Differential risk and clinical characteristics of placenta accreta spectrum in twin and singleton pregnancies: implications for perinatal outcomes.

Background: This study compares the prevalence of placenta accreta in singleton and twin pregnancies and examines its impact on adverse perinatal outcomes, exploring whether twin gestation increases the risk of poor outcomes in placenta accreta cases.

Methods: A multivariate logistic regression analysis assessed the link between twin pregnancy and placenta accreta, comparing associated adverse perinatal outcomes in twin vs. singleton pregnancies.

Unraveling the role of the WIPF1/ACTN4 complex in podosome formation of human placental EVTs: Insights into recurrent spontaneous abortion.

Successful placental development and pregnancy rely on effective extravillous trophoblast (EVT) invasion. The mechanisms underlying inadequate EVT invasion in recurrent spontaneous abortion (RSA) remain unclear. WAS/WASL interacting protein family member 1 (WIPF1), the key regulator of cytoskeletal dynamics, is exclusively expressed in first-trimester placental EVTs.

Identifying the impact and critical windows of extreme temperatures on the risk of gestational diabetes mellitus in twin pregnancies.

Extreme temperature events have become more frequent due to industrialization, urbanization, and climate change, leading to health risks. Women with twin pregnancies are particularly vulnerable, yet research on how these temperatures affect gestational diabetes mellitus (GDM) remains limited. This study investigates the impact of extreme temperatures on GDM incidence in twin pregnancies, focusing on identifying critical periods of susceptibility.

Genomic characterization of an ESBL-producing ST37 recovered from a hospitalized patient in Armenia.

Multidrug-resistant continues to challenge healthcare services globally. However, our understanding of its occurrence, genomic characteristics, and epidemiology in low- and middle-income countries (LMICs) remains severely limited. In this study, we report the whole-genome sequencing of an extended-spectrum β-lactamase (ESBL)-producing, sequence type (ST) 37 .

Identification of shared pathogenetic mechanisms between endometriosis and RSA based on comprehensive bioinformatics analysis.

Purpose: Endometriosis (EM) and recurrent spontaneous abortion (RSA) exhibit clinical associations, yet their shared molecular mechanisms remain unclear. This study aimed to identify shared molecular mechanisms and potential hub genes underlying EM and RSA.

Methods: Differentially expressed genes (DEGs) were identified from EM (GSE7305) and RSA (GSE165004) datasets.

The impact of extreme air pollution on preterm birth in twin pregnancies: identifying susceptible exposure windows.

Background: Accelerated industrialization globally has intensified air pollution, but the susceptibility periods for extreme air pollution in twin pregnancies remain undefined.

Methods: This study investigated the association between extreme air pollution exposure and preterm birth risk in twin pregnancies. Data on 3623 twin pregnancies in Chongqing from 2017 to 2022 and air pollution readings from 12 monitoring stations were analyzed using distributed lag non-linear quasi-Poisson regression models.

Three-year impact of COVID-19 pandemic on hospitalized twin pregnancies: evaluation of characteristics and changes in antibiotic prescribing.

Background: The COVID-19 pandemic has significantly impacted healthcare systems worldwide, including obstetric care. However, the long-term effects on twin pregnancies remain unclear. This study investigates the impact of COVID-19 on the clinical characteristics and antibiotic prescribing patterns in hospitalized twin pregnancies.

Patients with mutations in DNAH2, DNAH6 and DNAH10 causing multiple morphological abnormalities of human sperm flagella achieve good ICSI outcomes.

Research Questions: What additional genetic mutations in DNAH2, DNAH6 and DNAH10 are linked to multiple morphological abnormalities of sperm flagella (MMAF), and what are the assisted reproductive outcomes in couples affected by these mutations?

Design: A cohort of 75 infertile males with MMAF underwent whole-exome sequencing and Sanger sequencing to identify pathogenic mutations. Papanicolaou staining and electron microscopy were employed to evaluate sperm morphology and ultrastructure. Immunofluorescence was performed to characterize ultrastructural abnormalities at the molecular level, and explore the underlying molecular mechanisms by which mutations in DNAH2, DNAH6 and DNAH10 genes lead to MMAF.

Selective Reductive Coupling of Formaldehyde into Carbohydrate Precursors.

Direct and highly selective conversion of formaldehyde to multicarbon (C) products is a highly desirable but challenging approach to synthesize carbohydrate precursors. In this study, we investigated the use of environmentally friendly imidazolium-based ionic liquids (ILs)-NHC to promote formaldehyde coupling under a base-free condition. The highly selective conversion of formaldehyde into glycolaldehyde precursor (GP) and dihydroxyacetone precursor was achieved through a one-pot, two-step process with [BHMIm][OAc] as a crucial intermediate.

The role of FAK signaling in early placental development and trophoblast lineage specification in human pregnancy.

The placenta serves as a vital interface for fetal-maternal exchange, relying on trophoblast differentiation for development. This process involves cytotrophoblasts (CTBs) transitioning into syncytiotrophoblasts (STBs) and extravillous trophoblasts (EVTs), driving placental maturation. Focal adhesion kinase (FAK), a key cytoplasmic tyrosine kinase, regulates cellular processes such as proliferation, survival, and signaling.

TNIK Regulates Cytoskeletal Organization to Promote Focal Adhesion Turnover and Mitosis in Lung Adenocarcinoma.

