Successful treatment of disfiguring facial scar using surgery combined with superficial radiotherapy: a case report with literature review.

Introduction: Facial scars are generally disfiguring and can cause both physiological and psychological trauma. Currently, there is a lack of effective treatment options for facial scars. In recent years, local superficial radiation therapy has emerged as a clinically proven treatment to effectively prevent scar recurrence after surgery.

Characteristics, Exposure risk and Occurrence of Environmental Persistent Free Radicals in PM2.5-A case study in Baoding.

Environmental Persistent Free Radicals (EPFRs) in fine atmospheric particulate matter (PM2.5) can help the production of reactive oxygen species, leading to oxidative damage to people. In this study, Electron Spin Resonance (ESR) spectroscopy was utilized to detect EPFRs in PM2.

Strong Translation Elongation Factor 1-Alpha () Promoter Reporter Systems for .

Strong promoters are crucial for microbial metabolic engineering and synthetic biology, enabling high-level gene expression and pathway optimization. In this study, we have identified the translation elongation factor 1-α gene promoter (p) with its first intron (p) as the strongest promoter reported to date in . It exhibited more than 20-fold higher activity in a methylumbelliferone reporter assay than the commonly used glyceraldehyde-3-phosphate dehydrogenase () promoter.

Mechanistic exploration of obesity-related indicators and motor cognitive risk syndrome: a mediated effect based on C-reactive protein triglyceride glucose index.

Objective: To investigate the relationships between obesity-related indicators and motor cognitive risk syndrome (MCR), as well as the mediating role of the C-reactive protein triglyceride glucose index (CTI).

Methods: The aim of this study was to provide evidence-based support to optimize MCR screening programs and develop prevention strategies for cognitive impairment in elderly individuals. This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) in 2015, and 5,665 participants were ultimately included.

as a model system for studying the effects of porcine rotavirus on intestinal immunity.

Introduction: is a quintessential model organism that has been used in many scientific studies. The intestinal immune response of flies is a critical component of their innate immune system. Given that flies primarily consume decaying organic matter, harmful microorganisms present in their food can enter the intestine, leading to frequent infections by exogenous pathogens.

Divergent aryne regulation for polycyclic aromatic hydrocarbons.

Arynes are straightforward and effective synthons for π-extension accompanying by vicinal difunctionalization simultaneously, thereby being ideal building blocks for polycyclic aromatic hydrocarbons (PAHs) construction. However, CC triple bond in an aromatic system, with the distorted bond angle and shortened bond distance, arouses tremendous challenges for thermodynamic stability and kinetically reactive selectivity, especially for heteroarynes. Herein, controllable aryne generation was achieved for nitrogen-doped polycyclic aromatic hydrocarbons via designed cyclic pyridine-benzene λ-iodanes, in which the iodine ensured the thermodynamic stability and kinetic site-selectivity via p→π* interaction with aryne for chemo- and regio-selectivity.

Correlation between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with prognosis in gastric cancer patients undergoing neoadjuvant chemotherapy: a meta-analysis.

Introduction: Inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with poorer prognosis of gastric cancer (GC) patients and may guide treatment decisions. This meta-analysis aims to evaluate the impact of NLR and PLR on the prognosis of GC patients undergoing neoadjuvant chemotherapy (NAC).

Methods: Cochrane, Embase, PubMed and Web of science were searched for studies up to November 30, 2024.

Application of dielectric discharge barrier plasma: A technique for reducing microorganisms, improving antioxidant capacity, and inhibiting softening of winter jujube.

Postharvest deterioration of winter jujube, characterized by peel browning, textural softening, and microbial proliferation, was addressed using in-package dielectric barrier discharge (DBD) plasma technology. Through Box-Behnken design optimization (voltage: 93 kV, treatment time: 99 s, frequency: 92 Hz), storage-induced changes in microbial count, visual characteristics, antioxidant capacity, and cell wall-degrading enzymes were systematically evaluated. Results indicated the optimized treatment reduced the total viable bacteria and mold/yeast count by 1.

Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer via extracellular vesicle transfer of RNA.

