A holistic review of buffalo productivity, reproductive efficiency, genetic improvement, and disease management in Bangladesh.

Buffaloes play a vital role in Bangladesh's livestock sector, contributing significantly to the nation's milk and meat production. However, their productivity remains below potential due to limited genetic capacity, poor reproductive performance, and inadequate health and management practices. This review critically synthesizes findings from scientific literature, field studies, and national reports to assess the status of buffalo production, reproductive efficiency, genetic improvement efforts, and disease management strategies in Bangladesh.

Immune-Redox Biomarker Responses to Short- and Long-Term Exposure to Naturally Emitted Compounds from Korean Red Pine () and Japanese Cypress (): In Vivo Study.

Volatile organic compounds (VOCs) are highly volatile chemicals in natural and anthropogenic environments, significantly affecting indoor air quality. Major sources of indoor VOCs include emissions from building materials, furnishings, and consumer products. Natural wood products release VOCs, including terpenes and aldehydes, which exert diverse health effects ranging from mild respiratory irritation to severe outcomes, such as formaldehyde-induced carcinogenicity.

Protective Effect of Extract on 2,4-Dinitrochlorobenzene (DNCB)-Induced Atopic Dermatitis in an SKH-1 Mouse Model.

Atopic dermatitis (AD) is a common chronic inflammatory skin disorder characterized by immune dysregulation and skin barrier impairment. This study evaluated the anti-inflammatory and immunomodulatory effects of extract in a 2,4-dinitrochlorobenzene (DNCB)-induced AD mouse model using SKH-1 hairless mice. Topical application of extract for four weeks significantly alleviated AD-like symptoms by reducing epidermal thickness, mast cell infiltration, and overall skin inflammation.

Efficacy of Probiotic VITA-PB2 from Fermented Foods on Alcohol Consumption and Hangover Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial.

: Modulating ethanol metabolism and attenuating alcohol-induced oxidative stress are promising therapeutic strategies for reducing the severity of hangovers and alleviating their associated physiological burden. : A randomized, double-blind, placebo-controlled, crossover study was conducted to evaluate the effects of the probiotic strain VITA-PB2 on ethanol metabolism, oxidative stress, and hangover-related symptoms in 28 healthy adults. The participants consumed either VITA-PB2 or a placebo before standardized alcohol intake, with a 7-day washout period and subsequent crossover.

Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer's Disease Models.

Alzheimer's disease (AD) is a neurodegenerative condition in which amyloid-beta (Aβ) plaques trigger oxidative stress (OS) and neuroinflammation, causing memory loss. OS and neurodegeneration can also be caused by reactive astrocytes, thereby promoting AD via toxic metabolite accumulation in the astrocytic urea cycle. However, the effect of molecular hydrogen (H) on this cycle remains unknown.

In silico evaluation and therapeutic targeting of LVDD9B protein for WSSV inhibition: molecular and ecological insights for aquaculture solutions.

Unlabelled: This study aimed to investigate structural dynamics, binding interactions, stability, pharmacokinetics, ecological risks, and bioactivity of shrimp receptor protein LVDD9B to identify potential therapeutic candidates against White Spot Syndrome Virus (WSSV). LVDD9B protein's 3D structure was predicted using SWISS-MODEL and validated with ProSA and Ramachandran plots. Protein-protein docking between LVDD9B and VP26 (WSSV protein) was performed using HADDOCK 2.

Impact of Short- and Long-Term Exposure to Engineered Wood (Plywood and Particle Board) on Immune and Oxidative Biomarkers: A C57BL/6 Mouse Model Study.

Plywood and particle boards, commonly used in construction and interior environments, are sources of indoor chemical emissions from synthetic adhesives, resins, and surface treatments. Among these, formaldehyde, classified as a group 1 carcinogen by the International Agency for Research on Cancer, and other compounds are associated with oxidative stress, inflammation, and organ toxicity. This study aimed to evaluate the toxicological and physiological effects of plywood and particleboard emissions in female C57BL/6 mice.

A pilot clinical trial to explore the effects of UV exposure on vitamin D synthesis and inflammatory responses in vitamin D-Deficient adults.

