The isolation of a novel Streptomyces zaomyceticus and its effects on disease resistance of Ctenopharyngodon idellus.

This research has identified Streptomyces zaomyceticus S1-6 as a promising probiotic candidate exhibiting broad-spectrum antibacterial properties against nine prevalent fish pathogens. Toxicity assessments conducted using liver cells from grass carp (Ctenopharyngodon idella) and subsequent feeding trials demonstrated that S1-6 is both safe and non-cytotoxic. After a 30-day feeding period, S1-6 significantly enhanced growth performance relative to the control group (P < 0.

Case Report: Congenital candidemia due to non- species-A report of two cases and literature review.

Congenital candidiasis caused by non- (NAC) species represents a life-threatening condition with significant underreporting in clinical literature. It mainly manifests as systemic invasive candidiasis. Premature infants are affected more easily due to the immaturity of their immune system.

Electrohydrodynamically-printed Serpentine Fiber Scaffolds with Enhanced Conductivity and Elasticity for Post-Myocardial Infarction Repair.

Myocardial infarction remains a leading threat to cardiovascular health, with electrical conduction abnormalities in the infarcted myocardium significantly exacerbating cardiac dysfunction. Enhancing the conductive microenvironment in the infarcted region is essential for promoting myocardial repair. In this study, we developed gold-coated serpentine microfiber-based cardiac scaffolds using electrohydrodynamic printing, which mimicked the intricate architecture of the myocardial tissue's fibrous membrane and allowed for up to 20 % elastic deformation, similar to the maximum strain of the natural heart.

Micro/Nanofibrous Polycaprolactone Scaffolds Loaded with Gentamicin for Improved Antimicrobial Activities under Seawater Immersion.

Marine open traumatic brain injuries (oTBI) face high infection risks due to seawater-borne pathogens, demanding dura scaffolds with dual antibacterial and osteogenic functions under seawater immersion. Conventional scaffolds lack this dual capacity. Here, a biomimetic triple-layer polycaprolactone (PCL)-based scaffold is developed.

Environmental and Historical Determinants of African Horse Sickness: Insights from Predictive Modeling.

African horse sickness (AHS) is a viral disease transmitted by arthropods that impacts Equidae, specifically horses and related species. Recognized as a notifiable disease by the World Organisation for Animal Health (WOAH), AHS is associated with a high mortality rate of 80%-90% in susceptible hosts and exhibits rapid transmission dynamics. Historical records document numerous instances of mass horse deaths attributed to AHS, with recent occurrences in Thailand and Malaysia in 2020 causing heightened concerns within the local horse industry.

Synthesis of two new polyoxometalate-based organic complexes from 2D to 3D structures for improving supercapacitor performance.

As an emerging energy-storage technology, research on supercapacitors is vital for advancing new energy applications, which rely on the development of electrode materials with superior properties. In this study, two novel polyoxometalate-based metal-organic complexes (POMOCs), Ag(imbta)(PMoMoO) (PMo-Ag-imbta, 1) (imbta = 1-imidazole-1-methylene-1-benzotriazole) and Ag(pybta)(PMoMoO)(PMo-Ag-pybta, 2) (pybta = 1-pyridine-3-methylene-1-benzotriazole), were synthesized a hydrothermal method utilizing Ag, imbta/pybta and [PMoO], respectively. In 1, Ag, imbta, and [PMoO] form 2D layers coordination bonds.

Lactate-induced protein lactylation in cancer: functions, biomarkers and immunotherapy strategies.

Lactate, long viewed as a byproduct of glycolysis and metabolic waste. Initially identified within the context of yogurt fermentation, lactate's role extends beyond culinary applications to its significance in biochemical processes. Contemporary research reveals that lactate functions not merely as the terminal product of glycolysis but also as a nexus for initiating physiological and pathological responses within the body.

Differentiation of Early Sacroiliitis Using Machine-Learning- Supported Texture Analysis.

We wished to compare the diagnostic performance of texture analysis (TA) against that of a visual qualitative assessment in identifying early sacroiliitis (nr-axSpA). A total of 92 participants were retrospectively included at our university hospital institution, comprising 30 controls and 62 patients with axSpA, including 32 with nr-axSpA and 30 with r-axSpA, who underwent MR examination of the sacroiliac joints. MRI at 3T of the lumbar spine and the sacroiliac joint was performed using oblique T1-weighted (W), fluid-sensitive, fat-saturated (Fs) T2WI images.

