The Influence of Fracture Defect Size on Treatment Outcomes in Distal Femur Fractures: A Comparative Study Between Lateral Locking Plate and Double Plate Fixation.

Objective: Double plate (DP) fixation does not significantly improve outcomes compared to lateral locking plate (LLP-only) fixation for distal femur fractures (DFFs). We hypothesize this is due to the absence of clear indications for the application of these two fixation methods. This study aims to clarify the impact of metaphyseal defect size on the outcomes of these two treatments, in order to optimize surgical efficacy and minimize complications.

[Poster Fusion Cage combined with xenogeneic bone graft augmentation for bone defect management in distal radius fractures].

Objective: To evaluate the effectiveness of Poster Fusion Cage combined with xenogeneic bone graft augmentation for bone defect management in distal radius fractures.

Methods: A retrospective analysis was conducted on 20 patients with bone defects complicating distal radius fractures who met the selection criteria and were treated between June 2022 and June 2024. The cohort comprised 2 males and 18 females, aged 54-87 years (mean, 63.

Therapeutic Mechanism of Kynurenine, a Metabolite of Probiotics, on Atopic Dermatitis in Mice.

Atopic Dermatitis (AD) is a common inflammatory skin disease characterized primarily by its chronic and recurrent nature. This has a significant impact on productivity and human longevity. Dysbiosis of gut flora has been demonstrated to be significantly associated with the progression of AD.

Feasibility and Mechanical Strength Evaluation of New Customized Implants for Tibial Plateau Fractures Fixation.

Background And Objective: Customized implants could improve the capture of fracture fragments for strengthened stability of tibial plateau fractures (TPFs) fixation. This study aimed to validate the feasibility of customized implants through optimized manufacturing within a clinically acceptable timeframe and evaluate the mechanical strength of customized internal implants through finite element analysis.

Methods: A retrospective was conducted.

Uncovering a novel biosynthetic gene cluster for sordarin through genome mining in the fungus Talaromyces adpressus.

To explore the chemical and biological diversities of diterpenoids from the fungus Talaromyces adpressus, a previously unknown biosynthetic gene cluster (BGC, tdn) for sordarin (a well-known fungal antibiotics) was discovered by leveraging the genome mining method. Heterologous expressions of key genes of tdn in Aspergillus oryzae, led to the determination of one new diterpenoid, cycloaraneosene-9-ol-8-one (4), and three known diterpenoids, cycloaraneosene (1), cycloaraneosene-9-ol (2), cycloaraneosene-8,9-diol (3). The structures of 1-4 was elucidated well via detailed analysis of 1D and 2D NMR, GCMS, HRESIMS, IR data, and comparison with reported data.

Pre-carbonization-mediated construction of urchin-like NiFeO superparticles with enhanced CNT growth for efficient oxygen evolution.

In this study, we report the rational design and synthesis of carbonized NiFeO superparticles (CarSPs) hierarchically integrated with densely aligned carbon nanotube (CNT) architectures, hereafter denoted as CarSP-CNTs, which exhibit a biomimetic urchin-like morphology. Through exploitation of the colloidal self-assembly and catalytic functionalities inherent to NiFeO nanoparticles (NPs), we achieve seamless integration of one-dimensional CNT arrays with three-dimensional superstructural frameworks. Systematic investigation reveals that the pre-carbonization of surface-bound organic ligands coupled with subsequent CNT growth induces synergistic interplay between conductive carbon matrices and active spinel oxide phases.

A one-pot method for universal Dengue virus detection by combining RT-RPA amplification and CRISPR/Cas12a assay.

Dengue Virus (DENV) is a life-threatening pathogen leading to dengue fever, which brings about huge public health challenges globally. However, traditional detection methods currently fail to meet the increasing demands of clinic practice in terms of speed, simplicity, and accuracy. To address these limitations, we developed a novel, rapid, and highly sensitive diagnostic method for universal DENV detection by integrating recombinase polymerase amplification (RPA) assay and the Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) and associated (Cas) protein 12a (CRISPR/Cas12a) system into one-pot.