Ultraviolet radiation (UVR) is essential for vitamin D synthesis and influences various biological processes. This study examined the effects of controlled UV exposure on vitamin D synthesis and skin inflammation in healthy adults. In a randomized clinical trial, 24 volunteers received four 5-min standardized UV exposures (UVB: 1.

Uncovering dendritic cell specific biomarkers for diagnosis and prognosis of cardiomyopathy using single cell RNA sequencing and comprehensive bioinformatics analysis.

Cardiomyopathy is a type of cardiovascular disorder that is a primary cause of death globally, killing millions of people each year. Cardiomyopathy detection and early diagnosis are crucial in reducing negative health effects. Thus, this study aims to use single cell RNA sequencing, and bioinformatics analysis to uncover dendritic cell-specific biomarkers, gene ontology, pathways, regulatory interaction networks, and protein-chemical compounds related to the molecular mechanism of cardiomyopathy progression.

Identification of cell specific biomarkers for intellectual disability via single cell RNA sequencing and transcriptomic bioinformatics approaches.

Limitations in cognitive functioning and adaptive behavior are hallmarks of Intellectual Disability (ID), a neurodevelopmental disease. Specific genetic disorders that result in ID can also have immune system anomalies, such as changes in T (CD4 and CD8) cell activity. This work aimed to compare single-cell RNA-sequencing (scRNA-seq) and transcriptome data to find biomarkers linked to T cells that could potentially be utilized for the diagnosis and assessment of ID.

Decadal variability and anthropogenic influence on trace element dynamics in the Bay of Bengal: Evidence from high-resolution coral records.

The Bay of Bengal (BoB) exhibits dynamic trace element (TE) chemistry shaped by a complex interplay of natural processes and anthropogenic influences. Despite its significance, the temporal variability of TEs in this region is poorly understood. This study investigates decadal (2011-2022) TE dynamics by analyzing trace element-to-calcium ratios (TEs/Ca: B/Ca, Mn/Ca, Fe/Ca, Ba/Ca, P/Ca, As/Ca, Zn/Ca, Cd/Ca, and Sn/Ca) and strontium-to-calcium (Sr/Ca) ratios in modern Porites corals, supplemented by data from a sub-fossil coral as a benchmark.

Binding Interaction and Stability Analysis of Quercetin and its Derivatives as Potential Inhibitors of Triple Negative Breast Cancer (TNBC) against PARP1 Protein: An in-silico Study.

Background: Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by the absence of estrogen and progesterone receptors (ER, PR) and low or absent HER2 expression, limiting treatment options. Quercetin, a flavonoid with anti-cancer properties, has the potential to be a therapeutic intervention.

Objectives: The study aimed to explore the potential of Quercetin derivatives as therapeutic agents for TNBC using several computational methods.

Structural and Functional Characterization of a Putative Type VI Secretion System Protein in as a Potential Therapeutic Target: A Computational Study.

Background: , a foodborne pathogen with a fatality rate of 33%, is a rod-shaped, Gram-negative, non-spore-forming bacterium responsible for causing meningitis, bacteremia, and necrotizing enterocolitis. Despite many unknown functions of hypothetical proteins in bacterial genomes, bioinformatic techniques have successfully annotated their roles in various pathogens.

Objectives: The aim of this investigation is to identify and annotate the structural and functional properties of a hypothetical protein (HP) from 7G strain (accession no.

Exploring the Therapeutic Potential of Evodia rutaecarpa in Early-Onset Pancreatic Cancer: A Network Pharmacology and Molecular Docking Approach.

Introduction: Pancreatic cancer (PC) remains a formidable challenge in cancer, which requires innovative approaches to identify novel therapeutic strategies. Evodia rutaecarpa, a traditional herbal remedy known for its analgesic and antiemetic properties, has been reported to exhibit anticancer effects.

Method: We employed network pharmacology to elucidate the bioactive ingredients of Evodia rutaecarpa and their potential targets in the context of early-onset pancreatic cancer.

Prevalence of anxiety disorder and its association with BMI: an analysis of women's experiences in Bangladesh using BDHS-2022 data.

Background: Anxiety disorders are a significant and growing public health concern, impacting individuals' daily lives and professional development. Women exhibit higher rates compared to men. Changes in body mass index (BMI) can affect the mental health of an individual.

