98%
921
2 minutes
20
Objective: Double plate (DP) fixation does not significantly improve outcomes compared to lateral locking plate (LLP-only) fixation for distal femur fractures (DFFs). We hypothesize this is due to the absence of clear indications for the application of these two fixation methods. This study aims to clarify the impact of metaphyseal defect size on the outcomes of these two treatments, in order to optimize surgical efficacy and minimize complications.
Methods: We screened patients with distal femoral fractures treated with lateral locking plate or dual plate fixation at our hospital between January 2018 and June 2023 retrospectively. Information such as demographic data, fracture classification, operation details, metaphyseal bone defect size, pre-nd post-operative imaging data, and other medical records were compiled. Additionally, patients' recovery status was follow-up, including evaluation of knee joint function (Lysholm score), range of motion (ROM), and EQ-5D-3L health score. We used diverse statistical methods for further analysis, such as t-test, chi-square test, Pearson correlation coefficients, and binary logistic regression analysis.
Results: According to the specified criteria, 55 distal femur fracture cases were ultimately included, with 38 cases in the LLP-only group and 17 cases in the DP fixation group. In terms of surgical and follow-up information, there were no statistical differences in healing status, but there were statistically significant differences in average blood loss (p = 0.013), metaphyseal bone defect size (p < 0.001), Lysholm score (p = 0.003), and EQ-5D score (p = 0.010). Notably, compared to other parameters, the size of the fracture defect exhibited the highest correlation (0.69) with healing outcomes. In logistic regression analysis, the defect size (OR 1.052, 95% CI 1.008-1.098, p = 0.021) was independently associated with the healing outcome. Upon further analysis, non-healing cases in the LLP-only group were predominantly associated with A3, C2, and C3 type fractures, with 83.3% of these patients presenting metaphyseal defects exceeding 15 mm.
Conclusions: We carried out a comparative evaluation of LLP-only versus DP fixation in addressing DFFs. Our research outcomes revealed that LLP-only fixation yielded notably suboptimal results compared to DP fixation, especially in intricate fractures accompanied by defects, such as those classified under types A3, C2, and C3. Furthermore, the more significant the defect, the less effective the fixation of LLP-only will be. This observation underscores the pivotal role of the scope of metaphysical damage in determining the most suitable internal fixation techniques for DFFs.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318682 | PMC |
http://dx.doi.org/10.1111/os.70103 | DOI Listing |
Front Pediatr
August 2025
Department of Pediatrics, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Background And Objective: This study aims to analyze the clinical characteristics of anti-GABAR encephalitis in pediatric patients. Due to its rarity and diagnostic challenges in children, we compare clinical features between adult and pediatric cases.
Materials And Methods: Using the key words "anti-GABAR encephalitis, children, autoimmune encephalitis, limbic encephalitis", we conduct a comprehensive literature review of all studies related to anti-GABAR encephalitis published from January 2010 to January 2024.
Beilstein J Nanotechnol
August 2025
Facultad de Ingeniería Mecánica y Eléctrica, Universidad Autónoma de Nuevo León. San Nicolás de los Garza, Nuevo León, 66455, México.
Nanoparticles in their pure colloidal form synthesized by laser-assisted processes such as laser ablation/fragmentation/irradiation/melting in liquids have attained much interest from the scientific community because of their specialties like facile synthesis, ultra-high purity, biocompatibility, colloidal stability in addition to other benefits like tunable size and morphology, crystalline phases, new compounds and alloys, and defect engineering. These nanocolloids are useful for fabricating different devices mainly with applications in optoelectronics, catalysis, sensors, photodetectors, surface-enhanced Raman spectroscopy (SERS) substrates, and solar cells. In this review article, we describe different methods of nanocolloidal synthesis using laser-assisted processes and corresponding thin film fabrication methods, particularly those utilized for device fabrication and characterization.
View Article and Find Full Text PDFJ Anat
September 2025
Institute of Biology, Biotechnology and Environmental Protection, Faculty of Natural Sciences, University of Silesia in Katowice, Katowice, Poland.
Vertebrates exhibit remarkable morphological diversity, with the head representing an exceptionally complex anatomical structure shaped by adaptations to feeding ecology, brain size, and sensory organ specialization. Proper fusion of facial prominences and the coordinated growth of the skull and brain are essential for normal craniofacial development in vertebrates, including humans. Disruptions in these processes, whether due to gene mutations or external factors, can result in craniofacial malformations.
View Article and Find Full Text PDFEMBO Mol Med
September 2025
Institute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, National Stem Cell Translational Resource Center & Ministry of Education Stem Cell Resource Center, Frontier Science Center for Stem Cell Research, School of Li
Primary microcephaly, a rare congenital condition characterized by reduced brain size, occurs due to impaired neurogenesis during brain development. Through whole-exome sequencing, we identified compound heterozygous loss-of-function mutations in CENTRIN 3 (CETN3) in a 5-year-old patient with primary microcephaly. As CETN3 has not been previously linked to microcephaly, we investigated its potential function in neurodevelopment in human pluripotent stem cell-derived cerebral organoids.
View Article and Find Full Text PDFHernia
September 2025
Center for Perioperative Optimization, Department of Surgery, Copenhagen University Hospital - Herlev and Gentofte, Borgmester Ib Juuls Vej 1, Herlev, DK-2730, Denmark.
Purpose: Primary ventral hernia repair is a common elective procedure; however, mesh placement practices vary widely, and there is limited evidence to guide optimal placement. This international study examined surgeons' preferences and considerations regarding mesh placement in elective primary ventral hernia repair.
Methods: We conducted an international cross-sectional survey targeting surgeons experienced in primary ventral hernia repair.