Decoding the healing secrets of Gegenqinlian decoction: A promising approach to radiation-induced intestinal injury.

Ethnopharmacological Relevance: Gegenqinlian Decoction (GQD), a Traditional Chinese Medicine formula comprising Pueraria lobata(Willd.)Ohwi, Scutellaria baicalensis Georgi, Coptis teeta Wall. and Glycyrrhiza uralensis Fisch.

Inhibition of FAK promotes pancreatic cancer immunotherapy by mediating CXCL10 secretion to enhance CD8 T cell infiltration.

Immunotherapy has demonstrated potential in treating various malignant tumors, but its efficacy in pancreatic cancer (PC) remains limited, possibly due to the dense stromal components and immunosuppressive microenvironment of PC. Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, plays a crucial role in the tumor microenvironment and intracellular signaling pathways. However, the specific role of FAK in the development and progression of PC, as well as its regulatory mechanisms on the tumor immune microenvironment (TIM), are still not fully understood.

Aldolase A accelerates hepatocarcinogenesis by refactoring c-Jun transcription.

Hepatocellular carcinoma (HCC) expresses abundant glycolytic enzymes and displays comprehensive glucose metabolism reprogramming. Aldolase A (ALDOA) plays a prominent role in glycolysis; however, little is known about its role in HCC development. In the present study, we aim to explore how ALDOA is involved in HCC proliferation.

A Multicenter Comparative Study on Two Techniques for Creating Multifenestrated Physician-Modified Stent Grafts in the Treatment of Aortic Arch Pathologies.

Objective: Physician-modified stent grafts (PMEGs) are widely used to treat complex pathologies in the aortic arch, but featured by varied preparation methods. This study was conducted to investigate the differences in operative characteristics and postoperative outcomes of PMEGs prepared using 2 methods: 3D printed models (Group A) and traditional measurement (Group B).

Methods: This retrospective study included 201 patients treated with multiple fenestrated/branched endovascular repair in the aortic arch at 3 vascular centers in China.

Construction of Metal-NO Sites on Poly(ionic liquid) for Highly Efficient Electrocatalytic CO Reduction.

In this study, atomically dispersed metal catalysts of Salen-PIL(M) (M = Zn and Cu) for electrochemical CO-to-C conversion were fabricated by polymerization of a vinyl-decorated ionic liquid (IL) monomer bearing a Salen-M moiety with -diethylbenzene. The characterization results indicated that the Salen-Zn/Cu complex was atomically dispersed in the PIL skeleton. They differed significantly in the electron transfer speed to CO, CO affinity, and HO activation, which influenced both the activity and selectivity toward CO or CH.

A Retrospective Multicenter Clinical Trial of Venastent for Patients with Iliac Vein Compression Syndrome.

Background: This study aimed to evaluate the safety and efficacy of Venastent for the patients with iliac vein compression syndrome (IVCS).

Methods: A multicenter retrospective clinical trial enrolling 199 IVCS patients was conducted by the department of vascular surgery of 3 hospitals from October 2021 to January 2023. Among them, 91 were treated with a new type of iliac vein stent and defined as the experimental group, and 108 cases in the control group were using Zilver Vena venous stent (Cook Medical).

Advances in the diagnosis and treatment of primary deep venous valve insufficiency.

Primary deep venous valve insufficiency (PDVVI) is a common lower extremity venous disease in vascular surgery, distinguished from simple lower extremity varicose veins and lower extremity thrombotic diseases, and requires clinical management as a separate disease. Surgical procedures alone in the superficial venous system cannot completely correct valve reflux and venous hypertension and require surgical valve repair. In addition, the development of non-autologous prosthetic valve transplantation provides a new breakthrough point.

Role of disturbance coefficient in monitoring and treatment of cerebral edema in patients with cerebral hemorrhage.

Background: At present, the conventional methods for diagnosing cerebral edema in clinical practice are computed tomography (CT) and magnetic resonance imaging (MRI), which can evaluate the location and degree of peripheral cerebral edema, but cannot realize quantification. When patients have symptoms of diffuse cerebral edema or high cranial pressure, CT or MRI often suggests that cerebral edema is lagging and cannot be dynamically monitored in real time. Intracranial pressure monitoring is the gold standard, but it is an invasive operation with high cost and complications.