Exploration of Shrimp and Their Environments for the Detection of Antibiotic Resistance Genes of Vibrio parahaemolyticus and Spectrophotometry of Shrimp Muscles for Heavy Metals and Their Human Health Risk Assessment in Bangladesh.

Through deteriorating the quality of shrimp, Vibrio parahaemolyticus and heavy metals have become threatened to food safety. The study was conducted to explore shrimp and their environments for antibiotic resistance genes of V. parahaemolyticus and perform spectrophotometry of shrimp muscles for heavy metals and their human health risk assessment.

Molecular screening and dynamics simulation reveal potential phytocompounds in Swertia chirayita targeting the UspA1 protein of Moraxella catarrhalis for COPD therapy.

Chronic obstructive pulmonary disease (COPD) is a global health burden, with Moraxella catarrhalis significantly contributing to acute exacerbations and increased healthcare challenges. This study aimed to identify potential drug candidates in Swertia chirayita, a traditional Himalayan medicinal plant, demonstrating efficacy against the ubiquitous surface protein A1 (UspA1) of M. catarrhalis through an in-silico computational approach.

Discovery of novel PARP1 inhibitors through computational drug design approaches.

Background: Triple-negative breast cancer (TNBC) is the most frequent malignancy in women. It is a prevalent condition, representing 15-20 % of all breast cancer cases, characterized by its aggressive subtype and unfavorable prognosis.

Objectives: The main aim of this study is to find and develop a potential novel therapeutic candidate for TNBC treatment utilizing luteolin derivatives compounds.

Global epidemiology of HIV among dialysis patients: a systematic review and meta-analysis.

HIV transmission and infection among dialysis patients have become a major healthcare concern and a rising threat throughout the world. Our current systematic review and meta-analysis targeted to determine the global epidemiologic state of HIV infection among dialysis patients. Three online databases: Google Scholar, PubMed, and ScienceDirect were searched for eligible studies using specific keywords.

Explore the factors related to the death of offspring under age five and appraise the hazard of child mortality using machine learning techniques in Bangladesh.

Background: Child mortality is a reliable and significant indicator of a nation's health. Although the child mortality rate in Bangladesh is declining over time, it still needs to drop even more in order to meet the Sustainable Development Goals (SDGs). Machine Learning models are one of the best tools for making more accurate and efficient forecasts and gaining in-depth knowledge.

Fruit quality retention and shelf-life extension of papaya through organic coating.

Papaya ( L.) is a climacteric fruit which lose quality and shelf life quickly due to physiological decay and microbial infection after harvest. The study was conducted to evaluate newly applied clybio formulation (0.

Unraveling the interplay between cardiovascular diseases and alcohol use disorder: A bioinformatics and network-based exploration of shared molecular pathways and key biomarkers validation via western blot analysis.

Clinical observations indicate a pronounced exacerbation of Cardiovascular Diseases (CVDs) in individuals grappling with Alcohol Use Disorder (AUD), suggesting an intricate interplay between these maladies. Pinpointing shared risk factors for both conditions has proven elusive. To address this, we pioneered a sophisticated bioinformatics framework and network-based strategy to unearth genes exhibiting aberrant expression patterns in both AUD and CVDs.

First report of contagious caprine pleuropneumonia (CCPP) in Bangladeshi goats: Seroprevalence, risk factors and molecular detection from lung samples.

Background And Objective: Contagious caprine pleuropneumonia (CCPP) is a highly contagious mycoplasmal respiratory disease primarily affecting goats and sheep caused by subsp. (Mccp). So far, there is no available information on either the serological or molecular identification of Mccp in Bangladesh.

Network Pharmacology and Elucidation of Phytochemicals Extracted from Ajwa Dates ( L.) to Inhibit Akt and PI3K Causing Triple Negative Breast Cancer (TNBC).

Background: About 10-15% of all breast cancers comprise triple-negative breast cancer (TNBC), defined as cancer cells that lack ER, PR, and HER2 protein receptors. Due to the absence of these receptors, treating TNBC using conventional chemotherapy is challenging and, therefore, requires the discovery of novel chemotherapeutic agents derived from natural sources.

Objective: The current work was intended to study the potential phytochemicals of Ajwa dates ( L.