Asymmetric Triple Helical Nonbenzenoid Nanographenes with Controllable Helicene Lengths.

Helical nanographenes (NGs) play a crucial role in the development of chiral nanomaterials due to their distinctive optoelectronic and chiroptical properties. Herein, we report the efficient synthesis of two unprecedented azulene-embedded asymmetric triple helical NGs ( and ) with controllable helicene subunit lengths and π-extension. The crystallographic analysis confirms their highly twisted and asymmetric geometries.

Efficacy of postoperative immunotherapy on MPM patients after CRS + HIPEC: A single-center retrospective study based on propensity score matching.

To investigate the efficacy of postoperative immunotherapy in patients with malignant peritoneal mesothelioma (MPM) after cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC). The clinical data of 160 MPM patients who underwent CRS + HIPEC at our center from April 2015 to February 2024 were retrospectively analyzed. All patients received postoperative chemotherapy and were divided into the Chemo-only group and the Immunotherapy group according to whether they received postoperative immunotherapy or not.

Solvent-Driven Precise Control of Stacking Configurations in Covalent Organic Frameworks for High-Efficiency Photocatalysis.

Two-dimensional covalent organic frameworks (2D COFs) have emerged as promising photocatalysts due to their high surface areas and precisely tunable physicochemical properties. However, it remains a significant challenge to precisely control over interlayer stacking configurations in 2D COFs, which critically influence charge carrier transport and consequently determine catalytic efficiency. In this study, we demonstrate a solvent-driven strategy to precisely regulate the interlayer stacking configurations of metal-incorporated 2D COFs, successfully achieving both AA eclipsed (COF-TD-AA) and ABC staggered (COF-TD-ABC) configurations.

Lateral π-extended helical nanographenes with large spin polarization.

The possibility that current passing through an organic molecule becomes spin-polarized is highly intriguing. Amongst these molecules, helicene units have recently been shown to exhibit such a chiral-induced spin selectivity (CISS) effect. Thus, helical nanographenes (NGs), whose core building block is a helicene unit, are natural candidates for generating CISS.

Anode-Protective Covalent Organic Framework Layer with Synergistic Cation-Anion Regulation for Dendrite-Free Lithium Metal Batteries.

Lithium (Li) dendrite formation in Li metal batteries intrinsically challenges Coulombic efficiency (CE) and safety. While constructing an anode protective layer offers a potential solution for dendrite suppression, existing approaches are limited by insufficient molecular-level control over both Li and anion dynamics simultaneously. Herein, we construct a binary cooperative magnesium porphyrin-based covalent organic framework (Mg-Por-COF) protective layer designed for synergetic cation-anion regulation at the anode-electrolyte interface.

Enhanced Nanoconfinement of Copper-Organic Interfaces within Phthalocyanine Frameworks for Selective Electroreduction of CO to Acetate.

Acetate is an essential raw material in the chemical industry, supporting sustainable processes and efficient carbon utilization, driving interest in electrochemical CO-to-acetate conversion. However, this process is limited by catalyst instability and the complexity of the reaction pathway, making precise control difficult. Herein, we engineer nanoconfined copper-organic interfaces within a series of nucleophilic substituted heterocyclic copper phthalocyanine covalent organic frameworks (CuPc-COFs) with AA' stacking configuration to selectively steer CO electroreduction toward acetate.

Ammonia-Assisted Chemical Vapor Deposition Growth of Two-Dimensional Conjugated Coordination Polymer Thin Films.

As emerging electroactive materials, the controlled synthesis of highly ordered two-dimensional (2D) conjugated coordination polymer (c-CP) films ensuring the long-range π-electron delocalization is essential for advancing high-performance (opto-)electronics. Here, we demonstrate the growth of highly crystalline 2D c-CP thin films on inert substrates by chemical vapor deposition with the assistance of ammonia (NH) for the first time, leveraging its deprotonation effect on ligands and competing effect as additional coordinating species. The resulting Fe-HHB (HHB = hexahydroxybenzene) films exhibit large-area uniformity and a 2 order-of-magnitude increase in crystal grain size, which translates into significant improvements in electrical conductivity (from 0.

Cisplatin + docetaxel improves survival over cisplatin + mitomycin C in hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei: a retrospective study based on propensity score matching.

Objective: Pseudomyxoma peritoneum (PMP) of appendiceal origin poses significant treatment challenges with hyperthermic intraperitoneal chemotherapy (HIPEC) regimens offering viable outcomes. This study aimed to compare the efficacy and safety profiles of two HIPEC regimens: cisplatin + docetaxel (CD) and cisplatin + mitomycin C (CM).

