Synthesis and antibacterial activities of quercetagetin derivatives.

The global rise of bacterial drug resistance has prompted growing attention towards the development of novel antibacterial lead compounds. This work reports the synthesis and characterisation of a series of quercetagetin derivatives () using comprehensive spectroscopic techniques (H/³C NMR, HRMS). Antimicrobial screening against four bacterial strains (, , and ) identified compound as the most potent agent, exhibiting an MIC of 16 µg/mL against .

How Do Educational Settings Influence College Students' Reading Behavior? An Empirical Study of China's Top Universities.

The rapid rise of digital media and the accelerated pace of modern life have triggered a "reading crisis" among college students in China, which is characterized by declining deep reading abilities and increasing reliance on fragmented digital content. Understanding the multifaceted factors influencing student reading behavior is crucial for improving educational outcomes and fostering lifelong learning skills. This study examines these factors in China's top universities using an ecological systems theory framework, which considers how individual attributes (micro), university environment (mezzo), and broader social contexts (macro) interact to shape reading behavior.

Synthesis and Biological Evaluation of Quercetagetin Derivatives as the Inhibitors of Mcl-1 and Bcl-2 Against Leukemia.

B-cell lymphoma-2 (Bcl-2) family proteins are fundamental regulators of intrinsic cell apoptosis, and overexpression of apoptotic proteins (Bcl-2 and Mcl-1) is a characteristic of many haematological malignancies. Thus, it is necessary to discover novel inhibitors to treat leukemia. In the current study, we synthesized a series of quercetagetin derivatives (compounds -, - and -) and evaluated their anticancer activities on four leukemia cells (U937, K562, K562R and KG-1).

Metabolomic and transcriptomic analyses provide insight into the variation of floral scent and molecular regulation in different cultivars and flower development of .

is an important ornamental plant of significant economic value, while the floral fragrance has been rarely investigated, leading to a lack of knowledge about the floral scent. By performing metabolomic and transcriptomic analyses, we investigated the variation of 906 volatile organic compounds (VOCs) in florets of eight cultivars and four different developmental stages of "Chiang Mai Pink" (CMP). The metabolite profiling revealed that the terpenoid group (213 out of 906) was the predominant VOC, accounting for 33.

Rational design, synthesis and anti-inflammatory activity of 6-substituted dihydrobenzophenanthridine derivatives.

a series of 6-substituted dihydrobenzophenanthridine alkaloids were synthesized by introduction of different functional groups to C-6 of dihydrobenzophenanthridine backbone. The preliminary anti-inflammatory activities of all compounds were screened by investigating the inhibitory ability on NO production in LPS-stimulated RAW 264.7 cells.

Emerging translocator protein-positron emission tomographic imaging improves detection of focal cortical dysplasia.

Objective: The identification of epileptic lesions is crucial for improving surgical outcomes. Nevertheless, substantial focal cortical dysplasia (FCD) may be invisible on magnetic resonance imaging (MRI). We aimed to characterize the expression pattern of 18-kDa translocator protein (TSPO) in FCD and to evaluate the effectiveness of this inflammation-reflective molecular imaging technique for detecting FCD.

Risk Assessment of Global Animal Melioidosis Under Current and Future Climate Scenarios.

Melioidosis is a zoonotic disease that is caused by , which is a serious public health and safety risk. In order to explore the global animal melioidosis risk distribution and its dynamic response to future climate scenarios, we collected global data about reported animal incidence sites. Data regarding the density of in the environment were created by collecting and sorting information about the occurrence sites in contaminated air, soil, and water.

Inverted U-shaped association between the systemic immune-inflammation index and colorectal polyps in Chinese patients: a cross-sectional study.

Purpose: The systemic immune-inflammation index (SII) has been found to be associated with various inflammatory and neoplastic diseases. The aim of this study was to investigate the relationship between the SII and colorectal polyps (CPs) in Chinese patients.

Methods: This was a cross-sectional study.

Predicting Tuberculosis Risk in Cattle, Buffaloes, Sheep, and Goats in China Based on Air Pollutants and Meteorological Factors.

Tuberculosis is a zoonotic chronic respiratory infectious disease caused by the complex. The outbreak and epidemic of tuberculosis can seriously threaten human and veterinary health. To investigate the effects of environmental factors on tuberculosis in domestic ruminants, we collected data regarding the prevalence of tuberculosis in cattle, buffaloes, sheep, and goats in China (1956-2024) from publicly published literature and available databases.

Molecular Characterization of Odorant-Binding Protein Genes Associated with Host-Seeking Behavior in .

The identification of odorant-binding proteins (OBPs) involved in host location by ( Weise, 1922, Coleoptera, Galerucinae) is significant for its biological control. Tools in the NCBI database were used to compare and analyze the transcriptome sequences of with OBP and other chemosensory-related proteins of other Coleoptera insects. Subsequently, MEGA7 was utilized for OBP sequence alignment and the construction of a phylogenetic tree, combined with expression profiling to screen for candidate antennae-specific OBPs.