Larimichthys crocea isinglass polysaccharide attenuates DSS-induced colitis via gut microbiota regulation and NF-κB signaling inhibition.

This study aimed to investigate the therapeutic efficacy of Larimichthys Crocea Isinglass polysaccharide (CIP) in ameliorating DSS-induced colitis. CIP, a complex polysaccharide composed of six monosaccharides with a molecular weight of 3.97 kDa.

Optimized oxygen therapy improves sleep deprivation-induced cardiac dysfunction through gut microbiota.

Adequate sleep is of paramount importance for relieving stress and restoring mental vigor. However, the adverse physiological and pathological responses resulting from sleep insufficiency or sleep deprivation (SD) are becoming increasingly prevalent. Currently, the impact of sleep deficiency on gut microbiota and microbiota-associated human diseases, especially cardiac diseases, remains controversial.

Identification and validation of a major QTL, QFhb-6AL, for Fusarium head blight resistance on chromosome 6AL in wheat.

A novel major QTL, QFhb-6AL, accounting for 34.6% phenotypic variation for FHB resistance, was identified in the Chinese cultivar Xunong 029, and a near-diagnostic marker was developed for marker-assisted selection. Fusarium head blight (FHB) is a destructive disease in wheat (Triticum aestivum L.

Hyaluronic Acid-Based Therapy for Alleviating Early Lipid Peroxidation in Peripheral Nerve Compression Injury Repair.

Background: Peripheral nerve injuries compromise sensory and motor functions, severely affecting patients' quality of life. Early lipid peroxidation drives oxidative stress, disrupting the regenerative microenvironment. Hyaluronic acid (HA), an essential extracellular matrix component, shows promise in mitigating oxidative damage and fostering repair.

Fucoidan alleviated colitis aggravated by fiber deficiency through protecting the gut barrier, suppressing the MAPK/NF-κB pathway, and modulating gut microbiota and metabolites.

Insufficient dietary fiber intake has become a global public health issue, affecting the development and management of various diseases, including intestinal diseases and obesity. This study showed that dietary fiber deficiency enhanced the susceptibility of mice to colitis, which could be attributed to the disruption of the gut barrier integrity, activation of the NF-κB pathway, and oxidative stress. fucoidan (UPF) alleviated colitis symptoms in mice that fed with a fiber deficient diet (FD), characterized by increased weight gain and reduced disease activity index, liver and spleen indexes, and histological score.

Mapping and validation of QTkw.cau-3DL, a major QTL controlling thousand-kernel weight in wheat.

A novel major QTL, QTkw.cau-3DL, for thousand-kernel weight has been identified on the wheat chromosome arm 3DL and enhances grain yield by 6.2% under field conditions.

Positive impacts of typical desert photovoltaic scenarios in China on the growth and physiology of sand-adapted plants.

Desert regions are characterized by complex terrain, frequent wind-sand activities, and extreme environmental conditions making vegetation recovery after disturbances difficult. The construction of large-scale photovoltaic (PV) power stations presents a significant challenge in balancing with vegetation protection. This study focused on a large PV site in the Hobq Desert examining the growth characteristics of at different positions within fixed PV arrays.

Swimming by Spinning: Spinning-Top Type Rotations Regularize Sperm Swimming Into Persistently Progressive Paths in 3D.

Sperm swimming is essential for reproduction, with movement strategies adapted to specific environments. Sperm navigate by modulating the symmetry of their flagellar beating, but how they swim forward with asymmetrical beats remains unclear. Current methods lack the ability to robustly detect the flagellar symmetry state in free-swimming spermatozoa, despite its importance in understanding sperm motility.

Human Color Perception: The Impact of Color Perception on Fine-Grained Emotion Prediction in Movie and Television Videos.

