Environmental risks from impacts of industrial solid wastes applied on agricultural land in China: a comprehensive overview.

With the rapid development of industrialization in China, more and more industrial solid wastes (ISWs) are generated in industrial production processes. Under the pressure for safe disposals or utilization of ISWs as resources, and the demand for soil pollution remediation in China, there have been attempts to incorporate ISWs into agricultural land as soil amendments, while the environmental impacts of ISWs applied on agricultural land have aroused great concerns. This paper presents a comprehensive overview regarding the environmental risks from impacts of 7 types of ISWs (including blast furnace slag, steel slag, magnesium slag, coal-fired flue gas desulfurization gypsum, phosphogypsum, calcium carbide slag, and ammonia-soda residue) applied on agricultural land.

Innexin DNA-binding domains regulate bracoviral transcription in symbiotic wasps.

Bracoviruses have two hosts: symbiotic wasps and infected hosts. Although symbiotic wasps and infected larva host bracoviruses, mature virions form only in the wasps after the integrated bracovirus (MbBV) proviral genome replicates. However, the associated mechanisms of transcription regulation have not been characterized.

Bta-miR-25 alleviates lipopolysaccharide-induced endometritis in cows by targeting DUSP10 to inhibit MAPK signaling.

Bovine endometritis is a common and serious disease that has caused huge economic losses and a decline in production performance in the dairy cattle industry. This study aimed to investigate the regulatory role of bta-miR-25 in Lipopolysaccharide (LPS)-induced BEND and its impact on endometritis. In this study, an in vitro endometritis model was constructed using LPS.

mutation leads to different genders of twinning: a case report and literature review.

Background: Loss-of-function variants in protein phosphatase 1 regulatory subunit 12A () can lead to urogenital and/or brain malformation syndrome (UBMS). When UBMS individuals exhibit genital abnormalities, it is combined with disorders of sex development (DSD). To report a variation in a case of 46,XY twins exhibiting different phenotypes of genital development.

Performance simulations for a spaceborne ozone lidar mission.

The future range resolved spaceborne ozone differential absorption lidar (SODIAL) is expected to fill the current observation gap, especially in areas where in-situ observation and passive remote sensing are difficult. The spaceborne ozone lidar preparatory research mission (SOLPRM) proposed by the State Administration of Science, Technology, and Industry for National Defense, People's Republic of China, aims to develop the SODIAL. This study globally simulated and estimated the observational performance of SODIAL through MERRA-2, CALIPSO, and GOME-2 satellite data.

Potentials and limitations of large-scale, individual-level mobile location data for food acquisition analysis.

Understanding food acquisition is crucial for developing strategies to combat food insecurity, a major public health concern. The emergence of large-scale mobile location data (typically exemplified by GPS data), which captures people's movement over time at high spatiotemporal resolutions, offers a new approach to study this topic. In this study, we use a high-resolution dataset of 286 million GPS records from individuals in Jacksonville, Florida, to analyze the area's food outlet visit behaviors.

Structural and functional studies of rabbit SAMD9 reveal a distinct tRNase module that underlies the antiviral activity.

Human SAMD9 and SAMD9L (collectively SAMD9/9L) are large cytoplasmic proteins with antiviral and antiproliferative activities, recently shown to regulate protein synthesis by specifically depleting phenylalanine tRNA (tRNAPhe). The enzymatic activity of human SAMD9 (hSAMD9) resides within its N-terminal tRNase domain, which depends on three essential basic residues for tRNA binding and biological activity. While these residues are highly conserved across mammalian SAMD9/9L, lagomorph SAMD9 orthologs uniquely harbor a charge-reversal acidic residue at one of three sites, a change known to inactivate hSAMD9/9L.

The effect of repetitive transcranial magnetic stimulation (rTMS) on perioperative neurocognitive disorders in patients after cardiac surgery: study protocol for a randomized controlled trial.

