Publications by authors named "Chang-Gui Yang"

Dipsaci Radix is a commonly used Chinese herbal medicine in China, with triterpenoid saponins as the main active components. β-Amyrin synthase, a member of the oxidosqualene cyclase superfamily, plays a crucial role in the biosynthesis of oleanane-type triterpenoid saponins. Asperosaponin Ⅵ is an oleanane-type triterpenoid saponin.

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A method for simultaneous determination of multiple mycotoxins in Bombyx Batryticatus and Eupolyphaga Steleophaga was established to provide technical support for monitoring and quality control of such medicinal materials. The mildew-prone Bombyx Batryticatus and Eupolyphaga Steleophaga were detected by UPLC-MS/MS technology, and the chromatographic conditions, mass spectrometry conditions, test sample preparation methods, and QuEChERS purification parameters were optimized. Scanning was conducted under multiple reaction monitoring mode(MRM), and quantitative analysis was performed by matrix standard curve method.

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Ethnopharmacological Relevance: Ardisia Crispae Radix et Rhizoma comprises three primary source plants: Ardisia crenata Sims, Ardisia crispa (Thunb.) A. DC.

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(HC) is a widely distributed plant in Asia and is used extensively for both food and medicinal purposes. A preliminary investigation found that HC is often bleached with sodium metabisulfite solution during its field processing, leading to health risks. In this study, the effects of sodium metabisulfite on the quality of HC were comprehensively evaluated using volatile and non-volatile targeted metabolomic methods.

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Pseudostellaria heterophylla in large-scale cultivation needs to apply pesticides to control diseases, and non-standard use of pesticide may cause excessive pesticide residues in medicinal materials, increasing the risk of clinical medication. To accurately monitor the residual pesticides, this paper investigated the drug use during the process of P. heterophylla disease prevention in 25 P.

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Based on the data of 56 kinds of diseases and drug use in 100 kinds of cultivated Chinese herbal medicines, this paper used frequency analysis method to count the types of diseases and their drug use characteristics, and systematically analyzed the status of drug registration and monitoring standards for disease prevention and control of Chinese herbal medicines. The results showed that 14 diseases such as root rot, powdery mildew, and drooping disease were common in the production of Chinese herbal medicines. Among the 99 pesticides reported, 67.

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Article Synopsis
  • The study examines mycotoxin contamination in Coicis Semen, highlighting risks to safety in Chinese medicinal materials and suggesting updates for mycotoxin limits.
  • The analysis used UPLC-MS/MS to measure 14 mycotoxins across 100 samples, revealing high detection rates for some toxins like zearalenone and aflatoxins, with certain toxins exceeding safety standards.
  • Despite a low exposure risk for the detected mycotoxins, the presence of multiple toxins in 86% of samples indicates a need for further research on combined toxicity and a reassessment of existing contamination limits.
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The present study counted the frequency of detection technologies and monitoring frequency of pesticide species by frequency analysis based on the 28 258 pieces of data on pesticide content of Chinese medicinal materials in CNKI, calculated the detection rate and exceeding rate of different types of pesticides, and systematically analyzed the pesticide residue pollution of Chinese medicinal materials. The results showed that there were 40 types of pesticides with detection rates higher than 10%, where new pesticides such as organochlorines and nicotine accounted for 55%, and organic phosphorus, pyrethroids, and carbamates accounted for 17.5%, 15.

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This study aimed to establish a method for synchronous detection of 14 mycotoxins in Pseudostellariae Radix and investigate its contamination with mycotoxins, so as to provide technical guidance for monitoring the quality of Chinese medicinal materials and medication safety. The sample was extracted with 80% acetonitrile in an oscillator for 1 h, purified using the modified QuEChERS purifying agent(0.1 g PSA + 0.

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Article Synopsis
  • - The study investigates the distribution of Fusarium species and their toxin contamination in the tuberous roots of Pseudostellaria heterophylla, identifying 29 strains as Fusarium out of 89 fungal isolates.
  • - Five Fusarium species were identified, with various strains capable of producing toxins like ZEN, DON, and T2 in differing amounts; strain JK3-3 was notable for producing all three toxins.
  • - Key synthase genes responsible for toxin production were found to be strongly linked to the toxins produced by the strains, suggesting genetic control over toxin biosynthesis, and paving the way for PCR methods in detecting mycotoxin contamination in P. heterophylla.
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Zearalenone(ZEN) is a mycotoxin produced by Fusarium, possessing estrogen-like effects, carcinogenicity, and multiple toxicities. To seek more efficient and practical agents for biological detoxification and broaden their application, this study isolated 194 bacterial strains from the moldy tuberous root of Pseudostellaria heterophylla, which were co-cultured with ZEN. An efficient ZEN-degrading strain H4-3-C1 was screened out by HPLC and identified as Acinetobacter calcoaceticus by morphological observation and molecular identification.