Structural characterization of a polysaccharide from Qi-Gui herb pair and its anti-tumor activity in colon cancer cells.

(Fisch.) Bunge and (Oliv.) Diels forms a classic herb pair (Qi-Gui her pair) in Chinese medicine, which was commonly used for treating menstrual anemia and microvascular ischemic diseases.

Explore the key targets and mechanism of Danggui Buxue decoction against ulcerative colitis: Network pharmacology and experimental validation.

Ethnopharmacological Relevance: The traditional Chinese herbal formula, Danggui Buxue decoction (DBD), is known for its ability in tonifying Qi and promoting the production of blood. It is extensively utilized in treating menstrual anemia and chronic non-healing ulcers. Whereas the impact of DBD on ulcerative colitis (UC) has not been explored, and its therapeutic mechanisms are not well comprehended.

The structures of two polysaccharides from Fructus Corni and their protective effect on insulin resistance.

Type 2 diabetes mellitus (T2DM) is characterized by impaired cellular or organ responsiveness to insulin, which results in ineffective glucose disposal and lacks a definitive treatment. Previous studies suggest that polysaccharides hold promise as natural agents for the prevention and treatment of T2DM. In this study, we identified two polysaccharides from Fructus Corni, PFC-CI and PFC-CII, with molecular weights of 59.

Structure characteristics of a novel pectic polysaccharide from Fructus Corni and its protective effect on alcoholic fatty liver.

Alcoholic fatty liver disease (AFLD) is characterized by the accumulation of hepatic lipid and has no effective treatment yet. Fructus Corni is a traditional Chinese medicinal herb, and its extractions have demonstrated hepatoprotective properties. We hypothesize that the polysaccharides in Fructus Corni might have therapeutic effects on AFLD.

Pathological diagnosis and clinical feature analysis of descending duodenal mucosal adenocarcinoma: A case report.

Background: Mucosal adenocarcinoma of the descending duodenum is a very rare gastrointestinal tumor. Due to its low incidence, it has rarely been the focus of clinical and pathological studies. The clinical manifestations of these tumors are usually nonspecific, and they are easily misdiagnosed or missed.

Transient receptor potential channels in viral infectious diseases: Biological characteristics and regulatory mechanisms.

Background: Viral infectious diseases have long posed a challenge to humanity. In recent decades, transient receptor potential (TRP) channels have emerged as newly investigated cation channels. Increasing evidence suggests that TRP channel-mediated Ca homeostasis disruptions, along with associated pathological changes, are critical factors in the onset and progression of viral infectious diseases.

The structural features and anti-inflammatory properties of a glucogalactan from Holotrichia diomphalia Bates (Qi Cao).

Ethnopharmacological Relevance: The dried larvae of Holotrichia diomphalia Bates, named Qi Cao, is a traditional Chinese medicine treat for liver diseases and arthritis. Polysaccharides is a principal component in Qi Cao, which exhibiting antioxidant and anti-inflammatory effects. However, the structural characteristics and underlying mechanisms of the polysaccharides remain inadequately elucidated.

Viral myocarditis: From molecular mechanisms to therapeutic prospects.

Myocarditis is characterized as local or diffuse inflammatory lesions in the myocardium, primarily caused by viruses and other infections. It is a common cause of sudden cardiac death and dilated cardiomyopathy. In recent years, the global prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the widespread vaccination have coincided with a notable increase in the number of reported cases of myocarditis.

The role of m6A in angiogenesis and vascular diseases.

Angiogenesis, whether physiological or pathological, plays a pivotal role in various physiological and disease conditions. This intricate process relies on a complex and meticulously orchestrated signal transduction network that connects endothelial cells, their associated parietal cells (VSMCs and pericytes), and various other cell types, including immune cells. Given the significance of m6A and its connection to angiogenesis and vascular disease, researchers must adopt a comprehensive and ongoing approach to their investigations.

