High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy.

Liver kinase B1 (LKB1)-deficient non-small cell lung cancers (NSCLCs) exhibit primary resistance to immune checkpoint inhibitors (ICIs). The redox imbalance inherent in these tumors may represent a potential therapeutic vulnerability. High-dose ascorbic acid (AA) could induce cell redox imbalance.

mutation leads to different genders of twinning: a case report and literature review.

Background: Loss-of-function variants in protein phosphatase 1 regulatory subunit 12A () can lead to urogenital and/or brain malformation syndrome (UBMS). When UBMS individuals exhibit genital abnormalities, it is combined with disorders of sex development (DSD). To report a variation in a case of 46,XY twins exhibiting different phenotypes of genital development.

End-tidal CO corrected for ambient CO risk adjusted phototherapy threshold for the management of neonatal hyperbilirubinemia: a randomized clinical trial.

Background: Neonatal hyperbilirubinemia risk factors determination is challenging due to the lack of quantifiable indicators for bilirubin production, resulting in phototherapy decisions made without real-time information. End-tidal carbon monoxide (CO) corrected for ambient CO (ETCOc) may be helpful for identifying hemolysis, but evidence on the application of ETCOc as a risk factor for the development of neonatal hyperbilirubinemia is scarce. This study aimed to evaluate whether the use of ETCOc to adjust neonatal hyperbilirubinemia risk categories and thus phototherapy thresholds can reduce the rate of phototherapy within the first seven days of life.

Micheliolide interferes PKM2-P65 interaction and inhibits inflammasome activation in macrophage after ischemic stroke.

Confronting post-stroke neural inflammation is regarded as a promising therapeutic strategy for cerebral ischemia. Macrophage inflammasome activation plays a vital role in driving neural inflammation, and thus directly impacts stroke outcomes. Micheliolide (MCL), a newly discovered modifier of macrophage function, mechanistically suppresses NLRP3 macrophage signaling.

Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti-PD-1 immunotherapy efficacy in colorectal cancer liver metastasis.

Background: Colorectal cancer liver metastasis (CRLM) is characterized by an immunosuppressive microenvironment and a blunted response to immunotherapy. Notably, tumor-associated macrophages (TAMs) play a critical role in modulating immune responses and exhibit significant heterogeneity in CRLM. Sphingosine kinase 1 (SPHK1) serves as a pivotal kinase in maintaining the balance between ceramide and sphingosine-1-phosphate (S1P) levels.

Non-invasive neurally adjusted ventilatory assist versus nasal continuous positive airway pressure for premature infants: a systematic review and meta-analysis.

Objective: The purpose of this study was to compare the benefits of non-invasive neurally adjusted ventilatory assist (NIV-NAVA) versus Nasal continuous positive airway pressure (NCPAP) as respiratory support for premature infants.

Methods: Literature on NIV-NAVA and NCPAP as respiratory support of premature infants was comprehensively searched from PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Database, and VIP database. The search time was from the establishment of the database to June 20, 2023.

Psychological distress and turnover intention among Chinese nurses: a moderated mediation model of job satisfaction and social support.

Background: Nurses' turnover intention has long been a global concern due to its impact on the stability of the nursing workforce and the quality of healthcare services. Numerous studies have highlighted a strong relationship between psychological distress and turnover intention. However, very little is known about how psychological distress influences turnover intention among nurses.

Subacute dibutyl phthalate exposure impairs hepatic T cells and facilitates hepatitis B progression in mouse liver.

The hepatic immune microenvironment governs liver disease susceptibility by balancing immune defense and tolerance. While phthalate esters (PAEs), emerging pollutants derived from plastics, have been acknowledged as hepatoxic substances, the immunomodulatory and clinical impacts of subacute PAEs exposure remain underexplored. In this study, we identified dibutyl phthalate (DBP) as a predominant PAE in liver tissues from hepatitis B virus (HBV)-infected patients.

End-tidal carbon monoxide levels as a point-of-care biomarker for the early detection of hemolytic disease in Chinese neonates.

Objective: Hemolytic disease of newborn (HDN) is a leading risk factor for severe neonatal hyperbilirubinemia. While end-tidal carbon monoxide (CO) corrected for ambient CO (ETCOc) reflects the endogenous rate of bilirubin production, there remain translational gaps in understanding the link between ETCOc and HDN. We aimed to evaluate ETCOc levels as an indicator of increased bilirubin production in HDN.

Latent profile analysis of parental burnout among parents of children with and without autism spectrum disorder.

Background: Parental burnout is an emerging global focus on parental mental health and parenting practices. However, parental burnout among parents of children with autism spectrum disorder (ASD) in China remains largely unexplored.

Objective: This study aimed to identify differences in parental burnout severity and patterns between Chinese parents raising children with and without ASD, while exploring key sociodemographic factors contributing to these disparities.

Traditional Herbal Medicine Pithecellobium clypearia (Jack) Benth: Research progress in chemical constituents and pharmacological activities.

Ethnopharmacological Relevance: Pithecellobium clypearia, a traditional herbal medicine, has garnered widespread attention for its significant anti-infective benefits. However, there is currently a lack of comprehensive reviews examining the chemical constituents and pharmacological activities of P. clypearia.

PAI-1-driven SFRP2 cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy.

The abscopal effect of radioimmunotherapy, wherein tumor shrinkage occurs beyond the irradiated field, is therapeutically promising but clinically rare. The mechanisms underlying this effect remain elusive. Here, in vivo genome-wide CRISPR screening identifies SFRP2 as a potential stromal regulator of the abscopal effect.

