Tissue-specific endophytic microbiome responses to " Liberibacter asiaticus" in two citrus cultivars.

Citrus Huanglongbing (HLB), caused by "Candidatus Liberibacter asiaticus" (CLas), is a destructive disease threatening global citrus industry. Although citrus cultivars differ in HLB sensitivity, how infection alters endophytic bacterial communities in cultivars with contrasting susceptibility remains unclear. Here, we compared endophytic microbiome shifts in leaf and root tissue of HLB-susceptible Shatangju mandarin (C.

Life cycle environmental and economic assessment of co-combustion strategies for raw and landfilled municipal solid waste.

Co-combustion of landfilled municipal solid waste (LMSW) in raw municipal solid waste (RMSW) incinerators addressed regional incineration overcapacity and waste scarcity. However, the economic-environmental trade-offs at high co-combustion ratios remained unclear. This study integrated life cycle assessment (LCA) and life cycle costing (LCC) to quantify the impacts of LMSW co-combustion at varying ratios: 0 %, 15 %, 25 %, 35 %, and 45 %.

Distribution characteristics and formation mechanisms of PCDD/Fs during pyrolysis and gasification of municipal solid waste.

Pyrolysis gasification (PG) technology is a promising waste disposal technology, which is more efficient and cleaner compared with incineration technology. However, few work has studied the generation characteristics of polychlorinated dibenzo-p-dioxin and furans (PCDD/Fs) and the influencing factors in the PG process. This study investigates the effects of air ratio (AR) and gasification temperature on the generation and distribution of PCDD/Fs during the PG process of municipal solid waste (MSW).

Diversity and interdomain networks of bacterial, pico-protist and nano-protist communities in a marine ranching.

Microbes of diverse sizes and classifications collaborate to mediate a variety of biogeochemical processes. Although seasonal fluctuations in environmental variables generally influence microbial community dynamics, our comprehension of interdomain microbial co-occurrence patterns remains incomplete. Here, we analyzed high-throughput sequencing datasets of bacteria, pico-protists (0.

Self-Assembled Ag2S-Au Janus Nanoparticles for Targeted Photo-Responsive Thermal Ablation of Cancer Cells and Bacteria.

Janus nanoparticles (JNPs) represent one of the most complex nanoparticles, and achieving precise control over their synthesis remains a significant challenge. Here, we explore gold-silver sulfide (Au-Ag₂S) JNPs for targeted anticancer and antibacterial therapies. Au-Ag₂S JNPs were synthesized and characterized using TEM, HRTEM, XRD, EDS, and XPS, confirming their distinct dimeric structure with Au and Ag₂S components.

IPSC-induced podocytes from a BORS patient with EYA1 gene mutation showed glucocorticoid-resistant and cytoskeletal rearrangement.

The primary cause of branchio-oto-renal syndrome (BORS) is mutations in the EYA1 gene. The aim of this study was to investigate the clinical characteristics associated with induced podocyte reappearance in children with BORS and EYA1 mutations. We collected clinical and genetic data from a 4-year-old girl diagnosed with BORS and her family.

Diagnostic interchangeability of deep-learning based Synth-STIR images generated from T1 and T2 weighted spine images.

Objectives: To evaluate image quality and diagnostic interchangeability of synth short-tau inversion recovery (STIR) generated by deep learning in comparison with standard STIR.

Materials And Methods: This prospective study recruited participants between July 2023 and August 2023. Participants were scanned with T1WI and T2WI, then generated Synth-STIR.

Improving Operator Depth Vision in Gastrointestinal Endoscopy: A Pilot Study of a New Three-dimensional Imaging System.

Background And Aims: Traditional two-dimensional (2D) gastrointestinal endoscopy lacks depth perception, leading to potential diagnostic errors. This study evaluates a novel software-based three-dimensional (3D) endoscopy system that converts 2D images into 3D, compatible with existing endoscopes.

Methods: A randomized comparative study was conducted with 32 endoscopists at NTT Medical Center.

Apelin-to-total cholesterol ratio predicts long-term major adverse cardiovascular events in ST-elevation myocardial infarction patients after primary percutaneous coronary intervention: a retrospective cohort analysis.