Introduction: Perioperative neurocognitive disorders (PND) is one of the most common postoperative complications among elderly patients (above 65 years old) undergoing cardiac surgery. However, thus far, there have not been any effective therapies for managing PND. Recent research has shown that repetitive transcranial magnetic stimulation (rTMS) alters brain plasticity and improves cognitive function in several neurodegenerative disorders and psychiatric disorders.

Targeting KAT8 alleviates self-RNA-driven skin inflammation by modulating histone H4 lysine 16 acetylation in psoriasis.

Psoriasis is a persistent inflammatory skin disease characterized by the adverse infiltration of inflammatory cells and epidermal hyperplasia. Self-RNA is the most abundant damage-associated molecular pattern (DAMP) in psoriasis tissues, which triggers and amplifies inflammatory responses through TLR7 pathway. However, the pathogenic effects of self-RNA on immune cell activation and chemotaxis during psoriasis and the underlying mechanisms remain largely unknown.

Non-invasive quantitative assessment of urethral compliance in rabbit tubularized incised plate model using ultrasound and uroflowmetry.

Low urinary flow rates are frequently observed following tubularized incised plate urethroplasty. The underlying cause is not yet fully understood and may be associated with low urethral compliance. The purpose of this study is to non-invasively evaluate the urethral compliance in a rabbit model.

The bZIP transcription factor CibZIP43 positively regulates salt and heat tolerance in pecan (Carya illinoinensis).

Pecan (Carya illinoinensis) is an economically and ecologically important tree species, but its growth is frequently challenged by salt stress and heat stress. bZIP transcription factors are key regulators of plant responses to abiotic stresses. This study aimed to functionally characterize the pecan transcription factor CibZIP43 and reveal its role in salt and heat stress tolerance.

Characterization of the JAZ family in Osmanthus fragrans and the role of OfLJAZ2 in flavonoid synthesis mediated regulation of salt and drought stress tolerance.

As an important ornamental plant, the application of Osmanthus fragrans in landscape gardening is limited by abiotic stresses such as drought and salinity. JAZs, as key negative regulators in the jasmonic acid signaling pathway, play crucial roles in regulating stress responses in plants. However, the JAZ family in O.

Identification of the bHLH transcription factor family and functional characterization of CibHLH141 and CibHLH127 in response to iron deficiency stress of pecan (Carya illinoinensis).

The basic helix-loop-helix (bHLH) gene family plays vital roles across various plant species. However, the bHLH family has not been reported in pean (Carya illinoinensis). In this study, 164 CibHLHs were identified, exhibiting high evolutionary conservation as revealed by gene structure, conserved motifs, domains, and collinearity analyses.

Robot-Assisted Laparoscopic Nephrectomy for Wilms' Tumour in Children.

Background: The purpose of this study was to share our experiences with robot-assisted laparoscopic nephrectomy (RALN) for WT in children and to discuss the technical points and indications.

Methods: Patients with WT undergoing RALN between May 2020 and December 2022 were retrospectively analysed. Patient demographics, operative details, postoperative outcomes and follow-up were recorded.

Ureteral Stents in the Management of Pediatric Urolithiasis: A Systematic Review.

Ureteral stents are extensively utilized in the treatment of urolithiasis. Given the anatomical and physiological differences between children and adults, the rational, effective, and safe application of ureteral stents in pediatric patients is a matter of significant clinical interest. This review summarizes the classification, application scenarios, and potential adverse effects of ureteral stents in pediatric urolithiasis, aiming to provide a reference for clinical decision-making related to ureteral stents in children with urinary tract stones.

Exploring MFSD9: From Expression Patterns to Therapeutic Implications in LUAD.

Introduction: This study explores the role of Major Facilitator Superfamily Domain-containing Protein 9 (MFSD9) in lung adenocarcinoma (LUAD) using bioinformatics and experimental validation, aiming to identify its potential as a biomarker and therapeutic target.