This article investigates the impact of visual color perception on fine-grained emotion prediction in videos, analyzing the contribution of color perception features in fine-grained emotion prediction. A total of 20 subjects were involved in this experiment. First, 10 subjects conducted a fine-grained emotional subjective evaluation experiment on 50 video clips.

Low molecular fucoidan alleviated alcohol-induced liver injury in BALB/c mice by regulating the gut microbiota-bile acid-liver axis.

Fucoidan has attracted significant attention owing to its remarkable bioactivities, but the effect of molecular weight (Mw) on its activities in the context of alcoholic liver diseases (ALD) is poorly understood. In this study, low Mw fucoidan (OSLF) was prepared, and its protective effect against alcohol-induced liver injury was assessed in a mouse model. OSLF increased weight gain and colon length, improved lipid disorders, and reduced oxidative stress in mice exposed to alcohol, alleviating liver injury.

Curcumin-loaded polysaccharide microparticles alleviated DSS-induced ulcerative colitis by improving intestinal microecology and regulating MAPK/NF-κB/Nrf2/NLRP3 pathways.

Curcumin (Cur) exerts many benefits on the host, but its application is limited by its poor bioavailability. In this study, composite polysaccharide microparticles loading Cur (Cur-CPM) was prepared by food-grade materials and gel technology. Its properties were analyzed via the in vitro and in vivo models, and then its benefit on gut health was assessed in DSS-treated mice.

RBM25 is required to restrain inflammation via ACLY RNA splicing-dependent metabolism rewiring.

Spliceosome dysfunction and aberrant RNA splicing underline unresolved inflammation and immunopathogenesis. Here, we revealed the misregulation of mRNA splicing via the spliceosome in the pathogenesis of rheumatoid arthritis (RA). Among them, decreased expression of RNA binding motif protein 25 (RBM25) was identified as a major pathogenic factor in RA patients and experimental arthritis mice through increased proinflammatory mediator production and increased hyperinflammation in macrophages.

Fucoidan ameliorates alcohol-induced liver injury in mice through Parabacteroides distasonis-mediated regulation of the gut-liver axis.

Polysaccharides can benefit the liver via modulation of the gut microbiota, but the exact mechanism is still unclear. This study demonstrated that the effect of Scytosiphon lomentaria fucoidan (SLF) on alcohol-induced liver injury can be closely related to the level of Parabacteroides distasonis (Pd) via in vivo and in vitro models. Further mice experiment showed that Pd alleviated liver injury and inflammation by suppressing the NF-κB/MAPK pathways and activating Nrf2 pathway.

Fluid flow reconstruction around a free-swimming sperm in 3D.

We investigate the dynamics and hydrodynamics of a human spermatozoa swimming freely in 3D. We simultaneously track the sperm flagellum and the sperm head orientation in the laboratory frame of reference via high-speed high-resolution 4D (3D+t) microscopy, and extract the flagellar waveform relative to the body frame of reference, as seen from a frame of reference that translates and rotates with the sperm in 3D. Numerical fluid flow reconstructions of sperm motility are performed utilizing the experimental 3D waveforms, with excellent accordance between predicted and observed 3D sperm kinematics.

Potential role of salivary lactic acid bacteria in pathogenesis of oral lichen planus.

Background: Emerging evidence emphasized the role of oral microbiome in oral lichen planus (OLP). To date, no dominant pathogenic bacteria have been identified consistently. It is noteworthy that a decreased abundance of Streptococcus, a member of lactic acid bacteria (LAB) in OLP patients has been commonly reported, indicating its possible effect on OLP.

Consumers' risk perception, market demand, and firm innovation: Evidence from China.

Major product safety incidents often cause widespread concern among consumers, and these product safety incidents will stimulate consumers' psychology, change their risk perception, and affect the demand for products and services of risk consumers. The change in consumer demand will eventually lead to a change in firm innovation decisions. Using Chinese firm-level data, this paper employs the news reporting of the Bawang event as a quasi-natural experiment to study the impact of risk perception changes on innovation.