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As there is no clear biomarker to diagnose Parkinson's disease, this meta-analysis aims to comprehensively evaluates the correlation between serum Cystatin C levels and Parkinson's disease in the Chinese population by the meta-analysis method. PubMed, Web of Science, Embase, Cochrane Library, China national knowledge infrastructure, and China WanFang databases were systematically searched on the correlation between serum Cystatin C and Parkinson's disease. The results showed that Cystatin C level in Parkinson's disease patients compared with the control group, the standardized mean difference = 1.

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In order to understand the pollution of heavy metals in Guizhou soil planting Eucommia ulmoides,the paper has determined the contents of five heavy metals respectively( Cu,Cd,Pb,Hg and As) by atomic absorption spectrophotometry. The soil environmental quality by single factor pollution index was evaluated,nemerow integrated pollution index and potential ecological risk index,the correlation of 5 heavy metals was analyzed and the relationship between heavy medals content and p H value was discussed. The results showed that: ①The soils of LP,SB and ZA-2 had low heavy metals content,LP soil met the first national standard,and other soils met the second national standard; ②The soils of LP,ZA-1 and ZA-2 were all in a clean state,while HX and BZ-1 were in a light pollution state,and the pollution degree was Cu>Pb>As>Cd>Hg; ③The soil of BZ-2 was light warning( medium ecological risk),the soils of HX,BZ-1 and MT were early warning( low ecological risk),the main warning source was Cu and Pb,and the rest were no warning( no ecological risk); ④Cd and As were positively correlated with Pb and Hg,and Cd,Pb and As were positively correlated with p H.

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Article Synopsis
  • - The research focused on analyzing the appearance characteristics and quality of Dipsaci Radix samples from various markets to update its commodity specifications and grading standards based on production practices.
  • - Results showed that longer and thicker roots with a specific fracture surface quality were preferred, but most samples in the market lacked proper grading.
  • - While some relationships were found between moisture content and extract yield, there was no significant correlation between physical appearance and intrinsic quality; ultimately, the study aimed to standardize trade practices for Dipsaci Radix.
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  • - The paper investigates the specification and grading standards of Galla Chinensis, aiming to standardize market practices and enhance circulation of this herbal product using 33 market samples.
  • - It employs various statistical methods such as descriptive statistics, principal component analysis, and cluster analysis to develop grading indicators for Galla Chinensis, identifying characteristics of high-quality samples.
  • - The findings facilitate a division into two main categories (gallnuts and horned galls) and two grades (selected goods and mixed goods), revealing that there is a minimal correlation between internal quality metrics and physical appearance traits.
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  • The study investigates the quality characteristics and grade standards of Pinelliae Rhizoma to aid in its classification and specification in the market.
  • Various samples were collected and analyzed using statistical methods (like SPSS) to identify labeling criteria based on attributes such as length, weight, and grain count.
  • The findings revealed no significant correlation between the appearance traits and internal quality indicators, ultimately leading to established guidelines for Pinelliae Rhizoma's classification in the market.
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  • The study evaluates the genetic diversity and medicinal quality of 21 cultivated germplasm of Rehmannia glutinosa, using SRAP molecular markers and HPLC to measure catalpol and verbascoside levels.
  • It found that the levels of catalpol ranged from 2.393%-6.519% and verbascoside from 0.063%-0.478%, with certain germplasm (14, 16, 15, and 20) exhibiting higher contents of these compounds.
  • The findings suggest that germplasm 7 and 18 are preferred for cultivation, while germplasm 15 and 16 are recommended for preservation and breeding efforts due to their genetic diversity.
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To provide guidance for certification, popularization and application of Pseudostellariae Radix new variety, the regional adaptation and stabilities of "Shitai No.1" were evaluated. The "Qian taizishen No.

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Based on collections and researches of Pesudostellaria heterophylla germplasm resources from different areas of China, by using Shibing SB-4 provenance as materials, the new variety "Shitai No.1" was bred by mass selection, small plot variety comparative test, regional variety comparative test and field trial planting. Compared with "Qian taizishen No.

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Objective: To provide new germplasm materials for breeding new varieties of Pseudostellaria heterophylla.

Method: The method of single plant selection was adopted, with the comparative experiments being carried out under the same conditions in Shibing county. The 8 plants of Shibing SB-4 were compared respectively with factor analysis for 27 phenotypic traits and 8 yield traits, and single factor variance analysis for the contents of polysaccharides.

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