Postpartum depression risk prediction using explainable machine learning algorithms.

Objective: Postpartum depression (PPD) is a common and serious mental health complication after childbirth, with potential negative consequences for both the mother and her infant. This study aimed to develop an explainable machine learning model to predict the risk of PPD and to identify its key predictive factors.

Methods: A retrospective analysis was conducted on 1,065 women who attended their 6-week postpartum follow-up visit at a tertiary maternal and child healthcare hospital in Shenyang, China, from January to December 2021.

Correction: Elevated mean arterial pressure and risk of impaired fasting glucose: a multicenter cohort study revealing age and sex interactions.

[This corrects the article DOI: 10.3389/fendo.2025.

In vitro assessment of the osteogenic and antibacterial capabilities of Mg-MOF particles with encapsulated Levofloxacin within polydopamine.

Infectious bone defect is a condition where infection and bone defect occur simultaneously. The simultaneous achievement of effective antimicrobial management and enhanced bone regeneration continues to present a major hurdle in musculoskeletal therapeutics. To address these limitations, we have developed a novel osteoconductive material, this material (PDA@Mg-MOF-LEV) consists of Magnesium-based metal-organic frameworks (Mg-MOF) particles loaded with the antibiotic levofloxacin (LEV) and coated with polydopamine (PDA), which integrates photothermal therapy with antibiotic delivery to combat bacterial drug resistance and facilitate bone tissue regeneration.

The associations of calf circumference and cardiovascular and all-cause mortality among population with chronic kidney disease stages 3-5.

Previous studies have described the association between calf circumference (CC) and chronic kidney disease (CKD). We aim to evaluate the associations between CC and cardiovascular and all-cause mortality in patients with CKD stages 3-5. Data on CKD were sourced from the National Health and Nutritional Examination Survey (NHANES) 1999-2004.

Effectiveness and safety of a hydrophobic aspheric monofocal intraocular lens with molding process for cataract surgery.

Background: To evaluate the effectiveness and safety of a novel hydrophobic aspheric monofocal intraocular lens (IOL) in cataract surgery.

Methods: This is a prospective, multicenter, randomized, open-label, parallel-controlled clinical study, conducted at nine sites in P.R.

Source apportionment and ecological risk of heavy metals in sediments from estuaries and bays in China: insights into cross-regional transport.

Heavy metals (HMs), recognized as global pollutants, pose a serious threat to ecological security and human health. HMs sources and pollution characteristics exhibit considerable complexity under varying climatic conditions and regional environmental contexts. This study investigates the migration patterns, sources, and spatial distribution of HMs in sediments from representative estuaries and bays in China between 2017 and 2020.

Clinical outcomes of arthroscopic triangular anchor-stellate suture technique for massive L/U-shaped rotator cuff tears.

Background: Massive rotator cuff tears are a major cause of shoulder pain and limited function. While arthroscopic repair is common, treating complex L- or U-shaped tears, which involve tendon retraction and uneven tension, remains difficult. Specialized surgical methods are needed to restore normal anatomy and improve function.

Controllable Synthesis of Hollow Porous SiO Nanoparticles with Tunable Pore Sizes and Their Pesticide Release Kinetic Studies.

Pesticides are widely used to ensure crop yields and quality in agriculture. However, most pesticides are easily decomposed, leading to the overuse of pesticides for long-lasting control of pests and diseases, which pose serious hazards to the environment and human health. Herein, we propose a strategy to prepare hollow porous silica nanoparticles (SiO NPs) using 1,3,5-trimethylbenzene (TMB) as a pore-expanding agent and CaCO NPs as templates.

Elevated mean arterial pressure and risk of impaired fasting glucose: a multicenter cohort study revealing age and sex interactions.

Background: Evidence connecting mean arterial pressure (MAP) with impaired fasting glucose (IFG) was currently insufficient. The purpose of our research was to investigate how age and sex individually affect the relationship between MAP and the onset of IFG.

Methods: Our study was a retrospective cohort analysis involving 184,291 participants from a multicenter health examination in China.

Postpartum depression in Northeastern China: a cross-sectional study 6 weeks after giving birth.

Introduction: Postpartum depression (PPD) is a prevalent mental health issue that poses significant challenges to maternal wellbeing and infant development. We aimed to determine the prevalence of PPD and to investigate its associated determinants and predictors in in Shenyang, China.

Methods: This cross-sectional study, conducted between January and December 2021, included 1,065 postpartum women in Shenyang, China, at 6 weeks postpartum.

Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer via extracellular vesicle transfer of RNA.

The pathological role and mechanism of psychological stress in cancer progression are little known. Here we show in a mouse model that psychological stress drives pancreatic ductal adenocarcinoma (PDAC) progression by stimulating tumour nerve innervation. We demonstrate that nociception and other stressors activate sympathetic nerves to release noradrenaline, downregulating RNA demethylase alkB homologue 5 (Alkbh5) in tumour cells.

Identification of novel plasma proteins as promising noninvasive biomarker for early diagnosis and surveillance of pancreatic ductal adenocarcinoma.

Background: Although cancer antigen 19-9 (CA 19-9) is the only FDA-approved biomarker for pancreatic ductal adenocarcinoma (PDAC), its diagnostic effectiveness is limited, as it may not be elevated in 15-25% of patients. This study aims to explore novel plasma proteins associated with PDAC as potential biomarkers for early diagnosis and clinical surveillance.

Methods: Novel plasma protein biomarkers potentially causally associated with PDAC were identified using Mendelian randomization (MR).