Methods: PMP patients who underwent cytoreductive surgery (CRS) and HIPEC between January 2008 and December 2023 at our center were retrospectively analyzed.

Integrating Electronic-Storage Piperazine into Covalent Organic Frameworks for Promoting Oxygen Reduction Reaction.

Metal-free covalent organic frameworks (COFs) have emerged as potential electrocatalysts for oxygen reduction reaction (ORR) in new environmental-friendly electrochemical energy conversion technologies. However, their catalytic activity is hindered by inefficient electron transfer from electrodes to catalytic sites along extended frameworks. To overcome this bottleneck, herein, we first incorporated redox-active piperazine units into the COFs to catalyze ORR.

Rational Construction of Layered Two-Dimensional Conjugated Metal-Organic Frameworks with Room-Temperature Quantum Coherence.

Two-dimensional conjugated metal-organic frameworks (2D c-MOFs) have emerged as an intriguing class of quantum materials due to their high crystallinity, persistent spin centers, and tunable structures and topologies. However, it remains unclear how to achieve long spin relaxation time at room temperature in 2D c-MOFs via a bottom-up design strategy. Herein, we design a hexahydroxytrithiatruxene ligand (HHTH) to minimize the influence of nuclear spin on electron spin relaxation while weakening -π conjugation to construct a "spin docking" for preserving spin centers, which enables the resulting 2D c-MOFs, NiHHTH, to exhibit quantum coherence and Rabi oscillations at room temperature.

Supramolecular Engineering of Vinylene-Linked Covalent Organic Framework - Ruthenium Oxide Hybrids for Highly Active Proton Exchange Membrane Water Electrolysis.

The controlled formation of a functional adlayer at the catalyst-water interface is a highly challenging yet potentially powerful strategy to accelerate proton transfer and deprotonation for ultimately improving the performance of proton-exchange membrane water electrolysis (PEMWE). In this study, the synthesis of robust vinylene-linked covalent organic frameworks (COFs) possessing high proton conductivities is reported, which are subsequently hybridized with ruthenium dioxide yielding high-performance anodic catalysts for the acidic oxygen evolution reaction (OER). In situ spectroscopic measurements corroborated by theoretical calculations reveal that the assembled hydrogen bonds formed between COFs and adsorbed oxo-intermediates effectively orient interfacial water molecules, stabilizing the transition states for intermediate formation of OER.

Orthorhombic Covalent Organic Frameworks with fmj Topology as Photocatalyst for Hydrogen Evolution.

Three-dimensional covalent organic frameworks (3D COFs), a class of highly porous crystalline polymers, have exhibited great potentials in many applications. However, the reported topologies of 3D COFs have been limited to high-symmetry crystal systems, which significantly hindered the development of such functional materials. Herein, we demonstrate the first construction of four highly crystalline orthorhombic 3D COFs with an unprecedented fmj topology, based on judiciously choosing rotatable monomers.

Imidazopyridinium-Linked Covalent Organic Frameworks for Efficient Gold Recovery.

Covalent organic frameworks (COFs) with high surface areas and specialized binding sites garnered attention in the field of gold (Au) adsorption. The adsorption capacity mostly depends on the functional skeletons and porous structures, however, the roles of linkages have not been thoroughly explored. In this study, imidazopyridinium-linked COFs, specifically im-PYTA-PZDH-COF and im-PYTA-BPDH-COF were synthesized, to enhance gold adsorption efficacy.

Prognostic Factors of Long-Term Survival and Conditional Survival Analysis in MPM Patients Treated with CRS+HIPEC: A Retrospective Study of Two Centers.

Objectives: This study was designed to explore the survival benefit factors of malignant peritoneal mesothelioma (MPM) patients after cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) and to make dynamic survival prediction by conditional survival (CS).

Methods: Data of 212 patients with MPM who underwent CRS+HIPEC were retrospectively analyzed. Patients were divided into long-term survival (LTS) group (≥48.

Three-Dimensional Covalent Organic Framework with Dense Lithiophilic Sites as Protective Layer to Enable High-Performance Lithium Metal Battery.

Lithium (Li) metal batteries with remarkable energy densities are restrained by short lifetime and low Coulombic efficiency (CE), resulting from the accumulative Li dendrites and dead Li during cycling. Here, we prepared a new three-dimensional (3D) covalent organic framework (COF) with dense lithiophilic sites (heteoatom weight contents of 32.32 wt %) as an anodic protective layer of Li metal batteries.

