LncRNA OIP5-AS1 Knockdown Targets miR-183-5p/GLUL Axis and Inhibits Cell Proliferation, Migration and Metastasis in Nasopharyngeal Carcinoma.

Nasopharyngeal carcinoma (NPC) is often associated with the infection of Epstein-Barr virus in nasopharynx and is mainly happened in South China and Southeast Asia. Recently, noncoding RNAs have been reported to regulate NPC carcinogenesis. LncRNA OIP5-AS1 participates in tumorigenesis and progression; however, the inherent mechanism of OIP5-AS1-mediated progression of NPC is unclear.

Research on the Road Performance of Asphalt Mixtures Based on Infrared Thermography.

Temperature segregation during the paving of asphalt pavements is one of the causes of asphalt pavement distress. Therefore, controlling the paving temperature is crucial in the construction of asphalt pavements. To quickly evaluate the road performance of asphalt mixtures during paving, in this work, we used unmanned aerial vehicle infrared thermal imaging technology to monitor the construction work.

Alcohol consumption, blood DNA methylation and breast cancer: a Mendelian randomisation study.

Alcohol intake is thought to be a risk factor for breast cancer, but the causal relationship and carcinogenic mechanisms are not clear. We performed an up-to-date meta-analysis of prospective studies to assess observational association, and then conducted MR analysis to make causal inference based on the genetic predisposition to alcohol consumption ("drinks per week") and pathological drinking behaviours ("alcohol use disorder" and "problematic alcohol use"), as well as genetically predicted DNA methylation at by alcohol-related CpG sites in blood. We found an observational dose-response association between alcohol intake and breast cancer incidence with an additional risk of 4% for per 10 g/day increase in alcohol consumption.

Glyphosate decreases bovine oocyte quality by inducing oxidative stress and apoptosis.

Glyphosate is a universal herbicide with genital toxicity, but the effect of glyphosate on oocytes has not been reported. This study aimed to evaluate the effect of glyphosate (0, 10, 20, 50 and 100 mM) on bovine oocyte maturation. We showed that 50 mM glyphosate adversely affects the development of bovine oocytes.

AgSe quantum dots damage the nervous system of nematode Caenorhabditis elegans.

Silver selenide quantum dots (AgSe QDs), as a novel type of QDs, are valuable in the biomedical application due to their low-toxic and excellent optical property in near infrared region, but the biosafety assessment of AgSe QDs is rare. In this study, the findings suggested that the accumulation of AgSe QDs in the body of nematodes decreased the lifespan and damaged normal neurobehaviors of Caenorhabditis elegan (C. elegans).

Compact cities and the Covid-19 pandemic: Systematic review of the associations between transmission of Covid-19 or other respiratory viruses and population density or other features of neighbourhood design.

Living in compact neighbourhoods that are walkable, well connected, with accessible green space can benefit physical and mental health. However, the pandemic raises concern up to what extent features of compact neighbourhood design affect transmission of viral respiratory infections. We conducted a systematic review to identify, appraise and synthesise evidence reporting associations between transmission of respiratory viruses, including Covid-19, and dwelling or population density or other features of neighbourhood design.

Discovery of 1,6-Naphthyridin-2(1)-one Derivatives as Novel, Potent, and Selective FGFR4 Inhibitors for the Treatment of Hepatocellular Carcinoma.

Fibroblast growth factor receptor 4 (FGFR4) has been identified as a potential target due to its transmission of the FGF19 signaling pathway, which is critical to hepatocellular carcinoma (HCC). Therefore, focusing on the specific Cys552 of FGFR4 subtype, we designed and synthesized a novel family of 1,6-naphthyridin-2(1)-one derivatives as potent and highly selective FGFR4 inhibitors. Through detailed structural optimizations, the representative compound exhibited improved FGFR4 inhibitory capability and selectivity and excellent anti-proliferative activities against FGFR4-dependent HCC cell lines.

Dimensional Optimization for ZnO-Based Mechano-ATRP with Extraordinary Activity.

Various piezoelectric nanomaterials were utilized in ultrasound-mediated atom transfer radical polymerization (ATRP), owing to their outstanding piezoelectric effect. However, the relationship between the morphology of those piezocatalysts and polymerization has not been clearly established. Herein, we employed different piezoelectric zinc oxide (ZnO) nanomaterials to achieve novel mechano-induced ATRP (mechano-ATRP).

