A wireless sensor for nanosecond transient electric field measurement based on asymptotic conical antenna and high-speed data acquisition technology.

The transient electromagnetic field generated by the operation of high-voltage switches in substations can cause electromagnetic interference to the communication and control electronic equipment in the substation. On the other hand, it can also reflect the working status of the high-voltage switch itself. Therefore, it is necessary to measure and study it.

Tumor Microenvironment-Responsive Nanodrug for Embolotherapy and Enhanced Chemotherapy.

Embolotherapy is an effective antitumor method, which essentially blocks the oxygen supply and induces hypoxia to treat tumors; however, traditional practices demand high expertise and harbor risks of complications. This study presents a mesoporous polydopamine-based (MPDA) drug delivery platform modified by engineered fusion proteins, which can specifically embolize tumor blood vessels and deliver the hypoxia-activated prodrug tirapazamine (TPZ). The fusion protein consists of an affibody targeting HER-2, a substrate for MMP-2, an RGD tripeptide, and a truncated tissue factor (tTF), which is then connected to MPDA loaded with TPZ.

Ursodeoxycholic acid inhibits the uptake of cystine through SLC7A11 and impairs synthesis of glutathione.

Ursodeoxycholic acid (UDCA) is a naturally occurring, low-toxicity, and hydrophilic bile acid (BA) in the human body that is converted by intestinal flora using primary BA. Solute carrier family 7 member 11 (SLC7A11) functions to uptake extracellular cystine in exchange for glutamate, and is highly expressed in a variety of human cancers. Retroperitoneal liposarcoma (RLPS) refers to liposarcoma originating from the retroperitoneal area.

Construction of Z-scheme heterojunction interfacial charge transfer pathways in ZnInS@NENU-5 for photocatalytic hydrogen evolution.

Utilizing the design of heterojunction structures formed between photocatalysts to enhance photoelectrochemical performance represents an effective strategy for improving the efficiency of photocatalytic hydrogen production. In this work, a straightforward one-step solvothermal method was employed to embed NENU-5 nano-octahedra within ZnInS nanoflowers, forming ZnInS@NENU-5 heterostructures. Hydrogen production tests conducted over 5 h revealed a hydrogen evolution activity of 5282.

Targeting Nuclear Receptor Coactivator SRC-1 Prevents Colorectal Cancer Immune Escape by Reducing Transcription and Protein Stability of PD-L1.

Programmed death-ligand 1 (PD-L1) is overexpressed in multiple cancers and critical for their immune escape. It has previously shown that the nuclear coactivator SRC-1 promoted colorectal cancer (CRC) progression by enhancing CRC cell viability, yet its role in CRC immune escape is unclear. Here, we demonstrate that SRC-1 is positively correlated with PD-L1 in human CRC specimens.

Effect of scanning speeds on mechanical properties of CoCrNi medium entropy alloy prepared by laser additive manufacturing.

Medium entropy alloy (MEA) is a hot spot in the field of material research in recent years. At present, the most widely used processing method of MEAs is "casting-rolling-heat treatment", and the preparation of CoCrNi MEA by laser additive manufacturing (LAM) is still in primary stage. In this study, CoCrNi MEAs were fabricated with different scanning speeds by laser additive manufacturing, and the influence of scanning speed on its mechanical properties was investigated.

Hybrid coordination for the fast formation building of multi-small-AUV systems with the on-board cameras and limited communication.

Formation building for multi-small-AUV systems with on-board cameras is crucial under the limited communication underwater environment. A hybrid coordination strategy is proposed for the rapid convergence to a leader-follower pattern. The strategy consists of two parts: a time-optimal local-position-based controller (TOLC) and a distributed asynchronous discrete weighted consensus controller (ADWCC).

High performance of visible-light driven hydrogen production over graphdiyne (g-CH)/MOF S-scheme heterojunction.

Among carbon allotropes, 2D graphdiyne (GDY) possesses the merits of good ductility, strong conductivity and an adjustable energy band structure. In this study, a GDY/ZnCo-ZIF S-scheme heterojunction photocatalyst has been successfully prepared by a low-temperature mixing method. Using eosin as a photosensitizer and triethanolamine as a solvent, the hydrogen production of the GDY/ZnCo-ZIF-0.

Identification of MDM2 as a prognostic and immunotherapeutic biomarker in a comprehensive pan-cancer analysis: A promising target for breast cancer, bladder cancer and ovarian cancer immunotherapy.

Background: The murine double minute 2 (MDM2) gene is a crucial factor in the development and progression of various cancer types. Multiple rigorous scientific studies have consistently shown its involvement in tumorigenesis and cancer progression in a wide range of cancer types. However, a comprehensive analysis of the role of MDM2 in human cancer has yet to be conducted.

Comparative Study of Gravimetric Humidity Sensor Platforms Based on CMUT and QCM.