Deep-Saddle-Shaped Nanographene Induced by Four Heptagons: Efficient Synthesis and Properties.

The construction of multiple heptagonal rings in nanographene is the key step for obtaining exotic carbon nanostructures with a negative curvature and intriguing properties. Herein, a novel saddle-shaped nanographene () with four embedded heptagons is synthesized via a highly efficient one-shot Scholl reaction from a predesigned oligophenylene precursor. Notably, a quadruple [6]helicene intermediate was also obtained and isolated by controlling the Scholl reaction conditions.

Effect of postoperative normothermic intraperitoneal chemotherapy on the prognosis of MPM patients receiving CRS+HIPEC: A single-center case-control study.

Background: The comprehensive treatment strategy, mainly cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC), combined with systemic and intraperitoneal chemotherapy, is the standard treatment for malignant peritoneal mesothelioma (MPM), which can significantly prolong the survival of patients. The aim of this study is to investigate the clinical significance of postoperative normothermic intraperitoneal chemotherapy (NIPEC) in MPM patients.

Methods: Data of 152 MPM patients who underwent CRS + HIPEC and postoperative intravenous chemotherapy were retrospectively analyzed.

Drug sensitivity tumor cell clusters in malignant peritoneal mesothelioma.

Background: To explore the most effective adjuvant chemotherapy regimen for malignant peritoneal mesothelioma (MPM) through patient derived tumor-like cell clusters (PTC) drug sensitivity test.

Methods: PTC were cultured in vitro with intraoperative specimens, and drug sensitivity test was performed to calculate the most effective chemotherapy regimen for MPM. The patients were divided into conventional and individualized chemotherapy group according to whether they received PTC drug testing.

Azobenzene-Bridged Covalent Organic Frameworks Boosting Photocatalytic Hydrogen Peroxide Production from Alkaline Water: One Atom Makes a Significant Improvement.

Covalent organic frameworks (COFs) have been demonstrated as promising photocatalysts for hydrogen peroxide (HO) production. However, the construction of COFs with new active sites, high photoactivity, and wide-range light absorption for efficient HO production remains challenging. Herein, we present the synthesis of a novel azobenzene-bridged 2D COF (COF-TPT-Azo) with excellent performance on photocatalytic HO production under alkaline conditions.

Research progress of malignant peritoneal mesothelioma with paraneoplastic syndrome: A review.

Malignant peritoneal mesothelioma (MPM) is a rare and invasive tumor, and some patients will develop paraneoplastic syndrome (PS) during the course of the disease. This review summarizes PS associated with MPM, focusing on the clinical characteristics and treatment progress in hematological, endocrine, rheumatic, neurological, urinary, and other systems to decrease missed diagnosis and misdiagnosis, help early diagnosis and prompt treatment, and provide guidance for the clinical decision-making of this kind of patients.

Synergistic Linker and Linkage of Covalent Organic Frameworks for Enhancing Gold Capture.

The tunable pore walls and skeletons render covalent organic frameworks (COFs) as promising absorbents for gold (Au) ion. However, most of these COFs suffered from low surface areas hindering binding sites exposed and weak binding interaction resulting in sluggish kinetic performance. In this study, COFs have been constructed with synergistic linker and linkage for high-efficiency Au capture.

Intraoperative urinary tract resection and construction in CRS + HIPEC procedures: a single center retrospective analysis.

Introduction: The safety and efficacy of CRS + HIPEC combined with urinary tract resection and reconstruction are controversial. This study aims to summarize the clinicopathological features and to evaluate the safety and survival prognosis of CRS + HIPEC combined with urinary tract resection and reconstruction.

Methods: The patients who underwent urinary tract resection and reconstruction as part of CRS surgery were retrospectively selected from our disease-specific database for analysis.

Zirconium-Based Metal-Organic Frameworks with Free Hydroxy Groups for Enhanced Perfluorooctanoic Acid Uptake in Water.

Perfluorooctanoic acid (PFOA) is a highly recalcitrant organic pollutant, and its bioaccumulation severely endangers human health. While various methods are developed for PFOA removal, the targeted design of adsorbents with high efficiency and reusability remains largely unexplored. Here the rational design and synthesis of two novel zirconium-based metal‒organic frameworks (MOFs) bearing free ortho-hydroxy sites, namely noninterpenetrated PCN-1001 and twofold interpenetrated PCN-1002, are presented.