Unveiling the yeast interaction: Insights into the role of Saccharomyces cerevisiae metabolites in regulating Torulaspora delbrueckii aroma biosynthesis during wine fermentation.

The interactions between Saccharomyces cerevisiae and non-Saccharomyces yeasts through secreted metabolites play a crucial role in shaping wine aroma profiles, yet the underlying mechanisms remain inadequately understood. This study used a cell/medium separation strategy coupled with transcriptomic and metabolomic analyses to elucidate the influence of S. cerevisiae metabolites on aroma biosynthesis in Torulaspora delbrueckii during wine fermentation.

Predicting textbook outcome after pancreaticoduodenectomy for invasive intraductal papillary mucinous neoplasm: An international validation cohort study.

Background: Textbook outcome, a composite measure of optimal recovery, remains poorly defined for invasive intraductal papillary mucinous neoplasm after pancreaticoduodenectomy. This study aimed to develop and validate the first nomogram predicting textbook outcome in this distinct cohort, addressing gaps in tailored prognostic tools for patients meeting contemporary surgical criteria on the basis of high-risk features.

Methods: Using multicenter data from 327 US patients (training cohort) and 152 Chinese patients (external test cohort), we evaluated 43 preoperative and intraoperative variables.

Residues and Dietary Risk of Lambda-Cyhalothrin in Fresh and Dried Panax notoginseng, Lilium, and Lonicera japonica.

In this study, a method for the determination of three medicinal and food homologous crops (fresh and dried Panax notoginseng, Lilium, and Lonicera japonica) was established, which had good linearity (R > 0.9971), accuracy (77%-104%) and precision (intraday RSD of 0.4% to 8.

Molecular Dynamics Simulation on Orientation-Dependent Mechanical Behaviors of ZnO Single Crystals Under Nanoindentation.

The present study aims to investigate the orientation-dependent mechanical behaviors of ZnO single crystals under nanoindentation by molecular dynamics simulation. The load-indentation depth curves, atomic displacement, shear strain and dislocations for the c-plane, m-plane and a-plane ZnO single crystals were analyzed in detail. The simulation results showed that the elastic deformation stage of the loading curves for the three oriented ZnO single crystals can be described well by the Herz elastic contact model.

Machine learning model for postpancreaticoduodenectomy haemorrhage prediction: an international multicentre cohort study.

Objectives: To develop and validate a machine learning model for precise risk stratification of postpancreaticoduodenectomy haemorrhage (PPH), enabling early identification of high-risk patients to guide clinical intervention.

Design: Retrospective international multicentre cohort study with model development and external validation.

Setting: Training data from the American College of Surgeons-National Surgical Quality Improvement Program database (USA, 2014-2017) and external validation data from the National Cancer Center (China, 2014-2019).

Impact of Fluxapyroxad and Mefentrifluconazole on Microbial Succession and Metabolic Regulation in Rice Under Field Conditions.

This study systematically evaluated the residual behavior of fluxapyroxad (FXP) and mefentrifluconazole (MFZ) in rice-soil systems, alongside their soil and metabolic impacts. Analytical methods validated via linear regression (0.0001-0.

Chemically active wetting.

Wetting of liquid droplets on passive surfaces is ubiquitous in our daily lives, and the governing physical laws are well understood. When surfaces become active, however, the governing laws of wetting remain elusive. Here, we propose chemically active wetting as a class of active systems where the surface is active due to a binding process that is maintained away from equilibrium.

2,4-Epibrassinolide Regulates Polysaccharide Substance Biosynthesis after Field Application to .

This study investigated the effects of 2,4-epibrassinolide (EBR) residues on quality. The residues decreased from 0.164 to 0.

Assembly of tight junction belts by ZO1 surface condensation and local actin polymerization.

Tight junctions play an essential role in sealing tissues, by forming belts of adhesion strands around cellular perimeters. Recent work has shown that the condensation of ZO1 scaffold proteins is required for tight junction assembly. However, the mechanisms by which junctional condensates initiate at cell-cell contacts and elongate around cell perimeters remain unknown.

A cross-sectional study on post-stroke depression and the quality of life.

Background: Post-stroke depression (PSD) is a common mood disorder associated with stroke. By investigating the differences in life quality factors among stroke survivors, the results of this study offer insights into how to better prevent and manage the onset and progression of depression.

Methods: This study is a cross-sectional study that selected patients receiving treatment in the Department of Rehabilitation Medicine at Hebei University Affiliated Hospital from September 1 to November 30, 2023.

Pharmacological targets and validation of remdesivir for the treatment of COVID-19-associated pulmonary fibrosis: A network-based pharmacology and bioinformatics study.

The objective of this study was to employ bioinformatics and network pharmacology methodologies to investigate the targets and molecular mechanisms of remdesivir in the treatment of coronavirus disease 2019 (COVID-19)-associated pulmonary fibrosis (PF). Several open-source databases were utilized to confirm the shared targets of remdesivir, COVID-19, and PF. Following this, a comprehensive analysis incorporating function enrichment, protein-protein interaction (PPI), transcription factor (TF), and molecular docking was conducted to investigate the potential mechanisms underlying the effectiveness of remdesivir in the treatment of COVID-19-associated PF.

Impact of superabsorbent hydrogels on microbial community and atrazine fate in soils by C-labeling techniques.

The accumulation of atrazine in soils can create environmental challenges, potentially posing risks to human health. Superabsorbent hydrogel (SH)-based formulations offer an eco-friendly approach to accelerate herbicide degradation. However, the impact of SHs on soil microbial community structure, and thus on the fate of atrazine, remains uncertain.