Humidity sensors with comprehensive performance are of great interest for industrial and environmental applications. Most sensors, however, have to compromise on at least one characteristic such as sensitivity, response speed, and linearity. This paper reports a gravimetric humidity sensor based on a capacitive micromachined ultrasonic transducer (CMUT) with exceptional all-around performance, and presents a side-by-side comparative investigation of two types of gravimetric humidity sensors for a better understanding of their characteristics and sensing mechanisms.

A broadband optical fiber transmission-based time domain measurement system for nanosecond-level transient electric field.

A novel nanosecond transient electric field (E-field) measurement system is developed in this paper to measure the E-field pulse caused by the operation of the high-voltage switch (switching E-field pulse) in the substation. An electrically small rod antenna is used as the receiving antenna and is matched by the operational amplifier with high input impedance to achieve broadband frequency response and stable working performance. A broadband analog optical fiber transmission system is further designed based on the high-frequency circuit model of the electronic components.

Identification of the potential roles of ring finger protein 8 in TP53-mutant breast cancer.

Breast cancer is one of the malignant tumors with the highest mortality rate. With the development of precise treatment technology for cancer, numerous molecular targets have been identified and applied in the treatment of diseases. The present study investigated the potential role of ring finger protein 8 (RNF8) in TP53-mutant breast cancer and explored its possible mechanisms of action through a combination of bioinformatics techniques and cell biology.

Demethylase-independent function of JMJD2D as a novel antagonist of p53 to promote Liver Cancer initiation and progression.

As a histone demethylase, JMJD2D can enhance gene expression by specifically demethylating H3K9me2/3 and plays an important role in promoting colorectal cancer progression. However, its role in liver cancer remains unclear. The expression of JMJD2D was examined in human liver cancer specimens and non-tumorous liver tissues by immunohistochemical or immunoblot analysis.

Design For The First Narrowband Filter For The Dark Energy Camera: Optimizing The LAGER Survey For ~ 7 Galaxies.

We present the design for the first narrowband filter NB964 for the Dark Energy Camera (DECam), which is operated on the 4m Blanco Telescope at the Cerro Tololo Inter-American Observatory. The NB964 filter profile is essentially defined by maximizing the power of searching for Lyman alpha emitting galaxies (LAEs) in the epoch of reionization, with the consideration of the night sky background in the near-infrared and the DECam quantum efficiency. The NB964 filter was manufactured by Materion in 2015.

RNA binding protein 24 deletion disrupts global alternative splicing and causes dilated cardiomyopathy.

RNA splicing contributes to a broad spectrum of post-transcriptional gene regulation during normal development, as well as pathological manifestation of heart diseases. However, the functional role and regulation of splicing in heart failure remain poorly understood. RNA binding protein (RBP), a major component of the splicing machinery, is a critical factor in this process.

Microdissected thin anterolateral thigh perforator flaps with multiple perforators: A series of case reports.

Introduction: The study aimed to explore the effect of microdissected thin anterolateral thigh (MTALT) perforator flap with multiple perforators on patients with complex defects on the hand, elbow, heel, or knee.

Methods: From March 2012 to February 2013, 5 patients with complex defects on the hand, elbow, heel, or knee were included. During the flap preparation, 2 to 3 perforators penetrating the fascia of the anterolateral femoral area were initially detected, and the deep fascia was incised.

New estimations on the upper bounds for the nuclear norm of a tensor.

Using the orthogonal rank of the tensor, a new estimation method for the upper bounds on the nuclear norms is presented and some new tight upper bounds on the nuclear norms are established. Taking into account the structure information of the tensor, an important factor affecting the upper bounds is discussed and some corresponding properties related to the nuclear norms are given. Meanwhile, some new results of the upper bounds on the nuclear norms are obtained.

Global profiling of Rbm24 bound RNAs uncovers a multi-tasking RNA binding protein.

RNA binding proteins serve as critical molecular switches in a multitude of post-transcriptional regulatory processes. In the heart and muscles, the tissue specific RNA binding protein, Rbm24, is known to play important developmental roles via driving different post-transcriptional processes. Nonetheless, the currently identified molecular targets and regulatory pathways seem inadequate to completely explain the observed developmental effects upon Rbm24 knockdown/knockout.

Corrigendum: Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes.

This corrects the article DOI: 10.1038/srep44870.

Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes.

RNA-binding protein Rbm24 is a key regulator of heart development and required for sarcomere assembly and heart contractility. Yet, its underlying mechanism remains unclear. Here, we link serine/threonine kinase 38 (Stk38) signaling to the regulation of Rbm24 by showing that Rbm24 phosphorylation and its function could be modulated by Stk38.

Rbm24 Regulates Alternative Splicing Switch in Embryonic Stem Cell Cardiac Lineage Differentiation.

The transition of embryonic stem cell (ESC) pluripotency to differentiation is accompanied by an expansion of mRNA and proteomic diversity. Post-transcriptional regulation of ESCs is critically governed by cell type-specific splicing. However, little is known about the splicing factors and the molecular mechanisms directing ESC early lineage differentiation.