Medium- and long-term outcomes of tunneled labial mucosa tube grafts for the repair of primary severe hypospadias and failed hypospadias.

Objective: This study aimed to evaluate the medium and long-term outcomes of tunneled labial mucosa tube graft urethroplasty in the treatment of primary severe hypospadias and failed hypospadias.

Methods: We retrospectively reviewed the medical records of the patients who underwent tunneled labial mucosa tube graft urethroplasty at a single center between 2007 and 2020. Data collected included patient demographic, operative and post-operative characteristics.

The Role of Dectin-1-Akt-RNF146 Pathway in β-Glucan Induced Immune Trained State of Monocyte in Sepsis.

Background: Sepsis is regarded as a dysregulated immune response to infections. Recent study showed partially reversal of immunosuppression by trained immunity, which fosters an enhanced immune response towards a secondary challenge. However, the role of trained immunity in sepsis has not been fully understood.

Spermine synthase engages in macrophages M2 polarization to sabotage antitumor immunity in hepatocellular carcinoma.

Disturbances in tumor cell metabolism reshape the tumor microenvironment (TME) and impair antitumor immunity, but the implicit mechanisms remain elusive. Here, we found that spermine synthase (SMS) was significantly upregulated in tumor cells, which correlated positively with the immunosuppressive microenvironment and predicted poor survival in hepatocellular carcinoma (HCC) patients. Via "subcutaneous" and "orthotopic" HCC syngeneic mouse models and a series of in vitro coculture experiments, we identified elevated SMS levels in HCC cells played a role in immune escape mainly through its metabolic product spermine, which induced M2 polarization of tumor-associated macrophages (TAMs) and subsequently corresponded with a decreased antitumor functionality of CD8 T cells.

Ardisia Crispae Radix et Rhizoma: A review of botany, traditional uses, phytochemistry, pharmacology, and toxicology.

Ethnopharmacological Relevance: Ardisia Crispae Radix et Rhizoma comprises three primary source plants: Ardisia crenata Sims, Ardisia crispa (Thunb.) A. DC.

The potential mechanisms underlying the effect of acute alcohol use on duration perception.

Acute alcohol consumption has been found to cause duration perception distortions, but the directions of these distortions are not consistent. The mechanisms underlying this effect are also unclear. The present study seeks to elucidate the effect of acute alcohol consumption on duration perception and the mechanisms involved.

Lower-dose vs high-dose oral bisphenol S action of lipid metabolism in liver of male SD rat via mediating different SREBP isoforms.

Bisphenol S (BPS) is commonly used for the industrial production of thermal paper, polycarbonate plastics, epoxy resins and other materials. Studies have reported that BPS can lead to triglyceride (TAG) or/and cholesterol (CHO) accumulation in the liver in zebrafish and mice, but the reasons for the different types of lipids that accumulate in the liver following BPS exposure are unclear. Here, the influences of lower-dose (10 mg/kg body weight/day) and high-dose (50 mg/kg body weight/day) BPS exposure to male SD rats on the accumulation of different lipids in the liver were explored.

Radiation-sensitive circRNA hsa_circ_0096498 inhibits radiation-induced liver fibrosis by suppressing EIF4A3 nuclear translocation to decrease CDC42 expression in hepatic stellate cells.

Background: Radiation-induced liver fibrosis (RILF) is a common manifestation of radiation-induced liver injury (RILI) and is caused primarily by activated hepatic stellate cells (HSCs). Circular RNAs (circRNAs) play critical roles in various diseases, but little is known about the function and mechanism of circRNAs in RILF.

Methods: RNA pull-down and liquid chromatography-tandem mass spectrometry (LC-MS/MS) were used to screen binding proteins of hsa_circ_0096498 (circ96498).

Antiangiogenic Treatment Facilitates the Abscopal Effect of Radiation Therapy Combined With Anti-PD-1 in Hepatocellular Carcinoma.

Purpose: Metastasis is one of the most important factors contributing to poor prognosis in hepatocellular carcinoma. Radiation therapy (RT), along with its induced abscopal effect, is a promising treatment for metastatic patients. However, the incidence of abscopal effect in clinical practice is rare, even when RT is combined with immune checkpoint inhibitors (ICIs).

Temperature seasonality and soil phosphorus availability shape ginseng quality via regulating ginsenoside contents.

The accumulation of secondary metabolites in Panax ginseng Meyer (P. ginseng) exhibits significant geographical variation, normally due to environmental factors. The current study aimed at elucidating the key environmental factors modulating the accumulation of secondary metabolites in P.

A thalamic nucleus reuniens-lateral septum-lateral hypothalamus circuit for comorbid anxiety-like behaviors in chronic itch.

Chronic itch often clinically coexists with anxiety symptoms, creating a vicious cycle of itch-anxiety comorbidities that are difficult to treat. However, the neuronal circuit mechanisms underlying the comorbidity of anxiety in chronic itch remain elusive. Here, we report anxiety-like behaviors in mouse models of chronic itch and identify γ-aminobutyric acid-releasing (GABAergic) neurons in the lateral septum (LS) as the key player in chronic itch-induced anxiety.

Quality evaluation and identification of bleached with sodium metabisulfite based on whole spectrum metabolomics.

(HC) is a widely distributed plant in Asia and is used extensively for both food and medicinal purposes. A preliminary investigation found that HC is often bleached with sodium metabisulfite solution during its field processing, leading to health risks. In this study, the effects of sodium metabisulfite on the quality of HC were comprehensively evaluated using volatile and non-volatile targeted metabolomic methods.