-111 from bovine β-lactoglobulin.

The absence of multi-functional antimicrobial agents in clinical settings hinders cutaneous wound healing. Milk-derived antimicrobial peptides (MAPs) may be the imperative solution to wound repair, combining the dermatic curative properties of antimicrobial peptides with the biological activity of milk. Three novel MAPs, which were hLFT-68 (IAENRADAV) and hLFT-309 (GSPSGQKDLLF) identified in human milk and bLGB-111 (LDTDYKKY) identified in bovine milk in our previous work, were initially investigated for their function in wound healing.

Altered post-fracture systemic bone loss in a mouse model of osteocyte dysfunction.

Femur fracture leads to loss of bone at uninjured skeletal sites, which may increase risk of subsequent fracture. Osteocytes, the most abundant bone cells, can directly resorb bone matrix and regulate osteoclast and osteoblast activity, but their role in systemic bone loss after fracture remains poorly understood. In this study we used a transgenic (TG+) mouse model that overexpresses human B-cell lymphoma 2 (BCL-2) in osteoblasts and osteocytes.

Fisher discriminant analysis of multimodal ultrasound in diagnosis of cervical metastatic lymph nodes in papillary thyroid cancer.

Background/aims: The purpose of this study was to develop a diagnostic model utilizing multimodal ultrasound parameters to aid in the detection of cervical lymph node metastasis in papillary thyroid cancer (PTC) patients.

Methods: The study included 84 suspicious lymph nodes from 69 PTC patients, all of whom underwent fine needle aspiration with pathological results. Data from conventional grayscale ultrasound, shear wave elastography (SWE), and superb microvascular imaging were analyzed.

Star Ratings in Long-Term Care Facilities in Australia: Facility Characteristics Associated with High Ratings and Changes in Ratings Over Time.

Objectives: A Star Rating system (1 to 5 stars) of long-term care facilities in Australia is based on 4 sub-categories: compliance, quality measures, residents' experience, and staffing. The objectives were to examine associations between facility characteristics and the odds of receiving a 4- or 5-star rating, and changes in ratings between the earliest reporting period (October-December 2022) to the most recent (April-June 2023).

Design: Cross-sectional, ecological study, with an additional longitudinal component.

Concurrent Joint Contact in Anterior Cruciate Ligament Injury induces cartilage micro-injury and subchondral bone sclerosis, resulting in knee osteoarthritis.

Objective: Anterior Cruciate Ligament (ACL) injury initiates post-traumatic osteoarthritis (PTOA) via two distinct processes: initial direct contact injury of the cartilage surface during ACL injury, and secondary joint instability due to the ACL deficiency. Using the well-established Compression-induced ACL rupture method (ACL-R) and a novel Non-Compression ACL-R model, we aimed to reveal the individual effects of cartilage compression and joint instability on PTOA progression after ACL injury in mice.

Design: Twelve-week-old C57BL/6J male were randomly divided to three experimental groups: Compression ACL-R, Non-Compression ACL-R, and Intact.

Surgical restabilization reduces the progression of post-traumatic osteoarthritis initiated by ACL rupture in mice.

Objective: People who sustain joint injuries such as anterior cruciate ligament (ACL) rupture often develop post-traumatic osteoarthritis (PTOA). In human patients, ACL injuries are often treated with ACL reconstruction. However, it is still unclear how effective joint restabilization is for reducing the progression of PTOA.

Combinatorial preparation and structural characterization of anthocyanins and aglycones from Purple-heart Radish for evaluation of physicochemical stability and pancreatic lipase inhibitory activity.

In this study, an efficient approach to preparation of different anthocyanins from Purple-heart Radish was developed by combining microwave-assisted extraction (MAE), macroporous resin purification (MRP) and ultrasound-assisted acid hydrolysis (UAAH) for evaluation of physicochemical stability and pancreatic lipase (PL) inhibitory activity. By optimization of MAE, MRP and UAAH processes, the anthocyanins reached the yield of 6.081 ± 0.

Integration of ultrasound-based radiomics with clinical features for predicting cervical lymph node metastasis in postoperative patients with differentiated thyroid carcinoma.

Objective: The primary objective was to establish a radiomics model utilizing longitudinal +cross-sectional ultrasound (US) images of lymph nodes (LNs) to predict cervical lymph node metastasis (CLNM) following differentiated thyroid carcinoma (DTC) surgery.

Methods: A retrospective collection of 211 LNs from 211 postoperative DTC patients who underwent neck US with suspicious LN fine needle aspiration cytopathology findings at our institution was conducted between June 2021 and April 2023. Conventional US and clinicopathological information of patients were gathered.

Non-Invasive Compression-Induced Anterior Cruciate Ligament (ACL) Injury and In Vivo Imaging of Protease Activity in Mice.

Traumatic joint injuries such as anterior cruciate ligament (ACL) rupture or meniscus tears commonly lead to post-traumatic osteoarthritis (PTOA) within 10-20 years following injury. Understanding the early biological processes initiated by joint injuries (e.g.

Validation of a Low-Cost Portable Device for Inducing Noninvasive Anterior Cruciate Ligament Injury in Mice.

Noninvasive compression-induced anterior cruciate ligament rupture (ACL-R) is an easy and reproducible model for studying post-traumatic osteoarthritis (PTOA) in mice. However, equipment typically used for ACL-R is expensive, immobile, and not available to all researchers. In this study, we compared PTOA progression in mice injured with a low-cost custom ACL-rupture device (CARD) to mice injured with a standard system (ElectroForce 3200).

MSC-Exos: Important active factor of bone regeneration.

Bone defect and repair is a common but difficult problem in restorative and reconstructive surgery. Bone tissue defects of different sizes caused by different reasons bring functional limitations and cosmetic deformities to patients. Mesenchymal stem cells (MSC), a major hotspot in the field of regeneration in recent years, have been widely used in various studies on bone tissue regeneration.

Design and experimental performance of a novel piezoelectric inchworm actuator based on screw clamping principle.

The requirements of large thrust in bidirectional motion, high specific power (power/weight ratio), reliable self-locking at power off state, and compact size envelope for various applications of existing piezoelectric actuators are still urgent. To address these challenges, this study makes full use of the piezoelectric material's excellent dynamic performance, robust force output, and high energy density to propose a novel inchworm piezoelectric actuator, which relies on the alternate clamping of two nuts independently rotated by two ultrasonic motors on a feed-screw in accordance with a piezoelectric stack (piezo-stack) excitation to accumulate the piezo-stack's electric field-induced strain periodically and realize power output. The operation principle and design process of the presented actuator were elaborated, and a prototype was fabricated and experimented.

Quantification of smelter-derived contributions to thallium contamination in river sediments: Novel insights from thallium isotope evidence.

Thallium(Tl), an extremely toxic metal, is posing great hazards to water safety through anthropogenic activities (e.g., Pb-Zn smelter) and natural weathering in riverine systems.