Retraction note to: Association between triglyceride-glucose index and colorectal polyps: A retrospective cross-sectional study.

[This retracts the article on p. 55 in vol. 16, PMID: 38464818.

Assessing the impact of repetitive transcranial magnetic stimulation on effective connectivity in autism spectrum disorder: An initial exploration using TMS-EEG analysis.

Initial indications propose that repetitive transcranial magnetic stimulation (rTMS) could mitigate clinical manifestations in patients with autism spectrum disorder (ASD). Nevertheless, the precise mechanisms responsible for these therapeutic and behavioral outcomes remain elusive. We examined alterations in effective connectivity induced by rTMS using concurrent transcranial magnetic stimulation and electroencephalography (TMS-EEG) in children with ASD.

Association between triglyceride-glucose index and colorectal polyps: A retrospective cross-sectional study.

Background: Colorectal polyps (CPs) are frequently occurring abnormal growths in the colorectum, and are a primary precursor of colorectal cancer (CRC). The triglyceride-glucose (TyG) index is a novel marker that assesses metabolic health and insulin resistance, and has been linked to gastrointestinal cancers.

Aim: To investigate the potential association between the TyG index and CPs, as the relation between them has not been documented.

Fusing WGCNA and Machine Learning for Immune-Related Gene Prognostic Index in Lung Adenocarcinoma: Precision Prognosis, Tumor Microenvironment Profiling, and Biomarker Discovery.

Background: The objective is to create an IRGPI (Immune-related genes prognostic index), which could predict the survival and effectiveness of immune checkpoint inhibitor (ICI) treatment for lung adenocarcinoma (LUAD).

Methods: By applying weighted gene co-expression network analysis (WGCNA), we ascertained 13 genes associated with immune functions. An IRGPI was constructed using four genes through multicox regression, and its validity was assessed in the GEO dataset.

Corrigendum: Organization, phylogenetic marker exploitation, and gene evolution in the plastome of (Ranunculaceae).

[This corrects the article DOI: 10.3389/fpls.2022.

RHBDD1 Promotes the Growth and Stemness Characteristics of Gastric Cancer Cells by Activating Wnt/β-catenin Signaling Pathway.

Backgrounds: Gastric cancer (GC) is threatening public health, with at least one million new cases reported each year. Rhomboid domain-containing protein 1 (RHBDD1) has been identified to regulate the proliferation, migration, and metastasis of cancer cells. However, the role of RHBDD1 in GC has not been elucidated.

Association of nonalcoholic fatty liver disease with colorectal adenomatous polyps and non-adenomatous polyps: a cross-sectional study.

Aim: This study aimed to investigate the association between non-alcoholic fatty liver disease (NAFLD) and both colorectal adenomatous polyps and non-adenomatous polyps, in order to provide evidence for the prevention of colorectal cancer (CRC) in patients with NAFLD.

Methods: A retrospective, cross-sectional study was conducted at the First People's Hospital of Kunshan, Jiangsu, China. The study included 3028 adults who underwent abdominal ultrasonography and colonoscopy over a 5 year period.

A chromosome-scale and haplotype-resolved genome assembly of carnation () based on high-fidelity sequencing.

is an economic species often considered excellent cut flowers and is suitable for bouquets and gardens. Here, we assembled the haplotype-resolved genome of 'Aili' at the chromosome level for the first time. The total lengths of the two assembled haplotypes of carnation were 584.

Identification of novel and potent dual-targeting HDAC1/SPOP inhibitors using structure-based virtual screening, molecular dynamics simulation and evaluation of and antitumor activity.

Cancer is one of the important factors threatening human health. Hence, it is essential to create novel potent drugs to treat it. Due to the strong correlation among histone deacetylase1 (HDAC1), speckle-type POZ protein (SPOP) and cancers, dual inhibition of HDAC1 and SPOP may be a promising strategy for cancer treatment.

Maresin1 alleviates liver ischemia/reperfusion injury by reducing liver macrophage pyroptosis.

Background: Cell pyroptosis has a strong proinflammatory effect, but it is unclear whether pyroptosis of liver macrophages exacerbates liver tissue damage during liver ischemia‒reperfusion (I/R) injury. Maresin1 (MaR1) has a strong anti-inflammatory effect, and whether it can suppress liver macrophage pyroptosis needs further study.

Methods: This study aimed to investigate whether MaR1 can alleviate liver I/R injury by inhibiting macrophage pyroptosis.

Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening.

ATM plays an important role in DNA damage response and is considered a potential target in cancer therapies. In this study, a goal-directed molecular generation approach based on ligand similarity and target specificity was applied to sample active molecules, and they were screened virtually to identify the theoretical lead compound , which was later shown to inhibit ATM adequately. However, there is a main concern about its poor metabolic stability .