Ultrafast Visible-Light-Induced ATRP in Aqueous Media with Carbon Quantum Dots as the Catalyst and Its Application for 3D Printing.

Photoinduced atom transfer radical polymerization (ATRP) has been proved to be a versatile technique for polymer network formation. However, the slow polymerization rates of typical ATRP limited its application in the field of additive manufacturing (3D printing). In this work, we introduced carbon quantum dots (CQDs) for the first time to the ATRP in aqueous media and developed an ultrafast visible-light-induced polymerization system.

Initial ecological restoration assessment of an urban river in the subtropical region in China.

Rivers in urbanised cities are often polluted, black, and odorous, with poor water quality and deteriorated ecology. Despite many river restoration studies, assessments of ecological responses to river restoration practices remain scant. Benthic animals are useful biological indicators showing the change and succession of river ecosystems; however, previous studies have mainly focussed on a few target species without considering overall ecosystem integrity.

Integrated physiological, transcriptomic and metabolomic analysis of the response of Trifolium pratense L. to Pb toxicity.

Lead (Pb) interferes with plant gene expression, alters metabolite contents and affects plant growth. However, the molecular mechanism underlying the plant response to Pb is not completely understood. In the present study, Trifolium pratense L.

Inherent Flame-Retardant, Humid Environment Stable and Blue Luminescent Polyamide Elastomer Regulated by Siloxane Moiety.

The rapid development of the polymeric materials market has created an urgent demand for the thermoplastic polyamide elastomer (TPAE) owing to its greater functionality, and ability to be synthesized via a facile and industrial route. In this work, a series of novel silicone-containing polyamides (PA1212/Si12) were successfully synthesized from 1,12-dodecarboxylic acid (LA), 1,12-dodecarbondiamine (DMDA), and 1,3-bis (amino-propyl) tetramethyldisiloxane (BATS), via a one-pot melt polycondensation method in the absence of a catalyst. FTIR, H-NMR, GPC and inherent viscosity results cohesively prove that the polymerization of monomers was well conducted, and the chemical structure was in high accordance with the design.

Grpel2 alleviates myocardial ischemia/reperfusion injury by inhibiting MCU-mediated mitochondrial calcium overload.

Mitochondrial calcium ([Ca]) overload is considered a major trigger of cardiomyocyte death during myocardial ischemia/reperfusion (I/R) injury. Grpel2 is located in mitochondria and facilitates the mtHSP70 protein folding cycle in oxidative stress. However, Grpel2 expression during I/R injury and its impact on I/R injury remain poorly understood.

The combination sequence effect on nitrogen removal pathway in hybrid constructed wetlands treating raw sewage from multiple perspectives.

The combination sequence of traditional hybrid constructed wetlands (HCWs) affects the removal of nitrogen in raw sewage, but the effect of the combination sequence on nitrogen removal pathway have seldom been reported, especially the specific conditions allowing anammox to occur. Three-stage HCWs, namely vertical flow (VF), horizontal flow (HF) and surface flow (SF) constructed wetlands, were arranged in six different sequences to investigate nitrogen removal efficiencies and microbial removal pathways using metagenomic and stable isotope analyses. Results showed that the combination sequence significantly affected nitrogen removal pathways in HCWs.

Mindfulness Moderates the Association Between Perceived Discrimination and Cyber Aggression Among Emerging Adults with Early Left-Behind Experience: A Longitudinal Study.

Purpose: Although the risk effect of perceived discrimination on left-behind youth's mental health (mainly emotional problems) has been demonstrated in prior studies, there is a lack of longitudinal studies examining the effect of perceived discrimination on behavioral problems, particularly in emerging adults with early left-behind experience. In addition, little is known about individual differences in terms of this association. In the present study, we draw on the social information processing model of aggression to examine the effect of perceived discrimination and mindfulness on cyber aggression.

Identification and responding to exogenous hormone of HB-KNOX family based on transcriptome data of Caucasian clover.

Caucasian clover (Trifolium ambiguum M. Bieb.) is a strongly rhizomatous, low-crowned perennial leguminous and ground-covering grass.

MAG2 and MAL Regulate Vesicle Trafficking and Auxin Homeostasis With Functional Redundancy.