The pathological role and mechanism of psychological stress in cancer progression are little known. Here we show in a mouse model that psychological stress drives pancreatic ductal adenocarcinoma (PDAC) progression by stimulating tumour nerve innervation. We demonstrate that nociception and other stressors activate sympathetic nerves to release noradrenaline, downregulating RNA demethylase alkB homologue 5 (Alkbh5) in tumour cells.

Enabling malic acid production from corn-stover hydrolysate in Lipomyces starkeyi via metabolic engineering and bioprocess optimization.

Background: Lipomyces starkeyi is an oleaginous yeast with a native metabolism well-suited for production of lipids and biofuels from complex lignocellulosic and waste feedstocks. Recent advances in genetic engineering tools have facilitated the development of L. starkeyi into a microbial chassis for biofuel and chemical production.

[Retracted] Crocin protects against dexamethasone‑induced osteoblast apoptosis by inhibiting the ROS/Ca‑mediated mitochondrial pathway.

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the flow cytometric plots shown in Fig. 2A on p. 404, the 'Ctrl' and 'Dex + Cro 5μM' panels appeared to share a very similar distribution of data in their lower left quadrants, whereas the other parts of the panels appeared differently, which would not have been anticipated if these experiments had been performed discretely under different experimental conditions, suggesting a fundamental flaw either in the way in which these experiments were performed or in how the results were outputted.

Wet oxidation of NO with NaClO in alkaline conditions: effects of acidic components in flue gas.

Excessive ClO tends to be produced and escape, causing secondary pollution when wet oxidation of NO with NaClO is conducted under acidic conditions. NaClO alkaline oxidation has accordingly received a wide attention. In this work, NaClO alkaline oxidation of NO has been systematically studied in a self-built spray tower.

Triple cross-electrophile coupling enabled by palladium/norbornene cooperative catalysis.

Cross-electrophile coupling (XEC) is a powerful strategy for forming C-C bonds in synthetic organic chemistry. While XEC reactions between two electrophiles are well established, those involving three distinct electrophiles have remained underdeveloped. Herein, we report an intriguing formal triple XEC enabled by palladium/norbornene cooperative catalysis.

Identification of novel plasma proteins as promising noninvasive biomarker for early diagnosis and surveillance of pancreatic ductal adenocarcinoma.

Background: Although cancer antigen 19-9 (CA 19-9) is the only FDA-approved biomarker for pancreatic ductal adenocarcinoma (PDAC), its diagnostic effectiveness is limited, as it may not be elevated in 15-25% of patients. This study aims to explore novel plasma proteins associated with PDAC as potential biomarkers for early diagnosis and clinical surveillance.

Methods: Novel plasma protein biomarkers potentially causally associated with PDAC were identified using Mendelian randomization (MR).

Porous-dual-shell structure and heterojunction CoO@NiCoO accelerating polysulfides conversion for all-solid-state lithium sulfur batteries.

All-solid-state lithium sulfur batteries (ASSLSBs) hold significant promise in the application of high energy density batteries, yet they suffer from poor ionic conductivity, low Li transference number and unsatisfactory lithium polysulfides (LiPSs) conversion. In this paper, porous-dual-shell structure and heterojunction CoO@NiCoO is prepared and composited with polyethylene oxide (PEO)-based solid polymer electrolytes (SPEs) to address these problems. The superimposed electric field for CoO@NiCoO composed of the heterointerfaces -build-in electric field and the surface oxygen-rich vacancies-build-in electric field facilitates the dissociation of Li salts, thus improving the ionic conductivity.

An innovative high-throughput genome releaser for rapid and efficient PCR screening.

High-throughput PCR screening is vital in synthetic biology and metabolic engineering, enabling rapid and precise analysis of genetic modifications. However, current methods face challenges including inefficient DNA extraction, high variability across sample types, scalability limitations, and the high cost of template DNA extraction. To address these common challenges, we developed a High-Throughput Genome Releaser (HTGR).

A uranyl-based metal-organic framework featuring an eight-connected UL cage for guest capture.