Network Pharmacology and Experiments to Verify the Effect and Potential Mechanism of Baicalein on Osteoporosis.

Background: Baicalein (BN), a potent flavonoid derived from scutellaria scutellaria, exhibits an array of noteworthy attributes, such as anti-inflammatory, antibacterial, and antipyretic properties. Furthermore, its potential in treating osteoporosis has been highlighted. Nonetheless, the exact modes of action responsible for its therapeutic effects remain obscure.

Spatiotemporal variations, source apportionment, and cross-regional impacts of microplastics in surface seawater of Chinese Marginal Seas.

Microplastics (MPs) are widely distributed as a global pollutant, with dynamic patterns driven by horizontal diffusion and vertical mixing in marine ecosystems across different hydrological seasons and regions. This study employed MATLAB for image processing and interactive operations to extract data from existing studies on the Chinese Marginal Seas conducted from 2016 to 2022, focusing on the distribution, sources, and transport processes of MPs. The results revealed that the Bohai Sea exhibited the highest pollution levels during both the rainy (9328.

CSTF2-impeded innate αβ T cell infiltration and activation exacerbate immune evasion of pancreatic cancer.

Alternative cleavage and polyadenylation (APA) have gained increasing attention in cancer biology, yet its role in modulating anti-tumor immune response remains largely unexplored. Here, we identify the cleavage stimulation factor 2 (CSTF2), an APA-related gene, as a pivotal suppressor of anti-tumor immunity in pancreatic ductal adenocarcinoma (PDAC). CSTF2 promotes tumor development by inhibiting the infiltration and cytotoxic immune cell recruitment function of TCRαβCD4CD8NK1.

The De Ritis ratio mediates the association between creatinine-to-body weight ratio and normoglycemic conversion in Chinese health examinees.

To assess the associations between the creatinine-to-body weight (Cre/BW) ratio and reversion to normoglycemia mediated by the aspartate aminotransferase-to-alanine aminotransferase (De Ritis) ratio. This retrospective cohort study included 24,884 prediabetic participants from health check-ups in 32 regions across 11 Chinese cities. We employed multivariable Cox regression to assess time-to-event outcomes, smooth curve fitting for trend analysis, and inflection point analysis to determine critical thresholds.

Association between hepatic steatosis index and glucose status conversion from impaired fasting glucose base on Chinese adults: a cohort study from real-world.

Objective: Evidence regarding the relationship between the hepatic steatosis index (HSI) and glycemic conversion outcomes in individuals with impaired fasting glucose (IFG) is still limited. Our study aims to explore the role of HSI in the reversion to normoglycemia or the progression to diabetes among Chinese IFG individuals.

Methods: We conducted a retrospective analysis using data from 11,327 IFG individuals who had undergone wellness examinations at Rich Healthcare Group.

Long-term storage of rainwater: Assessing the efficacy of disinfection methods on water quality and pathogenic species dynamics.

Ultraviolet (UV) disinfection and solar pasteurization are commonly used methods for rainwater treatment, but the changes in water quality and pathogenic species during long-term storage require further investigation. This study conducts a 60-day static rainwater storage experiment to evaluate changes in microbial community structure and pathogen characteristics under different disinfection methods, providing guidance for the resource utilization of rainwater. The results show that both UV disinfection and solar pasteurization effectively reduce microbial diversity and the abundance of pathogenic species.

Potential mechanisms of non-coding RNA regulation in Alzheimer's disease.

Alzheimer's disease, a progressively degenerative neurological disorder, is the most common cause of dementia in the elderly. While its precise etiology remains unclear, researchers have identified diverse pathological characteristics and molecular pathways associated with its progression. Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.

Targeting MXD1 sensitises pancreatic cancer to trametinib.

Background: The resistance of pancreatic ductal adenocarcinoma (PDAC) to trametinib therapy limits its clinical use. However, the molecular mechanisms underlying trametinib resistance in PDAC remain unclear.

Objective: We aimed to illustrate the mechanisms of resistance to trametinib in PDAC and identify trametinib resistance-associated druggable targets, thus improving the treatment efficacy of trametinib-resistant PDAC.

Efficacy and safety of Epimedium total flavonoids for primary osteoporosis: a systematic review and meta-analysis.

Background: Epimedium total flavonoids (EF) have been recommended to be one of the effective components in Traditional Chinese Medicine (TCM) for the treatment of primary osteoporosis (POP) in China. Due to the lack of evidence-based medical evidence on the efficacy and safety of EF for the treatment of POP, the current systematic review and meta-analysis was carried out aimed at evaluating the curative effects and safety profile of EF treatment for POP in order to provide decision making references for clinical research.

Methods: The PubMed, Cochrane Library, EMBASE, Web of Science, CNKI, Wanfang, and VIP databases were searched from the date of inception to 11 August 2024.

Gut Microbiota Dysbiosis Facilitates Susceptibility to Bloodstream Infection.

To study the role of intestinal flora in the development of bloodstream infections (BSIs). 42 patients and 19 healthy controls (HCs) were screened into the study and their intestinal flora was measured by 16S rRNA gene sequencing. The bacterial diversity was significantly lower in the BSI group compared with that in the HCs (P < 0.

Association of triglyceride-glucose index with diabetes or prediabetes in Chinese hypertensive patients: A retrospective cohort study.

Insulin resistance is a key factor in diabetes development. This study aimed to investigate the association between baseline triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, and the onset of hyperglycemia in Chinese individuals with hypertension. Using the Rich Healthcare Group database, this retrospective cohort study included 28,687 hypertensive individuals without preexisting diabetes.