Background: Despite advancements in ST-segment elevation myocardial infarction (STEMI) management, residual risks of major adverse cardiovascular events (MACE) persist. Apelin, a cardioprotective peptide with anti-inflammatory properties, and total cholesterol (TC), a key atherogenic factor, may synergistically influence outcomes. This study evaluated the prognostic value of the Apelin/TC ratio for long-term MACEs in STEMI patients undergoing primary percutaneous coronary intervention (PCI).

Contrasting patterns in diversity and community assembly of bacterioplankton and three size fractions of protists in the South China Sea.

The microbial food web plays a critical role in marine ecosystems, composed of various cell sizes of microbial organisms. Here, high-throughput sequencing of the 16S and 18S rRNA genes was conducted to detect the community structure and distribution patterns of bacterioplankton (0.2 µm-2 µm) and three size fractions of protist communities, i.

The Role of Computed Tomography and Artificial Intelligence in Evaluating the Comorbidities of Chronic Obstructive Pulmonary Disease: A One-Stop CT Scanning for Lung Cancer Screening.

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Comorbidities in patients with COPD significantly increase morbidity, mortality, and healthcare costs, posing a significant burden on the management of COPD. Given the complex clinical manifestations and varying severity of COPD comorbidities, accurate diagnosis and evaluation are particularly important in selecting appropriate treatment options.

Clinical Efficacy of Continuous Renal Replacement Therapy in Patients with Pulmonary Tuberculosis Complicated with Sepsis: A Retrospective Observational Study.

Objective: To explore the clinical efficacy of continuous renal replacement therapy (CRRT) in patients with pulmonary tuberculosis (TB) complicated with sepsis, particularly focusing on 28-day mortality (primary objective), and to assess the impact of CRRT on inflammatory response, renal function, haemodynamics and overall prognosis (secondary objectives).

Methods: A total of 98 patients with pulmonary TB complicated by sepsis were included: 49 patients were enrolled in the control group and received routine treatment, whereas 49 patients were enrolled in the CRRT group and received CRRT based on the control group. Renal function indicators, inflammatory indicators, haemodynamic indicators and recovery status were analysed and compared.

Synergistic Enhancement of Hydrolysis-Oxidation Drives Efficient Catalytic Elimination of Chlorinated Aromatics over VO/TiO Catalysts at Low Temperature.

The efficient catalytic elimination of toxic chlorinated aromatics (i.e., dioxins, chlorobenzenes, etc.

A novel integrated method for ultrasonic-assisted MSWI fly ash decarbonization with PCDD/Fs detoxification and synergistic heavy metals stabilization.

A novel ultrasonic-assisted flotation method was developed to enhance the harmless treatment and resource utilization of municipal solid waste incineration fly ash (MSWI FA). This study examined ultrasound effects on collector (kerosene) and frother (2-octanol) emulsification and its role in flotation decarbonization. Additionally, the mechanism of PCDD/Fs detoxification and heavy metals migration and stabilization were revealed.

Effectiveness and Safety of Simnotrelvir/Ritonavir and Nirmatrelvir/Ritonavir in the Treatment of Moderate to Severe COVID-19.

Background And Aim: Simnotrelvir/ritonavir and nirmatrelvir/ritonavir are major treatments for COVID-19, but their comparative efficacy and safety, especially in patients with moderate to severe COVID-19, remain unclear.

Methods: This was a retrospective cohort study using electronic medical record data. From May 30, 2023, to October 8, 2023, 115 patients with moderate to severe COVID-19 were retrospectively collected from Wenzhou Central Hospital.

Development and characterization of biodegradable antibacterial hydrogels of xanthan gum for controlled ciprofloxacin release.

The global public health challenge of antimicrobial resistance necessitates new treatment strategies, as existing antibiotics like ciprofloxacin face limitations such as short half-life, frequent dosing, adverse effects, and poor patient compliance. To attempt this, ciprofloxacin-loaded xanthan gum hydrogels were developed and characterized, and their cytotoxicity and antibacterial activities were evaluated. The interaction among hydrogel contents was confirmed by FTIR, whereas a decrease in the crystallinity of xanthan gum and drug was shown by XRD analysis of prepared hydrogels.

CT-Based radiomics nomogram of lung and mediastinal features to identify cardiovascular disease in chronic obstructive pulmonary disease: a multicenter study.