Background: Lung cancer is the primary cause of cancer-related mortality, but the molecular mechanisms behind this malignancy remain unclear.

Methods: The Cancer Genome Atlas (TCGA) online database and tissue chips were used to analyze the expression levels of tumor necrosis factor receptor-associated factor 2 (TRAF2)- and non-catalytic region of tyrosine kinase adaptor protein (NCK)- interacting kinase (TNIK) protein in lung cancer. A549 and PC-9 lung adenocarcinoma (LUAD) cells with stable TNIK knockdown were generated by lentivirus infection.

Dysregulation of MYBL2 impairs extravillous trophoblast lineage development and function, contributing to recurrent spontaneous abortion.

Recurrent spontaneous abortion (RSA) is a pregnancy-related condition characterized by a complex etiology. While placental trophoblast dysfunction is strongly associated with the development and progression of RSA, the underlying molecular mechanisms remain poorly understood. In this study, we observed a significant decrease in the expression of MYB Proto-Oncogene Like 2 (MYBL2) in the villous tissue of patients with RSA and the placentas of abortion-prone (AP) mice.

Dose-response association between OGTT and adverse perinatal outcomes after IVF treatment: A cohort study based on a twin population.

Background: Investigate the association between Oral Glucose Tolerance Test (OGTT) after in vitro fertilization (IVF) treatment and adverse maternal and neonatal outcomes in twin pregnancies.

Methods: This retrospective study encompassed 2,541 twin pregnancies conceived through IVF treatment. Adverse maternal and neonatal outcomes were compared across different subgroups based on individual and combined OGTT classifications.

T3-THR Signaling Governed by DIO2 Contributes to Endometrial Receptivity by Regulating Epithelial Cell Membrane Fluidity.

Maintaining normal thyroid function is crucial in pregnancy, and the thyroid hormone signaling pathway is involved in embryo implantation. However, the regulation of iodothyronine deiodinase 2 (DIO2), which is the central hub controlling thyroid hormone signaling, and the intracellular pathway activated by triiodothyronine (T3) binding to the thyroid hormone receptor (THR) in endometrial cells, remains unclear. Here, we demonstrate that DIO2 expression increases in endometrium during the establishment of endometrial receptivity and is involved in this process.

Rictor stability mediated by USP9X regulates embryo implantation by participating in lipid metabolism of endometrium.

The receptive endometrium is a prerequisite for successful embryo implantation, and abnormal endometrial receptivity would lead to infertility. Many key proteins involved in endometrial receptivity have been confirmed to undergo post transcriptional modifications. However, there are limited reports on deubiquitination modification during this process.

Dysregulation of the circ-Hdac4/miR-30c/RBPJ axis in decidua impairs placental function in preeclampsia.

Embryo implantation relies on complex mother-fetus interactions. Abnormal decidualization can cause various pregnancy complications such as placental abnormalities, preeclampsia, and fetal growth restriction. circRNAs play a key role in various cellular processes.

Residential environment and risk of chronic diseases: A prospective study.

The impact of green-blue spaces on human health remains inconclusive, and the current understanding of disease spectrum associated with these spaces is still incomplete. We aimed to comprehensively investigate the relationship between residential environment and chronic diseases, while also examining the potential mediating role of air pollutants in these relationships. Using data from the UK Biobank, we created a residential environment score (RES) based on four types of green-blue spaces: natural environment, green space, domestic garden, and water area, with scores assigned according to the percentage of each space within a 300 m buffer.

KRT14 is a promising prognostic biomarker of breast cancer related to immune infiltration.

Background: Breast cancer (BC) is the leading cancer among women globally, which has the highest incidence and mortality rate in over a hundred countries. This study was intended to discover a new prognostic biomarker, facilitating personalized treatment approaches.

Methods: RNA sequencing data from The Cancer Genome Atlas database and Gene Expression Omnibus database were utilized to download to evaluate expression levels and prognostic significance of Keratin 14 (KRT14).

Screening of Oxidative Stress-related Biomarkers and Antioxidant Drugs for Polycystic Ovary Syndrome Based on Bioinformatics and Molecular Docking.

Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder affecting women of reproductive age. Oxidative stress (OS) is suggested to play a significant role in the development of PCOS. Using antioxidants to reduce OS and maintain a healthy balance in the body could be a novel treatment approach for PCOS.

Causal Relationships Between Leukocyte Subsets and Adverse Fetal Outcomes: A Mendelian Randomization Study.

The tolerance and dynamic regulation of the maternal immune system during pregnancy are pivotal for ensuring fetal health. Immune cell subsets play a complex and crucial role in this process, closely linked to the neonatal health status. Despite recognizing the significance of dysregulation in the quantity and activity of immune cells in neonatal disease occurrence, their specific roles remain elusive, resulting in a dearth of clinically viable interventions for immune-mediated neonatal diseases.

Emergence of -bearing MDR-hypervirulent ST307.

We report for the first time whole-genome sequencing of four multidrug-resistant sequence type (ST) 307 recovered from patients in two hospitals in Armenia. Comparative genomic analysis revealed that the isolates were closely related, with a maximum of 39 single nucleotide polymorphism (SNP) differences in the core genome. All Armenian isolates carried the integrative and conjugative element ICE4, which bears the yersiniabactin locus, and shared a common evolutionary origin, diverging around 2005 (95% CI: 1999 to 2011).