Blockade of PVN neuromedin B receptor alleviates inflammation via the RAS/ROS/NF-κB pathway in spontaneously hypertensive rats.

Neuromedin B (NMB) has potentially great impacts on the development of cardiovascular diseases by promoting hypertensive and sympatho-excitation effects. However, studies regarding the NMB function in paraventricular nucleus (PVN) are lacking. With selective neuromedin B receptor (NMBR) antagonist, BIM-23127, we aim to determine whether the blockade of NMB function in PVN could alleviate central inflammation and attenuate hypertensive responses.

Interaction between coronaviruses and the autophagic response.

In recent years, the emergence and widespread dissemination of the coronavirus SARS-CoV-2 has posed a significant threat to global public health and social development. In order to safely and effectively prevent and control the spread of coronavirus diseases, a profound understanding of virus-host interactions is paramount. Cellular autophagy, a process that safeguards cells by maintaining cellular homeostasis under diverse stress conditions.

Neural functions vary by return-to-sport status in participants with anterior cruciate ligament reconstruction: a retrospective cohort study using sub-bands of resting-state functional magnetic resonance.

Objective: This study aimed to characterize the differences in neural function among patients with different functional abilities 2 years after anterior cruciate ligament reconstruction (ACLR).

Design: Resting-state functional magnetic resonance imaging was performed to obtain blood-oxygen-level-dependent values for ACLR returned to sports coper participants (CP), non-coper participants (NP), and healthy controls (HC). The amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) calculated changes in the standard frequency band (SFB) (0.

Application of CAR-T cell therapy in B-cell lymphoma: a meta-analysis of randomized controlled trials.

Background: This study aims to compare the efficacy and safety of chimeric antigen receptor T-cell (CAR-T) immunotherapy with standard treatment for B-cell lymphoma, providing evidence-based support for the more efficient use of CAR-T cell immunotherapy.

Methods: We conducted a comprehensive literature search of high-quality randomized controlled trials (RCTs) on CAR-T therapy for B-cell lymphoma in the following databases: Wanfang, Web of Science, CNKI, VIP database, and PubMed, up to February 2024. The outcome measures included objective remission rate (ORR), complete remission rate (CRR), and incidence of adverse reactions.

The emerging role of BLyS/APRIL in autoimmune diseases: Biological characteristics, functions, and therapeutic potential.

Autoimmune diseases (AIDs) are common diseases in the world. Some cases are difficult to cure and can only delay the progression of the diseases. The B lymphocyte stimulator (BLyS)/a proliferation-inducing ligand (APRIL) plays an important role in B cell homeostasis, regulation of both innate and adaptive immune responses.

Inhibition of CB1R in the Hypothalamic Paraventricular Nucleus Ameliorates Hypertension Through Wnt/β-Catenin/RAS Pathway.

The hypothalamic paraventricular nucleus (PVN), as an important integrating center, plays a prominent role in the pathogenesis of hypertension, in maintaining the stability of cardiovascular activity through peripheral sympathetic nervous activity and secretion of various humoral factors. Acknowledging that the mechanistic targets of the endocannabinoid type 1 receptor (CB1R) are the key signaling systems involved in the regulation of hypertension, we sought to clarify whether inhibition of CB1R within the PVN ameliorates hypertension through Wnt/β-catenin/RAS pathway. Spontaneously hypertensive rats (SHRs) and Wistar Kyoto rats were randomly assigned to different groups and treated with bilateral PVN injections of AM251 (CB1R antagonist, 10 µg/h) or vehicle (artificial cerebrospinal fluid, aCSF) for four weeks.

m6Am Methyltransferase PCIF1 Promotes LPP3 Mediated Phosphatidic Acid Metabolism and Renal Cell Carcinoma Progression.