Rationale And Objectives: To investigate the performance of two diagnostic models based on CT-derived lung and mediastinum radiomics nomograms for identifying cardiovascular disease (CVD) in Chronic Obstructive Pulmonary Disease (COPD) patients.

Materials And Methods: Hospitalized participants with COPD were retrospectively recruited between September 2015 and April 2023. Clinical data and visual coronary artery calcium score (CACS) were collected.

Collaborative prediction and intelligent control of multiple pollutants emission from a large-scale waste incinerator.

Owing to the complexity of municipal solid waste (MSW), flue gas composition and operating conditions, it is challenging to predict pollutant emissions accurately and control them intelligently in the MSW incineration process. This study uses a 750 t/d large-scale grate-type MSW incinerator as the research object. Based on a long short-term memory (LSTM) model, collaborative prediction (co-prediction) of multiple pollutants (HCl, SO, NO, and PM) emissions from MSW incinerator flue gas was achieved.

Insight into the performance of VO-WO/TiO catalysts modified by various cerium precursors: A combined study on synergistic NO and chlorobenzene removal.

Cerium is widely used as a modifier to enhance the catalytic performance of the selective catalytic reduction (SCR) catalysts due to its exceptional low-temperature properties. However, the effects of different cerium precursors on catalytic performance remains unclear. In this study, VO-WO/TiO catalysts are modified using Ce(NO)·6HO (cata-N), CeO (cata-O), and Ce(OH) (cata-OH), and their synergistic removal of NO and chlorobenzene (CB), as well as their resistance to water and sulfur poisoning, were systematically investigated.

Difference of clinical characteristics in patients with reinfection and primary infection variants of SARS-CoV-2: a retrospective study in China.

Background: The number of patients experiencing re-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is progressively increasing. In this study, we aimed to explore the differences in clinical characteristics between patients with primary infection and those with re-infection of SARS-CoV-2.

Methods: A retrospective data analysis was conducted involving patients diagnosed with coronavirus disease 2019 between April 1, 2023, and June 20, 2023.

The efficacy and safety of first-line monotherapies in primary therapy of invasive aspergillosis: a systematic review.

Objective: Several antifungals are available for the treatment of patients with invasive aspergillosis (IA). This study aims to evaluate the relative efficacy and safety of the first-line monotherapies in primary therapy of IA through network meta-analysis (NMA).

Methods: We systematically searched PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, VIP database, Wanfang database, and China Biology Medicine for randomized controlled trials (RCTs) up to July 2023 that evaluated the efficacy and safety of monotherapies.

L-Aspartic Acid with Dual Functions: An Eco-Friendly and Affordable Choice to Accelerate High Salinity Brine Utilization.

L-Aspartic acid (L-Asp) poses a dual function, which can affect the evaporation and crystallization process of the high-salinity brine by altering the physical or chemical properties of the salts. MSWI (municipal solid waste incineration) fly ash washing leachate, as a typical high-salinity brine, is utilized here to validate this hypothesis under the simulation guidance. Since L-Asp has stronger adsorption energy on the (110) crystal face of CaCO, L-Asp can facilitate the preferential growth of more valuable vaterite during the softening process (pretreatment before crystallization).

Rapid electrothermal upcycling hexachlorobutadiene (HCBD) polluted distillation residue into turbostratic graphene for enhanced electromagnetic wave absorption.

The trichloroethylene production industry generates high-boiling-point solid residues during rectification, which contain high concentrations of chlorinated contaminants, particularly hexachlorobutadiene (HCBD). Traditionally, these distillation residues are managed through co-incineration or landfilling, leading to environmental and economic challenges. In this study, we present a rapid and environmentally friendly electrothermal approach for both detoxifying and upcycling distillation residue into graphene-based electromagnetic wave (EMW) absorbing materials.

Comparison of the clinicopathological characteristics of children with anti-neutrophil cytoplasmic antibody-associated vasculitis with/without infection at diagnosis.

Background: Infectious episodes contribute to morbidity and mortality in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Renal involvement, also known as ANCA-associated glomerulonephritis (AGN), is frequently observed in AAV. Little is known about whether co-infection at initial diagnosis is associated with renal outcome and prognosis in children with AGN.