Methods: Comprehensive analysis of MFSD9 expression across cancers, particularly LUAD, was carried out using The Cancer Genome Atlas (TCGA) dataset. Correlations between MFSD9 expression and clinical outcomes, immune infiltration, immune checkpoint genes, tumor mutational burden (TMB), microsatellite instability (MSI), mRNA expression-stemness index (mRNAsi), and drug sensitivity were examined.

Metabolic evaluation and disease characteristics of urolithiasis in children from 2020 to 2024: a retrospective single-center study at the national children's medical center.

Objective: To analyze the composition and disease characteristics of pediatric urolithiasis in a single center, providing a scientific basis for clinical diagnosis, treatment, and prevention.

Methods: This study included 266 pediatric patients with urolithiasis admitted from September 2020 to September 2024. Composition analysis was conducted on 174 stone samples using infrared spectroscopy, and 24-h urinary metabolic evaluations were performed on 124 patients.

Development and validation of a small-sample machine learning model to predict 5-year overall survival in patients with hepatocellular carcinoma.

Background: Early-onset hepatocellular carcinoma (HCC) is insidious, with characteristics of easy metastasis, high recurrence rate, and significant mortality. To address the substantial time and resource demands associated with HCC prognostic prediction, we extract meaningful insights from limited small-sample data to develop and validate a prediction model for HCC 5-year overall survival (OS) by machine learning (ML).

Methods: 76 newly diagnosed patients with HCC were eventually enrolled between September 2018 and July 2019.

Global, regional, and national burden of congenital anomalies of the kidney and urinary tract from 1990 to 2021, with projections to 2036: a systematic analysis of the global burden of disease study 2021.

Background: Congenital anomalies of the kidney and urinary tract (CAKUT) represents an important global health challenge. However, the emerging analysis of the burden of CAKUT is limited and outdated. This study aimed to evaluate the global burden and temporal trends of CAKUT across 204 countries and territories from 1990 to 2021.

Case report: a R0 resection successfully induced by T-DXd plus PD-1 inhibitor regimen in a primary unresectable stage IIIB NSCLC with ERBB2-mutation.

Chemoradiotherapy (CRT) with consolidative immunotherapy(IO) remains the standard care for unresectable stage III NSCLC, yet survival remains suboptimal in molecular subgroups. Emerging targeted therapies offer the potential for converting unresectable cases to resectable status. We present a 54-year-old female with stage IIIB (T1cN3M0) ERBB2 exon 20-mutated lung adenocarcinoma (PD-L1 50%) and supraclavicular metastasis.

Induction therapy with dabrafenib, trametinib, and PD-1 inhibitor and surgical conversion in unresectable stage III non-small cell lung cancers with BRAF V600E mutation: 2 cases.

Chemoradiotherapy followed by consolidative immunotherapy is the standard-of-care for unresectable stage III non-small cell lung cancers (NSCLC), yet confers limited benefit in those with driver mutations, BRAF-V600x included. Here, we report two cases of unresectable stage III NSCLC harboring BRAF V600E mutation treated with induction dabrafenib, trametinib, and a PD-1 inhibitor. Both patients exhibited significant tumor regression, enabling surgical conversion and achieving pathological complete or major response, without significant adverse events.

Three novel heterozygous ANK1 loss-of-function variants cause hereditary spherocytosis in Chinese families.

Background And Purposes: Hereditary spherocytosis (HS) is an inherited hemolytic anemia caused by variants in red blood cell cytoskeleton proteins. Advances in sequencing technology have revealed numerous novel variants; however, accurate genome annotation remains a significant challenge. In precision medicine, the precise identification of variants responsible for genetic diseases is crucial.

Ti-Based Metallic Biomaterials for Antitumor Applications.

Titanium (Ti)-based metallic biomaterials (MBs) are traditionally employed as mechanical supports and constraints in clinical practice, owing to their superb comprehensive mechanical properties, great corrosion resistance, and good biocompatibility. Recently, Ti-based MBs have emerged as promising candidates for antitumor applications. These developments focus on the functionalization of Ti-based MBs to inhibit tumor propagation and recurrence.