N6-methyl-2'-O-methyladenosine (m6Am), occurring adjacent to the 7-methylguanosine (m7G) cap structure and catalyzed by the newly identified writer PCIF1 (phosphorylated CTD interacting factor 1), has been implicated in the pathogenesis of various diseases. However, its involvement in renal cell carcinoma (RCC) remains unexplored. Here, significant upregulation of PCIF1 and m6Am levels in RCC tissues are identified, unveiling their oncogenic roles both in vitro and in vivo.

Effects of Bony Pelvic and Prostate Dimensions on Surgical Difficulty of Robot-Assisted Radical Prostatectomy: An Original Study and Meta-analysis.

Background: Due to the deep location of the prostate within the pelvic cavity, procedures of robot-assisted radical prostatectomy (RARP) might be challenged by the prostate size and the limited pelvic cavity space. This study aimed to investigate the roles of bony pelvic and prostate dimensions in RARP procedures by an original study coupled with a meta-analysis.

Methods: In the original study, patients undergoing multiport RARP between 2021 and 2022 were consecutively assessed.

Mechanistic insight into near-infrared light-driven CuO/WO Ohmic contact photothermal catalysts for high-efficiency antibiotic wastewater purification.

Near-infrared (NIR) light-induced photothermal effect is beneficial for accelerating catalytic processes; thus, it is imperative to develop novel photothermal catalysts for promoting practical application. Herein, we synthesized NIR-responsive CuO/WO Ohmic contact photothermal catalysts through a facile ethylene glycol-assisted liquid-phase reduction method. In this photothermal catalyst, a new-type NIR-responsive CuO semiconductor is integrated with an NIR-responsive WO semimetal component to form an Ohmic contact, which is more beneficial for simultaneously promoting photocharge separation and enhancing NIR light absorption for a high-efficiency photothermal effect.

Capsaicin pretreatment attenuates salt-sensitive hypertension by alleviating AMPK/Akt/Nrf2 pathway in hypothalamic paraventricular nucleus.

Background: Long term hypertension seriously promotes target organ damage in the brain and heart, and has increasingly become serious public health problem worldwide. The anti-hypertensive effects of capsaicin has been reported, however, the role and mechanism of capsaicin within the brain on salt-induced hypertension have yet to be elucidated. This study aimed to verify the hypothesis that capsaicin attenuates salt-induced hypertension via the AMPK/Akt/Nrf2 pathway in hypothalamic paraventricular nucleus (PVN).

Testis-Specific Protein, Y-Encoded-Like 2 Activates JAK2/STAT3 Pathway in Hypothalamic Paraventricular Nucleus to Sustain Hypertension.

Background: In the hypothalamic paraventricular nucleus (PVN) of spontaneously hypertensive rats (SHRs), the expression of the testis-specific protein, Y-encoded-like 2 (TSPYL2) and the phosphorylation level of Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) are higher comparing with the normotensive Wistar Kyoto rats (WKY). But how they are involved in hypertension remains unclear. TSPYL2 may interact with JAK2/STAT3 in PVN to sustain high blood pressure during hypertension.

Restoration of CD3CD56 NKT-like cell function by TIGIT blockade in inactive carrier and immune tolerant patients of chronic hepatitis B virus infection.

Chronic hepatitis B (CHB) virus infection, which can be divided into immune-tolerant (IT), immune-active (IA), inactive carrier (IC) phases, and HBeAg-negative hepatitis (ENEG), can induce liver cirrhosis and eventually hepatocellular carcinoma (HCC). CD3CD56 NKT-like cells play an important role in antiviral immune response. However, the mechanism of NKT-like cells to mediate immune tolerance remains largely elusive.

Grassland productivity in arid Central Asia depends on the greening rate rather than the growing season length.

Climate change has induced substantial impact on the gross primary productivity (GPP) of terrestrial ecosystems by affecting vegetation phenology. Nevertheless, it remains unclear which among the mean rates of grass greening (RG), yellowing (RY), and the length of growing season (LOS) exhibit stronger explanatory power for GPP variations, and how RG and RY affect GPP variations under warming scenarios. Here, we explored the relationship between RG, RY, LOS, and GPP in arid Central Asia (ACA) from 1982 to 2019, elucidating the response mechanisms of RG, RY, and GPP to the mean temperature (TMP), vapor pressure deficit (VPD), precipitation (PRE), and soil moisture (SM).