Stabilizing High-Valence Copper(I) Sites with Cu-Ni Interfaces Enhances Electroreduction of CO to C Products.

In this study, the copper-nickel (Cu-Ni) bimetallic electrocatalysts for electrochemical CO reduction reaction(CORR) are fabricated by taking the finely designed poly(ionic liquids) (PIL) containing abundant Salen and imidazolium chelating sites as the surficial layer, wherein Cu-Ni, PIL-Cu and PIL-Ni interaction can be readily regulated by different synthetic scheme. As a proof of concept, Cu@Salen-PIL@Ni(NO) and Cu@Salen-PIL(Ni) hybrids differ significantly in the types and distribution of Ni species and Cu species at the surface, thereby delivering distinct Cu-Ni cooperation fashion for the CORR. Remarkably, Cu@Salen-PIL@Ni(NO) provides a C2+ faradaic efficiency (FE) of 80.

A novel glycoglycerolipid from Holotrichia diomphalia Bates: Structure characteristics and protective effect against DNA damage.

A lipidated polysaccharide, HDPS-2II, was isolated from the dried larva of Holotrichia diomphalia, which is used in traditional Chinese medicine. The molecular weight of HDPS-2II was 5.9 kDa, which contained a polysaccharide backbone of →4)-β-Manp-(1 → 4,6)-β-Manp-(1 → [6)-α-Glcp-(1] → 6)-α-Glcp→ with the side chain α-Glcp-(6 → 1)-α-Glcp-(6 → linked to the C-4 of β-1,4,6-Manp and four types of lipid chains including 4-(4-methyl-2-(methylamino)pentanamido)pentanoic acid, 5-(3-(tert-butyl)phenoxy)hexan-2-ol, N-(3-methyl-5-oxopentan-2-yl)palmitamide, and N-(5-amino-3-methyl-5-oxopentan-2-yl)stearamide.

Controlling the nutritional status score: a new tool for predicting postoperative mortality in patients with infrarenal abdominal aortic aneurysm treated with endovascular aneurysm repair.

Background: AAA is a fatal condition that commonly occurs during vascular surgery. Nutritional status exerts a significant influence on the prognosis of various pathological conditions Scores from the CONUT screening tool have been shown to predict outcomes of certain malignancies and chronic diseases. However, the ramifications of nutritional status on AAA patients undergoing EVAR have not been elucidated in prior studies.

Pathological diagnosis and immunohistochemical analysis of giant retrosternal goiter in the elderly: A case report.

Background: Elderly giant retrosternal thyroid goiter is a rare yet significant medical condition, often presenting clinical symptoms that can be confused with other diseases, posing diagnostic and therapeutic challenges. This study aims to delve into the characteristics and potential mechanisms of this ailment through pathological diagnosis and immunohistochemical analysis, providing clinicians with more precise diagnostic and treatment strategies.

Case Summary: A 77-year-old male, was admitted to hospital with the chief complaint of finding a goiter in the semilunar month during physical examination, accompanied by dyspnea.

Clinical Outcomes at 3 Years After Stenting for Thrombotic and Non-thrombotic Iliac Vein Compression Syndrome Patients.

Iliac vein stenting for the treatment of iliac vein compression syndrome (IVCS) has been gradually developed. This article investigated the long-term patency and improvement of clinical symptoms after endovascular stenting for iliac vein obstruction patients. From 2020 to 2022, 83 patients at a single institution with IVCS underwent venous stent implantation and were divided into two groups: non-thrombotic IVCS ( = 55) and thrombotic IVCS ( = 28).

Canonical transient receptor potential channel 1 aggravates myocardial ischemia-and-reperfusion injury by upregulating reactive oxygen species.

The canonical transient receptor potential channel (TRPC) proteins form Ca-permeable cation channels that are involved in various heart diseases. However, the roles of specific TRPC proteins in myocardial ischemia/reperfusion (I/R) injury remain poorly understood. We observed that TRPC1 and TRPC6 were highly expressed in the area at risk (AAR) in a coronary artery ligation induced I/R model.