Auxin is a central phytohormone and controls almost all aspects of plant development and stress response. Auxin homeostasis is coordinately regulated by biosynthesis, catabolism, transport, conjugation, and deposition. Endoplasmic reticulum (ER)-localized MAIGO2 (MAG2) complex mediates tethering of arriving vesicles to the ER membrane, and it is crucial for ER export trafficking.

Respiratory exposure to graphene quantum dots causes fibrotic effects on lung, liver and kidney of mice.

Graphene quantum dots (GQDs), as a novel graphene-based nanoparticle, presented a bright prospect in fields of biomedicine due to their excellent optical property. However, the biosafety assessment of GQDs is far behind their rapid development, which could restrict their wilder applications. This study focused on the potential adverse effects of two kinds of promising GQDs, i.

Exploring the Multicomponent Synergy Mechanism of Yinzhihuang Granule in Inhibiting Inflammation-Cancer Transformation of Hepar Based on Integrated Bioinformatics and Network Pharmacology.

Background: The Chinese patent drug Yinzhihuang granule (YZHG) is used to treat hepatitis B. This research is aimed at exploring the multicomponent synergistic mechanism of YZHG in the treatment of inflammation-cancer transformation of hepar and at providing new evidence and insights for its clinical application.

Methods: To retrieve the components and targets of Yinzhihuang granules.

Enhancing Brackish Water Desalination using Magnetic Flow-electrode Capacitive Deionization.

Flow-electrode capacitive deionization (FCDI) is viewed as a potential alternative to the current state-of-the-art electrodriven technology for the desalination of brackish water. However, the key shortcoming of the FCDI is still the discontinuous nature of the electrode conductive network, resulting in low electron transport efficiency and ion adsorption capacity. Here, a novel magnetic field-assisted FCDI system (termed magnetic FCDI) is proposed to enhance brackish water desalination, simply by using magnetic activated carbon (MAC) as flow electrodes.

A new set of 20 Multi-InDel markers for forensic application.

Insertion/deletion markers (InDels) become an important marker for forensic medicine because of their compatible typing techniques with STRs and lower mutation rates. Recent years, a new kind of DNA marker named Multi-InDel was reported as characterized by two or more tightly linked InDel loci within a short length of physical position, usually 200-300 nucleotides. Many pieces of research showed that Multi-InDels had excellent application values in ancestry inference and forensic medicine.

Reconfigurable Light Imaging in Photonic Higher-Order Topological Insulators.

Topological phases of matter with robust edge states have revolutionized the fundamental intuitions for wave control. The recent development of higher-order topological insulators (HOTIs) realizes even lower dimensional topological states that enable versatile wave manipulations (e.g.

Synthetic role of miR-200b-3p, ABCD score, and carotid ultrasound in the prediction of cerebral infarction in patients with transient ischemic attack.

Background: Transient ischemic attack (TIA) is a major risk factor for the occurrence of cerebral infarction (CI). This study aimed to evaluate the predictive value of the synthetic role of miR-200b-3p, ABCD score, and carotid ultrasound for CI onset in patients with TIA.

Methods: Expression of miR-200b-3p was detected by reverse transcription quantitative PCR and carotid stenosis degree was evaluated using carotid ultrasound examination.

One-pot synthesis of dihydro-β-ionone from carotenoids using carotenoid cleavage dioxygenase and enoate reductase.

Dihydro-β-ionone is a characteristic aroma compound of Osmanthus fragrans and is widely applied in the flavor & fragrance industry. However, the main focus is on chemical synthesis due to the metabolic pathways of dihydro-β-ionone is still unclear. Here, we explored the one-pot synthesis system for dihydro-β-ionone production using carotenoid cleavage dioxygenase (CCD) and enoate reductase.

Transcriptome Co-expression Network and Metabolome Analysis Identifies Key Genes and Regulators of Proanthocyanidins Biosynthesis in Brown Cotton.

Brown cotton fiber (BCF) is a unique raw material of naturally colored cotton (NCC). But characteristics of the regulatory gene network and metabolic components related to the proanthocyanidins biosynthesis pathway at various stages of its fiber development remain unclear. Here, the dynamic changes in proanthocyanidins biosynthesis components and transcripts in the BCF variety "Zong 1-61" and its white near-isogenic lines (NILs) "RT" were characterized at five fiber developmental stages (0, 5, 10, 15, and 20 days post-anthesis; DPA).