Combined toxic effects of fluxapyroxad and multi-walled carbon nanotubes in Xenopus laevis larvae.

Carbon nanomaterials rarely exist in isolation in the natural environment, and their combined effects cannot be ignored. Multi-walled carbon nanotubes (MWCNTs) have shown tremendous potential applications in diverse fields, including pollution remediation, biomedicine, energy, and smart agriculture. However, the combined toxicities of MWCNTs and pesticides on non-target organisms, particularly amphibians, are often overlooked.

Preparation of tomato peel pomace powder/polylactic acid foams under supercritical CO conditions: Improvements in cell structure and foaming behavior.

Polylactic acid (PLA) is an eco-friendly material that can help address the problems of petroleum depletion and pollution. Blending renewable biomass materials with PLA to create composite foams with a tunable pore structure, superior performance, and low cost is a green technique for improving the pore structure and mechanical characteristics of single PLA foams. PLA/TP composites were created using melted tomato peel pomace powder (TP), which has a lamellar structure, as a reinforcing agent.

A ternary mixture model with dynamic boundary conditions.

The influence of short-range interactions between a multi-phase, multi-component mixture and a solid wall in confined geometries is crucial in life sciences and engineering. In this work, we extend the Cahn-Hilliard model with dynamic boundary conditions from a binary to a ternary mixture, employing the Onsager principle, which accounts for the cross-coupling between forces and fluxes in both the bulk and surface. Moreover, we have developed a linear, second-order and unconditionally energy-stable numerical scheme for solving the governing equations by utilizing the invariant energy quadratization method.

Macrophage-specific deletion of Notch-1 induced M2 anti-inflammatory effect in atherosclerosis via activation of the PI3K-oxidative stress axis.

Objective: Notch-1 signaling is significantly associated with the occurrence and development of atherosclerosis (AS). However, the molecular mechanisms underlying the specific deletion of Notch-1 in AS-associated macrophages are not fully understood. This study aimed to investigate the effects of Notch-1 in AS.

Current-use pesticides monitoring and ecological risk assessment in vegetable soils at the provincial scale.

Pesticides represent one of the largest intentional inputs of potentially hazardous compounds into agricultural soils. However, as an important vegetable producing country, surveys on pesticide residues in soils of vegetable production areas are scarce in China. This study presented the occurrence, spatial distribution, correlation between vegetable types and pesticides, and ecological risk evaluation of 94 current-use pesticides in 184 soil samples from vegetable production areas of Zhejiang province (China).

Residue analysis and dietary risk assessment of abamectin in fresh corn, bitter melon, and Fritillaria.

To clarify the residue behavior and possible dietary risk of abamectin in fresh corn, bitter melon, and Fritillaria, a method was developed for the simultaneous determination of abamectin residues in fresh corn, bitter melon, and Fritillaria by QuEChERS (quick, easy, cheap, effective, rugged, safe) ultra-performance liquid chromatography-tandem mass spectrometry. The mean recovery of abamectin in fresh corn, bitter melon, and Fritillaria was 86.48%-107.

Dissipation behavior and dietary risk assessment of cyclaniliprole and its metabolite in cabbage under field conditions.

Cyclaniliprole, a novel diamide insecticide, can successfully control Spodoptera litura (Fabricius, 1775) in cabbage. Understanding the residual level of cyclaniliprole in crops and the risk related to its dietary intake is imperative for safe application. Here, we established a simplified, sensitive method for simultaneous analysis of cyclaniliprole and its metabolite NK-1375 (3-bromo-2-((2-bromo-4H-pyrazolo[1,5-d]pyrido[3,2-b]-[1,4]oxazin-4-ylidene)amino)-5-chloro-N-(1-cyclopropylethyl)benzamide) in cabbage by liquid chromatography-tandem mass spectrometry (LC-MS/MS) to investigate their dissipation behavior and residual characteristics.

Trifloxystrobin induced developmental toxicity by disturbing the ABC transporters, carbohydrate and lipid metabolism in adult zebrafish.

The environmental risks of trifloxystrobin (TR) have drawn attention because of its multiplex toxicity on aquatic organisms, but few studies have paid close attention to its chronic toxicity at environmental concentrations. In present study, histopathology, metabolomics and transcriptomics were comprehensively performed to investigate the toxic effects and biological responses on adult zebrafish after exposure to 0.1, 1 and 10 μg/L TR for 21 d.

Uptake, accumulation and toxicity of short chain chlorinated paraffins to wheat (Triticum aestivum L.).

Short chain chlorinated paraffins (SCCPs) are ubiquitous persistent organic pollutants. They have been widely detected in plant-based foods and might cause adverse impacts on humans. Nevertheless, uptake and accumulation mechanisms of SCCPs in plants remain unclear.

Identification of endoplasmic reticulum stress-related signature characterizes the tumor microenvironment and predicts prognosis in lung adenocarcinoma.

Lung adenocarcinoma (LUAD) remains one of the most lethal malignancies worldwide, with a high mortality rate and unfavorable prognosis. Endoplasmic reticulum (ER) stress is a key regulator of tumour growth, metastasis, and the response to chemotherapy, targeted therapies and immune response. It acts via responding to misfolded proteins and triggering abnormal activation of ER stress sensors and downstream signalling pathways.

In vitro assessment of the pesticide bioaccessibility in Dendrobium officinale Kimura et Migo.

Bioaccessibility (BA) is a crucial factor for evaluating the absorption of pollutants in the human digestion system, which is of vital importance for risk assessment of pollutants via food intake. Multi-pesticides were detected in Dendrobium officinale Kimura et Migo (D. officinale), a popular dual-use plant with both botanical medicine and food applications.