A novel (3,6)-connected uranyl-based MOF (IHEP-50) was synthesized by a judicious combination of UO and polycarboxylic acid, 4,4',4'',4''',4'''',4'''''-(((1,3,5-triazine-2,4,6-triyl)tris(azanetriyl))hexakis(methylene))hexabenzoic acid (HDTPCA). Two DTPCA ligands are connected together four uranyl cations to form a lantern-shaped cage UL, which is further connected with other eight equivalent ones to form a 3D porous framework with two kinds of 1D channels. These large pore structures give it certain potential for guest molecule capture.

Progress of porous tantalum surface-modified biomaterial coatings in bone tissue engineering.

Tantalum (Ta) metal has emerged as a prominent material within the realm of bone tissue engineering, owing to its favorable biocompatibility, commendable mechanical attributes, and notable biological properties such as osteoconductivity, osteoinductivity, and angiogenic potential. However, as clinical applications have expanded, Ta implants have unveiled a spectrum of limitations. Consequently, porous tantalum (PTa) has garnered escalating interest, attributable to its unique microstructural attributes, tunable mechanical characteristics, and inherent biocompatibility.

Relationship between albumin-corrected anion gap and lumbar spine bone mineral density: a cross-sectional study.

Objectives: This study aimed to investigate the relationship between albumin-corrected anion gap (ACAG) and lumbar spine bone mineral density (BMD) in a diverse population, assessing how variations in ACAG levels correlate with changes in lumbar spine BMD and the potential implications for osteoporosis risk.

Methods: A cross-sectional analysis was conducted involving 3,057 participants (1,555 males and 1,502 females). Participants were stratified into quartiles based on baseline ACAG levels.

Application and progress of 3D printed biomaterials in osteoporosis.

Osteoporosis results from a disruption in skeletal homeostasis caused by an imbalance between bone resorption and bone formation. Conventional treatments, such as pharmaceutical drugs and hormone replacement therapy, often yield suboptimal results and are frequently associated with side effects. Recently, biomaterial-based approaches have gained attention as promising alternatives for managing osteoporosis.

Application of Light-Responsive Nanomaterials in Bone Tissue Engineering.

The application of light-responsive nanomaterials (LRNs) in bone tissue engineering shows broad prospects, especially in promoting bone healing and regeneration. With a deeper understanding of the mechanisms of bone defects and healing disorders, LRNs are receiving increasing attention due to their non-invasive, controllable, and efficient properties. These materials can regulate cellular biological reactions and promote bone cell adhesion, proliferation, and differentiation by absorbing specific wavelengths of light and converting them into physical and chemical signals.

Targeting MXD1 sensitises pancreatic cancer to trametinib.

Background: The resistance of pancreatic ductal adenocarcinoma (PDAC) to trametinib therapy limits its clinical use. However, the molecular mechanisms underlying trametinib resistance in PDAC remain unclear.

Objective: We aimed to illustrate the mechanisms of resistance to trametinib in PDAC and identify trametinib resistance-associated druggable targets, thus improving the treatment efficacy of trametinib-resistant PDAC.

Cage-Based Metal-Organic Framework Featuring a Double-Yolk Core-Shell UL@UL Structure for Iodine Capture.

Cage-based MOFs, with their customizable chemical environments and precisely controllable nanospaces, show great potential for the selective adsorption of guest molecules with specific structures. In this work, we have constructed a novel cage-based MOF [(CH)NH][(UO)(TMTTA)]·11.5DMF·2HO (IHEP-51), utilizing a triazine derivative poly(carboxylic acid), 4,4',4″-(((1,3,5-triazine-2,4,6-triyl)tris(((4-carboxycyclohexyl)methyl)azanediyl))tris(methylene))tribenzoic acid (HTMTTA), as an organic ligand and uranyl as a metal node.

A real-world disproportionality analysis of the US Food and Drug Administration (FDA) adverse event reporting system (FAERS) events for Durvalumab.

Background: In the past few years, an increasing number of research studies have documented the utilization of durvalumab in the field of immunotherapy for cancerous tumors. However, there remains insufficient documentation regarding its associated adverse event (AEs). In order to enhance our comprehension of its toxicological profile, this investigation retrospectively examined the AEs linked to durvalumab using data from the US Food and Drug Administration adverse event reporting system (FAERS).